WO2003035645A1 - Nouvelles 4-(2-furoyl)aminopiperidines, intermediaires utilises dans la synthese de ces dernieres, leur procede de production et leur utilisation medicale - Google Patents

Nouvelles 4-(2-furoyl)aminopiperidines, intermediaires utilises dans la synthese de ces dernieres, leur procede de production et leur utilisation medicale Download PDF

Info

Publication number: WO2003035645A1
Authority: WO; WIPO (PCT)
Prior art keywords: same; furoyl; aminopiperidines; intermediates; synthesizing
Prior art date: 2001-10-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

PCT/JP2002/010449

Other languages

English (en)

French (fr)

Inventor

Ryuuta Fukutomi

Hitoshi Inoue

Koji Kawamura

Takuya Kishimoto

Masashi Suzuki

Rie Shibayama

Kazuko Kojima

Kouichirou Hagihara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kyorin Pharmaceutical Co Ltd

Nisshin Pharma Inc

Original Assignee

Kyorin Pharmaceutical Co Ltd

Nisshin Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-09

Filing date

2002-10-08

Publication date

2003-05-01

2002-10-08 Priority to KR1020047005180A priority Critical patent/KR100938369B1/ko

2002-10-08 Priority to DK02772984T priority patent/DK1443046T3/da

2002-10-08 Priority to MXPA04003330A priority patent/MXPA04003330A/es

2002-10-08 Priority to BR0213186-2A priority patent/BR0213186A/pt

2002-10-08 Priority to JP2003538161A priority patent/JP4009251B2/ja

2002-10-08 Priority to EP02772984A priority patent/EP1443046B1/en

2002-10-08 Application filed by Kyorin Pharmaceutical Co Ltd, Nisshin Pharma Inc filed Critical Kyorin Pharmaceutical Co Ltd

2002-10-08 Priority to CA2468529A priority patent/CA2468529C/en

2002-10-08 Priority to US10/492,065 priority patent/US7375115B2/en

2002-10-08 Priority to DE60230437T priority patent/DE60230437D1/de

2003-05-01 Publication of WO2003035645A1 publication Critical patent/WO2003035645A1/ja

2004-04-09 Anticipated expiration legal-status Critical

2008-03-20 Priority to US12/077,687 priority patent/US20080194826A1/en

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PCT/JP2002/010449 2001-10-09 2002-10-08 Nouvelles 4-(2-furoyl)aminopiperidines, intermediaires utilises dans la synthese de ces dernieres, leur procede de production et leur utilisation medicale Ceased WO2003035645A1 (fr)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
CA2468529A CA2468529C (en)	2001-10-09	2002-10-08	4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
DK02772984T DK1443046T3 (da)	2001-10-09	2002-10-08	Nye 4-(2-furoyl)-amino-piperidiner, mellemprodukter til deres syntese, fremgangsmåde til deres fremstilling og deres medicinske anvendelse
MXPA04003330A MXPA04003330A (es)	2001-10-09	2002-10-08	4-(2-furoil) aminopiperidinas novedosas, compuestos intermedios en la sintesis de las mismas, proceso para producirlas y su uso medicinal.
BR0213186-2A BR0213186A (pt)	2001-10-09	2002-10-08	4-(2-furoil)aminopiperidinas, intermediários na sìntese dos mesmos, processo para produzir os mesmos e uso medicinal dos mesmos
JP2003538161A JP4009251B2 (ja)	2001-10-09	2002-10-08	新規な４−（２−フロイル）アミノピペリジン、その合成中間体、その製造方法および医薬としてのその用途
KR1020047005180A KR100938369B1 (ko)	2001-10-09	2002-10-08	신규 4-(2-푸로일)아미노피페리딘, 그의 합성 중간체,그의 제조방법 및 의약으로서의 그의 용도
DE60230437T DE60230437D1 (de)	2001-10-09	2002-10-08	Neue 4-(2-furoyl)-amino-piperidine, zwischenprodukte für deren synthese, verfahren zu deren herstellung und deren medizinische verwendung
EP02772984A EP1443046B1 (en)	2001-10-09	2002-10-08	Novel 4-(2furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
US10/492,065 US7375115B2 (en)	2001-10-09	2002-10-08	4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
US12/077,687 US20080194826A1 (en)	2001-10-09	2008-03-20	Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001/311828		2001-10-09
JP2001311828		2001-10-09

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
US12/077,687 Division US20080194826A1 (en)	2001-10-09	2008-03-20	Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same

Publications (1)

