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WO2003011299A3 - Procede et composition pour le traitement de l'hypertension oculaire et des glaucomes - Google Patents

Procede et composition pour le traitement de l'hypertension oculaire et des glaucomes Download PDF

Info

Publication number
WO2003011299A3
WO2003011299A3 PCT/JP2002/007699 JP0207699W WO03011299A3 WO 2003011299 A3 WO2003011299 A3 WO 2003011299A3 JP 0207699 W JP0207699 W JP 0207699W WO 03011299 A3 WO03011299 A3 WO 03011299A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
glaucoma
ocular hypertension
micrograms
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/007699
Other languages
English (en)
Other versions
WO2003011299A2 (fr
Inventor
Ryuji Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
Sucampo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo GmbH filed Critical Sucampo GmbH
Priority to CA002454422A priority Critical patent/CA2454422A1/fr
Priority to EP02751774A priority patent/EP1411950A2/fr
Priority to BR0211545-0A priority patent/BR0211545A/pt
Priority to MXPA04000980A priority patent/MXPA04000980A/es
Priority to JP2003516529A priority patent/JP2004538306A/ja
Priority to KR10-2004-7001587A priority patent/KR20040023707A/ko
Priority to US10/485,370 priority patent/US20040254247A1/en
Publication of WO2003011299A2 publication Critical patent/WO2003011299A2/fr
Publication of WO2003011299A3 publication Critical patent/WO2003011299A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention se rapporte à un procédé servant à traiter l'hypertension oculaire et les glaucomes et qui consiste à administrer en mode topique dans les yeux d'un sujet mammifère nécessitant un tel traitement plus de 5 νg et moins de 50 νg par oeil par administration d'un composé de 15-céto-prostaglandine comportant une structure cyclique à l'extrémité de la chaîne φ. Le traitement faisant l'objet de cette invention ne produit pour ainsi dire pas d'effets secondaires irritants l'oeil ou en produit à un niveau réduit, même à une telle dose élevée.
PCT/JP2002/007699 2001-07-31 2002-07-30 Procede et composition pour le traitement de l'hypertension oculaire et des glaucomes Ceased WO2003011299A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002454422A CA2454422A1 (fr) 2001-07-31 2002-07-30 Procede et composition pour le traitement de l'hypertension oculaire et des glaucomes
EP02751774A EP1411950A2 (fr) 2001-07-31 2002-07-30 Procede et composition pour le traitement de l'hypertension oculaire et des glaucomes
BR0211545-0A BR0211545A (pt) 2001-07-31 2002-07-30 Método e composição para tratamento de hipertensão ocular e glaucoma
MXPA04000980A MXPA04000980A (es) 2001-07-31 2002-07-30 Tratamiento de hipertension ocular y glaucoma.
JP2003516529A JP2004538306A (ja) 2001-07-31 2002-07-30 高眼圧症および緑内障の処置
KR10-2004-7001587A KR20040023707A (ko) 2001-07-31 2002-07-30 안내압항진 및 녹내장의 치료
US10/485,370 US20040254247A1 (en) 2001-07-31 2002-07-30 Method and composition for treatnment of ocular hypertension and glaucoma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30858901P 2001-07-31 2001-07-31
US60/308,589 2001-07-31

Publications (2)

Publication Number Publication Date
WO2003011299A2 WO2003011299A2 (fr) 2003-02-13
WO2003011299A3 true WO2003011299A3 (fr) 2003-10-30

Family

ID=23194562

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2002/007699 Ceased WO2003011299A2 (fr) 2001-07-31 2002-07-30 Procede et composition pour le traitement de l'hypertension oculaire et des glaucomes
PCT/US2002/024072 Ceased WO2003011178A2 (fr) 2001-07-31 2002-07-31 Procede de traitement pour l'hypertension oculaire et le glaucome

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024072 Ceased WO2003011178A2 (fr) 2001-07-31 2002-07-31 Procede de traitement pour l'hypertension oculaire et le glaucome

Country Status (8)

Country Link
EP (1) EP1411950A2 (fr)
JP (1) JP2004538306A (fr)
KR (1) KR20040023707A (fr)
CN (1) CN1646134A (fr)
BR (1) BR0211545A (fr)
CA (1) CA2454422A1 (fr)
MX (1) MXPA04000980A (fr)
WO (2) WO2003011299A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003215820A1 (en) * 2002-03-28 2003-10-13 Sucampo Ag Method for treating ocular hypertension and glaucoma
AR043161A1 (es) * 2003-02-14 2005-07-20 Sucampo Pharmaceuticals Inc Composicion oftalmica para tratar hipertension ocular y glaucoma
AU2007272683B2 (en) * 2006-07-10 2012-08-23 Allergan, Inc. Substituted cyclopentane derivatives as therapeutic agents
BRPI0714885B8 (pt) * 2006-07-11 2021-05-25 Allergan Inc compostos terapêuticos e seu uso
US20080015219A1 (en) * 2006-07-11 2008-01-17 Allergan, Inc. Therapeutic compounds
JP5453254B2 (ja) * 2007-07-03 2014-03-26 アラーガン インコーポレイテッド 眼圧降下用の治療用置換シクロペンタン類

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366279A2 (fr) * 1988-10-01 1990-05-02 R-Tech Ueno Ltd. Agents oculaires hypotenseurs
WO2001068072A2 (fr) * 2000-03-16 2001-09-20 Sucampo Ag Traitement de l'hypertension oculaire et du glaucome
WO2002007731A2 (fr) * 2000-07-20 2002-01-31 Sucampo Ag Composition destinee au traitement de l'hypertension oculaire et du glaucome

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366279A2 (fr) * 1988-10-01 1990-05-02 R-Tech Ueno Ltd. Agents oculaires hypotenseurs
WO2001068072A2 (fr) * 2000-03-16 2001-09-20 Sucampo Ag Traitement de l'hypertension oculaire et du glaucome
WO2002007731A2 (fr) * 2000-07-20 2002-01-31 Sucampo Ag Composition destinee au traitement de l'hypertension oculaire et du glaucome
US20020035149A1 (en) * 2000-07-20 2002-03-21 Ryuji Ueno Treatment of ocular hypertension and glaucoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STJERNSCHANTZ J ET AL: "MICROVASCULAR EFFECTS OF SELECTIVE PROSTAGLANDIN ANALOGUES IN THE EYE WITH SPECIAL REFERENCE TO LATANOPROST AND GLAUCOMA TREATMENT", PROGRESS IN RETINAL AND EYE RESEARCH, OXFORD, GB, vol. 19, no. 4, July 2000 (2000-07-01), pages 459 - 496, XP001126960, ISSN: 1350-9462 *

Also Published As

Publication number Publication date
KR20040023707A (ko) 2004-03-18
JP2004538306A (ja) 2004-12-24
BR0211545A (pt) 2004-07-13
WO2003011299A2 (fr) 2003-02-13
CA2454422A1 (fr) 2003-02-13
MXPA04000980A (es) 2004-04-20
EP1411950A2 (fr) 2004-04-28
CN1646134A (zh) 2005-07-27
WO2003011178A2 (fr) 2003-02-13

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