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WO2003068150A3 - Methods of treating and diagnosing arthritis - Google Patents

Methods of treating and diagnosing arthritis Download PDF

Info

Publication number
WO2003068150A3
WO2003068150A3 PCT/US2003/003708 US0303708W WO03068150A3 WO 2003068150 A3 WO2003068150 A3 WO 2003068150A3 US 0303708 W US0303708 W US 0303708W WO 03068150 A3 WO03068150 A3 WO 03068150A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating
methods
diagnosing arthritis
diagnosing
arthritis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/003708
Other languages
French (fr)
Other versions
WO2003068150A2 (en
Inventor
Christophe O Benoist
Diane J Mathis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joslin Diabetes Center Inc
Original Assignee
Joslin Diabetes Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joslin Diabetes Center Inc filed Critical Joslin Diabetes Center Inc
Priority to AU2003209049A priority Critical patent/AU2003209049A1/en
Publication of WO2003068150A2 publication Critical patent/WO2003068150A2/en
Publication of WO2003068150A3 publication Critical patent/WO2003068150A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods of diagnosing, screening and treating a subject having an autoimmune disorder include evaluating of modulating the alternative pathway of complement activation.
PCT/US2003/003708 2002-02-11 2003-02-06 Methods of treating and diagnosing arthritis Ceased WO2003068150A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003209049A AU2003209049A1 (en) 2002-02-11 2003-02-06 Methods of treating and diagnosing arthritis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35604102P 2002-02-11 2002-02-11
US60/356,041 2002-02-11
US35777502P 2002-02-19 2002-02-19
US60/357,775 2002-02-19

Publications (2)

Publication Number Publication Date
WO2003068150A2 WO2003068150A2 (en) 2003-08-21
WO2003068150A3 true WO2003068150A3 (en) 2004-01-08

Family

ID=27737514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003708 Ceased WO2003068150A2 (en) 2002-02-11 2003-02-06 Methods of treating and diagnosing arthritis

Country Status (2)

Country Link
AU (1) AU2003209049A1 (en)
WO (1) WO2003068150A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9248162B2 (en) 2013-03-14 2016-02-02 Baxalta Incorporated Factor H for treatment of rheumatoid arthritis

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524453B2 (en) 2006-02-10 2013-09-03 The Brigham And Woman's Hospital, Inc. Lectin complement pathway assays and related compositions and methods
AU2008214359B2 (en) * 2007-02-05 2014-01-16 Apellis Pharmaceuticals, Inc. Local complement inhibition for treatment of complement-mediated disorders
JP7156827B2 (en) * 2018-06-08 2022-10-19 デンカ株式会社 Reagent for measuring complement titer and method for stabilizing measured value of complement titer using the same
EP3771468A1 (en) * 2019-07-31 2021-02-03 Universitätsklinikum Hamburg-Eppendorf C3/c5 convertase assays

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053824A1 (en) * 2000-01-18 2001-07-26 The General Hospital Corporation Mouse model for rheumatoid arthritis
US6319897B1 (en) * 1996-03-13 2001-11-20 John D. Lambris Peptides which inhibit complement activation
US20020081293A1 (en) * 1998-02-20 2002-06-27 Tanox, Inc., Delaware Corporation Inhibitors of complement activation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319897B1 (en) * 1996-03-13 2001-11-20 John D. Lambris Peptides which inhibit complement activation
US20020081293A1 (en) * 1998-02-20 2002-06-27 Tanox, Inc., Delaware Corporation Inhibitors of complement activation
WO2001053824A1 (en) * 2000-01-18 2001-07-26 The General Hospital Corporation Mouse model for rheumatoid arthritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JI H. ET AL.: "Arthritis critically dependent on innate immune system players", IMMUNITY, vol. 16, February 2002 (2002-02-01), pages 157 - 168, XP002968950 *
MCGRATH Y. ET AL.: "Development of adenovirus vectors encoding rat complement regulators for use in therapy in rodent models of inflammatory diseases", J. IMMUNOL., vol. 163, 1999, pages 6834 - 6840, XP002968951 *
YOSHIDA K. ET AL.: "An immunochemical method for assessing the function of the alternative complement pathway", INT. ARCHS. ALLERGY APPL. IMMUN., vol. 75, 1984, pages 173 - 178 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9248162B2 (en) 2013-03-14 2016-02-02 Baxalta Incorporated Factor H for treatment of rheumatoid arthritis

Also Published As

Publication number Publication date
AU2003209049A1 (en) 2003-09-04
WO2003068150A2 (en) 2003-08-21
AU2003209049A8 (en) 2003-09-04

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