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WO2003095651A1 - Procede de production d'acide mevalonique - Google Patents

Procede de production d'acide mevalonique Download PDF

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Publication number
WO2003095651A1
WO2003095651A1 PCT/JP2003/005765 JP0305765W WO03095651A1 WO 2003095651 A1 WO2003095651 A1 WO 2003095651A1 JP 0305765 W JP0305765 W JP 0305765W WO 03095651 A1 WO03095651 A1 WO 03095651A1
Authority
WO
WIPO (PCT)
Prior art keywords
mevalonic acid
microorganism
coa
acetyl
producing mevalonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/005765
Other languages
English (en)
French (fr)
Inventor
Kazuhiko Tabata
Shin-Ichi Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2004508516A priority Critical patent/JPWO2003095651A1/ja
Priority to EP03728047A priority patent/EP1510583A1/en
Priority to AU2003234790A priority patent/AU2003234790A1/en
Priority to US10/513,759 priority patent/US20050287655A1/en
Publication of WO2003095651A1 publication Critical patent/WO2003095651A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
PCT/JP2003/005765 2002-05-10 2003-05-08 Procede de production d'acide mevalonique Ceased WO2003095651A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2004508516A JPWO2003095651A1 (ja) 2002-05-10 2003-05-08 メバロン酸の製造方法
EP03728047A EP1510583A1 (en) 2002-05-10 2003-05-08 Process for producing mevalonic acid
AU2003234790A AU2003234790A1 (en) 2002-05-10 2003-05-08 Process for producing mevalonic acid
US10/513,759 US20050287655A1 (en) 2002-05-10 2003-05-08 Process for producing mevalonic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002135073 2002-05-10
JP2002-135073 2002-05-10

Publications (1)

Publication Number Publication Date
WO2003095651A1 true WO2003095651A1 (fr) 2003-11-20

Family

ID=29416731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/005765 Ceased WO2003095651A1 (fr) 2002-05-10 2003-05-08 Procede de production d'acide mevalonique

Country Status (5)

Country Link
US (1) US20050287655A1 (ja)
EP (1) EP1510583A1 (ja)
JP (1) JPWO2003095651A1 (ja)
AU (1) AU2003234790A1 (ja)
WO (1) WO2003095651A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107418978A (zh) * 2017-06-24 2017-12-01 天津大学 一种利用生物柴油副产物制备金合欢烯的方法
JP2018502059A (ja) * 2014-11-12 2018-01-25 ビゾリス インコーポレイテッド メバロノラクトンから調製されるポリマーおよび誘導体

