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WO2003018013B1 - Derives de stilbene ayant une activite inhibitrice du cytochrome p450 1b1, sel pharmaceutiquement acceptable de ces derives, methode de preparation desdits derives et composition les contenant - Google Patents

Derives de stilbene ayant une activite inhibitrice du cytochrome p450 1b1, sel pharmaceutiquement acceptable de ces derives, methode de preparation desdits derives et composition les contenant

Info

Publication number
WO2003018013B1
WO2003018013B1 PCT/KR2002/000977 KR0200977W WO03018013B1 WO 2003018013 B1 WO2003018013 B1 WO 2003018013B1 KR 0200977 W KR0200977 W KR 0200977W WO 03018013 B1 WO03018013 B1 WO 03018013B1
Authority
WO
WIPO (PCT)
Prior art keywords
chemical formula
stilbene derivative
amended
hydroxy
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2002/000977
Other languages
English (en)
Other versions
WO2003018013A1 (fr
Inventor
Sang-Hee Kim
Young-Jin Chun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promeditech Inc
Original Assignee
Promeditech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promeditech Inc filed Critical Promeditech Inc
Publication of WO2003018013A1 publication Critical patent/WO2003018013A1/fr
Anticipated expiration legal-status Critical
Publication of WO2003018013B1 publication Critical patent/WO2003018013B1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Dérivé de stilbène ayant une activité inhibitrice du cytochrome P450 1B1, sel pharmaceutiquement acceptable dudit dérivé, méthode de préparation de ce dérivé et composition le contenant. Ce dérivé de stilbène est un inhibiteur puissant et sélectif du cytochrome P450 1B1 qui permet de réduire ou de prévenir la carcinogenèse chimique chez les mammifères, en particulier le développement du cancer du sein. Il peut également être utilisé en tant qu'outil pharmaceutique pour élucider la fonction du cytochrome P450.
PCT/KR2002/000977 2001-08-31 2002-05-23 Derives de stilbene ayant une activite inhibitrice du cytochrome p450 1b1, sel pharmaceutiquement acceptable de ces derives, methode de preparation desdits derives et composition les contenant Ceased WO2003018013A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR2001/53363 2001-08-31
KR1020010053363A KR20030018800A (ko) 2001-08-31 2001-08-31 시토크롬 피450 1비1 억제활성을 갖는 페닐환 유도체 및약학적으로 허용가능한 그의 염, 그의 제조방법 및 이를함유하는 조성물

Publications (2)

Publication Number Publication Date
WO2003018013A1 WO2003018013A1 (fr) 2003-03-06
WO2003018013B1 true WO2003018013B1 (fr) 2004-04-08

Family

ID=19713806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2002/000977 Ceased WO2003018013A1 (fr) 2001-08-31 2002-05-23 Derives de stilbene ayant une activite inhibitrice du cytochrome p450 1b1, sel pharmaceutiquement acceptable de ces derives, methode de preparation desdits derives et composition les contenant

Country Status (2)

Country Link
KR (1) KR20030018800A (fr)
WO (1) WO2003018013A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1331856C (zh) * 2005-08-05 2007-08-15 大连理工大学 多羟基茋类化合物的制备和抑制sars病毒药物的用途
WO2009001046A2 (fr) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen 2,3',4,5'-tétraméthylstilbène (tms) radiomarqué par [11c]méthoxy et ses préparation et utilisation
KR101035010B1 (ko) * 2009-02-25 2011-05-17 주식회사 엠.에스.라이팅 공기정화 및 조명 복합장치
PL223452B1 (pl) * 2012-03-30 2016-10-31 Univ Medyczny Im Karola Marcinkowskiego W Poznaniu Nowe pochodne trans-stilbenu oraz ich zastosowanie
WO2015039036A2 (fr) * 2013-09-13 2015-03-19 Cortendo Ab(Publ) Nouveaux inhibiteurs du cytochrome p450 et leur méthode d'utilisation
WO2021127743A1 (fr) 2019-12-23 2021-07-01 Kynan Duke IP, LLC Synthèse de composés et de dérivés hydroxystilbène substitués et utilisations de ceux-ci

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0489436A (ja) * 1990-07-27 1992-03-23 Ricoh Co Ltd 新規芳香族化合物及び非線形光学材料
GB9802522D0 (en) * 1998-02-06 1998-04-01 Montford University De Hydroxylation activated prodrugs
NZ507221A (en) * 1998-04-03 2003-04-29 Ajinomoto Kk Antitumor agent
KR100383366B1 (ko) * 2000-12-19 2003-05-12 주식회사 태평양 신규한 페닐환 유도체, 그의 제조방법 및 이를 포함하는약학 조성물 및 화장료 조성물

Also Published As

Publication number Publication date
KR20030018800A (ko) 2003-03-06
WO2003018013A1 (fr) 2003-03-06

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