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WO2003034063A1 - Procede de criblage d'un medicament destine a la fibrillation atriale - Google Patents

Procede de criblage d'un medicament destine a la fibrillation atriale Download PDF

Info

Publication number
WO2003034063A1
WO2003034063A1 PCT/JP2002/010663 JP0210663W WO03034063A1 WO 2003034063 A1 WO2003034063 A1 WO 2003034063A1 JP 0210663 W JP0210663 W JP 0210663W WO 03034063 A1 WO03034063 A1 WO 03034063A1
Authority
WO
WIPO (PCT)
Prior art keywords
channel
atrial fibrillation
screening
regulators
confirming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/010663
Other languages
English (en)
Japanese (ja)
Inventor
Fumiaki Yamasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Publication of WO2003034063A1 publication Critical patent/WO2003034063A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un procédé de criblage d'une substance qui se lie à un canal Na activé mais qui est rapidement libérée lorsqu'un canal Na est inactivé ou stationnaire. Ledit procédé est caractérisé en ce qu'il consiste 1) en une étape visant à confirmer que pendant l'inhibition de l'utilisation-dépendance d'une substance d'essai sur un canal sodium, la vitesse d'expression est égale ou supérieure à 0,3 AP-1 ou la constante de récupération est égale ou inférieure à 1000 msec, et 2) ) en une étape visant à confirmer que la substance d'essai possède une affinité élevée pour un canal Na activé. L'invention concerne également des régulateurs de fibrillation atriale et des inhibiteurs de canaux Na contenant les substances précitées spécifiées. Ces substances utilisables dans des régulateurs de fibrillation atriale et analogues peuvent facilement être distinguées.
PCT/JP2002/010663 2001-10-16 2002-10-15 Procede de criblage d'un medicament destine a la fibrillation atriale Ceased WO2003034063A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001/318752 2001-10-16
JP2001318752A JP2005090957A (ja) 2001-10-16 2001-10-16 心房細動治療薬のスクリーニング方法

Publications (1)

Publication Number Publication Date
WO2003034063A1 true WO2003034063A1 (fr) 2003-04-24

Family

ID=19136399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/010663 Ceased WO2003034063A1 (fr) 2001-10-16 2002-10-15 Procede de criblage d'un medicament destine a la fibrillation atriale

Country Status (2)

Country Link
JP (1) JP2005090957A (fr)
WO (1) WO2003034063A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090247572A1 (en) * 2005-08-23 2009-10-01 Koichi Wada Agent for treating atrial fibrillation
WO2024257774A1 (fr) * 2023-06-15 2024-12-19 富士フイルム株式会社 Dispositif d'aide à la recherche de médicaments, procédé de fonctionnement d'un dispositif d'aide à la recherche de médicaments, et programme de fonctionnement d'un dispositif d'aide à la recherche de médicaments

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063667A2 (fr) * 1999-04-21 2000-10-26 American Home Products Corporation Procedes d'identification de modulateurs d'inactivation de canaux ioniques de type n

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063667A2 (fr) * 1999-04-21 2000-10-26 American Home Products Corporation Procedes d'identification de modulateurs d'inactivation de canaux ioniques de type n

Also Published As

Publication number Publication date
JP2005090957A (ja) 2005-04-07

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