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WO2003013420A3 - Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification - Google Patents

Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification Download PDF

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Publication number
WO2003013420A3
WO2003013420A3 PCT/EP2002/008917 EP0208917W WO03013420A3 WO 2003013420 A3 WO2003013420 A3 WO 2003013420A3 EP 0208917 W EP0208917 W EP 0208917W WO 03013420 A3 WO03013420 A3 WO 03013420A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
prevention
treatment
osteoporosis
women
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/008917
Other languages
French (fr)
Other versions
WO2003013420A2 (en
Inventor
Ceer Vermeer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VITAK BV
Original Assignee
VITAK BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VITAK BV filed Critical VITAK BV
Priority to AU2002333378A priority Critical patent/AU2002333378A1/en
Priority to EP02794586A priority patent/EP1414387A2/en
Publication of WO2003013420A2 publication Critical patent/WO2003013420A2/en
Publication of WO2003013420A3 publication Critical patent/WO2003013420A3/en
Priority to US10/770,991 priority patent/US20050176778A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C07C50/06—Quinones with monocyclic quinoid structure with unsaturation outside the quinoid structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A non-toxic biologically active compound is provided having the following general formula (I), wherein n is an integer from 1 to 14, preferably from 2 to 4, and R is an organic moiety, preferably a group different from but structurally substantially similar to 2-methyl naphthoquinone, or a group P-C(R1)-P, where each P stands for a -PO(OH)2 group and R1 is a (poly)isoprenyl group, hydroxy, halogen (preferably chloro or bromo), or hydrogen, or a pharmaceutically acceptable derivative thereof. These compounds are useful for the treatment or prevention of certain disorders in a mammal, especially a human being, for example postmenopausal loss of bone in women, juvenile or senile osteoporosis in men and women, cardiovascular calcification and other ectopic calcifications.
PCT/EP2002/008917 2001-08-03 2002-08-05 Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification Ceased WO2003013420A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002333378A AU2002333378A1 (en) 2001-08-03 2002-08-05 Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification
EP02794586A EP1414387A2 (en) 2001-08-03 2002-08-05 Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification
US10/770,991 US20050176778A1 (en) 2001-08-03 2004-02-02 Isoprenyl derivatives and their use in the title treatment and prevention of osteoporosis and cardiovascular calcification

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202955 2001-08-03
EP01202955.9 2001-08-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/770,991 Continuation US20050176778A1 (en) 2001-08-03 2004-02-02 Isoprenyl derivatives and their use in the title treatment and prevention of osteoporosis and cardiovascular calcification

Publications (2)

Publication Number Publication Date
WO2003013420A2 WO2003013420A2 (en) 2003-02-20
WO2003013420A3 true WO2003013420A3 (en) 2003-11-06

Family

ID=8180752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008917 Ceased WO2003013420A2 (en) 2001-08-03 2002-08-05 Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification

Country Status (3)

Country Link
EP (1) EP1414387A2 (en)
AU (1) AU2002333378A1 (en)
WO (1) WO2003013420A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE361001T1 (en) 2000-05-12 2007-05-15 Vitak Bv FOODS CONTAINING VITAMIN K2
GB0220182D0 (en) 2002-08-30 2002-10-09 Cardiovascular Res Inst Maastr Organic compounds
US20050158329A1 (en) 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
DE602006020658D1 (en) † 2005-06-03 2011-04-28 Nattopharma Asa Use of Vitamin K to reverse the calcification of the blood vessels
GB2476644B (en) 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis
EP2651250A1 (en) * 2010-12-17 2013-10-23 VitaK B.V. Use of vitamin k for weight maintenance and weight control

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243849A2 (en) * 1986-04-23 1987-11-04 Yeda Research And Development Company Limited Process for the production of polyprenoid type compounds
EP0636598A1 (en) * 1993-07-26 1995-02-01 Eisai Chemical Co., Ltd. Preparation process of naphthoquinone derivatives and intermediates for the preparation thereof
WO1999000135A1 (en) * 1997-06-28 1999-01-07 The Boots Company Plc Composition comprising vitamin k and vitamin d, for treating or preventing osteoporosis
EP1153548A1 (en) * 2000-05-12 2001-11-14 Unilever N.V. Vitamin k2 containing food product

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243849A2 (en) * 1986-04-23 1987-11-04 Yeda Research And Development Company Limited Process for the production of polyprenoid type compounds
EP0636598A1 (en) * 1993-07-26 1995-02-01 Eisai Chemical Co., Ltd. Preparation process of naphthoquinone derivatives and intermediates for the preparation thereof
WO1999000135A1 (en) * 1997-06-28 1999-01-07 The Boots Company Plc Composition comprising vitamin k and vitamin d, for treating or preventing osteoporosis
EP1153548A1 (en) * 2000-05-12 2001-11-14 Unilever N.V. Vitamin k2 containing food product

Also Published As

Publication number Publication date
AU2002333378A1 (en) 2003-02-24
WO2003013420A2 (en) 2003-02-20
EP1414387A2 (en) 2004-05-06

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