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WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
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US20090111154A1 (en) * 2007-04-04 2009-04-30 The Regents Of The University Of California Butanol production by recombinant microorganisms
MX2009012839A (es) * 2007-06-01 2010-02-24 Sapphire Energy Seleccion quimica ultrarrapida de organismos fotosinteticos modificados geneticamente.
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
EP2543657A3 (en) 2007-08-10 2013-08-14 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
WO2009036087A1 (en) * 2007-09-11 2009-03-19 Sapphire Energy, Inc. Methods of producing organic products with photosynthetic organisms and products and compositions thereof
AR073437A1 (es) * 2007-09-11 2010-11-10 Sapphire Energy Inc Produccion de isoprenoides mediante organismos fotosinteticos
BRPI0817545A2 (pt) * 2007-10-12 2014-11-25 Univ California Microorganismo recombinante, métodos para produzir um microorganismo recombinante e para produzir isopropanol, vetor recombinante, e, célula hospedeira recombinante.
EP3354740A1 (en) 2007-12-13 2018-08-01 Danisco US Inc. Compositions and methods for producing isoprene
JP2011509691A (ja) * 2008-01-22 2011-03-31 ジェノマティカ， インコーポレイテッド 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体
CA2717586C (en) 2008-03-05 2020-08-11 Genomatica, Inc. Primary alcohol producing organisms
SI2265709T1 (en) 2008-03-27 2018-03-30 Genomatica, Inc. MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS
US8173410B2 (en) 2008-04-23 2012-05-08 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
CA2722680A1 (en) * 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
EP2304039B1 (en) 2008-06-17 2019-08-21 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
EP2334800B1 (en) 2008-09-10 2018-12-26 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
MY169163A (en) 2008-09-15 2019-02-19 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
WO2010031077A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
CA2759700A1 (en) 2009-04-23 2010-10-28 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
KR101774400B1 (ko) 2009-04-30 2017-09-04 게노마티카 인코포레이티드 1,3-부탄다이올 생산 유기체
AU2010242849A1 (en) 2009-04-30 2011-11-24 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
KR20200104931A (ko) 2009-05-07 2020-09-04 게노마티카 인코포레이티드 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법
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US8129169B2 (en) 2009-06-04 2012-03-06 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
AU2010256520B2 (en) 2009-06-04 2016-02-25 Genomatica, Inc. Process of separating components of a fermentation broth
US8420375B2 (en) 2009-06-10 2013-04-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
US20110124911A1 (en) 2009-08-05 2011-05-26 Burk Mark J Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
CN102625845A (zh) 2009-09-09 2012-08-01 基因组股份公司 协同产生异丙醇与伯醇，二元醇和酸的微生物和方法
CN102762735B (zh) 2009-10-13 2016-08-03 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
BR112012009332A2 (pt) 2009-10-23 2015-09-15 Genomatica Inc micro-organismo para a produção de anilina
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
SG181607A1 (en) 2009-12-10 2012-07-30 Genomatica Inc Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
EP2516654B1 (en) 2009-12-23 2015-01-21 Danisco US Inc. Compositions and methods for the increased production of isoprene with 6-phosphogluconolactonase (pgl)
PH12012501526A1 (en) 2010-01-29 2018-03-21 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
SG185432A1 (en) 2010-05-05 2012-12-28 Genomatica Inc Microorganisms and methods for the biosynthesis of butadiene
EP2607340B1 (en) 2010-07-26 2017-09-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
CA2834633A1 (en) 2011-04-29 2012-11-01 Danisco Us Inc. Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
CA2834379A1 (en) 2011-04-29 2012-11-01 The Goodyear Tire & Rubber Company Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities
CA2844064A1 (en) 2011-08-04 2013-02-07 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
CA2851265A1 (en) 2011-10-07 2013-05-10 Danisco Us Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
JP2015510392A (ja) 2011-12-23 2015-04-09 ダニスコ・ユーエス・インク 低減したｉｓｐａ活性を有する宿主細胞を用いるイソプレン産生増強法
WO2013096917A1 (en) 2011-12-23 2013-06-27 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
WO2013184602A2 (en) 2012-06-04 2013-12-12 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
BR112015014843A2 (pt) 2012-12-21 2017-10-10 Danisco Us Inc produção de isopreno, isoprenoide, e precursores de isoprenoide usando uma via de mevalonato inferior alternativa
JP6530375B2 (ja) 2013-04-10 2019-06-12 ダニスコ・ユーエス・インク アセチル補酵素ａ由来代謝産物、イソプレン、イソプレノイド前駆体、およびイソプレノイドの改善された生産のためのホスホケトラーゼ
KR102255114B1 (ko) 2013-04-18 2021-05-21 리젠츠 오브 더 유니버시티 오브 미네소타 생합성 경로 및 생성물
WO2015127305A2 (en) 2014-02-20 2015-08-27 Danisco Us Inc. Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products
JP2021505154A (ja) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
WO2021060923A1 (ko) * 2019-09-25 2021-04-01 한국생명공학연구원 메탄으로부터 탄소 수 4 이상인 화합물을 생산하는 방법 및 조성물
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Citations (1)

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WO2001042476A1 (fr) * 1999-12-08 2001-06-14 Haruo Seto Genes a origine actinomycete d'enzymes intervenant dans la voie du mevalonate

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2001042476A1 (fr) * 1999-12-08 2001-06-14 Haruo Seto Genes a origine actinomycete d'enzymes intervenant dans la voie du mevalonate

Non-Patent Citations (2)

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Title
BOLOTIN ALEXANDER ET AL.: "The complete genome sequence of the lactic acid bacterium lactococcus lactis ssp. lactis IL1403", GENOME RESEARCH, vol. 11, no. 5, 2001, pages 731 - 753, XP001109416 *
WILDING E. IMOGEN ET AL.: "Identification, evolution and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci", JOURNAL OF BACTERIOLOGY, vol. 182, no. 15, 2000, pages 4319 - 4327, XP002232852 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502059A (ja) * 2014-11-12 2018-01-25 ビゾリス インコーポレイテッド メバロノラクトンから調製されるポリマーおよび誘導体
CN107418978A (zh) * 2017-06-24 2017-12-01 天津大学 一种利用生物柴油副产物制备金合欢烯的方法

Also Published As

Publication number Publication date
JPWO2003095651A1 (ja) 2005-09-15
US20050287655A1 (en) 2005-12-29
AU2003234790A1 (en) 2003-11-11
EP1510583A1 (en) 2005-03-02

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