WO2003082014A1 - Disinfection of instruments - Google Patents

Abstract

The invention relates to a disinfectant powder, comprising a peroxide, an acylating agent and non-ionic surfactants. The invention also relates to the use of the aforementioned disinfectants for disinfecting surfaces and instruments, especially in the field of medicine.

Description

 "Instrument disinfection"

The present invention relates to a powdery disinfectant comprising a peroxide, an acylating agent and nonionic surfactants and the use of such disinfectants for surface and instrument disinfection, in particular in the field of medicine.

For the chemical disinfection of instruments with the aid of aqueous preparations, numerous proposals have been made in the course of time in which the most varied antimicrobial agents are provided for disinfection. In practice, preparations based on aldehydes have found widespread use, but also preparations containing quaternary ammonium compounds, phenols, alcohols and others

Disinfectants in use. Preparations based on peroxidic active ingredients, in particular peracetic acid, on the other hand, have gained little importance for this application. An important reason is the low storage stability of such aqueous preparations. Because of the broad antimicrobial effectiveness of the peroxides, there has been no shortage of attempts to overcome the disadvantage of the poor storage stability. For example, it has been proposed in German Offenlegungsschriften 26 55 599 and 28 15 400 that the aqueous preparations required for disinfection be prepared shortly before use from more stable precursors, namely from sodium perborate and acid anhydrides. According to German Offenlegungsschrift 27 01 133, the aqueous preparations are obtained from hydrogen peroxide releasers and aromatic acyloxycarboxylic acids. However, only a few of these compounds provide disinfectant solutions with a sufficiently broad activity, and the storage of these acylating agents in a mixture with the necessary inorganic peroxides is only possible for a limited time because of the decomposition reactions. Under the name Sekusept powder is a product on the market, when it is dissolved in water by reacting sodium perborate with tetraacetylethyl lendiamine (TAED) is a disinfectant preparation. This product based on an N-acyl compound has a broad spectrum of activity and is stable in storage. Although a high standard has already been achieved in the disinfection of medical instruments in this way, efforts have been made to improve the peroxidic systems in order to eliminate any gaps in use and disadvantages in use. A particular disadvantage of such powdery systems is that they dissolve very slowly in water. On the one hand, this results in the disadvantage that the desired disinfectant concentration is only fully available very late. On the other hand, there is also the risk that undissolved components remain in the system to be disinfected or on the surface to be disinfected and are not rinsed out.

The object of the present invention was therefore to provide a sufficient disinfectant concentration within a short time and to keep the risk of residues in the system and on the surfaces low.

It should also be achieved to kill microorganisms, including mycobacteria, within a shorter period of time.

This object was achieved by the means according to the invention.

Accordingly, the present invention relates to a powdery disinfectant based on active oxygen, containing a peracetic acid-generating system consisting of a peroxide and an acylating agent together with nonionic surfactants.

The nonionic surfactants mentioned are preferably free from alkoxylated alkylphenols and include straight-chain or ether alcohols of the formula which are methyl-branched in the 2-position

R-0- (PO) ι. ₂ - (EO) ₆ -8-H (I) where the alkyl or alkenyl radicals R are composed as follows: C ₈ = 0-5% by weight; C ₉ - _10% by weight = 75-90;. Cn-ι ₂ = 5-15% by weight; C _13-14 = 4-10% by weight; C _15-16 = 0-3% by weight.

Said peroxide is preferably selected from the group sodium perborate monohydrate, sodium perborate tetrahydrate, sodium percarbonate and mixtures thereof.

The acylating agent mentioned is preferably selected from the group tetraacetylglycoluril, tetraacetylethylenediamine, diacetylhexahydrotriazinedione and mixtures thereof.

Of course, other N-acyl compounds can also be used, which have also been described in the field of detergent chemistry as so-called bleach activators for reaction with hydrogen peroxide in alkaline washing liquors. Suitable N-acyl compounds are in particular those which have a further keto group on the nitrogen which carries the acyl group and / or in which the nitrogen is part of a heterocyclic ring system. Examples of suitable N-acyl compounds are the multiply acylated alkylenediamines, such as tetraacetylethylenediamine, acylated glycolurils, primarily tetraacetylglycoluril, N-acylated hydantoins, hydrazides, triazoles, triazines, urazoles, diketopiperazines, sulfurylamides, lactams and cyanurates.

The disinfectant according to the invention preferably contains

10 to 70 wt .-%, preferably 15 to 60 wt .-% of the above

peroxide,

10 to 40 wt .-%, preferably 15 to 30 wt .-% of the above

acylating agent,

0.1 to 10 wt .-%, preferably 0.5 to 5 wt .-% of said nonionic surfactant and the remainder to 100% by weight of soluble inorganic salt and possibly other auxiliaries.

Alkalizing agents, complexing agents for water hardness, complexing agents for heavy metal ions and water-soluble inorganic salts, corrosion inhibitors and other surfactants are also suitable as auxiliary agents. The amount of such auxiliaries in the preparations can vary within very wide limits, depending on the intended effect. It is usually not more than about 3% by weight, preferably between about 0.001 and about 1% by weight, based on the overall preparation

Sodium triphosphate is to be mentioned primarily as a complexing agent for the water hardness, but other polyphosphates, salts of nitrilotriacetic acid and salts of organic polycarboxylic acids, for example citric acid, or of polymeric polycarboxylic acids, for example acrylic acid / maleic acid copolymers, are also suitable for this purpose. Sodium triphosphate, which also acts as an alkalizing agent, is particularly preferred.

