[go: up one dir, main page]

WO2003008945A1 - Imagerie optique multi-longueurs d'ondes simultanee et basee sur la fonction tpsf - Google Patents

Imagerie optique multi-longueurs d'ondes simultanee et basee sur la fonction tpsf Download PDF

Info

Publication number
WO2003008945A1
WO2003008945A1 PCT/CA2002/001082 CA0201082W WO03008945A1 WO 2003008945 A1 WO2003008945 A1 WO 2003008945A1 CA 0201082 W CA0201082 W CA 0201082W WO 03008945 A1 WO03008945 A1 WO 03008945A1
Authority
WO
WIPO (PCT)
Prior art keywords
wavelengths
light
imaging
tpsf
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2002/001082
Other languages
English (en)
Inventor
David Jonathan Hall
Richard Boudreault
Pierre A. Beaudry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ART Advanced Research Technologies Inc
Original Assignee
ART Advanced Research Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ART Advanced Research Technologies Inc filed Critical ART Advanced Research Technologies Inc
Priority to CA2453644A priority Critical patent/CA2453644C/fr
Priority to JP2003514240A priority patent/JP2004536304A/ja
Priority to EP02757990A priority patent/EP1409995A1/fr
Publication of WO2003008945A1 publication Critical patent/WO2003008945A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Definitions

