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WO2003098183A3 - Broad spectrum optically addressed sensor - Google Patents

Broad spectrum optically addressed sensor Download PDF

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Publication number
WO2003098183A3
WO2003098183A3 PCT/US2003/013972 US0313972W WO03098183A3 WO 2003098183 A3 WO2003098183 A3 WO 2003098183A3 US 0313972 W US0313972 W US 0313972W WO 03098183 A3 WO03098183 A3 WO 03098183A3
Authority
WO
WIPO (PCT)
Prior art keywords
colloidal particles
chemical
broad spectrum
dielectric constant
target stimulus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/013972
Other languages
French (fr)
Other versions
WO2003098183A2 (en
Inventor
David G Grier
Lewis Gruber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arryx Inc
Original Assignee
Arryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arryx Inc filed Critical Arryx Inc
Priority to NZ537050A priority Critical patent/NZ537050A/en
Priority to EP03733937A priority patent/EP1549954B1/en
Priority to DE60324953T priority patent/DE60324953D1/en
Priority to AU2003239353A priority patent/AU2003239353A1/en
Priority to CA002488597A priority patent/CA2488597A1/en
Publication of WO2003098183A2 publication Critical patent/WO2003098183A2/en
Publication of WO2003098183A3 publication Critical patent/WO2003098183A3/en
Anticipated expiration legal-status Critical
Priority to IL16553504A priority patent/IL165535A0/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4788—Diffraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • G03H2001/0044—Adaptation of holography to specific applications in hologrammetry for measuring or analysing holographic fringes deformations; holographic sensors
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0077—Adaptation of holography to specific applications for optical manipulation, e.g. holographic optical tweezers [HOT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The present invention relates to a sensor for detecting chemical, biological, biochemical or other environmental stimuli, and includes a plurality of colloidal particles having chemical receptors bound to each particle's surface, wherein when a target stimulus is directed to the bound chemical receptor, the gelled matrix contracts or expands, which changes the lattice constant, thereby changing the pattern of diffracted light in a measurable manner so that the target stimulus' presence can be detected by a spectrometer. The plurality of colloidal particles are composed of a material having a first dielectric constant, and the gel and surrounding medium have a second dielectric constant. The colloidal particles can be assembled using holographic optical tweezers and polymerized to create an integrated sensor array, which diffracts light in a detectable characteristic manner.
PCT/US2003/013972 2002-05-14 2003-05-05 Broad spectrum optically addressed sensor Ceased WO2003098183A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
NZ537050A NZ537050A (en) 2002-05-14 2003-05-05 Broad spectrum optically addressed sensor having colloidal particles which respond to a target stimulus
EP03733937A EP1549954B1 (en) 2002-05-14 2003-05-05 Broad spectrum optically addressed sensor
DE60324953T DE60324953D1 (en) 2002-05-14 2003-05-05 OPTICALLY ADDRESSED SENSOR WITH WIDE SPECTRUM
AU2003239353A AU2003239353A1 (en) 2002-05-14 2003-05-05 Broad spectrum optically addressed sensor
CA002488597A CA2488597A1 (en) 2002-05-14 2003-05-05 Broad spectrum optically addressed sensor
IL16553504A IL165535A0 (en) 2002-05-14 2004-12-02 Broad spectrum optically addressed sensor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37975102P 2002-05-14 2002-05-14
US60/379,751 2002-05-14
US45126403P 2003-03-04 2003-03-04
US60/451,264 2003-03-04

Publications (2)

Publication Number Publication Date
WO2003098183A2 WO2003098183A2 (en) 2003-11-27
WO2003098183A3 true WO2003098183A3 (en) 2004-07-08

Family

ID=29553487

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/013972 Ceased WO2003098183A2 (en) 2002-05-14 2003-05-05 Broad spectrum optically addressed sensor

Country Status (10)

Country Link
US (1) US7390461B2 (en)
EP (1) EP1549954B1 (en)
CN (1) CN1668924A (en)
AT (1) ATE415626T1 (en)
AU (1) AU2003239353A1 (en)
CA (1) CA2488597A1 (en)
DE (1) DE60324953D1 (en)
IL (1) IL165535A0 (en)
NZ (1) NZ537050A (en)
WO (1) WO2003098183A2 (en)

