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WO2003000170A1 - Bouche de recipient destinee a au traitement de melangeage et de remplissage et recipient d'infusion utilisant ladite bouche - Google Patents

Bouche de recipient destinee a au traitement de melangeage et de remplissage et recipient d'infusion utilisant ladite bouche Download PDF

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Publication number
WO2003000170A1
WO2003000170A1 PCT/JP2002/006092 JP0206092W WO03000170A1 WO 2003000170 A1 WO2003000170 A1 WO 2003000170A1 JP 0206092 W JP0206092 W JP 0206092W WO 03000170 A1 WO03000170 A1 WO 03000170A1
Authority
WO
WIPO (PCT)
Prior art keywords
infusion
infusion container
insertion port
valve
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/006092
Other languages
English (en)
Japanese (ja)
Inventor
Hideshi Okamoto
Keiichi Kawakami
Fujio Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP2003506616A priority Critical patent/JPWO2003000170A1/ja
Publication of WO2003000170A1 publication Critical patent/WO2003000170A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed

Definitions

  • the present invention relates to a co-infusion processing member used by being attached to an infusion container, and an infusion container for performing co-infusion and discharge from separate mouths.
  • Conventionally known infusion containers include a so-called one-port type and a two-port type.
  • co-injection processing and discharge processing are performed from the same mouth, and in the latter, each processing is performed using separate mouths.
  • the mouth of the infusion container is sealed with an elastic body or a thin film. Therefore, when performing the co-injection treatment, pierce the elastic body or break through the thin film before performing the co-infusion process. Will be Therefore, during co-injection treatment, chips and thin film fragments of the elastic body may enter the infusion container.However, since the usual infusion circuit is equipped with a filter, even if it is in the infusion container, Even if the swarf or the like is mixed, it is prevented from accidentally entering the human body.
  • the puncture mark of the medical infusion needle remains in the mouth due to the co-injection treatment, and the puncture mark impairs the hermeticity of the infusion container. There is also a problem that there is a risk of causing liquid leakage and the like.
  • an object of the present invention is to eliminate the possibility that foreign matter, such as chips and thin film fragments of an elastic body, may be mixed during the co-injection treatment of a medicinal solution or the like into an infusion container, and to remove the infusion container even after the co-infusion treatment is performed. It is an object of the present invention to provide an infusion port for an infusion container capable of ensuring the hermeticity of an infusion container, and an infusion container using the same. Disclosure of the invention
  • the present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, as a member for forming a co-injection port of an infusion container, injection of a syringe or the like used for co-infusion processing. Equipped with a substantially cylindrical insertion port for holding, locking or screwing members, a check valve inside to prevent the chemical solution from flowing out of the chemical solution container, and foreign matter entering from outside the chemical solution container.
  • a filter with a filter to prevent the infusion it is possible to eliminate the possibility that chips and thin film fragments of the elastic body are mixed in the co-injection treatment of the chemical solution into the infusion container.
  • the inventor has found a completely new fact that the infusion container can be kept hermetically sealed even after the co-injection treatment, and has completed the present invention.
  • the mouthpiece for co-infusion processing according to the present invention for solving the above-mentioned problem is attached to a chemical solution container to partition the mouth for co-infusion treatment, and (i) is directed toward the outside of the chemical solution container.
  • co-infusion processing can be performed without going through an operation of piercing an elastic body or piercing a thin film. Therefore, there is no generation of chips of the elastic body or fragments of the thin film during the co-injection treatment, and therefore there is no possibility that such chips or the like may be erroneously mixed.
  • the filter is provided together with the check valve, it is possible to prevent foreign substances and bacteria from entering the inside of the chemical solution container from the outside.
  • the co-infusion processing member of the present invention is provided with the above-described check valve, the infusion container is stored not only after the co-infusion processing but also when manufacturing the infusion container at the time of sterilization or the like. Even during transport, it is possible to prevent leakage of chemicals and the like.
  • the co-infusion processing member according to the present invention is extremely suitable as a member for defining the co-infusion port of the infusion container.
  • the valve body is arranged inside the cylinder to close the flow of the chemical solution, and when receiving the fluid pressure from the insertion port side, it is easily compressed and deformed to flow the chemical solution between the valve seat and the valve seat.
  • a gap is formed, and movement to the inside of the drug solution container is regulated by a locking portion that contacts the valve body from the inside of the infusion container,
  • the valve seat has a drug solution flow hole
  • the liquid medicine flow hole is closed by the valve element when the valve element is not receiving fluid pressure from the insertion port side, and is opened when the valve element is receiving the fluid pressure, and the gap is Communication with the department,