  • the present invention relates to the field of temporal point spread function (TPSF) based imaging in which objects which diffuse light, such as human body tissue, are imaged using signals resulting from the injection of light into the object and detection of the diffusion of the light in the object at a number of positions while gathering TPSF-based data to obtain information beyond simple attenuation such as scattering and absorption. More particularly, the present invention relates to a method and apparatus for simultaneous multi-wavelength TPSF-based imaging which reduces image acquisition time, and also promises to provide enhanced image information.
  • TPSF temporal point spread function
  • Time-domain optical medical images show great promise as a technique for imaging breast tissue, as well as the brain and other body parts.
  • the objective is to analyze at least a part of the temporal point spread function (TPSF) of an injected light pulse as it is diffused in the tissue, and the information extracted from the TPSF is used in constructing a medically useful image.
  • TPSF temporal point spread function
  • time domain Two fundamental techniques are known by which the TPSF can be obtained: time domain and frequency domain.
  • time domain a high intensity, short duration pulse is injected and the diffused light is detected within a much longer time frame than the pulse, but nonetheless requiring high-speed detection equipment.
  • frequency domain light is modulated in amplitude at a range of frequencies from the kHz range to about 0.5GHz.
  • the light injected is modulated but essentially continuous, and the information collected is the amplitude and the phase difference of the light at the detector.
  • lower intensities are required, and the demands of very short, high intensity injection pulse generation and high-speed detection are avoided.
  • the acquisition of the data requires the two parameters of amplitude and phase shift to be recorded for a large number of modulation frequencies within the dynamic range provided.
  • the TPSF could be calculated by inverse Fourier transform, however, the image is typically generated using the frequency domain data.
  • the breast is immobilized by stabilizing plates of the optical head.
  • the light injected is not harmful, prolonged imaging time is uncomfortable for patients, particularly in the case of female breast imaging in which the breast is typically secured between support members or plates, and is typically immersed in a bath or surrounded by a coupling medium contained in a bag.
  • optical imaging promises a safer and potentially a more medically useful technique
  • imaging time and related patient discomfort remains a problem in providing a competitively superior technique.
  • this object is achieved by using a plurality of distinguishable wavelengths simultaneously to acquire simultaneously a plurality of TPSF-based imaging data points.
  • different injection- detection positions may be used simultaneously to collect imaging data points simultaneously for the different injection-detection positions, thus covering more imaging area faster.
  • the wavelengths may provide complementary information about the object being imaged.
  • a method of TPSF-based optical imaging comprising the steps of injecting light at a plurality of wavelengths into an object to be imaged at one or more injection positions, and detecting the injected light after diffusing in the object at one or more detection positions simultaneously for the plurality of wavelengths to obtain separate TPSF-based data for each of the wavelengths.
  • the invention also provides a TPSF-based optical imaging apparatus comprising at least one source providing light at a plurality of wavelengths, a plurality of injection ports and lightguides coupled to the at least one source for injecting the light into an object to be imaged at one or more injection positions, a plurality of detection ports and lightguides, a wavelength selection device coupled to the plurality of detection ports and lightguides for separating the plurality of wavelengths, and a camera detecting the plurality of wavelengths separated by the device.
  • Fig. 1 illustrates schematically the components of the imaging system according to the preferred embodiment including the laser sources, injection and detection port apparatus, multiwavelength detector, detector signal processor and imaging computer station;
  • Fig. 2 illustrates an optical schematic diagram of the imaging system according to the preferred embodiment showing the multiple waveguide paths between the detection ports and the detector, as well as the multiplexed multiple wavelength source arrangement;
  • Fig. 3 illustrates a side view of the detection fibers coupled to a detector using a collimating fiber holder
  • Fig. 4 illustrates a plan view of the detector faceplate surface having four quadrants each provided with a different wavelength selective filter coating.
  • the invention is applied to the case of time domain optical medical imaging, however, it will be apparent to those skilled in the art that the invention is applicable to frequency domain techniques for optical imaging.
  • the injected pulses at each of the plurality of wavelengths are preferably simultaneously injected, however, for the imaging to be "simultaneous", the time window reserved for acquiring the TPSF from a single wavelength's injection pulse using the chosen detector overlaps between the respective wavelengths even if the injected pulses were not simultaneous.
  • the pulsed light source 10 has an output (in practice, it will comprise a plurality of laser source outputs at discrete wavelengths, as described further hereinbelow) optically coupled via a switch 11 to one of plurality of waveguides 12 to a number of injection ports of a support 14.
  • the injection ports are preferably positioned at a number of fixed positions over the imaging area for each wavelength to be used, although the injection port may alternatively be movable over the body surface, provided that the body part 16 is immobilized.
  • the injection and detection ports may directly contact the body or a coupling medium may be used between the body and the injection/detection ports.
  • the detection ports and support 18 are arranged in Fig. 1 in transmission mode for breast imaging. It also possible to arrange detection ports on the same surface of the patient as the injection ports, in which case imaging is achieved by measuring the TPSF of the diffused pulse reflected from the tissue.
  • the light injected is preferably pulses having a duration of about 1 to 100 picoseconds and an average power of about 100 mW.
  • the laser source 10 preferably comprises four laser sources operating at 760 nm, 780 nm, 830 nm, and 850 nm. These different wavelengths allow for complementary information to be acquired to build a physiological image of the breast tissue. As better shown in Fig. 2, the output of each wavelength laser source 10a to 10d, for the four wavelengths chosen, are coupled to fibers 12a to 12d respectively.
  • the fibers are preferably multimode fibers, such as 200/240 micron graded index multimode fibers.
  • Fig. 2 illustrates for simplicity four injection positions and four detection positions, it will be understood that there may be about 10 injection positions and typically up to about 50 detector positions.
  • the light from the four sources is preferably injected at the same point, and the light is coupled onto a same fiber 12f, as shown in Fig. 2, using a coupler 12e, or alternatively the four fibers 12a to 12d could be fed as a bundle to the same position within support 14. It will be appreciated that multiplexing the four wavelengths onto the same fiber 12f allows a conventional single wavelength support 14 to be used without taking into account different injection positions within the program of the imaging computer or processor 30.
  • FIG. 2 illustrates a single fiber (or bundle) 12 f, there is preferably 10 such fibers for the 10 injection positions.
  • a fiber switch 11 such as a conventional 1 by 32 JDS Uniphase switch is used to switch light from each laser source 10 to a desired one of the injection port positions.
  • the detected optical signals are communicated by waveguides 20, namely 400/440 micron graded index multimode optical fibers, to a spectral channel separator 22, namely a series of filters in the preferred embodiment.
  • the filters may comprise band-pass filter coatings 22a, 22b, 22c, and 22d on a faceplate 24 of the detector 26.
  • Each detection fiber 20 is coupled directly to the detector 26 without switching, in the preferred embodiment.
  • the separator 22 While it is possible for the separator 22 to switch and/or demultiplex the light from fibers 20 onto lightguides 24, as illustrated in Figure 1 , in the preferred embodiment shown in Figures 3 and 4, the fibers 20 are mounted in a collimating fiber holder or positioner 21 for directing the light from each fiber 20 to the filter 22 and then onto the detector surface 26.
  • the collimating holder has a collimating microlens for coupling the light exiting the core of the fiber 20 onto the detector surface with a small spot size.
  • an array of 50 fibers is arranged in each quadrant or zone of the faceplate 22 at the detector 26.
  • spectral separation may also be achieved using an optical spectrometer or a grating device, such as an arrayed waveguide grating or the like, instead of using a filtering medium or coating.
  • the injection and detection locations are the same for each wavelength, however, individual positions for lightguides for each wavelengths can be accommodated, e.g. the detector ports could support 200 positions fiber.
  • the wavelength separated signals are all detected simultaneously by a gated intensified CCD camera, for example a PicoStar Camera by LaVision.
  • the camera 26 is used to detect the light from each detection port 18 and at each desired wavelength with picosecond resolution.
  • the injected pulse may spread out over several picoseconds to several nanoseconds as a result of diffusion through the body tissue.
  • a large number of pulses are injected and their corresponding camera signals are processed by imaging computer 30 to determine one data point, i.e. the temporal point spread function for a particular wavelength and a particular injection port and detection port combination.
  • the TPSF is measured at a number of detector positions at which the detected signal provides good signal to noise.
  • Such data points are gathered for a large number of combinations of wavelengths and port positions to obtain sufficient "raw" data to begin constructing an image of the tissue.
  • the resulting image can be displayed on display 32 and printed on a printer 34.
  • the imaging computer 30 is also responsible for signaling a laser source 10 to select a desired wavelength and then switch that wavelength signal to a desired output fiber 12. The computer 30 thus progresses through all desired wavelength and position combinations to achieve the desired imaging.
  • the laser source 10 synchronizes the camera 26 with each pulse.
  • the laser source 10 may also comprise a number of fixed wavelength optical sources, as it may also comprise a single broadband source.
  • the laser 10 will be controlled to be modulated at the desired frequency and switch its output onto the desired fiber 12.
  • the computer 30 will then need to sweep through a large number of modulation frequencies at which the amplitude and phase shift of the detected light is recorded with good accuracy.
  • the TPSF for a single data point can be calculated from the amplitude and phase shift data set recorded, or typically, the frequency domain data is used directly to reconstruct the image. In the present application, reference is made to a plurality of wavelengths that can be separately detected.
  • While these distinct wavelengths can be generated from a monochromatic or broadband light source to directly provide the desired wavelengths, it is alternatively possible to mix a first basic wavelength with a second reference wavelength to create a beating of the wavelengths. This can be used to tune the basic wavelength to create the desired wavelength at the plurality of wavelengths and is another way of providing the light to be injected according to the invention. Given that the light source has two parts for the first and second wavelengths, it is possible to control or pulse only one to achieve the desired light injection.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention se rapporte à une technique d'imagerie basée sur la fonction TPSF qui utilise de multiples longueurs d'ondes simultanément pour imager un objet. Le temps d'acquisition d'une image peut être réduit sans qu'il soit nécessaire de sacrifier la quantité efficace ou la qualité des données d'imagerie brutes acquises. Il est possible d'utiliser une pluralité de longueurs d'ondes différenciables de manière simultanée en différents emplacements de détection-injection de manière à acquérir simultanément une pluralité de points de données d'imagerie basés sur la fonction TPSF pour les différents emplacements de détection-injection. Les multiples longueurs d'ondes peuvent fournir des informations complémentaires sur l'objet à imager.
PCT/CA2002/001082 2001-07-16 2002-07-16 Imagerie optique multi-longueurs d'ondes simultanee et basee sur la fonction tpsf Ceased WO2003008945A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2453644A CA2453644C (fr) 2001-07-16 2002-07-16 Imagerie optique multi-longueurs d'ondes simultanee et basee sur la fonction tpsf
JP2003514240A JP2004536304A (ja) 2001-07-16 2002-07-16 同時マルチ波長方式によるｔｐｓｆ光学イメージング
EP02757990A EP1409995A1 (fr) 2001-07-16 2002-07-16 Imagerie optique multi-longueurs d'ondes simultanee et basee sur la fonction tpsf

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30508001P 2001-07-16 2001-07-16
US60/305,080 2001-07-16
US10/050,941 2002-01-22
US10/050,941 US7047057B2 (en) 2001-07-16 2002-01-22 Simultaneous multiwavelength TPSF-based optical imaging

Publications (1)

Publication Number Publication Date
WO2003008945A1 true WO2003008945A1 (fr) 2003-01-30

Family

ID=26728877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001082 Ceased WO2003008945A1 (fr) 2001-07-16 2002-07-16 Imagerie optique multi-longueurs d'ondes simultanee et basee sur la fonction tpsf

Country Status (6)

Country Link
US (1) US7047057B2 (fr)
EP (1) EP1409995A1 (fr)
JP (1) JP2004536304A (fr)
CN (1) CN1543568A (fr)
CA (1) CA2453644C (fr)
WO (1) WO2003008945A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004081547A1 (fr) * 2003-03-12 2004-09-23 Art Advanced Research Technologies Inc. Procede et appareil permettant de combiner l'imagerie optique par ondes entretenues et l'imagerie optique du domaine temps
WO2008096289A1 (fr) 2007-02-05 2008-08-14 Koninklijke Philips Electronics N.V. Dispositif et procédé d'acquisition de données d'image d'un milieu trouble
EP2057941A1 (fr) * 2007-11-07 2009-05-13 Koninklijke Philips Electronics N.V. Procédé et dispositif d'imagerie de l'intérieur d'un milieu optiquement trouble

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004034878A2 (fr) * 2002-10-17 2004-04-29 Iridex Corporation Dispositif d'emission laser contenant une pluralite de fibres optiques de source laser
JP4499495B2 (ja) * 2004-07-01 2010-07-07 財団法人光科学技術研究振興財団 パルス光伝送装置及びパルス光伝送調整方法
US7859671B2 (en) * 2004-12-30 2010-12-28 Art, Advanced Research Technologies Inc. Method for determining optical properties of turbid media
WO2006116672A2 (fr) * 2005-04-27 2006-11-02 The Trustees Of Dartmouth College Systemes et procedes pour reconstruction d'images tomographiques
US7962198B2 (en) * 2005-04-27 2011-06-14 The Trustees Of Dartmouth College System and method for spectral-encoded high-rate hemodynamic tomography
US20090306519A1 (en) * 2006-07-31 2009-12-10 Koninklijke Philips Electronics N.V. Measurement with multiplexed detection
US20080218727A1 (en) * 2006-12-22 2008-09-11 Art, Advanced Research Technologies Inc. Method and apparatus for optical image reconstruction using contour determination
EP2760339A4 (fr) 2011-09-28 2015-07-08 Bruker Biospin Corp Système d'imagerie multi-longueurs d'onde séquentielle à trames et procédé associé
CN104076001A (zh) * 2013-12-17 2014-10-01 浙江工商大学 基于激光器阵列的检测装置及大黄鱼存储时间检测方法
CN105223137B (zh) * 2015-10-20 2017-10-24 希肯医疗技术（苏州）有限公司 一种用于生物样本检测的光学测量装置
WO2024081713A1 (fr) * 2022-10-12 2024-04-18 Ciena Corporation Procédé et appareil pour effectuer une spectroscopie optique à spectre étalé
US20240129054A1 (en) * 2022-10-12 2024-04-18 Ciena Corporation Method and apparatus for performing spread spectrum optical spectroscopy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515165A (en) * 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
US5807261A (en) * 1992-09-14 1998-09-15 Sextant Medical Corporation Noninvasive system for characterizing tissue in vivo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1230118C (zh) * 1995-01-03 2005-12-07 无创伤诊断技术公司 用于生物组织体内测量的光耦合器
US5694938A (en) * 1995-06-07 1997-12-09 The Regents Of The University Of California Methodology and apparatus for diffuse photon mimaging
EP1034417A4 (fr) * 1997-11-26 2005-07-06 Imaging Diagnostic Systems Inc Appareil pour imagerie mammaire a resolution temporelle
US6660001B2 (en) * 2000-01-21 2003-12-09 Providence Health System-Oregon Myocardial revascularization-optical reflectance catheter and method
US6509729B2 (en) * 2001-01-09 2003-01-21 The United States Of America As Represented By The Secretary Of The Navy Multiple simultaneous optical frequency measurement

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515165A (en) * 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
US5807261A (en) * 1992-09-14 1998-09-15 Sextant Medical Corporation Noninvasive system for characterizing tissue in vivo

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004081547A1 (fr) * 2003-03-12 2004-09-23 Art Advanced Research Technologies Inc. Procede et appareil permettant de combiner l'imagerie optique par ondes entretenues et l'imagerie optique du domaine temps
US7720525B2 (en) 2003-03-12 2010-05-18 New Art Advanced Research Technologies Inc. Method and apparatus for combining continuous wave and time domain optical imaging
WO2008096289A1 (fr) 2007-02-05 2008-08-14 Koninklijke Philips Electronics N.V. Dispositif et procédé d'acquisition de données d'image d'un milieu trouble
US8355131B2 (en) 2007-02-05 2013-01-15 Koninklijke Philips Electronics N.V. Device and method for acquiring image data from a turbid medium
EP2057941A1 (fr) * 2007-11-07 2009-05-13 Koninklijke Philips Electronics N.V. Procédé et dispositif d'imagerie de l'intérieur d'un milieu optiquement trouble
WO2009060370A3 (fr) * 2007-11-07 2009-07-02 Koninkl Philips Electronics Nv Procédé et dispositif de formation d'image de l'intérieur d'un milieu optiquement trouble

Also Published As

Publication number Publication date
CA2453644A1 (fr) 2003-01-30
CA2453644C (fr) 2012-09-11
US7047057B2 (en) 2006-05-16
CN1543568A (zh) 2004-11-03
JP2004536304A (ja) 2004-12-02
US20030085338A1 (en) 2003-05-08
EP1409995A1 (fr) 2004-04-21

Similar Documents

Publication Publication Date Title
CA2453644C (fr) Imagerie optique multi-longueurs d'ondes simultanee et basee sur la fonction tpsf
DE69738291T2 (de) Verfahren und vorrichtung zur durchführung optischer messungen mittels eines endoskops, katheters oder führungsdrahtes mit faseroptischem abbildungssystem
EP1051106B1 (fr) Procede et dispositif pour la modulation tissulaire
EP1828711B1 (fr) Systeme permettant de generer des images tridimensionnelles ou bidimensionnelles
US7414729B2 (en) System and method for coherent anti-Stokes Raman scattering endoscopy
KR100352689B1 (ko) 동기 발광 시스템
US5309907A (en) Measuring arrangement for examining a subject with visible, NIR or IR light
US9545223B2 (en) Functional near infrared spectroscopy imaging system and method
US7797119B2 (en) Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7643153B2 (en) Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US8634082B2 (en) Pulsed lasers in frequency domain diffuse optical tomography and spectroscopy
DE60317085T2 (de) Spektroskopisches kathetersystem mit breit abstimmbarer quelle
JPH09505407A (ja) 光による組織検査装置
AU2003210669A2 (en) Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography (OCT) signals by parallel detection of spectral bands
US20090073453A1 (en) Elasticity and viscosity measuring apparatus
DE10043162A1 (de) Lichtleitfaserbündel und Endoskopeinrichtung
WO2004046696A1 (fr) Procede de mesure spectrale composite et instrument de detection spectrale a cet effet
DE112004000376T5 (de) Vorrichtung und Verfahren zur Qualitätsauswertung einer Katheterverbindung unter Verwendung von Rückflussdämpfung
DE10038875A1 (de) Endoskopsystem
EP3812722A1 (fr) Spectromètre comprenant un laser accordable sur puce et procédé de mesure de spectre
DE60320024T2 (de) Spektroskopisches Kathetersystem mit leistungsstabiler abstimmbarer Lichtquelle
JP2004536304A5 (fr)
WO1995033987A1 (fr) Procede et dispositif d'imagerie d'un objet au moyen de lumiere
JP2004147706A (ja) 非侵襲型生体成分の定量装置及び定量方法
KR102746930B1 (ko) 빔 스플릿터를 이용한 고속 다중 모드 광학 영상장치 및 그 광학 영상장치를 이용한 혈류속도와 혈중 산소포화도 측정방법

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2453644

Country of ref document: CA

Ref document number: 2003514240

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002757990

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2002816086X

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2002757990

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642