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WO2003031467A3 - Derives amino-substitues de polymere de camptothecine et utilisations de ces derives pour la fabrication d'un medicament - Google Patents

Derives amino-substitues de polymere de camptothecine et utilisations de ces derives pour la fabrication d'un medicament Download PDF

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Publication number
WO2003031467A3
WO2003031467A3 PCT/CH2002/000562 CH0200562W WO03031467A3 WO 2003031467 A3 WO2003031467 A3 WO 2003031467A3 CH 0200562 W CH0200562 W CH 0200562W WO 03031467 A3 WO03031467 A3 WO 03031467A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino
medicament
manufacture
same
polymer derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CH2002/000562
Other languages
English (en)
Other versions
WO2003031467A2 (fr
Inventor
Francesco Veronese
Andrea Guiotto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debio Recherche Pharmaceutique SA
Yakult Honsha Co Ltd
Original Assignee
Debio Recherche Pharmaceutique SA
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debio Recherche Pharmaceutique SA, Yakult Honsha Co Ltd filed Critical Debio Recherche Pharmaceutique SA
Publication of WO2003031467A2 publication Critical patent/WO2003031467A2/fr
Publication of WO2003031467A3 publication Critical patent/WO2003031467A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un dérivé amino-substitué de polymère de 7-éthylcamptothécine, actif sur le plan pharmacologique, hydrosoluble et possédant une activité antitumorale.
PCT/CH2002/000562 2001-10-12 2002-10-14 Derives amino-substitues de polymere de camptothecine et utilisations de ces derives pour la fabrication d'un medicament Ceased WO2003031467A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB01/01912 2001-10-12
PCT/IB2001/001912 WO2003033525A1 (fr) 2001-10-12 2001-10-12 Derives polymeres de camptothecine amino-substitues et utilisation de ceux-ci pour la fabrication d'un medicament

Publications (2)

Publication Number Publication Date
WO2003031467A2 WO2003031467A2 (fr) 2003-04-17
WO2003031467A3 true WO2003031467A3 (fr) 2003-08-28

Family

ID=11004184

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IB2001/001912 Ceased WO2003033525A1 (fr) 2001-10-12 2001-10-12 Derives polymeres de camptothecine amino-substitues et utilisation de ceux-ci pour la fabrication d'un medicament
PCT/CH2002/000562 Ceased WO2003031467A2 (fr) 2001-10-12 2002-10-14 Derives amino-substitues de polymere de camptothecine et utilisations de ces derives pour la fabrication d'un medicament

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001912 Ceased WO2003033525A1 (fr) 2001-10-12 2001-10-12 Derives polymeres de camptothecine amino-substitues et utilisation de ceux-ci pour la fabrication d'un medicament

Country Status (1)

Country Link
WO (2) WO2003033525A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9504755B2 (en) 2008-08-11 2016-11-29 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20171094T1 (hr) 2003-09-17 2017-10-06 Nektar Therapeutics Višestruko razgranati polimerni prolijekovi
US8394365B2 (en) 2003-09-17 2013-03-12 Nektar Therapeutics Multi-arm polymer prodrugs
US7462627B2 (en) 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
AU2007232206B2 (en) 2006-03-30 2013-04-04 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
WO2008066902A2 (fr) 2006-11-30 2008-06-05 Nektar Therapeutics Al, Corporation Procédé de préparation d'un conjugué de polymère
CA2677798A1 (fr) 2007-02-09 2008-08-14 Enzon Pharmaceuticals, Inc. Traitement de cancers resistants ou refractaires avec des conjugues polymeres multibrins de 7-ethyl-10-hydroxycamptothecine
WO2012088422A1 (fr) 2010-12-22 2012-06-28 Nektar Therapeutics Conjugués promédicaments polymères à plusieurs bras de composés à base de taxane
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010304A1 (fr) * 1993-10-08 1995-04-20 Pharmacia S.P.A Derives de camptothecine lies a des polymeres
EP0757049A1 (fr) * 1995-08-02 1997-02-05 Tanabe Seiyaku Co., Ltd. Dérivés de campthothécin
EP0861842A1 (fr) * 1995-06-08 1998-09-02 Kyorin Pharmaceutical Co., Ltd. Nouveau derive hydrosoluble de la fluoroethylcamptothecine et son procede de production
EP1029863A1 (fr) * 1997-11-06 2000-08-23 Kabushiki Kaisha Yakult Honsha Nouveaux derives de la camptothecine
EP1044977A1 (fr) * 1999-03-09 2000-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Dérivés de camptothécine à activité anti-tumorale

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010304A1 (fr) * 1993-10-08 1995-04-20 Pharmacia S.P.A Derives de camptothecine lies a des polymeres
EP0861842A1 (fr) * 1995-06-08 1998-09-02 Kyorin Pharmaceutical Co., Ltd. Nouveau derive hydrosoluble de la fluoroethylcamptothecine et son procede de production
EP0757049A1 (fr) * 1995-08-02 1997-02-05 Tanabe Seiyaku Co., Ltd. Dérivés de campthothécin
EP1029863A1 (fr) * 1997-11-06 2000-08-23 Kabushiki Kaisha Yakult Honsha Nouveaux derives de la camptothecine
EP1044977A1 (fr) * 1999-03-09 2000-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Dérivés de camptothécine à activité anti-tumorale

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KEHRER DFS ET AL.: "Modulation of camptothecin analogs in the treatment of cancer: a review", ANTI-CANCER DRUGS, vol. 12, February 2001 (2001-02-01), pages 89 - 105, XP008002866 *
SINGER JW ET AL.: "Conjugation of Camptothecins to Poly-(L-Glutamic Acid)", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 922, 2000, pages 136 - 150, XP001023451 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9504755B2 (en) 2008-08-11 2016-11-29 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates

Also Published As

Publication number Publication date
WO2003033525A1 (fr) 2003-04-24
WO2003031467A2 (fr) 2003-04-17

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