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WO2003010507A3 - Systeme permettant de surveiller un processus intracellulaire et criblage de medicaments in vivo - Google Patents

Systeme permettant de surveiller un processus intracellulaire et criblage de medicaments in vivo Download PDF

Info

Publication number
WO2003010507A3
WO2003010507A3 PCT/IB2002/004257 IB0204257W WO03010507A3 WO 2003010507 A3 WO2003010507 A3 WO 2003010507A3 IB 0204257 W IB0204257 W IB 0204257W WO 03010507 A3 WO03010507 A3 WO 03010507A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug screening
process monitoring
vivo drug
intracellular process
intracellular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2002/004257
Other languages
English (en)
Other versions
WO2003010507A2 (fr
Inventor
Inhwan Hwang
Dae Heon Kim
Yong Jik Lee
Jing Bo Jin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ahram Biosystems Inc
Original Assignee
Ahram Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ahram Biosystems Inc filed Critical Ahram Biosystems Inc
Priority to AU2002339228A priority Critical patent/AU2002339228A1/en
Publication of WO2003010507A2 publication Critical patent/WO2003010507A2/fr
Anticipated expiration legal-status Critical
Publication of WO2003010507A3 publication Critical patent/WO2003010507A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un procédé permettant de détecter les caractéristiques associées au trafic intracellulaire et à la localisation sous-cellulaire d'une protéine reporter sélectionnée. L'invention concerne également un large éventail d'applications importantes notamment l'utilisation de ces caractéristiques dans des cribles pour détecter des composés qui modulent le trafic protéique in vivo.
PCT/IB2002/004257 2001-07-16 2002-07-16 Systeme permettant de surveiller un processus intracellulaire et criblage de medicaments in vivo Ceased WO2003010507A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002339228A AU2002339228A1 (en) 2001-07-16 2002-07-16 System for intracellular process monitoring and in vivo drug screening

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020010042886 2001-07-16
KR10-2001-0042886 2001-07-16

Publications (2)

Publication Number Publication Date
WO2003010507A2 WO2003010507A2 (fr) 2003-02-06
WO2003010507A3 true WO2003010507A3 (fr) 2004-05-27

Family

ID=19712212

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IB2002/004257 Ceased WO2003010507A2 (fr) 2001-07-16 2002-07-16 Systeme permettant de surveiller un processus intracellulaire et criblage de medicaments in vivo
PCT/KR2002/001345 Ceased WO2003008536A2 (fr) 2001-07-16 2002-07-16 Systeme de surveillance d'un processus intracellulaire et criblage in vivo de medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/KR2002/001345 Ceased WO2003008536A2 (fr) 2001-07-16 2002-07-16 Systeme de surveillance d'un processus intracellulaire et criblage in vivo de medicaments

Country Status (3)

Country Link
KR (2) KR20030007221A (fr)
AU (1) AU2002339228A1 (fr)
WO (2) WO2003010507A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030087869A1 (en) * 2001-09-28 2003-05-08 Ebens Allen James Assay for compounds affecting invertebrate cell secretory pathways
KR100863283B1 (ko) * 2002-10-11 2008-10-15 아람 바이오시스템 주식회사 세포내 과정의 관측 방법 및 그를 위해 사용되는 재조합유전자
DK1799829T3 (da) 2004-10-15 2012-04-10 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af en forbindelse i en eukaryot celle
FR2920878B1 (fr) * 2007-09-10 2019-07-26 Innovative Concepts In Drug Development (Icdd) Procede de toxicologie predictive ou de test d'efficacite par mesure de mobilite d'organites
CN108676075B (zh) * 2018-06-01 2022-04-01 山西省农业科学院果树研究所 一种引导蛋白分子进入植物细胞核的方法
CN109136321A (zh) * 2018-08-29 2019-01-04 北京艾普希隆生物科技有限公司 一种植物亚细胞定位试剂盒及其应用
KR102288367B1 (ko) 2018-11-15 2021-08-11 주식회사 바이오앱 식물체에서 바이러스-유사 입자를 발현하는 재조합 벡터 및 이를 이용한 써코바이러스-유사 입자를 포함하는 백신 조성물의 제조방법
CN110734480B (zh) * 2019-11-07 2021-08-24 中国科学院遗传与发育生物学研究所 大肠杆菌分子伴侣GroEL/ES在协助合成植物Rubisco中的应用
CN114317593A (zh) * 2021-12-31 2022-04-12 北京林业大学 一种超分辨显微技术观察植物原生质体膜蛋白动态的方法
CN117230109B (zh) * 2023-11-16 2024-03-19 三亚中国农业科学院国家南繁研究院 代替荧光蛋白的可视化质粒及其相关应用
CN119101709A (zh) * 2024-09-10 2024-12-10 深圳市第三人民医院(深圳市肝病研究所) 人源trem2蛋白的双重荧光标记活细胞样品及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999003997A1 (fr) * 1997-07-16 1999-01-28 University Of Florida Genes humanises de proteines fluorescentes vertes et procede d'utilisation associes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999003997A1 (fr) * 1997-07-16 1999-01-28 University Of Florida Genes humanises de proteines fluorescentes vertes et procede d'utilisation associes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BORDONNE ET AL.: "Functional characterization of nuclear localization signals in yeast Sm proteins", MOL. CELL. BIOL., vol. 21, 2000, pages 7943 - 7954 *
DATABASE BIOSIS [online] FEI ET AL.: "Nuclear trafficking of photoreceptor protein Crx: The targeting sequence and pathologic implications", Database accession no. 2000:429862 *
IOVS, vol. 41, no. 10, 2000, pages 2849 - 2856 *
KIM D. H.: "Trafficking of phosphatidylinositol 3-phosphate from the trans-golgi network to the lumen of the central vacuole in plant cells", THE PLANT CELL, vol. 13, February 2001 (2001-02-01), pages 287 - 301 *

Also Published As

Publication number Publication date
WO2003010507A2 (fr) 2003-02-06
KR100919637B1 (ko) 2009-09-30
WO2003008536A2 (fr) 2003-01-30
KR20030007221A (ko) 2003-01-23
KR20040015804A (ko) 2004-02-19
AU2002339228A1 (en) 2003-02-17

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