[go: up one dir, main page]

WO2003011335A3 - Polyvalente vakzine gegen durch papillomaviren verursachte erkrankungen, verfahren zu deren herstellung und deren verwendung - Google Patents

Polyvalente vakzine gegen durch papillomaviren verursachte erkrankungen, verfahren zu deren herstellung und deren verwendung Download PDF

Info

Publication number
WO2003011335A3
WO2003011335A3 PCT/EP2002/008360 EP0208360W WO03011335A3 WO 2003011335 A3 WO2003011335 A3 WO 2003011335A3 EP 0208360 W EP0208360 W EP 0208360W WO 03011335 A3 WO03011335 A3 WO 03011335A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
papilloma viruses
diseases caused
against diseases
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/008360
Other languages
English (en)
French (fr)
Other versions
WO2003011335A2 (de
Inventor
Lutz Gissmann
Martin Mueller
Kai Pohlmeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Priority to EP02791474A priority Critical patent/EP1411981A2/de
Priority to US10/485,454 priority patent/US7320861B2/en
Priority to AU2002355654A priority patent/AU2002355654A1/en
Publication of WO2003011335A2 publication Critical patent/WO2003011335A2/de
Publication of WO2003011335A3 publication Critical patent/WO2003011335A3/de
Anticipated expiration legal-status Critical
Priority to US10/778,936 priority patent/US7354714B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Beschrieben wird eine Vakzine gegen durch Papillomaviren verursachte Erkrankungen, die dadurch erhältlich ist, dass (a) Säugern ein oder mehrere Expressionsvektoren injiziert wird/werden, die die für ein Strukturprotein von Papillomaviren oder ein Fragment davon kodierende DNA aufweist/aufweisen, wobei mindestens bei einem Teil der Expressionsvektoren in die kodierende DNA zufällig generierte heterologe Sequenzen eingesetzt sind, (b) aus den Säugern Seren gewonnen werden, die auf das Vorhandensein von Antikörpern gegen Partikel verscheidener Papillomavirus-Typen untersucht werden und (c) mit Hilfe der untersuchten Seren diejenigen Strukturprotein-Klone identifiziert werden, die für eine polyvalente Vakzine kodieren und (d) aus denen dann die Vakzine hergestellt wird. Des weiteren wird ein Verfahren zur Herstellung der Vakzine beschrieben und deren Verwendung zur Impfung gegen durch Papillomaviren verursachte Erkrankungen.
PCT/EP2002/008360 2001-07-30 2002-07-26 Polyvalente vakzine gegen durch papillomaviren verursachte erkrankungen, verfahren zu deren herstellung und deren verwendung Ceased WO2003011335A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02791474A EP1411981A2 (de) 2001-07-30 2002-07-26 Polyvalente vakzine gegen durch papillomaviren verursachte erkrankungen, verfahren zu deren herstellung und deren verwendung
US10/485,454 US7320861B2 (en) 2001-07-30 2002-07-26 Polyvalent vaccine against diseases caused by papilloma viruses, method for the production and the use thereof
AU2002355654A AU2002355654A1 (en) 2001-07-30 2002-07-26 Polyvalent vaccine against diseases caused by papilloma viruses, method for the production and the use thereof
US10/778,936 US7354714B2 (en) 2001-07-30 2004-02-13 Production and applications for polyvalent vaccines against diseases caused by papilloma viruses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10137102.0 2001-07-30
DE10137102A DE10137102A1 (de) 2001-07-30 2001-07-30 Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10485454 A-371-Of-International 2002-07-26
US10/778,936 Continuation-In-Part US7354714B2 (en) 2001-07-30 2004-02-13 Production and applications for polyvalent vaccines against diseases caused by papilloma viruses

Publications (2)

Publication Number Publication Date
WO2003011335A2 WO2003011335A2 (de) 2003-02-13
WO2003011335A3 true WO2003011335A3 (de) 2003-11-06

Family

ID=7693601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008360 Ceased WO2003011335A2 (de) 2001-07-30 2002-07-26 Polyvalente vakzine gegen durch papillomaviren verursachte erkrankungen, verfahren zu deren herstellung und deren verwendung

Country Status (5)

