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WO2003066088A3 - Criblage de proteases et nouvelle utilisation de proteases - Google Patents

Criblage de proteases et nouvelle utilisation de proteases Download PDF

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Publication number
WO2003066088A3
WO2003066088A3 PCT/DE2003/000342 DE0300342W WO03066088A3 WO 2003066088 A3 WO2003066088 A3 WO 2003066088A3 DE 0300342 W DE0300342 W DE 0300342W WO 03066088 A3 WO03066088 A3 WO 03066088A3
Authority
WO
WIPO (PCT)
Prior art keywords
acute
myocardial infarction
thromboses
treatment
proteases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2003/000342
Other languages
German (de)
English (en)
Other versions
WO2003066088A2 (fr
Inventor
Rudy Susilo
Hans Christian Korting
Hans Guenther Gassen
Martin Hils
Ralf Pasternack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trommsdorff GmbH and Co KG
Original Assignee
Trommsdorff GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trommsdorff GmbH and Co KG filed Critical Trommsdorff GmbH and Co KG
Priority to AU2003212195A priority Critical patent/AU2003212195A1/en
Priority to EP03708017A priority patent/EP1471935A2/fr
Priority to DE10390318T priority patent/DE10390318D2/de
Publication of WO2003066088A2 publication Critical patent/WO2003066088A2/fr
Publication of WO2003066088A3 publication Critical patent/WO2003066088A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne une nouvelle utilisation de certaines protéases dans le cadre du traitement pour une guérison de plaies, notamment leur utilisation lors de la fibrinolyse, de la collagénolyse et de l'activation du plasminogène. La présente invention concerne également des procédés de criblage pour préparer des protéases adaptées aux utilisations susmentionnées. En outre, cette invention concerne l'utilisation des protéases ainsi obtenues pour produire une composition pharmaceutique utilisée pour la guérison de plaies, pour la prévention et/ou le traitement d'un infarctus, d'une thrombose, d'une thrombose veineuse, d'une resténose, d'une hypoxie, d'une ischémie, d'une nécrose de coagulation, d'une inflammation des vaisseaux sanguins, d'une embolie pulmonaire aiguë, d'une thrombose artérielle aiguë et subaiguë, d'un caillot frais ou plus ancien en cas de thrombose veineuse, d'une thrombose veineuse profonde du bassin et des extrémités, d'une thrombose précoce dans la zone de vaisseaux désoblitérés, d'une oblitération de vaisseau central aiguë de l'oeil, de brûlures et de gelures, d'une coagulation intravasculaire disséminée en cas de choc, d'une oblitération artérielle aiguë des extrémités, d'une artériopathie occlusive chronique, d'une thrombose de shunt artério-veineux et pour le traitement après un infarctus, après une opération de pontage, après une dilatation par ballonnet, pour une thérapie thrombolytique en cas d'infarctus aigu, pour une recanalisation de shunt artério-veineux et pour une reperfusion d'artère coronarienne oblitérée en cas d'infarctus aigu et après une angioplastie avec ou sans insertion d'endoprothèse.
PCT/DE2003/000342 2002-02-06 2003-02-06 Criblage de proteases et nouvelle utilisation de proteases Ceased WO2003066088A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003212195A AU2003212195A1 (en) 2002-02-06 2003-02-06 Protease screening and novel use of proteases
EP03708017A EP1471935A2 (fr) 2002-02-06 2003-02-06 Criblage de proteases et nouvelle utilisation de proteases
DE10390318T DE10390318D2 (de) 2002-02-06 2003-02-06 Protease-Screening und neue Verwendung von Proteasen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP02002706 2002-02-06
EP02002706.6 2002-02-06
US35781002P 2002-02-21 2002-02-21
US60/357,810 2002-02-21

Publications (2)

Publication Number Publication Date
WO2003066088A2 WO2003066088A2 (fr) 2003-08-14
WO2003066088A3 true WO2003066088A3 (fr) 2004-04-01

Family

ID=56290377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/000342 Ceased WO2003066088A2 (fr) 2002-02-06 2003-02-06 Criblage de proteases et nouvelle utilisation de proteases

Country Status (3)