  • valve body and the valve seat are arranged such that a direction in which the fluid pressure is applied to the valve body and a direction in which the chemical solution flows in the gap intersect.
  • the check valve itself has a simple structure and its manufacture is easy. Nevertheless, it is possible to further improve the sealing performance of the infusion container after the co-injection treatment, and to obtain excellent sealing performance during the production of the infusion container after the co-infusion treatment. be able to.
  • the elastic body forming the valve body has a hardness (JISA) of 0 to 20; a tensile stress of 0.05 to 2.0 OMPa; and a compression permanent strain rate of 30%.
  • JISA hardness
  • the following thermoplastic elastomers are preferred.
  • the substantially cylindrical insertion port has a protrusion or a thread on an outer peripheral surface thereof, and has an outer cylindrical portion provided with a female screw and an inner cylindrical portion for insertion. It is preferably one that can be screwed with a lure-mouth type injection device having a.
  • a projection or a thread on the outer peripheral surface of the insertion port when the injection member such as a syringe used for co-injection processing has a so-called Luer lock type locking portion, the injection member is screwed into the insertion port. Can be Holding and locking can be facilitated.
  • the filter has a pore diameter of 0.1 to 10 / m, while the co-injection processing of the chemical solution container is smoothly achieved, and foreign matter from outside is mixed. It is preferable from the viewpoint of reliably preventing it.
  • the filter preferably has a pore diameter of 0.15 to 0.25 / zm in the above range. In this case, it is possible not only to prevent foreign substances such as chips from the elastic body from being mixed, but also to surely prevent external bacteria from being mixed.
  • the infusion container according to the present invention includes any one of the co-injection treatment parts according to the present invention, and an outlet for discharging a content liquid.
  • co-injection processing and discharge processing can be achieved with different mouths.
  • the mouth for the co-injection treatment is defined by the roto-member for co-infusion treatment of the present invention, the co-infusion treatment can be performed without going through the operation of piercing the elastic body or piercing the thin film. It can be carried out. Therefore, there is no generation of chips of the elastic body or fragments of the thin film during the co-injection treatment, and therefore there is no possibility that such chips or the like may be erroneously mixed.
  • the filter is provided together with the check valve, foreign substances and bacteria can be prevented from entering the inside of the chemical solution container from the outside.
  • the infusion container of the present invention is provided with the above-described check valve, the infusion container is manufactured not only after the co-infusion process but also when manufacturing the infusion container for sterilization, etc., and storing and transporting the infusion container. In this case, leakage of the content liquid can be prevented.
  • the infusion container according to the present invention can be used as an infusion container that can prevent leakage of the content liquid during and after co-injection processing, and can realize safe administration without the risk of foreign substances being mixed. Very suitable.
  • the infusion container By providing the infusion container with a plurality of chambers partitioned by an openable partition, a plurality of infusions can be isolated and stored, and the partition can be opened for use and mixed for use.
  • the infusion container according to the present invention includes, for example, those containing a fat emulsion.
  • Fat emulsions are emulsions, that is, they are opaque. Therefore, if foreign matter such as elastic chips is mixed inside, it can be visually confirmed. Extremely difficult.
  • a filter is provided in the co-infusion processing port member, and in the first place, there is no risk of foreign matter entering from the co-infusion port during and after the co-infusion processing. Therefore, the infusion container of the present invention is also suitable for applications containing a fat emulsion.
  • the infusion container partitioned by the openable partition has two chambers partitioned by the partition, one containing a transfusion solution containing a sugar and a fat emulsion, and the other containing an amino acid and an electrolytic solution.
  • An infusion container in which an infusion containing a chamber is stored is mentioned.
  • An infusion container 10 using the co-infusion processing port member according to the present invention includes, as shown in FIG. 1, for example, an internal solution discharge processing port 11 and a co-infusion processing ro member 20 of the present invention. This is provided with two mouths, namely, a mouthpiece for co-infusion treatment 12 provided.
  • Such an infusion container 10 may be a so-called single-room infusion container having one accommodation room, or a so-called multiple-room infusion container having two or more accommodation rooms.
  • the accommodation room 14 is composed of two rooms (an upper accommodation room 14 a and a lower accommodation room 14 b) separated by an openable partition 13.
  • the shape of the partition is not particularly limited, and various known means can be adopted.
  • those which are heat-welded, which can be peeled off by pressing, are already employed in commercially available two-chamber infusions and are suitable.
  • an infusion solution containing bran and a fat emulsion is contained in one compartment, and an infusion solution containing amino acids and electrolytes is contained in the other compartment. This avoids the Maillard reaction of sugars and amino acids and the aggregation of fat emulsions due to electrolytes.
