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WO2003067952A3 - Complexe de glucosamine-polyacrylate inter-polymere et applications - Google Patents

Complexe de glucosamine-polyacrylate inter-polymere et applications Download PDF

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Publication number
WO2003067952A3
WO2003067952A3 PCT/IB2002/000415 IB0200415W WO03067952A3 WO 2003067952 A3 WO2003067952 A3 WO 2003067952A3 IB 0200415 W IB0200415 W IB 0200415W WO 03067952 A3 WO03067952 A3 WO 03067952A3
Authority
WO
WIPO (PCT)
Prior art keywords
inter
glucosamine
polyacrylate
applications
polymer complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2002/000415
Other languages
English (en)
Other versions
WO2003067952A2 (fr
Inventor
Clive Wilson
Gour Mukherji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Priority to PCT/IB2002/000415 priority Critical patent/WO2003067952A2/fr
Priority to AU2002230036A priority patent/AU2002230036A1/en
Priority to EP02733001A priority patent/EP1485421A1/fr
Priority to PCT/IB2002/001708 priority patent/WO2003068843A1/fr
Priority to AU2002304373A priority patent/AU2002304373A1/en
Publication of WO2003067952A2 publication Critical patent/WO2003067952A2/fr
Anticipated expiration legal-status Critical
Publication of WO2003067952A3 publication Critical patent/WO2003067952A3/fr
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/246—Intercrosslinking of at least two polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/005—Processes for mixing polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition solide particulaire formée par la complexation inter-polymère d'une glucosamine polymérique cationique ou de ses dérivés et d'un acide polyacrylique réticulé anionique ou de ses dérivés. Ce complexe est utilisé, en particulier, dans des compositions pharmaceutiques solides administrées par voie orale, y compris les comprimés et les capsules.
PCT/IB2002/000415 2002-02-12 2002-02-12 Complexe de glucosamine-polyacrylate inter-polymere et applications Ceased WO2003067952A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PCT/IB2002/000415 WO2003067952A2 (fr) 2002-02-12 2002-02-12 Complexe de glucosamine-polyacrylate inter-polymere et applications
AU2002230036A AU2002230036A1 (en) 2002-02-12 2002-02-12 Glucosamine-polyacrylate inter-polymer complex and applications thereof
EP02733001A EP1485421A1 (fr) 2002-02-12 2002-05-20 Complexe inter-polymere de glucosamine-polyacrylate et applications dudit complexe
PCT/IB2002/001708 WO2003068843A1 (fr) 2002-02-12 2002-05-20 Complexe inter-polymere de glucosamine-polyacrylate et applications dudit complexe
AU2002304373A AU2002304373A1 (en) 2002-02-12 2002-05-20 Glucosamine-polyacrylate inter-polymer complex and applications thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/000415 WO2003067952A2 (fr) 2002-02-12 2002-02-12 Complexe de glucosamine-polyacrylate inter-polymere et applications

Publications (2)

Publication Number Publication Date
WO2003067952A2 WO2003067952A2 (fr) 2003-08-21
WO2003067952A3 true WO2003067952A3 (fr) 2007-11-29

Family

ID=27676599

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IB2002/000415 Ceased WO2003067952A2 (fr) 2002-02-12 2002-02-12 Complexe de glucosamine-polyacrylate inter-polymere et applications
PCT/IB2002/001708 Ceased WO2003068843A1 (fr) 2002-02-12 2002-05-20 Complexe inter-polymere de glucosamine-polyacrylate et applications dudit complexe

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/001708 Ceased WO2003068843A1 (fr) 2002-02-12 2002-05-20 Complexe inter-polymere de glucosamine-polyacrylate et applications dudit complexe

Country Status (3)