Country Link
US (2) US7320861B2 (de)
EP (1) EP1411981A2 (de)
AU (1) AU2002355654A1 (de)
DE (1) DE10137102A1 (de)
WO (1) WO2003011335A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080160040A1 (en) * 2004-04-15 2008-07-03 Ghim Shin-Je Plant-produced compositions for treating papillomavirus infection and related methods
WO2007038145A2 (en) * 2005-09-08 2007-04-05 Large Scale Biology Corporation Modified tobacco mosaic virus particles as scaffolds for display of protein antigens for vaccine applications
US7445786B1 (en) 2006-04-10 2008-11-04 Manuela Rehtanz Diagnosing and protecting against tursiops truncatus papillomavirus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035479A1 (en) * 1998-12-17 2000-06-22 Merck & Co., Inc. Synthetic virus-like particles with heterologous epitopes
WO2001097840A1 (en) * 2000-06-21 2001-12-27 Medimmune, Inc. Chimeric human papillomavirus (hpv) l1 molecules and uses therefor

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2524487B1 (fr) * 1982-04-05 1985-11-22 Pasteur Institut Fragments d'adn codant pour des polypeptides contenant au moins un determinant antigenique des papillomavirus, notamment du type hpv 1a et polypeptides correspondants
US5045447A (en) * 1989-03-15 1991-09-03 Minson Anthony C Method of producing antibodies to HPV
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US6183745B1 (en) 1990-12-12 2001-02-06 The University Of Queensland Subunit papilloma virus vaccine and peptides for use therein
US6287792B1 (en) 1991-06-17 2001-09-11 The Regents Of The University Of California Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
DE4123760C2 (de) 1991-07-18 2000-01-20 Dade Behring Marburg Gmbh Seroreaktive Bereiche auf den HPV 16 Proteinen E1 und E2
DE69233687T2 (de) 1991-07-19 2007-10-18 University Of Queensland, St. Lucia Impfstoff gegen Humanes Papillomavirus (Typ 18)
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5302397A (en) 1991-11-19 1994-04-12 Amsden Brian G Polymer-based drug delivery system
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
ATE159179T1 (de) 1992-06-02 1997-11-15 Alza Corp Vorrichtung zur iontophoretischen verabreichung von medikamenten
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
DE4415743C2 (de) 1994-05-04 1996-10-10 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
US5888516A (en) 1994-05-16 1999-03-30 Merck & Co. Inc. Recombinant papillomavirus vaccines
BR9507657A (pt) 1994-05-16 1997-09-09 Merck & Co Inc Proteina isolada e purificada de papilomavirus recombinante capsideos particulas semelhantes a virus processos a virus processos para produzir a proteina para tratar ou prevenir a infecçao por papilomavirus para produzir uma proteina de capsideo de papilomavirus recombinante montada em um capsideo ou particula semelhante a virus e para induzir uma resposta imune em um animal vertebrado composiçoes farmacêuticas kit para a detecçao de papilomavirus ou anticorpos para papilomavirus e sistema sinte
IL113817A (en) 1994-06-30 2001-03-19 Merck & Co Inc Polynucleotide vaccne for papillomavirus
US5891108A (en) 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
DE122007000093I1 (de) 1994-10-07 2008-03-27 Univ Loyola Chicago Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung
US5820870A (en) 1995-03-22 1998-10-13 Merck & Co., Inc. Recombinant human papillomavirus type 18 vaccine
US5840306A (en) 1995-03-22 1998-11-24 Merck & Co., Inc. DNA encoding human papillomavirus type 18
US5821087A (en) 1995-03-30 1998-10-13 Merck & Co., Inc. Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6350780B1 (en) 1995-07-28 2002-02-26 Allergan Sales, Inc. Methods and compositions for drug delivery
US6068829A (en) 1995-09-11 2000-05-30 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo
US5981173A (en) 1996-02-14 1999-11-09 Institut Pasteur Genital human papillomavirus type 68a (HPV-68a), related to the potentially oncogenic HPV-39
US6245349B1 (en) 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
US6132765A (en) 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US6074673A (en) 1996-04-22 2000-06-13 Guillen; Manuel Slow-release, self-absorbing, drug delivery system
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6296621B1 (en) 1996-08-23 2001-10-02 Baxter International Inc. Receptacle for passive drug delivery
WO1998018452A1 (en) 1996-10-25 1998-05-07 Shire Laboratories, Inc. Soluble form osmotic dose delivery system
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
ZA982950B (en) 1997-04-08 1998-10-19 Merck & Co Inc Stabilized human papillomavirus formulations
ATE261734T1 (de) 1997-04-08 2004-04-15 Merck & Co Inc Stabilisierte humane papillomaviruszusammensetzungen
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US6183444B1 (en) 1998-05-16 2001-02-06 Microheart, Inc. Drug delivery module
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6083996A (en) 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
EP1563866B1 (de) 1998-02-05 2007-10-03 Biosense Webster, Inc. Gerät zum Freisetzen eines Medikaments im Herzen
US6086912A (en) 1998-02-11 2000-07-11 Gilman; Marvin S. Topical drug delivery system
US20020039584A1 (en) 1998-02-20 2002-04-04 Medigene Ag Papilloma virus capsomere vaccine formulations and methods of use
US6309410B1 (en) 1998-08-26 2001-10-30 Advanced Bionics Corporation Cochlear electrode with drug delivery channel and method of making same
US6251079B1 (en) 1998-09-30 2001-06-26 C. R. Bard, Inc. Transthoracic drug delivery device
US6309380B1 (en) 1999-01-27 2001-10-30 Marian L. Larson Drug delivery via conformal film
JP4841726B2 (ja) 1999-02-05 2011-12-21 メルク・シャープ・エンド・ドーム・コーポレイション ヒトパピローマウイルスワクチン製剤
US6245568B1 (en) 1999-03-26 2001-06-12 Merck & Co., Inc. Human papilloma virus vaccine with disassembled and reassembled virus-like particles
US6235312B1 (en) 1999-05-14 2001-05-22 Eastman Chemical Company Liquid crystalline phase drug delivery vehicle
DE19925199A1 (de) * 1999-06-01 2000-12-07 Medigene Ag Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie
US6283947B1 (en) 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
ES2233437T3 (es) 1999-08-25 2005-06-16 MERCK & CO., INC. Genes sinteticos del papilomavirus optimizados para expresion en celulas humanas.
US6283949B1 (en) 1999-12-27 2001-09-04 Advanced Cardiovascular Systems, Inc. Refillable implantable drug delivery pump
US6379382B1 (en) 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
DE10059631A1 (de) * 2000-12-01 2002-07-18 Medigene Ag T-Zellepitope des Papillomavirus L1-und E7-Proteins und ihre Verwendung in Diagnostik und Therapie
GB0206359D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035479A1 (en) * 1998-12-17 2000-06-22 Merck & Co., Inc. Synthetic virus-like particles with heterologous epitopes
WO2001097840A1 (en) * 2000-06-21 2001-12-27 Medimmune, Inc. Chimeric human papillomavirus (hpv) l1 molecules and uses therefor
EP1292328A1 (de) * 2000-06-21 2003-03-19 Medimmune, Inc. Chimäre humanes papillomavirus (hpv) l1 moleküle und deren verwendungen(03.01.02)