  • the check valve 21 in the co-infusion processing port member 20 of the present invention is disposed on the inner side of the infusion container 10 with respect to the insertion port 30 as described above.
  • This check valve 2 1 This blockades the flow of the chemical solution in the co-injection processing member 20 and allows the flow of the chemical solution when the fluid pressure P is received from the insertion port 30 side.
  • FIG. 2 shows the cross-sectional structure of the co-injection processing member 20 according to the present invention.
  • FIG. 2 shows a state in which the fluid pressure P is not applied to the valve body 23 of the check valve 21 from the insertion port 30 side, and the check valve 21 is a co-injection treatment member 20. This shows a state in which the circulation of the chemical solution is closed.
  • the fluid pressure P is applied to the check valve 21 from the insertion port 30 side to allow the chemical solution to flow through the co-injection treatment member 20 (that is, the use state).
  • 2 and 3 are cross-sectional views taken along the line AA of FIGS. 4 (a) and 4 (b) described later.
  • the check valve 21 shown in FIGS. 2 and 3 includes a cylindrical body 22 communicating with the insertion port 30 and a valve body 23 made of an elastic body.
  • the valve body 23 is disposed inside the cylindrical body 22 to close the flow of the chemical solution, and when the valve body 23 receives the fluid pressure P from the insertion port 30 side, it is easily compressed and deformed, and the liquid medicine between the valve seat 24 and the valve body 24 is formed.
  • An inflow gap 26 is formed. The movement of the valve body 23 to the inside is restricted by a locking portion 27 that comes into contact with the valve body 23 from the inside of the infusion container 10.
  • the valve seat 24 comes into contact with the valve body 23 from the insertion port 30 side.
  • the valve seat 24 is provided with a chemical solution flow hole 25.
  • the chemical solution flow hole 25 is formed by the valve body 23 when the valve body 23 is not receiving the fluid pressure P from the insertion port 30 side. It is closed, and opens when it receives fluid pressure P from the insertion port 30 side, and communicates with the above-mentioned gap 26.
  • valve body 23 and the valve seat 24 intersect with the direction in which the fluid pressure P is applied to the valve body 23 and the direction in which the chemical flows in the gap 26 (the direction indicated by the arrow in FIG. 3B). are arranged as follows.
  • the valve body 23 is brought into the state shown in FIGS. 3A and 3B by compression deformation. That is, a gap 26 is formed between the valve body 23 and the valve seat 24 due to the compression deformation of the valve body 23 caused by the load of the fluid pressure P from the insertion port 30 side.
  • the mixed liquid can flow in through the chemical solution flow holes 25 and the voids 26. Fluid to valve element 2 3
  • the valve 23 returns to its original state (ie, the state shown in FIG. 2), the gap 26 disappears, and the chemical solution flow hole 25 is formed by the valve 23. Closed.
  • the direction of the fluid pressure P applied to the valve body 23 coincides with the direction of operation when the valve body 23 compresses and deforms, and is coaxial with the direction of operation when the valve body 23 recovers (axial direction: X) is on.
  • the direction y in which the chemical solution flows into the gap portion 26 generated by the compression deformation of the valve body 23 is not coaxial with the direction in which the fluid pressure P is applied to the valve body 23, and intersects each other (preferably, , Orthogonal) (see Figure 3b).
  • the elastic body forming the valve body 23 of the check valve 21 is, for example, soft enough to be easily deformed by the fluid pressure P of the co-injection liquid generated by pressing the piston of the syringe, and When the fluid pressure P is not applied, the shape is required to be maintained (for example, a material exhibiting properties as a gel).
  • the elastic member that is strong include rubbers such as natural rubber, silicone rubber, isoprene rubber, butadiene rubber, and fluoro rubber; plastics such as polyethylene and polypropylene; various thermoplastic elastomers. Those having sufficiently low hardness and sufficiently exhibiting properties as a gel may be mentioned. Among them, thermoplastic elastomers are preferred.
  • thermoplastic elastomer for example, styrene-ethylene / butylene-styrene block copolymer (SEBS), styrene-butadiene-styrene block copolymer (SBS), styrene-isoprene-styrene block copolymer (SEBS) SIS), modified SEBS such as maleic acid, styrene-ethylene / propylene-styrene block copolymer (SEPS) ), Styrene-based elastomers such as styrene-ethylene / butylene block copolymer (SEB) and styrene-ethylene / propylene block copolymer (SEP); and olefin-based elastomers such as ethylene-propylene block copolymer; Polyurethane-based elastomers and the like, and mixtures thereof 0
  • the size of the valve body 23 is not particularly limited, and may be appropriately set according to the inner diameter of the cylindrical body 22 and the like. If the valve element 23 is too large, the bulge at the time of compression becomes too large, and the gap 26 may be closed. Conversely, if the valve body 23 is too small, there is a possibility that the flow of the chemical solution will be hindered. For this reason, the size of the valve element 23 needs to be set in consideration of the degree of compressive deformation. As an index indicating the deformability of the valve element 23 due to the fluid pressure P, for example, the hardness, tensile stress, compression modulus, and the like of the elastic body forming the valve element 23 are exemplified.
  • the hardness of the elastic body forming the valve body 23 is JISA hardness [spring hardness Hs (A type) measured by the method described in JISK 6301-5.2 “Spring hardness test”]. It is preferably from 0 to 20, and more preferably from 0 to: L0.