Country Link
EP (1) EP1485421A1 (fr)
AU (2) AU2002230036A1 (fr)
WO (2) WO2003067952A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097714A1 (fr) * 2002-05-20 2003-11-27 Ranbaxy Laboratories Limited Liaison a la graisse au moyen d'un complexe interpolymere de glucosamine et d'acide polyacrylique
WO2005030173A1 (fr) * 2003-09-25 2005-04-07 Ranbaxy Laboratories Limited Liberation de medicaments specifiques au colon au moyen de complexation interpolymeres
WO2005087202A1 (fr) * 2004-02-10 2005-09-22 Ranbaxy Laboratories Limited Complexe interpolymere de glucosamine polyacrylate et procedes de production correspondants
GB0625813D0 (en) * 2006-12-22 2007-02-07 Advanced Biopolymers As Process
EP3199147B1 (fr) * 2009-04-22 2020-05-27 MedSkin Solutions Dr. Suwelack AG Composition d'agents actifs lyophilisés
JP5724108B2 (ja) 2009-04-22 2015-05-27 メドスキン ソリューションズ ドクター ズベラック アーゲーＭｅｄＳｋｉｎ Ｓｏｌｕｔｉｏｎｓ Ｄｒ．Ｓｕｗｅｌａｃｋ ＡＧ 凍結乾燥組成物
US9309435B2 (en) 2010-03-29 2016-04-12 The Clorox Company Precursor polyelectrolyte complexes compositions comprising oxidants
US20110236582A1 (en) 2010-03-29 2011-09-29 Scheuing David R Polyelectrolyte Complexes
US9474269B2 (en) 2010-03-29 2016-10-25 The Clorox Company Aqueous compositions comprising associative polyelectrolyte complexes (PEC)
US9162098B2 (en) * 2012-01-13 2015-10-20 Icl Performance Products Lp Liquid gel concentrate compositions and methods of use
US8975220B1 (en) 2014-08-11 2015-03-10 The Clorox Company Hypohalite compositions comprising a cationic polymer
CN106310229A (zh) * 2015-06-30 2017-01-11 深圳翰宇药业股份有限公司 一种马昔瑞林薄膜衣片及其制备方法
KR101882820B1 (ko) 2015-12-30 2018-07-30 주식회사 삼양바이오팜 점막부착성 약학 조성물 및 그의 제조방법
CN109350606B (zh) * 2018-09-26 2021-08-13 青岛大学 一种聚电解质中空胶囊的制备方法及得到的中空胶囊
CN110477032A (zh) * 2019-07-15 2019-11-22 华南理工大学 一种基于紫茎泽兰提取物的羟丙基壳聚糖/羧甲基壳聚糖载药粒子及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962158A (en) * 1974-04-05 1976-06-08 Director-General Of The Agency Of Industrial Science And Technology Hydrophilic polymer membranes of polyvinyl alcohol and chitosan
US4501835A (en) * 1982-03-08 1985-02-26 Polaroid Corporation Polyacrylic acid/chitosan polyelectrolyte complex
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447562A (en) * 1981-07-15 1984-05-08 Ivani Edward J Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
US4767463A (en) * 1987-04-15 1988-08-30 Union Carbide Corporation Glycosaminoglycan and cationic polymer combinations
US6060410A (en) * 1998-04-22 2000-05-09 Gillberg-Laforce; Gunilla Elsa Coating of a hydrophobic polymer substrate with a nonstoichiometric polyelectrolyte complex

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962158A (en) * 1974-04-05 1976-06-08 Director-General Of The Agency Of Industrial Science And Technology Hydrophilic polymer membranes of polyvinyl alcohol and chitosan
US4501835A (en) * 1982-03-08 1985-02-26 Polaroid Corporation Polyacrylic acid/chitosan polyelectrolyte complex
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates

Also Published As

Publication number Publication date
EP1485421A1 (fr) 2004-12-15
WO2003068843A1 (fr) 2003-08-21
AU2002304373A1 (en) 2003-09-04
AU2002230036A1 (en) 2003-09-04
WO2003067952A2 (fr) 2003-08-21
AU2002230036A8 (en) 2003-09-04

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