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BREITBURD FRANCOISE ET AL: "Human papillomavirus vaccines.", SEMINARS IN CANCER BIOLOGY, vol. 9, no. 6, December 1999 (1999-12-01), pages 431 - 445, XP002248443, ISSN: 1044-579X *
DONNELLY JOHN J ET AL: "Protection against papillomavirus with a polynucleotide vaccine.", JOURNAL OF INFECTIOUS DISEASES, vol. 173, no. 2, 1996, pages 314 - 320, XP000877176, ISSN: 0022-1899 *
GIROGLOU TZENAN ET AL: "Immunological analyses of human papillomavirus capsids.", VACCINE, vol. 19, no. 13-14, 2001, pages 1783 - 1793, XP002248440, ISSN: 0264-410X *
KOWALCZYK DARIUSZ W ET AL: "Vaccine regimen for prevention of sexually transmitted infections with human papillomavirus type 16.", VACCINE, vol. 19, no. 25-26, 2001, pages 3583 - 3590, XP004238957, ISSN: 0264-410X *
LEDER CHRISTOPH ET AL: "Enhancement of capsid gene expression: Preparing the human papillomavirus type 16 major structural gene L1 for DNA vaccination purposes.", JOURNAL OF VIROLOGY, vol. 75, no. 19, October 2001 (2001-10-01), pages 9201 - 9209, XP002202893, ISSN: 0022-538X *
PASTRANA DIANA V ET AL: "NHPV16 VLP vaccine induces human antibodies that neutralize divergent variants of HPV16.", VIROLOGY, vol. 279, no. 1, 5 January 2001 (2001-01-05), pages 361 - 369, XP002248439, ISSN: 0042-6822 *
RODEN RICHARD B S ET AL: "Minor capsid protein of human genital papillomaviruses contains subdominant, cross-neutralizing epitopes.", VIROLOGY, vol. 270, no. 2, 10 May 2000 (2000-05-10), pages 254 - 257, XP002205239, ISSN: 0042-6822 *
SCHRECKENBERGER C ET AL: "Induction of an HPV 6bL1-specific mucosal IgA response by DNA immunization.", VACCINE, vol. 19, no. 2-3, 2000, pages 227 - 233, XP002248442, ISSN: 0264-410X *
SUNDARAM PAZHANI ET AL: "Intracutaneous vaccination of rabbits with the cottontail rabbit papillomavirus (CRPV) L1 gene protects against virus challenge.", VACCINE, vol. 15, no. 6-7, 1997, pages 664 - 671, XP004064529, ISSN: 0264-410X *
TOUZE ANTOINE ET AL: "The L1 major capsid protein of human papillomavirus type 16 variants affects yield of virus-like particles produced in an insect cell expression system.", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 36, no. 7, July 1998 (1998-07-01), pages 2046 - 2051, XP002248441, ISSN: 0095-1137 *