  • the hardness of the elastic body exceeds the above range (when the elastic body becomes too hard), there is a possibility that the fluid pressure P may not be able to generate sufficient compressive deformation.
  • the lower limit of the hardness is limited to the above value.
  • the tensile stress of the elastic body forming the valve body 23 is a tensile stress M 1 () at the time of 100% extension.
  • M 1 tensile stress
  • (MPa) [JISK 6 251] is preferably 0.05 to 2. OMPa, more preferably 0.05 to 0.5 MPa. If the tensile stress of the elastic body exceeds the above range, the elastic body may not be deformed by the fluid pressure. Conversely, if the tensile stress of the elastic body falls below the above range, the elastic body may not be sufficiently restored after removing the fluid pressure.
  • the compression set CS (%) of the elastic material that forms the valve element 23] [IS 6301, Measurement conditions: 70 ° C x 22 hours] can be obtained by repeating the loading and depressurization of the fluid pressure P. It is preferable to set the value to 30% or less so that the valve body 23 is not damaged. Further, as the above-mentioned elastic body, as long as it satisfies the above-mentioned properties, the above-mentioned properties may be obtained by a foam (a material having discontinuous holes and no liquid leakage) or an additive. It is also possible to adopt a material adjusted to satisfy the condition. As a specific example of such a material, a commercially available silicone-urethane gel (trade name: Chemitech Gel (manufactured by Chemitech)) to which a general-purpose additive is appropriately added can be mentioned.
  • the port member 20 for co-injection treatment of the present invention may be made of, for example, polyethylene, polypropylene, polyolefin such as poly 4-methylpentene (for example, trade name “TPXJ” of Mitsui Chemicals, Inc.); ethylene-tetracyclododecene copolymer [Mitsui Chemicals, Inc.
  • Polyolefins such as acrylonitrile-butadiene-styrene copolymer (ABS); polyethylene esters such as polyethylene naphthalate (PEN), polyethylene terephthalate (PET), and polyacrylate; It can be made of various plastics such as benzene-based polymers such as lensulphide (PPS).
  • a pedestal portion 40 on which the filter 41 is placed is formed by injection molding, extrusion molding, or the like, and this pedestal portion 40 is previously formed by injection molding or extrusion.
  • the valve body 23 may be arranged on a pedestal portion 40 that has been formed in advance, and then the pedestal portion 40 may be fitted with a member including the cylinder 22 and the insertion port 30.
  • the substantially cylindrical insertion port 30 is a part into which various injection tools and the like are inserted and fixed in order to inject a medicinal solution or the like for co-injection.
  • the outer peripheral surface of the insertion hole 30 is preferably provided with a projection 31 or a thread.
  • a so-called luer-lock type injecting device having an outer tube portion provided with a female screw and an inner tube portion for fitting (see FIG. ) Can be fixed to the insertion port 30 and the operability of the co-injection operation can be improved.
  • the filter 41 in the co-infusion processing member 20 of the present invention the same filter as a filter provided in a conventionally known infusion circuit (that is, a filter incorporated in an infusion set) can be adopted.
  • Specific examples of such a filter include a membrane filter made of a resin such as polyethylene, polypropylene, polyester, and polyamide (a nylon), and a flat membrane filter made of a non-woven fabric using fibers of the resin.
  • the pore size of the filter is 0.1 to 10 / m, preferably 0.1 to 0.3 ⁇ m, from the viewpoint of preventing the passage of foreign substances and bacteria, and achieving a smooth inflow of the mixed solution. It is preferable to set so that The pore diameter is preferably in the range of 0.15 to 0.25 ⁇ , and more preferably about 0.2 / im.
  • the location of the finoleta is not particularly limited as long as it is inside the co-injection processing material. Therefore, it may be arranged on the inner side of the infusion container with respect to the check valve, or may be arranged on the outer side.
  • FIG. 4B is a bottom view of the member 20.
  • FIG. 5 is a plan view showing only the pedestal portion 40 of the co-injection processing member 20 shown in FIG.
  • the tip of the insertion port 30 is sealed with a removable sealing means until the chemical solution container 10 is used (until the co-infusion process is performed). For example, it is preferable to attach a cap 35 or protect with a peel seal.
  • FIG. 4 (a) is a plan view of the mouthpiece for co-infusion treatment 20 shown in FIG.
  • the accommodation chamber 14 that forms the main body of the infusion container and the discharge treatment opening 11 are not particularly limited, and conventionally known ones can be adopted.
  • the co-infusion processing member 20 of the present invention and the infusion container using the same have no risk of foreign substances or bacteria being mixed in the co-infusion processing of a chemical solution or the like into the infusion container, and the infusion container can be used even after the co-infusion processing. Since the sealability can be ensured, it can be used practically and advantageously in the medical field.
  • FIG. 1 is a front view showing one embodiment of an infusion container according to the present invention.
  • FIG. 2 is a cross-sectional view showing one embodiment of the co-infusion processing port member according to the present invention.
  • FIG. 3A is a cross-sectional view showing a use state of the co-infusion processing port member 20 shown in FIG. (B) is a partially enlarged view of (a).
  • FIG. 4A is a plan view of the co-injection processing member 20 shown in FIG. 2, and FIG. 4B is a bottom view.
  • FIG. 5 is a plan view of the pedestal portion 40 of the co-injection treatment process member 20 shown in FIG.

