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WO2003064389A1 - Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient - Google Patents

Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient Download PDF

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Publication number
WO2003064389A1
WO2003064389A1 PCT/JP2003/000877 JP0300877W WO03064389A1 WO 2003064389 A1 WO2003064389 A1 WO 2003064389A1 JP 0300877 W JP0300877 W JP 0300877W WO 03064389 A1 WO03064389 A1 WO 03064389A1
Authority
WO
WIPO (PCT)
Prior art keywords
disease
diseases
allergic
nitrogen
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/000877
Other languages
English (en)
French (fr)
Inventor
Akira Ohhata
Yoshikazu Takaoka
Mikio Ogawa
Hisao Nakai
Susumu Yamamoto
Hiroshi Ochiai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP2003564012A priority Critical patent/JPWO2003064389A1/ja
Priority to US10/502,884 priority patent/US7378428B2/en
Publication of WO2003064389A1 publication Critical patent/WO2003064389A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/4965—Non-condensed pyrazines
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PCT/JP2003/000877 2002-01-31 2003-01-30 Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient Ceased WO2003064389A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003564012A JPWO2003064389A1 (ja) 2002-01-31 2003-01-30 含窒素二環性化合物およびその化合物を有効成分として含有する薬剤
US10/502,884 US7378428B2 (en) 2002-01-31 2003-01-30 Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2002023846 2002-01-31
JP2002-23846 2002-01-31
JP2002023845 2002-01-31
JP2002-23845 2002-01-31

Publications (1)

Publication Number Publication Date
WO2003064389A1 true WO2003064389A1 (en) 2003-08-07

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Application Number Title Priority Date Filing Date
PCT/JP2003/000877 Ceased WO2003064389A1 (en) 2002-01-31 2003-01-30 Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient

Country Status (4)

Country Link
US (1) US7378428B2 (ja)
JP (1) JPWO2003064389A1 (ja)
TW (1) TW200302726A (ja)
WO (1) WO2003064389A1 (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006080040A1 (en) * 2005-01-25 2006-08-03 Università Degli Studi Di Siena New potent and selective ligands of cannabinoid receptors
JP2006522789A (ja) * 2003-04-11 2006-10-05 グレンマーク・ファーマシューティカルズ・エス・エー 炎症性およびアレルギー性障害の治療に有用な新規な複素環式化合物；それらの調製方法および医薬組成物
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