Publication Number	Publication Date
WO2003035645A1 true WO2003035645A1 (fr)	2003-05-01

Family

ID=19130581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2002/010449 Ceased WO2003035645A1 (fr)	2001-10-09	2002-10-08	Nouvelles 4-(2-furoyl)aminopiperidines, intermediaires utilises dans la synthese de ces dernieres, leur procede de production et leur utilisation medicale

Country Status (14)

Country	Link
US (2)	US7375115B2 (ja)
EP (1)	EP1443046B1 (ja)
JP (1)	JP4009251B2 (ja)
KR (1)	KR100938369B1 (ja)
CN (1)	CN1326853C (ja)
AT (1)	ATE417845T1 (ja)
BR (1)	BR0213186A (ja)
CA (1)	CA2468529C (ja)
DE (1)	DE60230437D1 (ja)
DK (1)	DK1443046T3 (ja)
ES (1)	ES2319879T3 (ja)
MX (1)	MXPA04003330A (ja)
PT (1)	PT1443046E (ja)
WO (1)	WO2003035645A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004099194A1 (ja) *	2003-05-08	2004-11-18	Kyorin Pharmaceutical Co. Ltd.	掻痒治療薬として有用な４－（２－フロイル）アミノピペリジン類
JP2004352714A (ja) *	2003-05-08	2004-12-16	Kyorin Pharmaceut Co Ltd	新規な４−（２−フロイル）アミノピペリジン誘導体
JP2007308406A (ja) *	2006-05-17	2007-11-29	Nisshin Kyorin Pharmaceutical Co Ltd	［１−［２−［４−［ｎ−（５−メチルピリジン−２−イル）−２−フランカルボキサミド］ピペリジン−１−イル］エチル］シクロヘキシル］アセトヒドロキサム酸の製造方法及び精製方法
EP1622613A4 (en) *	2003-05-14	2008-04-02	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
JP2010525013A (ja) *	2007-04-23	2010-07-22	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
WO2011030537A1 (ja) *	2009-09-08	2011-03-17	杏林製薬株式会社	４－（５－メチルピリジン－２－イルアミノ）ピペリジン－１－カルボン酸誘導体の製造方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JO2769B1 (en)	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
KR20080073359A (ko) *	2005-12-01	2008-08-08	엘란 파마슈티칼스, 인크.	5(아릴설포닐)피라졸로피페리딘
MY145633A (en)	2006-03-01	2012-03-15	Theravance Inc	8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
JO2642B1 (en)	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en)	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
CA2682671C (en)	2007-04-23	2015-11-17	Janssen Pharmaceutica N.V.	Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
MX2009011415A (es)	2007-04-23	2009-11-05	Janssen Pharmaceutica Nv	Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion.
EP2310374B1 (en)	2008-07-03	2012-10-31	Janssen Pharmaceutica N.V.	Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists
EA019048B1 (ru)	2008-07-31	2013-12-30	Янссен Фармацевтика Нв	Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина
US8299079B2 (en)	2009-05-22	2012-10-30	Kaufman Herbert E	Preparations and methods for ameliorating or reducing presbyopia
US20100298335A1 (en) *	2009-05-22	2010-11-25	Kaufman Herbert E	Preparations and Methods for Ameliorating or Reducing Presbyopia
SG188996A1 (en) *	2010-09-20	2013-05-31	Kareus Therapeutics Sa	Methods and compositions for treatment of diabetes and dyslipidemia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0160422A1 (en) *	1984-04-09	1985-11-06	Anaquest, Inc.	N-Aryl-N-(4-Piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
EP0277794A2 (en) *	1987-02-02	1988-08-10	Ohmeda Pharmaceutical Products Division Inc.	N-heterocyclic-N-(4-piperidyl) amides
WO1994027967A1 (en) *	1993-05-26	1994-12-08	Smithkline Beecham Laboratoires Pharmaceutiques	Novel compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59112984A (ja) *	1982-12-21	1984-06-29	Shionogi & Co Ltd	１，４−ベンゾジアゼピン誘導体
US4912109A (en) *	1987-02-02	1990-03-27	Boc, Inc.	N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds

