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WO2003032809A3 - Modulation of akt-dependent response to prevent restenosis - Google Patents

Modulation of akt-dependent response to prevent restenosis Download PDF

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Publication number
WO2003032809A3
WO2003032809A3 PCT/US2002/032617 US0232617W WO03032809A3 WO 2003032809 A3 WO2003032809 A3 WO 2003032809A3 US 0232617 W US0232617 W US 0232617W WO 03032809 A3 WO03032809 A3 WO 03032809A3
Authority
WO
WIPO (PCT)
Prior art keywords
akt
modulation
dependent response
prevent restenosis
akt activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/032617
Other languages
French (fr)
Other versions
WO2003032809A2 (en
Inventor
Stephen E Epstein
Shmuel Fuchs
Eugenio Stabile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedStar Research Institute
Original Assignee
MedStar Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedStar Research Institute filed Critical MedStar Research Institute
Priority to AU2002332122A priority Critical patent/AU2002332122A1/en
Publication of WO2003032809A2 publication Critical patent/WO2003032809A2/en
Publication of WO2003032809A3 publication Critical patent/WO2003032809A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Restenosis of vessels after angioplasty, and narrowing of implanted blood vessels, such as arteries, veins, vascular grafts, and conduits, following implantation, is prevented or alleviated by inhibiting or modifying Akt activity in the cells of the vessel. The inhibition of Akt activity is achieved by administering to the blood vessel wall an effective amount of an agent capable of inhibiting Akt activity. The Akt inhibitor may be coated on a stent that is positioned within the blood vessel.
PCT/US2002/032617 2001-10-15 2002-10-15 Modulation of akt-dependent response to prevent restenosis Ceased WO2003032809A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002332122A AU2002332122A1 (en) 2001-10-15 2002-10-15 Modulation of akt-dependent response to prevent restenosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32880301P 2001-10-15 2001-10-15
US60/328,803 2001-10-15

Publications (2)

Publication Number Publication Date
WO2003032809A2 WO2003032809A2 (en) 2003-04-24
WO2003032809A3 true WO2003032809A3 (en) 2004-03-18

Family

ID=23282509

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032617 Ceased WO2003032809A2 (en) 2001-10-15 2002-10-15 Modulation of akt-dependent response to prevent restenosis

Country Status (2)

Country Link
AU (1) AU2002332122A1 (en)
WO (1) WO2003032809A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841307B2 (en) 2000-08-04 2014-09-23 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US8871772B2 (en) 2008-05-27 2014-10-28 Ampio Pharmaceuticals, Inc. Therapeutic methods and compounds
US8962568B2 (en) 2003-05-15 2015-02-24 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
US8980834B2 (en) 2011-10-10 2015-03-17 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
US9034878B2 (en) 2010-09-07 2015-05-19 Ampio Pharmaceuticals, Inc. Treatment of diseases

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2177510A1 (en) 2008-10-17 2010-04-21 Universität des Saarlandes Allosteric protein kinase modulators
WO2010104933A1 (en) 2009-03-11 2010-09-16 Merck Sharp & Dohme Corp. Inhibitors of akt activity
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
EP2755482B1 (en) 2011-09-15 2016-06-01 Merck Sharp & Dohme Corp. Combination of mk-1775 and mk-8776 for treating cancer
MX2014003856A (en) 2011-10-10 2015-01-16 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting.
SG11201400283RA (en) 2011-10-28 2014-03-28 Ampio Pharmaceuticals Inc Treatment of rhinitis
ME02925B (en) 2012-11-28 2018-04-20 Merck Sharp & Dohme COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
JP6588005B2 (en) 2013-03-15 2019-10-09 アンピオ ファーマシューティカルズ，インコーポレイテッド Pharmaceutical composition used to stimulate cartilage formation
JP6723222B2 (en) 2014-08-18 2020-07-15 アンピオ ファーマシューティカルズ，インコーポレイテッド Treatment of joint pathology
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHARLES ET AL.: "Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries", CIRCULATION RESEARCH, vol. 87, no. 4, 18 August 2000 (2000-08-18), pages 282 - 288, XP002190356 *
STABILE ET AL.: "Dominant negative mutant AKT-dependent phosphorylation of p70 S6K and smooth muscle cell proliferation in vitro and reduces neointimal development in the rat carotid artery", CIRCULATION, vol. 104, no. 17, SUPPL., 23 October 2001 (2001-10-23), pages II.315 - II.316, XP002965071 *
VIRMANI ET AL.: "Drug eluting stents: are human and animal studies comparable", HEART JOURNAL, vol. 89, September 2002 (2002-09-01), pages 133 - 138, XP002965072 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841307B2 (en) 2000-08-04 2014-09-23 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US8916568B2 (en) 2000-08-04 2014-12-23 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US9561226B2 (en) 2000-08-04 2017-02-07 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US8962568B2 (en) 2003-05-15 2015-02-24 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
US8969308B2 (en) 2003-05-15 2015-03-03 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
US8871772B2 (en) 2008-05-27 2014-10-28 Ampio Pharmaceuticals, Inc. Therapeutic methods and compounds
US9522893B2 (en) 2008-05-27 2016-12-20 Ampio Pharmaceuticals, Inc. Therapeutic methods and compounds
US9034878B2 (en) 2010-09-07 2015-05-19 Ampio Pharmaceuticals, Inc. Treatment of diseases
US8980834B2 (en) 2011-10-10 2015-03-17 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
US9060968B2 (en) 2011-10-10 2015-06-23 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease

Also Published As

Publication number Publication date
WO2003032809A2 (en) 2003-04-24
AU2002332122A1 (en) 2003-04-28

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