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WO2003035677A3 - Antimicrobial peptides from the venom of the spider cupiennius salei - Google Patents

Antimicrobial peptides from the venom of the spider cupiennius salei Download PDF

Info

Publication number
WO2003035677A3
WO2003035677A3 PCT/EP2002/009174 EP0209174W WO03035677A3 WO 2003035677 A3 WO2003035677 A3 WO 2003035677A3 EP 0209174 W EP0209174 W EP 0209174W WO 03035677 A3 WO03035677 A3 WO 03035677A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
salei
cupiennius
venom
spider
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/009174
Other languages
French (fr)
Other versions
WO2003035677A2 (en
Inventor
Johann Schaller
Alfred Walz
Wolfgang Nentwig
Lucia Kuhn-Nentwig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Bern
Original Assignee
Universitaet Bern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Bern filed Critical Universitaet Bern
Priority to AU2002363081A priority Critical patent/AU2002363081A1/en
Publication of WO2003035677A2 publication Critical patent/WO2003035677A2/en
Publication of WO2003035677A3 publication Critical patent/WO2003035677A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Insects & Arthropods (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Agronomy & Crop Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to highly cationic peptides from a novel family of antimicrobial compounds designated cupiennins with an unique helical structure isolated from the venom of the hunting spider Cupiennius salei. Said peptides are characterized by having antimicrobial, cytotoxic and/or insecticidal activity. The invention further comprises nucleic acid molecules encoding the peptides, vectors and host cells containing said nucleic acid molecules; methods for producing the peptides; and pharmaceutical compositions comprising them.
PCT/EP2002/009174 2001-08-17 2002-08-16 Antimicrobial peptides from the venom of the spider cupiennius salei Ceased WO2003035677A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002363081A AU2002363081A1 (en) 2001-08-17 2002-08-16 Antimicrobial peptides from the venom of the spider cupiennius salei

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01810794 2001-08-17
EP01810794.6 2001-08-17

Publications (2)

Publication Number Publication Date
WO2003035677A2 WO2003035677A2 (en) 2003-05-01
WO2003035677A3 true WO2003035677A3 (en) 2003-12-04

Family

ID=8184094

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009174 Ceased WO2003035677A2 (en) 2001-08-17 2002-08-16 Antimicrobial peptides from the venom of the spider cupiennius salei

Country Status (2)

Country Link
AU (1) AU2002363081A1 (en)
WO (1) WO2003035677A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101065131B (en) * 2004-09-27 2012-10-24 技术研究及发展基金有限公司 Antimicrobial agents
US7915223B2 (en) 2004-09-27 2011-03-29 Technion Research & Development Foundation Ltd. Antimicrobial agents
US8470770B2 (en) 2007-04-30 2013-06-25 Technion Research & Development Foundation Ltd. Antimicrobial agents

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"HOMOLOGY IN PROTEINS AND NUCLEIC ACIDS: A TERMINOLOGY MUDDLE AND A WAY OUT OF IT", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 50, 1987, pages 667, XP002913075, ISSN: 0092-8674 *
DATABASE SWALL [online] XP002234036, retrieved from EBI Database accession no. Q9BMY8 *
FROHLICH D R ET AL: "PEPTIDE AMPHIPATHY A NEW STRATEGY IN DESIGN OF POTENTIAL INSECTICIDES", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, vol. 37, no. 1, 1991, pages 2 - 6, XP009007035, ISSN: 0367-8377 *
HAEBERLI S ET AL: "Characterisation of antibacterial activity of peptides isolated from the venom of the spider Cupiennius salei (Araneae: Ctenidae).", TOXICON: OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY ON TOXINOLOGY. ENGLAND MAR 2000, vol. 38, no. 3, March 2000 (2000-03-01), pages 373 - 380, XP002234034, ISSN: 0041-0101 *
KARNOUP A S: "SIZE-EXCLUSION CHROMATOGRAPHY OF PROTECTED SYNTHETIC POLYPEPTIDE TANDEMS IN AN ORGANIC SOLVENT", JOURNAL OF PEPTIDE RESEARCH, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 49, no. 3, 1 March 1997 (1997-03-01), pages 232 - 239, XP000686233, ISSN: 1397-002X *
KUHN-NENTWIG LUCIA ET AL: "Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 13, 29 March 2002 (2002-03-29), March 29, 2002, pages 11208 - 11216, XP002234035, ISSN: 0021-9258 *
MEDVEDKIN VYACHESLAV N ET AL: "Interactions of (Ala*Ala*Lys*Pro)-n and (Lys*Lys*Ser*Pro)-n with DNA. Proposed coiled-coil structure of AlgR3 and AlgP from Pseudomonas aeruginosa.", PROTEIN ENGINEERING, vol. 8, no. 1, 1995, pages 63 - 70, XP009007036, ISSN: 0269-2139 *

Also Published As

Publication number Publication date
AU2002363081A1 (en) 2003-05-06
WO2003035677A2 (en) 2003-05-01

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