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WO2003068157A3 - Kinase inhibitors and methods of use thereof - Google Patents

Kinase inhibitors and methods of use thereof Download PDF

Info

Publication number
WO2003068157A3
WO2003068157A3 PCT/US2003/004163 US0304163W WO03068157A3 WO 2003068157 A3 WO2003068157 A3 WO 2003068157A3 US 0304163 W US0304163 W US 0304163W WO 03068157 A3 WO03068157 A3 WO 03068157A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
kinase inhibitors
relates
inflammatory
aspects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/004163
Other languages
French (fr)
Other versions
WO2003068157A2 (en
Inventor
Ling Gu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Priority to AU2003210983A priority Critical patent/AU2003210983A1/en
Publication of WO2003068157A2 publication Critical patent/WO2003068157A2/en
Publication of WO2003068157A3 publication Critical patent/WO2003068157A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates in some aspects to kinase inhibitors and methods of use thereof. The invention also relates to pharmaceutical preparations and their uses as anti-inflammatory and anti-cancer drugs.
PCT/US2003/004163 2002-02-11 2003-02-11 Kinase inhibitors and methods of use thereof Ceased WO2003068157A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003210983A AU2003210983A1 (en) 2002-02-11 2003-02-11 Kinase inhibitors and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35588502P 2002-02-11 2002-02-11
US60/355,885 2002-02-11

Publications (2)

Publication Number Publication Date
WO2003068157A2 WO2003068157A2 (en) 2003-08-21
WO2003068157A3 true WO2003068157A3 (en) 2004-03-04

Family

ID=27734578

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004163 Ceased WO2003068157A2 (en) 2002-02-11 2003-02-11 Kinase inhibitors and methods of use thereof

Country Status (2)

Country Link
AU (1) AU2003210983A1 (en)
WO (1) WO2003068157A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0416981A (en) 2003-12-11 2007-02-21 Univ Texas compounds for treating cell proliferative diseases
WO2008005954A2 (en) * 2006-06-30 2008-01-10 The Board Of Regents Of The University Of Texas System Tryphostin-analogs for the treatment of cell proliferative diseases
EP2307367B1 (en) 2008-07-08 2014-09-24 Board of Regents, The University of Texas System Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
JP6277121B2 (en) 2011-03-22 2018-02-07 アドヴィナス・セラピューティックス・リミテッド Substituted fused tricyclic compounds, compositions thereof and medical applications
PT2710005T (en) * 2011-05-17 2016-11-16 Principia Biopharma Inc Tyrosine kinase inhibitors
PT2892900T (en) 2012-09-10 2017-11-06 Principia Biopharma Inc PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
WO2014045305A1 (en) 2012-09-21 2014-03-27 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
PT3107544T (en) 2014-02-21 2021-01-05 Principia Biopharma Inc SALTS AND SOLID FORM OF A BTK INHIBITOR
CA2948883A1 (en) * 2014-06-02 2015-12-10 Pharmakea, Inc. Deubiquitinase inhibitors
CA2970723C (en) 2014-12-18 2023-09-05 Principia Biopharma Inc. Treatment of pemphigus
EP3313839A1 (en) 2015-06-24 2018-05-02 Principia Biopharma Inc. Tyrosine kinase inhibitors
IL293621B2 (en) 2016-06-29 2023-09-01 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
TWI846678B (en) * 2017-11-10 2024-07-01 美國德州系統大學評議委員會 Caffeic acid derivatives and uses thereof
CA3154257A1 (en) 2019-10-14 2021-04-22 Principia Biopharma Inc. Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
AU2021209884A1 (en) 2020-01-22 2022-09-15 Principia Biopharma Inc. Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5854285A (en) * 1997-04-03 1998-12-29 Natpro, Inc. Protein kinase inhibitor
WO2000055128A1 (en) * 1999-03-12 2000-09-21 Hsc Research And Development Limited Partnership Methods and compositions for treating leukemia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5854285A (en) * 1997-04-03 1998-12-29 Natpro, Inc. Protein kinase inhibitor
WO2000055128A1 (en) * 1999-03-12 2000-09-21 Hsc Research And Development Limited Partnership Methods and compositions for treating leukemia

Also Published As

Publication number Publication date
WO2003068157A2 (en) 2003-08-21
AU2003210983A1 (en) 2003-09-04
AU2003210983A8 (en) 2003-09-04

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