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
JP2007521494A (en) 2003-12-04 2007-08-02 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Detection of molecular interaction
CN101304781B (en) * 2004-06-28 2012-08-01 美国血液技术公司 Blood component separation system with stationary separation chamber
US7473890B2 (en) * 2004-11-23 2009-01-06 New York University Manipulation of objects in potential energy landscapes
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
CN100445747C (en) * 2005-06-24 2008-12-24 东南大学 Colloidal Crystal Based Biomolecular Detection Method
GB0514700D0 (en) * 2005-07-18 2005-08-24 Smart Holograms Ltd Use of holographic sensor
GB0617730D0 (en) * 2006-09-08 2006-10-18 Smart Holograms Ltd Analyte detection
WO2010042555A2 (en) * 2008-10-06 2010-04-15 The Brigham And Women's Hospital, Inc. Particles with multiple functionalized surface domains
CN101403742B (en) * 2008-10-29 2012-05-23 东南大学 Method for dielectric characterization of micro-nano biological particle by optoelectronic forceps
US9316578B2 (en) 2008-10-30 2016-04-19 New York University Automated real-time particle characterization and three-dimensional velocimetry with holographic video microscopy
CN102317760B (en) * 2009-03-16 2014-10-22 拉莫特亚特特拉维夫大学有限公司 Apparatus and method for optical sensing of substances or environmental conditions
WO2011046875A1 (en) 2009-10-12 2011-04-21 Nadia Pervez Photonic crystal spectrometer
NZ599524A (en) 2009-11-09 2014-04-30 Spotlight Technology Partners Llc Polysaccharide based hydrogels
US8795727B2 (en) 2009-11-09 2014-08-05 Spotlight Technology Partners Llc Fragmented hydrogels
JP2013515269A (en) * 2009-12-22 2013-05-02 ニュー・ヨーク・ユニヴァーシティ Classification of colloidal particles into multiple channels by optical force: Prism optical fractionation
WO2012088117A1 (en) * 2010-12-21 2012-06-28 Ioannis Kymissis Spectrometer including three-dimensional photonic crystal
CN104409561B (en) * 2014-10-27 2017-04-05 复旦大学 It is a kind of to be based on enhanced silicon thin film photo-detector of microsphere optical resonance and preparation method thereof
WO2016077472A1 (en) 2014-11-12 2016-05-19 New York University Colloidal fingerprints for soft materials using total holographic characterization
JP2016217914A (en) * 2015-05-21 2016-12-22 セイコーエプソン株式会社 Sensor gel and sensor
JP2016217929A (en) * 2015-05-22 2016-12-22 セイコーエプソン株式会社 Sensor gel and sensor
TWI731030B (en) 2016-02-08 2021-06-21 紐約大學 Holographic characterization of protein aggregates
US11543338B2 (en) 2019-10-25 2023-01-03 New York University Holographic characterization of irregular particles
US11948302B2 (en) 2020-03-09 2024-04-02 New York University Automated holographic video microscopy assay

Citations (2)

* Cited by examiner, † Cited by third party
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US6022748A (en) * 1997-08-29 2000-02-08 Sandia Corporation - New Mexico Regents Of The University Of California Sol-gel matrices for direct colorimetric detection of analytes
US6331438B1 (en) * 1999-11-24 2001-12-18 Iowa State University Research Foundation, Inc. Optical sensors and multisensor arrays containing thin film electroluminescent devices

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US4632517A (en) 1983-12-08 1986-12-30 University Of Pittsburgh Crystalline colloidal narrow band radiation filter
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US5854078A (en) * 1996-11-06 1998-12-29 University Of Pittsburgh Polymerized crystalline colloidal array sensor methods
US5898004A (en) 1996-11-06 1999-04-27 University Of Pittsburgh Of The Commonwealth System Of Higher Education Polymerized crystalline colloidal array sensors
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
US6224566B1 (en) * 1999-05-04 2001-05-01 Cardiodyne, Inc. Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium
SE9902479D0 (en) * 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Particle classification as marker
WO2001006253A2 (en) * 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System Detection system based on an analyte reactive particle
US6737634B2 (en) * 2002-01-16 2004-05-18 The University Of Chicago Use of multiple optical vortices for pumping, mixing and sorting

Patent Citations (2)

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US6022748A (en) * 1997-08-29 2000-02-08 Sandia Corporation - New Mexico Regents Of The University Of California Sol-gel matrices for direct colorimetric detection of analytes
US6331438B1 (en) * 1999-11-24 2001-12-18 Iowa State University Research Foundation, Inc. Optical sensors and multisensor arrays containing thin film electroluminescent devices

Also Published As

Publication number Publication date
IL165535A0 (en) 2006-01-15
CN1668924A (en) 2005-09-14
NZ537050A (en) 2007-07-27
WO2003098183A2 (en) 2003-11-27
AU2003239353A1 (en) 2003-12-02
EP1549954A2 (en) 2005-07-06
US7390461B2 (en) 2008-06-24
ATE415626T1 (en) 2008-12-15
CA2488597A1 (en) 2003-11-27
EP1549954B1 (en) 2008-11-26
US20040058455A1 (en) 2004-03-25
DE60324953D1 (en) 2009-01-08
EP1549954A4 (en) 2006-07-05

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