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Une bouche (20) destinée au traitement de mélangeage et de remplissage est aménagée à l'extérieur d'un récipient chimique et sépare une partie bouche de mélangeage et de remplissage d'un récipient d'infusion utilisant également ladite bouche. La bouche comprend (i) un bouchon généralement tubulaire (30) disposé vers l'extérieur du récipient chimique, (ii) un clapet anti-retour (21) disposé dans le récipient d'infusion du côté intérieur du bouchon (30) et bloquant le flux de produits chimiques en leur permettant cependant de pénétrer à l'intérieur sous l'effet de la pression de fluide (P) d'un côté bouchon (30), et (iii) un filtre disposé dans le récipient d'infusion du côté intérieur du clapet anti-retour (21), les risques de pénétration des matières étrangères et des bactéries étant éliminés grâce au traitement de mélangeage et de remplissage des produits chimiques dans le récipient d'infusion; même lorsque le traitement de mélangeage et de remplissage est terminé, on peut assurer l'étanchéité du récipient d'infusion.
PCT/JP2002/006092 2001-06-22 2002-06-19 Bouche de recipient destinee a au traitement de melangeage et de remplissage et recipient d'infusion utilisant ladite bouche Ceased WO2003000170A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003506616A JPWO2003000170A1 (ja) 2001-06-22 2002-06-19 混注処理用口部材およびそれを用いた輸液容器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001189743 2001-06-22
JP2001-189743 2001-06-22

