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WO2003033708A3 - Regulation of human serine/threonine protein kinase - Google Patents

Regulation of human serine/threonine protein kinase Download PDF

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Publication number
WO2003033708A3
WO2003033708A3 PCT/EP2002/011478 EP0211478W WO03033708A3 WO 2003033708 A3 WO2003033708 A3 WO 2003033708A3 EP 0211478 W EP0211478 W EP 0211478W WO 03033708 A3 WO03033708 A3 WO 03033708A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
threonine protein
human serine
regulation
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/011478
Other languages
French (fr)
Other versions
WO2003033708A2 (en
Inventor
Rainer H Koehler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of WO2003033708A2 publication Critical patent/WO2003033708A2/en
Publication of WO2003033708A3 publication Critical patent/WO2003033708A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents that regulate human serine/threonine protein kinase and reagents which bind to human serine/threonine protein kinase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cancer, diabetes, CNS disorders or COPD.
PCT/EP2002/011478 2001-10-15 2002-10-14 Regulation of human serine/threonine protein kinase Ceased WO2003033708A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US32880401P 2001-10-15 2001-10-15
US60/328,804 2001-10-15
US35968802P 2002-02-27 2002-02-27
US60/359,688 2002-02-27
US39236502P 2002-07-01 2002-07-01
US60/392,365 2002-07-01

Publications (2)

Publication Number Publication Date
WO2003033708A2 WO2003033708A2 (en) 2003-04-24
WO2003033708A3 true WO2003033708A3 (en) 2004-01-29

Family

ID=27406629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/011478 Ceased WO2003033708A2 (en) 2001-10-15 2002-10-14 Regulation of human serine/threonine protein kinase

Country Status (1)

Country Link
WO (1) WO2003033708A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE483976T1 (en) * 2001-06-05 2010-10-15 Exelixis Inc GFATS AS P53 PATHWAY MODIFIERS AND METHODS OF USE
US6492156B1 (en) * 2001-10-31 2002-12-10 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
EP2546355A1 (en) * 2007-03-14 2013-01-16 Washington University Methods for identifying diabetes and obesity therapeutics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060062A2 (en) * 1999-04-01 2000-10-12 Astrazeneca Uk Limited Human signal transduction serine/threonine protein kinase
WO2002010402A2 (en) * 2000-07-28 2002-02-07 Chiron Corporation Isolation of drosophila and human polynucleotides encoding par-1 kinase, polypeptides encoded by the polynucleotides and methods utilizing the polynucleotides and polypeptides
WO2003038115A2 (en) * 2001-10-31 2003-05-08 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060062A2 (en) * 1999-04-01 2000-10-12 Astrazeneca Uk Limited Human signal transduction serine/threonine protein kinase
WO2002010402A2 (en) * 2000-07-28 2002-02-07 Chiron Corporation Isolation of drosophila and human polynucleotides encoding par-1 kinase, polypeptides encoded by the polynucleotides and methods utilizing the polynucleotides and polypeptides
WO2003038115A2 (en) * 2001-10-31 2003-05-08 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 25 April 1997 (1997-04-25), XP002242844, Database accession no. Z83869 *
DATABASE EMBL [online] 31 July 2001 (2001-07-31), XP002242843, Database accession no. AF387638 *
DREWES ET AL.: "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 89, 18 April 1997 (1997-04-18), pages 297 - 308, XP002105681 *
SUN T-G ET AL: "Par-1 is a dishevelled-associated kinase and a positive regulator of WNT signalling", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 3, no. 7, July 2001 (2001-07-01), pages 628 - 636, XP008004678 *

Also Published As

Publication number Publication date
WO2003033708A2 (en) 2003-04-24

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