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WO2003014148A3 - Regulation de la ligase humaine acide gras-coa - Google Patents

Regulation de la ligase humaine acide gras-coa Download PDF

Info

Publication number
WO2003014148A3
WO2003014148A3 PCT/EP2002/008617 EP0208617W WO03014148A3 WO 2003014148 A3 WO2003014148 A3 WO 2003014148A3 EP 0208617 W EP0208617 W EP 0208617W WO 03014148 A3 WO03014148 A3 WO 03014148A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
coa ligase
human fatty
reagents
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/008617
Other languages
English (en)
Other versions
WO2003014148A2 (fr
Inventor
Jiing-Ren Liou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002355343A priority Critical patent/AU2002355343A1/en
Publication of WO2003014148A2 publication Critical patent/WO2003014148A2/fr
Publication of WO2003014148A3 publication Critical patent/WO2003014148A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01002—Butyrate-CoA ligase (6.2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01003—Long-chain-fatty-acid-CoA ligase (6.2.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention porte sur des réactifs régulant la ligase humaine acide gras-CoA et des réactifs se fixant aux produits géniques de la ligase humaine acide gras-CoA et qui peuvent jouer un rôle dans la prévention, l'amélioration ou la correction de dysfonctionnements ou maladies incluant non exclusivement l'obésité, le diabète ou les troubles cardio-vasculaires.
PCT/EP2002/008617 2001-08-06 2002-08-02 Regulation de la ligase humaine acide gras-coa Ceased WO2003014148A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002355343A AU2002355343A1 (en) 2001-08-06 2002-08-02 Human fatty acid-coa ligase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30979401P 2001-08-06 2001-08-06
US60/309,794 2001-08-06

Publications (2)

Publication Number Publication Date
WO2003014148A2 WO2003014148A2 (fr) 2003-02-20
WO2003014148A3 true WO2003014148A3 (fr) 2003-08-28

Family

ID=23199696

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008617 Ceased WO2003014148A2 (fr) 2001-08-06 2002-08-02 Regulation de la ligase humaine acide gras-coa

Country Status (2)

Country Link
AU (1) AU2002355343A1 (fr)
WO (1) WO2003014148A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138832A1 (en) * 2001-12-19 2003-07-24 Kadyk Lisa C. Modulating insulin receptor signaling through targeting FACL

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 4 December 1997 (1997-12-04), HILLIER L ET AL.: "zj66f12.s1 Soares fetal liver spleen 1NFLS S1 Homo sapiens cDNA clone 455279 3' similar to TR:G666014 G666014 SA SA GENE PRODUCT, COMPLETE CDS PRECURSOR", XP002230354, Database accession no. AA677577 *
DATABASE EMBL [online] 7 September 2001 (2001-09-07), FUJINO T ET AL.: "Homo sapiens MACS mRNA for medium-chain acyl-CoA synthetase, complete cds.", XP002230355, Database accession no. AB059429 *
FUJINO T ET AL: "MOLECULAR IDENTIFICATION AND CHARACTERIZATION OF TWO MEDIUM-CHAIN ACYL-COA SYNTHETHASES, MACS1 AND THE SA GENE PRODUCT", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 38, 24 July 2001 (2001-07-24), pages 35961 - 35966, XP001094129, ISSN: 0021-9258 *
FUJIWARA K ET AL: "Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 3 AUG 2001, vol. 276, no. 31, 3 August 2001 (2001-08-03), pages 28819 - 28823, XP002230353, ISSN: 0021-9258 *
IWAI N ET AL.: "Human SA gene locus as a candidate locus for essential hypertension", HYPERTENSION, vol. 23, no. 3, March 1994 (1994-03-01), pages 375 - 380, XP001097389 *
VESSEY D A ET AL: "Isolation and sequencing of cDNAs for the XL-I and XL-III forms of bovine liver xenobiotic-metabolizing medium-chain fatty acid:CoA ligase.", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. UNITED STATES 2000, vol. 14, no. 1, 2000, pages 11 - 19, XP009005546, ISSN: 1095-6670 *

Also Published As

Publication number Publication date
AU2002355343A1 (en) 2003-02-24
WO2003014148A2 (fr) 2003-02-20

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