Country Link
EP (1) EP1471935A2 (fr)
AU (1) AU2003212195A1 (fr)
WO (1) WO2003066088A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101808657A (zh) 2006-11-07 2010-08-18 赛诺菲巴斯德生物制剂公司 冻干法稳定疫苗
FR2966734B1 (fr) 2010-10-29 2014-07-18 Max Rombi Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002846A1 (fr) * 1983-01-21 1984-08-02 Advanced Drug Tech Onguent enzymatique
US4485095A (en) * 1981-08-10 1984-11-27 Kaken Pharmaceutical Co., Ltd. Pronase used for the treatment of diseases of the liver and kidneys in humans and animals
GB2147206A (en) * 1983-09-29 1985-05-09 Ceskoslovenska Akademie Ved Proteolytic enzyme treatment of wounds
EP0296787A1 (fr) * 1987-06-22 1988-12-28 JOHNSON & JOHNSON MEDICAL, INC. Pansement adhésif absorbant
US4918008A (en) * 1985-01-18 1990-04-17 Gauri Kailash Kumar Process for the preparation of protein hydrolysate and medicaments containing these hydrolysates
WO1990008555A1 (fr) * 1989-01-27 1990-08-09 Immunolytics, Inc. Procede et composition de traitement de l'hypertrophie prostatique benigne
EP0498532A1 (fr) * 1991-01-10 1992-08-12 E.R. SQUIBB & SONS, INC. Poudre pour le débridement des tissus nécropés contenant une enzyme protéolytique
US5206026A (en) * 1988-05-24 1993-04-27 Sharik Clyde L Instantaneous delivery film
WO1995023614A1 (fr) * 1994-03-01 1995-09-08 E.R. Squibb & Sons, Inc. Compositions et procedes pour traitement fibrinolytique par des enzymes
US5554366A (en) * 1992-04-02 1996-09-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care method and composition
US20030021775A1 (en) * 2001-07-27 2003-01-30 Ramot University Authority For Applied Research & Industrial Development Ltd. Device for and method of controlled enzymatic removal and retrieval of tissue

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485095A (en) * 1981-08-10 1984-11-27 Kaken Pharmaceutical Co., Ltd. Pronase used for the treatment of diseases of the liver and kidneys in humans and animals
WO1984002846A1 (fr) * 1983-01-21 1984-08-02 Advanced Drug Tech Onguent enzymatique
GB2147206A (en) * 1983-09-29 1985-05-09 Ceskoslovenska Akademie Ved Proteolytic enzyme treatment of wounds
US4918008A (en) * 1985-01-18 1990-04-17 Gauri Kailash Kumar Process for the preparation of protein hydrolysate and medicaments containing these hydrolysates
EP0296787A1 (fr) * 1987-06-22 1988-12-28 JOHNSON & JOHNSON MEDICAL, INC. Pansement adhésif absorbant
US5206026A (en) * 1988-05-24 1993-04-27 Sharik Clyde L Instantaneous delivery film
WO1990008555A1 (fr) * 1989-01-27 1990-08-09 Immunolytics, Inc. Procede et composition de traitement de l'hypertrophie prostatique benigne
EP0498532A1 (fr) * 1991-01-10 1992-08-12 E.R. SQUIBB & SONS, INC. Poudre pour le débridement des tissus nécropés contenant une enzyme protéolytique
US5554366A (en) * 1992-04-02 1996-09-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care method and composition
WO1995023614A1 (fr) * 1994-03-01 1995-09-08 E.R. Squibb & Sons, Inc. Compositions et procedes pour traitement fibrinolytique par des enzymes
US20030021775A1 (en) * 2001-07-27 2003-01-30 Ramot University Authority For Applied Research & Industrial Development Ltd. Device for and method of controlled enzymatic removal and retrieval of tissue

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAZLETT, LINDA D. ET AL: "Proteinase K decreases Pseudomonas aeruginosa adhesion to wounded cornea", EXPERIMENTAL EYE RESEARCH (1992), 55(4), 579-87, XP008024675 *

Also Published As

Publication number Publication date
EP1471935A2 (fr) 2004-11-03
AU2003212195A1 (en) 2003-09-02
WO2003066088A2 (fr) 2003-08-14

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