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WO2003009940A3 - Method and device for directed sort combinational synthesis - Google Patents

Method and device for directed sort combinational synthesis Download PDF

Info

Publication number
WO2003009940A3
WO2003009940A3 PCT/US2002/023489 US0223489W WO03009940A3 WO 2003009940 A3 WO2003009940 A3 WO 2003009940A3 US 0223489 W US0223489 W US 0223489W WO 03009940 A3 WO03009940 A3 WO 03009940A3
Authority
WO
WIPO (PCT)
Prior art keywords
directed
synthesis
sorting
reaction vessels
supports
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/023489
Other languages
French (fr)
Other versions
WO2003009940A2 (en
Inventor
Viktor Krchnak
Josef Vagner
Bruce A Seligmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HTG Molecular Diagnostics Inc
Original Assignee
High Throughput Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by High Throughput Genomics Inc filed Critical High Throughput Genomics Inc
Priority to JP2003515325A priority Critical patent/JP2005503370A/en
Priority to AU2002327323A priority patent/AU2002327323A1/en
Priority to EP02763336A priority patent/EP1417482A2/en
Publication of WO2003009940A2 publication Critical patent/WO2003009940A2/en
Publication of WO2003009940A3 publication Critical patent/WO2003009940A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A sorting apparatus and method for directed sort combinatorial chemical synthesis is provided. This invention relates to a directed flexible, sorting apparatus and method for combinatorial chemical synthesis using a directed split and recombine process. The process utilizes one algorithm that is universal in directing and sorting a library of any size. This invention further provides a method of sorting solid supports for combinatorial chemical synthesis comprising delivering one or more supports which are organized in a one dimensional linear array in one or more reaction vessels, to an isolation and transfer chamber, transferring one or more support from each of said reaction vessels to one or more subsequent reaction vessels, in a patterned distribution; wherein the patterned distribution of supports in each subsequent transfer is identical and the position of each support in a reaction vessel codes for its previous synthesis history. In another aspect, the invention provides a directed sort apparatus wherein all members of a set at a given point in time are reacted with the same chemical building blocks throughout synthesis.
PCT/US2002/023489 2001-07-24 2002-07-24 Method and device for directed sort combinational synthesis Ceased WO2003009940A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2003515325A JP2005503370A (en) 2001-07-24 2002-07-24 Method and apparatus for directed selective combinatorial synthesis
AU2002327323A AU2002327323A1 (en) 2001-07-24 2002-07-24 Method and device for directed sort combinational synthesis
EP02763336A EP1417482A2 (en) 2001-07-24 2002-07-24 Method and device for directed sort combinational synthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30718601P 2001-07-24 2001-07-24
US60/307,186 2001-07-24

Publications (2)

Publication Number Publication Date
WO2003009940A2 WO2003009940A2 (en) 2003-02-06
WO2003009940A3 true WO2003009940A3 (en) 2003-10-30

Family

ID=23188624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023489 Ceased WO2003009940A2 (en) 2001-07-24 2002-07-24 Method and device for directed sort combinational synthesis

Country Status (4)

Country Link
EP (1) EP1417482A2 (en)
JP (1) JP2005503370A (en)
AU (1) AU2002327323A1 (en)
WO (1) WO2003009940A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017173347A1 (en) 2016-04-01 2017-10-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Par2 mimetic peptides and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US6001579A (en) * 1993-10-01 1999-12-14 The Trustees Of Columbia University Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5968736A (en) * 1992-10-01 1999-10-19 Cold Spring Harbor Laboratory Methods for recording the reaction history of a solid support
US6001579A (en) * 1993-10-01 1999-12-14 The Trustees Of Columbia University Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags

Also Published As

Publication number Publication date
WO2003009940A2 (en) 2003-02-06
EP1417482A2 (en) 2004-05-12
AU2002327323A1 (en) 2003-02-17
JP2005503370A (en) 2005-02-03

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