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WO2003031405A3 - Methodes de synthese de purines substituees - Google Patents

Methodes de synthese de purines substituees Download PDF

Info

Publication number
WO2003031405A3
WO2003031405A3 PCT/US2002/032679 US0232679W WO03031405A3 WO 2003031405 A3 WO2003031405 A3 WO 2003031405A3 US 0232679 W US0232679 W US 0232679W WO 03031405 A3 WO03031405 A3 WO 03031405A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
substituted purines
synthesis
phenylsulfenylpurine
traceless
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/032679
Other languages
English (en)
Other versions
WO2003031405A2 (fr
Inventor
Sheng Ding
Qiang Ding
Nathanael S Gray
Peter G Schultz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IRM LLC
Scripps Research Institute
Original Assignee
IRM LLC
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IRM LLC, Scripps Research Institute filed Critical IRM LLC
Priority to CA002463507A priority Critical patent/CA2463507A1/fr
Priority to JP2003534389A priority patent/JP2005509612A/ja
Priority to AU2002334992A priority patent/AU2002334992B2/en
Priority to EP02801053A priority patent/EP1529048A4/fr
Publication of WO2003031405A2 publication Critical patent/WO2003031405A2/fr
Anticipated expiration legal-status Critical
Publication of WO2003031405A3 publication Critical patent/WO2003031405A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Cette invention concerne des méthodes générales de préparation de purines substituées par 2,9-, 2,6,9-, O6-aryle- et O6-alkyle- selon un mode combinatoire et sans trace. Ces méthodes font intervenir, dans certains modes de réalisation, une alkylation Mitsunobu de 2-fluoro-6-phénylsulfenylpurine à N9 avec des alcools en solution, suivie d'une capture C2 du noyau purique avec une amine liée à une résine, après quoi on procède à l'oxydation et au déplacement du groupe sulfonyle C6 avec des amines et des anilines.
PCT/US2002/032679 2001-10-12 2002-10-12 Methodes de synthese de purines substituees Ceased WO2003031405A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002463507A CA2463507A1 (fr) 2001-10-12 2002-10-12 Methodes de synthese de purines substituees
JP2003534389A JP2005509612A (ja) 2001-10-12 2002-10-12 置換プリンの合成方法
AU2002334992A AU2002334992B2 (en) 2001-10-12 2002-10-12 Methods for the synthesis of substituted purines
EP02801053A EP1529048A4 (fr) 2001-10-12 2002-10-12 Methodes de synthese de purines substituees

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US32874101P 2001-10-12 2001-10-12
US60/328,741 2001-10-12
US34655202P 2002-01-07 2002-01-07
US60/346,552 2002-01-07
US34703702P 2002-01-08 2002-01-08
US60/347,037 2002-01-08

Publications (2)

Publication Number Publication Date
WO2003031405A2 WO2003031405A2 (fr) 2003-04-17
WO2003031405A3 true WO2003031405A3 (fr) 2005-03-03

Family

ID=27406624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032679 Ceased WO2003031405A2 (fr) 2001-10-12 2002-10-12 Methodes de synthese de purines substituees

Country Status (5)

Country Link
EP (1) EP1529048A4 (fr)
JP (1) JP2005509612A (fr)
AU (1) AU2002334992B2 (fr)
CA (1) CA2463507A1 (fr)
WO (1) WO2003031405A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005087231A1 (ja) 2004-03-16 2008-01-24 アステラス製薬株式会社 ソリフェナシン含有組成物
AU2005249380C1 (en) 2004-04-23 2012-09-20 Exelixis, Inc. Kinase modulators and methods of use
BRPI0610824A8 (pt) * 2005-05-16 2017-04-04 Prometic Pharma Smt Ltd Compostos derivados de purina, uso dos mesmos e composição contendo os referidos compostos
JP5400388B2 (ja) * 2005-12-15 2014-01-29 ライジェル ファーマシューティカルズ， インコーポレイテッド キナーゼインヒビターおよびその利用
CA2730271A1 (fr) 2008-07-07 2010-01-14 Xcovery Holding Company Llc Inhibiteurs selectifs des isoformes de la pi3 kinase
JP6736253B2 (ja) * 2014-12-22 2020-08-05 ザ チャイニーズ ユニバーシティ オブ ホンコン 体細胞から多能性幹細胞を作製するための機械的操作とプログラミンの併用
EP4634186A1 (fr) 2022-12-16 2025-10-22 Astrazeneca AB Purines 2,6,9-trisubstituées

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030176699A1 (en) * 1997-08-07 2003-09-18 The Regents Of The University Of California Purine inhibitors of protein kinases, G proteins and polymerases
US20030191312A1 (en) * 2001-10-12 2003-10-09 Irm Llc, A Delaware Limited Liability Company Kinase inhibitor scaffolds and methods for their preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030176699A1 (en) * 1997-08-07 2003-09-18 The Regents Of The University Of California Purine inhibitors of protein kinases, G proteins and polymerases
US20030191312A1 (en) * 2001-10-12 2003-10-09 Irm Llc, A Delaware Limited Liability Company Kinase inhibitor scaffolds and methods for their preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DING.: "A Concise and Traceless Linker Strategy toward Combinatorial Libraries of 2,6,9-substituted Purines", J. ORG. CHEM., vol. 66, 2001, pages 8273 - 8276, XP001187531 *
See also references of EP1529048A4 *

Also Published As

Publication number Publication date
CA2463507A1 (fr) 2003-04-17
EP1529048A4 (fr) 2005-09-14
JP2005509612A (ja) 2005-04-14
EP1529048A2 (fr) 2005-05-11
AU2002334992B2 (en) 2009-07-02
WO2003031405A2 (fr) 2003-04-17

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