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WO2003079990A3 - Microencapsulation a l'aide d'atomiseurs ultrasoniques - Google Patents

Microencapsulation a l'aide d'atomiseurs ultrasoniques Download PDF

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Publication number
WO2003079990A3
WO2003079990A3 PCT/US2003/008559 US0308559W WO03079990A3 WO 2003079990 A3 WO2003079990 A3 WO 2003079990A3 US 0308559 W US0308559 W US 0308559W WO 03079990 A3 WO03079990 A3 WO 03079990A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
microcapsules
aqueous
solvent
aqueous core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/008559
Other languages
English (en)
Other versions
WO2003079990A2 (fr
Inventor
Kinam Park
Yoon Yeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Priority to AU2003225895A priority Critical patent/AU2003225895A1/en
Publication of WO2003079990A2 publication Critical patent/WO2003079990A2/fr
Anticipated expiration legal-status Critical
Publication of WO2003079990A3 publication Critical patent/WO2003079990A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/203—Exchange of core-forming material by diffusion through the capsule wall

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un procédé permettant de générer une pluralité de microgelules contenant un médicament qui utilise un ou plusieurs atomiseurs de façon à former ces microgelules par le phénomène d'échange de solvant. Une pluralité de microgouttelettes d'une solution aqueuse sont mises en contact avec une pluralité de microgouttelettes contenant un polymère dissout dans un solvant hydrophile dans des conditions dans lesquelles cette solution polymère enveloppe la microgouttelette aqueuse. L'échange de molécules de solvant entre le noyau aqueux et sa coque contenant le polymère dépose le polymère sous la forme d'une membrane autour du noyau aqueux. Un atomiseur préféré est un atomiseur coaxial ultrasonique. On peut générer des microgelules dans l'air de même qu'immergées dans un bain de recueil. On peut obtenir des propriétés recherchées de ces microgelules, par exemple une libération commandée, en apportant des excipients de protection à l'intérieur du noyau aqueux, fournissant un polymère hydrophile capable d'entreprendre une transition sol-gel à l'intérieur de ce noyau aqueux, optimisant la sélection du solvant de polymère, réglant les débits de flux relatifs et offrant d'autres avantages similaires.
PCT/US2003/008559 2002-03-19 2003-03-19 Microencapsulation a l'aide d'atomiseurs ultrasoniques Ceased WO2003079990A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003225895A AU2003225895A1 (en) 2002-03-19 2003-03-19 Microencapsulation using ultrasonic atomizers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36541102P 2002-03-19 2002-03-19
US60/365,411 2002-03-19

Publications (2)

Publication Number Publication Date
WO2003079990A2 WO2003079990A2 (fr) 2003-10-02
WO2003079990A3 true WO2003079990A3 (fr) 2006-01-26

Family

ID=28454653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008559 Ceased WO2003079990A2 (fr) 2002-03-19 2003-03-19 Microencapsulation a l'aide d'atomiseurs ultrasoniques

Country Status (2)

Country Link
AU (1) AU2003225895A1 (fr)
WO (1) WO2003079990A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2205221A2 (fr) 2007-10-23 2010-07-14 Koninklijke Philips Electronics N.V. Procédés de préparation de microparticules de polymère
EP2055299A1 (fr) 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Procédé de préparation de microparticules en polymère
JP4656167B2 (ja) * 2008-03-03 2011-03-23 株式会社日立プラントテクノロジー 流体機器装置
CZ306333B6 (cs) * 2013-12-19 2016-12-07 C2P S. R. O. Přípravek pro administraci kyseliny nikotinové a způsob jeho výroby
CZ306334B6 (cs) * 2013-12-19 2016-12-07 C2P S.R.O. Přípravek pro administraci nikotinamidu a způsob jeho výroby
CN115041074B (zh) * 2022-06-20 2023-09-29 安徽中科大禹科技有限公司 一种超声波雾化等离子体处理装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004602A (en) * 1981-02-16 1991-04-02 Imperial Chemical Industries Plc Continuous release pharmaceutical compositions formed by freeze drying acetic acid solutions of polylactide
US5100669A (en) * 1988-02-24 1992-03-31 Biomaterials Universe, Inc. Polylactic acid type microspheres containing physiologically active substance and process for preparing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004602A (en) * 1981-02-16 1991-04-02 Imperial Chemical Industries Plc Continuous release pharmaceutical compositions formed by freeze drying acetic acid solutions of polylactide
US5100669A (en) * 1988-02-24 1992-03-31 Biomaterials Universe, Inc. Polylactic acid type microspheres containing physiologically active substance and process for preparing the same

Also Published As

Publication number Publication date
AU2003225895A1 (en) 2003-10-08
AU2003225895A8 (en) 2003-10-08
WO2003079990A2 (fr) 2003-10-02

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