2002
- 2002-10-08 CA CA2468529A patent/CA2468529C/en not_active Expired - Fee Related
- 2002-10-08 KR KR1020047005180A patent/KR100938369B1/ko not_active Expired - Fee Related
- 2002-10-08 WO PCT/JP2002/010449 patent/WO2003035645A1/ja not_active Ceased
- 2002-10-08 DK DK02772984T patent/DK1443046T3/da active
- 2002-10-08 CN CNB028241568A patent/CN1326853C/zh not_active Expired - Fee Related
- 2002-10-08 US US10/492,065 patent/US7375115B2/en not_active Expired - Fee Related
- 2002-10-08 PT PT02772984T patent/PT1443046E/pt unknown
- 2002-10-08 DE DE60230437T patent/DE60230437D1/de not_active Expired - Lifetime
- 2002-10-08 MX MXPA04003330A patent/MXPA04003330A/es active IP Right Grant
- 2002-10-08 JP JP2003538161A patent/JP4009251B2/ja not_active Expired - Fee Related
- 2002-10-08 AT AT02772984T patent/ATE417845T1/de active
- 2002-10-08 BR BR0213186-2A patent/BR0213186A/pt not_active IP Right Cessation
- 2002-10-08 EP EP02772984A patent/EP1443046B1/en not_active Expired - Lifetime
- 2002-10-08 ES ES02772984T patent/ES2319879T3/es not_active Expired - Lifetime
2008
- 2008-03-20 US US12/077,687 patent/US20080194826A1/en not_active Abandoned

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0160422A1 (en) *	1984-04-09	1985-11-06	Anaquest, Inc.	N-Aryl-N-(4-Piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
EP0277794A2 (en) *	1987-02-02	1988-08-10	Ohmeda Pharmaceutical Products Division Inc.	N-heterocyclic-N-(4-piperidyl) amides
WO1994027967A1 (en) *	1993-05-26	1994-12-08	Smithkline Beecham Laboratoires Pharmaceutiques	Novel compounds

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004099194A1 (ja) *	2003-05-08	2004-11-18	Kyorin Pharmaceutical Co. Ltd.	掻痒治療薬として有用な４－（２－フロイル）アミノピペリジン類
JP2004352714A (ja) *	2003-05-08	2004-12-16	Kyorin Pharmaceut Co Ltd	新規な４−（２−フロイル）アミノピペリジン誘導体
EP1621538A4 (en) *	2003-05-08	2009-07-29	Kyorin Seiyaku Kk	4- (2-FUROYL) AMINOPIPERIDINE COMPOUND THAT IS SUITABLE AS A THERAPEUTIC AGENT AGAINST JUCKEN
US7601843B2 (en)	2003-05-08	2009-10-13	Kyorin Pharmaceutical Co., Ltd	4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching
EP2325183A1 (en)	2003-05-08	2011-05-25	Kyorin Pharmaceutical Co., Ltd.	4-(2-Furoyl) Aminopiperidine compound useful as therapeutic agent for itching
KR101160858B1 (ko) *	2003-05-08	2012-07-02	가부시끼가이샤 닛신 세이훈 그룹 혼샤	소양 치료약으로서 유용한 4-(2-푸로일)아미노피페리딘류
EP1622613A4 (en) *	2003-05-14	2008-04-02	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
JP2007308406A (ja) *	2006-05-17	2007-11-29	Nisshin Kyorin Pharmaceutical Co Ltd	［１−［２−［４−［ｎ−（５−メチルピリジン−２−イル）−２−フランカルボキサミド］ピペリジン−１−イル］エチル］シクロヘキシル］アセトヒドロキサム酸の製造方法及び精製方法
JP2010525013A (ja) *	2007-04-23	2010-07-22	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
WO2011030537A1 (ja) *	2009-09-08	2011-03-17	杏林製薬株式会社	４－（５－メチルピリジン－２－イルアミノ）ピペリジン－１－カルボン酸誘導体の製造方法
CN102498108A (zh) *	2009-09-08	2012-06-13	杏林制药株式会社	4-(5-甲基吡啶-2-基氨基)哌啶-1-甲酸衍生物的制造方法

Also Published As

Publication number	Publication date
EP1443046B1 (en)	2008-12-17
BR0213186A (pt)	2004-08-10
US7375115B2 (en)	2008-05-20
JPWO2003035645A1 (ja)	2005-02-10
ATE417845T1 (de)	2009-01-15
ES2319879T3 (es)	2009-05-14
EP1443046A4 (en)	2005-11-16
DE60230437D1 (de)	2009-01-29
US20080194826A1 (en)	2008-08-14
JP4009251B2 (ja)	2007-11-14
CA2468529A1 (en)	2003-05-01
KR20040039495A (ko)	2004-05-10
KR100938369B1 (ko)	2010-01-22
CN1582286A (zh)	2005-02-16
MXPA04003330A (es)	2004-07-08
PT1443046E (pt)	2009-02-26
CA2468529C (en)	2011-03-01
DK1443046T3 (da)	2009-04-14
EP1443046A1 (en)	2004-08-04
CN1326853C (zh)	2007-07-18
US20050085508A1 (en)	2005-04-21