Publications (1)

Publication Number Publication Date
WO2003000170A1 true WO2003000170A1 (fr) 2003-01-03

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PCT/JP2002/006092 Ceased WO2003000170A1 (fr) 2001-06-22 2002-06-19 Bouche de recipient destinee a au traitement de melangeage et de remplissage et recipient d'infusion utilisant ladite bouche

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TW (1) TW542731B (fr)
WO (1) WO2003000170A1 (fr)

Cited By (7)

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Publication number Priority date Publication date Assignee Title
WO2007053071A1 (fr) 2005-11-04 2007-05-10 Telefonaktiebolaget Lm Ericsson (Publ) Methode et unite d'emission pour codage adaptatif, modulation et emission de mots de donnees dans un systeme de communication sans fil
JP2009514641A (ja) * 2005-11-07 2009-04-09 インドゥストリー・ボルラ・ソシエタ・ペル・アチオニ 通気可能で安全に取り扱える薬瓶アダプタ
CN102131486A (zh) * 2008-07-09 2011-07-20 泰尔茂株式会社 药剂收纳容器
JP2019517376A (ja) * 2016-06-08 2019-06-24 エスエフエム・メディカル・ディバイシイズ・ゲーエムベーハーｓｆｍ ｍｅｄｉｃａｌ ｄｅｖｉｃｅｓ ＧｍｂＨ アダプタ
US11224555B2 (en) 2018-04-23 2022-01-18 Hospira, Inc. Access and vapor containment system for a drug vial and method of making and using same
JP2023518033A (ja) * 2020-03-16 2023-04-27 ベルテック アソシエイツ インコーポレイテッド 壊し得るシールが付いたポーチ
US12296055B2 (en) 2018-09-17 2025-05-13 Veltek Associates, Inc. Pouch with breakable seal

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CN102131486B (zh) * 2008-07-09 2013-06-05 泰尔茂株式会社 药剂收纳容器
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JP7751886B2 (ja) 2020-03-16 2025-10-09 ベルテック アソシエイツ インコーポレイテッド 壊し得るシールが付いたポーチ

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