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WO2003018598A3 - Monosaccharide derivatives - Google Patents

Monosaccharide derivatives Download PDF

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Publication number
WO2003018598A3
WO2003018598A3 PCT/IE2002/000126 IE0200126W WO03018598A3 WO 2003018598 A3 WO2003018598 A3 WO 2003018598A3 IE 0200126 W IE0200126 W IE 0200126W WO 03018598 A3 WO03018598 A3 WO 03018598A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
compounds
useful
fgf
potential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IE2002/000126
Other languages
French (fr)
Other versions
WO2003018598A2 (en
Inventor
Paul Vincent Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Dublin
Original Assignee
University College Dublin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Dublin filed Critical University College Dublin
Priority to AU2002330717A priority Critical patent/AU2002330717A1/en
Publication of WO2003018598A2 publication Critical patent/WO2003018598A2/en
Publication of WO2003018598A3 publication Critical patent/WO2003018598A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Monosaccharide (pyranoside) conjugates of the formula have been found to be useful as enhancers and/or inhibitors of heparin binding to FGF. The compounds have the potential to be useful in regenerative medicine or for treatment of pathological disease associated with FGF activity or as glycoprocessing inhibitors. In particular the compounds are potential modulators of fibroblast growth factors (FGFs) and fibronectin, as mitogenic agents and as inhibitors of endothelial cell survival.
PCT/IE2002/000126 2001-08-30 2002-08-30 Monosaccharide derivatives Ceased WO2003018598A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002330717A AU2002330717A1 (en) 2001-08-30 2002-08-30 Monosaccharide derivatives

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IE01650096.9 2001-08-30
EP01650096 2001-08-30
IE010971 2001-11-08
IE20010971 2001-11-08
IE20020258 2002-04-09
IE02/0258 2002-04-09
IE20020675 2002-08-14
IE02/0675 2002-08-14

Publications (2)

Publication Number Publication Date
WO2003018598A2 WO2003018598A2 (en) 2003-03-06
WO2003018598A3 true WO2003018598A3 (en) 2003-11-27

Family

ID=29554301

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE2002/000126 Ceased WO2003018598A2 (en) 2001-08-30 2002-08-30 Monosaccharide derivatives

Country Status (2)

Country Link
AU (1) AU2002330717A1 (en)
WO (1) WO2003018598A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2310020B1 (en) 2008-07-11 2017-03-15 Board of Regents, The University of Texas System Novel acetates of 2-deoxy monosaccharides with anticancer activity
RU2412712C1 (en) * 2009-06-29 2011-02-27 Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран Anti-inflammatory medication with anticoagulant, antitumour and antimetastetic activity
ES2910476T3 (en) 2010-12-23 2022-05-12 Univ North Carolina Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
WO2012142615A2 (en) * 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders
HUE056881T2 (en) 2013-04-05 2022-03-28 Univ Texas Esters of 2-deoxy-monosaccharides with anti proliferative activity
JP6670235B2 (en) 2013-06-17 2020-03-18 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ Reversible heparin molecules, methods of making and using the same
JP7330893B2 (en) 2017-03-10 2023-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル Short-acting heparin-based antiaggregant compounds and methods
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
CN111601603A (en) 2017-11-03 2020-08-28 北卡罗来纳大学查珀尔希尔分校 Sulfated oligosaccharides with anti-inflammatory activity
JP7538724B2 (en) 2018-06-20 2024-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル Cell protection methods and compositions
CN111196831B (en) * 2020-01-20 2023-05-09 山西医科大学 Preparation method of furan phenol glucuronic acid conjugate
WO2022146994A1 (en) * 2020-12-28 2022-07-07 Georgia Tech Research Corporation Glycosylated histone deacetylase inhibitors and methods of making and using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013258A1 (en) * 1994-09-30 1996-05-09 The Ohio State Research Foundation C-glycoside analogues of n-(4-hydroxyphenyl)retinamide-o-glucuronide
US5849709A (en) * 1995-05-10 1998-12-15 Glycomed Incorporated Saccharopeptides and derivatives thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013258A1 (en) * 1994-09-30 1996-05-09 The Ohio State Research Foundation C-glycoside analogues of n-(4-hydroxyphenyl)retinamide-o-glucuronide
US5849709A (en) * 1995-05-10 1998-12-15 Glycomed Incorporated Saccharopeptides and derivatives thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D.M. ORNITZ ET AL.: "FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides", SCIENCE, vol. 268, 1995, pages 432 - 436, XP002193983 *
LEE R T ET AL: "SOME SYNTHETIC INHIBITORS OF BETA-D-GLUCOSIDURONASE", CARBOHYDRATE RESEARCH, AMSTERDAM, NL, vol. 64, 1978, pages 302 - 308, XP000578985 *
UNAK T ET AL: "Synthesis and Iodine-125 Labelling of Glucuronide Compounds for Combined Chemo- and Radiotherapy of Cancer", APPLIED RADIATION AND ISOTOPES, PERGAMON PRESS LTD., EXETER, GB, vol. 48, no. 6, 1 June 1997 (1997-06-01), pages 777 - 783, XP004065273, ISSN: 0969-8043 *

Also Published As

Publication number Publication date
AU2002330717A1 (en) 2003-03-10
WO2003018598A2 (en) 2003-03-06

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