Also Published As

Publication number Publication date
AU2002355654A1 (en) 2003-02-17
DE10137102A1 (de) 2003-02-27
US20050004054A1 (en) 2005-01-06
US7354714B2 (en) 2008-04-08
EP1411981A2 (de) 2004-04-28
US7320861B2 (en) 2008-01-22
WO2003011335A2 (de) 2003-02-13
US20050026257A1 (en) 2005-02-03

Similar Documents

Publication Publication Date Title
ATE384785T1 (de) Herstellung von viren, virusisolaten, und impfstoffen
EA200100057A1 (ru) Инфекционные клоны вируса ньюкаслской болезни, вакцины и диагностические анализы
ID22208A (id) Klon virus rna menular dan vaksin serta analisa diagnostik yang diperoleh darinya
BR0214119A (pt) Processo de detecção e/ou identificação de sequências de vìrus adenoassociados (aav) e isolamento de novas sequências pelo que identificadas
HUP0102478A2 (hu) A HCV-burokfehérjék által alkotott részecskék alkalmazása vakcinázásban
WO2003002749A3 (en) Methods for the simultaneous detection of hcv antigens and hcv antibodies
JP2012229225A (ja) Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター
WO1995032292A3 (en) Detection of viral antigens coded by reverse-reading frames
WO2021252406A3 (en) Method for selecting antibody fragments, recombinant antibodies produced therefrom, and uses thereof
WO2003011335A3 (de) Polyvalente vakzine gegen durch papillomaviren verursachte erkrankungen, verfahren zu deren herstellung und deren verwendung
WO2007064844A3 (en) Anti-viral griffithsin compounds, compositions, and methods of use
AR020092A1 (es) Una cepa aislada de virus de hepatitis, acido nucleico aislado que codifica un polipeptido de la cepa, vector que comprende dicho acido nucleico, sistemavector huesped para la produccion del polipeptido, el polipeptido, metodo para su produccion, metodo para obtener anticuerpos contra el polipeptido
WO2001046696A3 (en) Methods and compositions for detecting hepatitis e virus
DK0750669T3 (da) Modificeret papillomavirus-L2-protein og VLP'er dannet derudfra
CA2514918A1 (en) Method to confer cell culture replication activity to different hepatitis c virus isolates
ATE414905T1 (de) Diabetesmodell
WO2001038498A3 (en) A new genotype of hepatitis b virus
Enzmann Molecular biology of the virus
WO2001049712A3 (en) Vaccine against isav (infectious salmon anaemia virus)
KR930012826A (ko) 변형된 소의 헤르페스바이러스 타입 1에 기초한 백신
ATE315649T1 (de) Mycoplasma mycoides subsp. mycoides sc antigenisches lppq protein, seine herstellung und verwendung
WO2003091386A3 (en) A new family of picornaviruses
EP1584628A3 (de) Virusprotein
WO2005090584A3 (de) Impfstoff gegen influenza basierend auf geflügelpestviren
WO2001078775A3 (en) A method for making an hiv vaccine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VN YU ZA ZM

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002791474

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002791474

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10485454

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP