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WO2003005034A3 - Procedes d'identification d'agents therapeutiques de traitement de maladies impliquant le gene - Google Patents

Procedes d'identification d'agents therapeutiques de traitement de maladies impliquant le gene Download PDF

Info

Publication number
WO2003005034A3
WO2003005034A3 PCT/CA2002/001004 CA0201004W WO03005034A3 WO 2003005034 A3 WO2003005034 A3 WO 2003005034A3 CA 0201004 W CA0201004 W CA 0201004W WO 03005034 A3 WO03005034 A3 WO 03005034A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agents
agents useful
processes
treating diseases
diseases involving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2002/001004
Other languages
English (en)
Other versions
WO2003005034A2 (fr
Inventor
Marcia L Macdonald
Jutta M Zeisler
Mark Samuels
Yigal P Goldberg
Johanne M Robataille
Michael R Hayden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Xenon Pharmaceuticals Inc
Original Assignee
University of British Columbia
Xenon Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia, Xenon Genetics Inc filed Critical University of British Columbia
Publication of WO2003005034A2 publication Critical patent/WO2003005034A2/fr
Publication of WO2003005034A3 publication Critical patent/WO2003005034A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/164—Retinal disorders, e.g. retinopathy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur des mutations de gènes sélectionnés tels que le gène 4 de Frizzled ('fzd4'), qui sont les agents responsables de troubles héréditaires de la vue chez l'homme, tels que la vitréorétinopathie exudative familiale ('FEVR'), ainsi que leurs méthodes d'utilisation y compris dans le criblage d'agents thérapeutiques traitant ces maladies et/ou en améliorant les effets, ainsi que sur des procédés de diagnostic de l'état des atteintes à la vue causées par les mutations de ces gènes.
PCT/CA2002/001004 2001-07-05 2002-07-04 Procedes d'identification d'agents therapeutiques de traitement de maladies impliquant le gene Ceased WO2003005034A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30328501P 2001-07-05 2001-07-05
US60/303,285 2001-07-05
US34040901P 2001-10-29 2001-10-29
US60/340,409 2001-10-29

Publications (2)

Publication Number Publication Date
WO2003005034A2 WO2003005034A2 (fr) 2003-01-16
WO2003005034A3 true WO2003005034A3 (fr) 2003-05-30

Family

ID=26973372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001004 Ceased WO2003005034A2 (fr) 2001-07-05 2002-07-04 Procedes d'identification d'agents therapeutiques de traitement de maladies impliquant le gene

Country Status (1)

Country Link
WO (1) WO2003005034A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005025590A2 (fr) * 2003-09-15 2005-03-24 Develogen Aktiengesellschaft Utilisation d'un produit proteique dg280 dans la prevention et le traitement de troubles metaboliques
DE102004050620A1 (de) * 2004-10-13 2006-04-20 Eberhard-Karls-Universität Tübingen Monoklonaler Antikörper gegen Frizzled-Rezeptoren
US7947805B2 (en) * 2004-12-23 2011-05-24 Merck Serono S.A. BCMA polypeptides and uses thereof
EP2491143B1 (fr) * 2009-10-21 2017-12-13 Retinal Solutions LLC Méthodes et compositions utilisées pour le diagnostic et le traitement d'une rétinopathie génétique
CN118440947B (zh) * 2024-07-08 2024-09-06 湖南家辉生物技术有限公司 Fzd4基因突变体、突变体蛋白及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039357A1 (fr) * 1996-04-12 1997-10-23 The Board Of Trustees Of The Leland Stanford Junior University COMPOSITIONS A BASE DU RECEPTEUR DE Wnt ET PROCEDES D'UTILISATION DE CELLES-CI
WO1999026960A2 (fr) * 1997-11-25 1999-06-03 Millennium Pharmaceuticals, Inc. Genes codant des proteines ressemblant a de la frisee
EP1001023A2 (fr) * 1998-09-09 2000-05-17 Smithkline Beecham Plc Frizzled-4, un possible récepteur pour Wnt

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039357A1 (fr) * 1996-04-12 1997-10-23 The Board Of Trustees Of The Leland Stanford Junior University COMPOSITIONS A BASE DU RECEPTEUR DE Wnt ET PROCEDES D'UTILISATION DE CELLES-CI
WO1999026960A2 (fr) * 1997-11-25 1999-06-03 Millennium Pharmaceuticals, Inc. Genes codant des proteines ressemblant a de la frisee
EP1001023A2 (fr) * 1998-09-09 2000-05-17 Smithkline Beecham Plc Frizzled-4, un possible récepteur pour Wnt

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIRIKOSHI H ET AL: "MOLECULAR CLONING AND CHARACTERIZATION OF HUMAN FRIZZLED-4 ON CHROMOSOME 11Q14-Q21", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 264, no. 3, 2 November 1999 (1999-11-02), pages 955 - 961, XP001057078, ISSN: 0006-291X *

Also Published As

Publication number Publication date
WO2003005034A2 (fr) 2003-01-16

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