Publication	Publication Date	Title
WO2003035645A1 (fr)	2003-05-01	Nouvelles 4-(2-furoyl)aminopiperidines, intermediaires utilises dans la synthese de ces dernieres, leur procede de production et leur utilisation medicale
HUT76476A (en)	1997-09-29	Morpholine and thiomorpholine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
CA2157117A1 (en)	1994-09-15	Spirocyclic Piperidine Derivatives
HK1046688A1 (zh)	2003-01-24	喹唑啉化合物和含有喹唑啉化合物的藥物組合物
GB0220581D0 (en)	2002-10-09	Organic Compound
NO178573C (no)	1996-04-24	Polycykliske aminforbindelser og deres enantiomere, mellomprodukter for fremstilling av dem og farmasöytiske blandinger inneholdende dem
CA2337825A1 (en)	2000-02-17	Disubstituted bicyclic heterocycles, the preparation thereof and their use as pharmaceutical compositions
EP1679069A4 (en)	2009-05-13	NEW PIPERIDINE DERIVATIVE
NO20005714D0 (no)	2000-11-13	Nye substituerte cykliske forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
KR950003275A (ko)	1995-02-16	1-벤젠술포닐-1, 3-디히드로-2h-벤즈이미다졸-2-온 유도체
AU4954793A (en)	1994-03-29	New aminoacid derivates, process for producing the same and pharmaceutical compositions containing these compounds
WO2002051819A3 (en)	2002-12-05	Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
AU8000594A (en)	1995-05-23	Novel 4-piperidinyl substituted lactames as neurokinin 2 receptor antagonists for the treatment of asthma
CA2395541A1 (en)	2001-07-12	New substituted piperidines, pharmaceutical compositions containing these compounds and processes for preparing them
YU30902A (sh)	2005-07-19	Novi ciklopropani kao cgrp antagonisti, lekovi koji sadrže navedena jedinjenja i postupak za njihovu proizvodnju
MY133445A (en)	2007-11-30	2-arylethyl-(piperidin-4-ylmethyl)amine derivetives
NO20052683L (no)	2005-06-03	Nye pyridopyrimidinonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
NO20016389L (no)	2002-02-21	Fremgangsmåte for fremstilling av substituerte cyklopentanderivater og nye krystallinske strukturer derav
CA2067758A1 (en)	1991-07-07	Piperidine and pyrrolidine derivatives
NO20002589L (no)	2000-07-19	Bifenylamidinderivater
WO1999062893A3 (de)	2000-03-09	Neue neurokininantagonisten, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
ATE402151T1 (de)	2008-08-15	2-(arylphenyl)amino-imidazolin-derivate
PL315052A1 (en)	1996-09-30	Condensed dihydropyridines, method of obtaining them, their application in producing pharmaceutic preparations and pharmaceutic preparations containing such compounds
NO960441D0 (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
WO1998053790A3 (en)	1999-03-04	Compounds that inhibit the binding of vascular endothelial growth factor to its receptors

Legal Events

Date	Code	Title	Description
2003-05-01	AK	Designated states	Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW
2003-05-01	AL	Designated countries for regional patents	Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
2003-07-02	121	Ep: the epo has been informed by wipo that ep was designated in this application
2003-07-31	DFPE	Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
2004-03-31	WWE	Wipo information: entry into national phase	Ref document number: 2003538161 Country of ref document: JP
2004-04-07	WWE	Wipo information: entry into national phase	Ref document number: PA/a/2004/003330 Country of ref document: MX
2004-04-08	WWE	Wipo information: entry into national phase	Ref document number: 1020047005180 Country of ref document: KR
2004-05-07	WWE	Wipo information: entry into national phase	Ref document number: 2002772984 Country of ref document: EP
2004-05-26	WWE	Wipo information: entry into national phase	Ref document number: 2468529 Country of ref document: CA
2004-06-02	WWE	Wipo information: entry into national phase	Ref document number: 20028241568 Country of ref document: CN
2004-08-04	WWP	Wipo information: published in national office	Ref document number: 2002772984 Country of ref document: EP
2004-10-20	WWE	Wipo information: entry into national phase	Ref document number: 10492065 Country of ref document: US