Suitable complexing agents for heavy metal ions, which have a decomposing effect on peroxidic compounds, are primarily aminopolycarboxylic acids or their salts, for example ethylenediaminetetraacetic acid, but in particular aminopolyphosphonic acids, such as ethylenediaminetetramethylenephosphonic acid, or else hydroxyethane diphosphonic acid or salts thereof.

Water-soluble salts can take on the function of fillers or builders, such as sodium sulfate, provided that they do not simultaneously have an alkalizing effect, such as sodium carbonate and sodium silicate. Corrosion inhibitors which should be mentioned are, in particular, alkylphosphonic acids, of which octanephosphonic acid is particularly preferred. Dyes, perfume and solubilizing additives should be mentioned as further possible auxiliaries. When used, the disinfectant is usually diluted with water.

It is preferably dissolved in water in an amount of 1 to 10% by weight.

In a preferred embodiment, the disinfectant according to the invention for surface disinfection and / or

Instrument disinfection used.

In addition, it is preferred to use the disinfectant according to the invention to kill gram-positive bacteria and / or to kill mycobacteria and / or to kill viruses.

B e i s p i e l e

1. Preparation of the active ingredient solution

It was assumed that three different powdery mixtures, each consisting of

50% by weight sodium perborate monohydrate and 25% by weight TAED powder and a) no surfactant b) 2% by weight ABS (alkylbenzenesulfonate) and c) 2% by weight dehydol 980

Corrosion inhibitors, complexing agents and other inorganic salts were used as the remainder to 100% by weight.

In a first experiment, the dissolution behavior of these different powder formulations 1a) to 1c) in water without stirring or other movement was examined.

For this purpose, 8 g of powder formulations 1a) to 1c) were placed in 100 ml of tap water at room temperature.

It was found that the time required to dissolve formulations 1a) and 1b) was over an hour. In addition, a sediment was also formed in powder formulation 1b).

In contrast, with powder formulation 1c), the powder was dissolved within one hour. In addition, no sediment was formed.

For explanation:

Dehydol 980 is a 2-position methyl branched ether alcohol of the formula

R-0- (PO) ₁ . ₂ - (EO) _6-8 -H (I) where the alkyl or alkenyl radicals R are composed as follows:

C ₈ = 0-5% by weight; C = _9- ιo 75-90% wt. Cn.ι ₂ = 5-15% by weight;

2. Testing the effectiveness against the gram-positive Enterococcus hirae bacterium

With powder formulations 1a) and 1c), application solutions for microbiological tests were prepared by dissolving 12.5 g each in 100 ml tap water.

These solutions were tested in a quantitative germ carrier test according to the new DGHM guideline under organic pollution ("dirty conditions") (status 1.3.2001) against the gram-positive bacterium Enterococcus hirae. The following log reduction factors (triple determination) were determined:

Exposure time 1c) 1a)

1 min 3.06 / 2.23 / 3.1 0.53 / 0.61 / 0.48

5 min 3.22 / 3.81 / 2.98 1, 74/1, 41/1, 33

10 min 6.8 / 6.8 / 6.8 3.72 / 3.46 / 3.8

A clear advantage of the formulations according to the invention can also be seen in terms of the antimicrobial activity.

3. Testing effectiveness against poliovirus

With the powder formulations 1a) and 1c), application solutions for microbiological tests were prepared by dissolving 12.5 g each in 100 ml tap water. These solutions were tested in quantitative suspension tests according to DW guidelines against poliovirus. The following average log reduction factors (triple determination) were determined:

Exposure time 1c) 1a)

5 min 1, 5 1, 5

10 min 3.3 2.6

The virological test results also show an advantage.

Claims

Patent claims 1. Powdery disinfectant based on active oxygen, containing a peracetic acid generating system consisting of a peroxide and an acylating agent together with nonionic surfactants. 2. Disinfectant according to claim 1, characterized in that the said nonionic surfactants are free from alkoxylated alkylphenols and straight-chain or in the 2-position methyl branched ether alcohols of the formula RO- (PO) _1-2 - (EO) _6-8 -H (I), the alkyl or alkenyl radicals R being composed as follows: C ₈ = 0-5% by weight; C9.10 = 75-90% by weight; Cιι- ₁₂ = 5-15 wt.%;

C 15-1 e = 0-3% by weight. 3. Disinfectant according to one of claims 1 or 2, characterized in that said peroxide is selected from the group sodium perborate monohydrate, sodium perborate tetrahydrate, sodium percarbonate and mixtures thereof. 4. Disinfectant according to one or more of claims 1 to 3, characterized in that said acylating agent is selected from the group tetraacetylglycoluril, tetraacetylethylene diamine, diacetylhexahydrotriazinedione and mixtures thereof. 5. Disinfectant according to one or more of claims 1 to 4, characterized in that it 10 to 70% by weight, preferably 15 to 60% by weight of the peroxide mentioned, 10 to 40% by weight, preferably 15 to 30% by weight, of the acylating agent mentioned, Contains 0.1 to 10% by weight, preferably 0.5 to 5% by weight of the nonionic surfactant mentioned and 100% by weight of soluble inorganic salt and, if appropriate, further auxiliaries. 6. Use of disinfectants according to one of claims 1 to 5 for surface disinfection. 7. Use of disinfectants according to one of claims 1 to 5 for instrument disinfection. 8. Use of disinfectants according to one of claims 1 to 5 for killing gram-positive bacteria. 9. Use of disinfectants according to one of claims 1 to 5 for killing mycobacteria. 10. Use of disinfectants according to one of claims 1 to 5 for killing viruses.