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WO2003063591A1 - Agent servant a inhiber des phytovirus et a lutter contre ces derniers - Google Patents

Agent servant a inhiber des phytovirus et a lutter contre ces derniers Download PDF

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Publication number
WO2003063591A1
WO2003063591A1 PCT/CN2001/001641 CN0101641W WO03063591A1 WO 2003063591 A1 WO2003063591 A1 WO 2003063591A1 CN 0101641 W CN0101641 W CN 0101641W WO 03063591 A1 WO03063591 A1 WO 03063591A1
Authority
WO
WIPO (PCT)
Prior art keywords
virus
plant
agent
ribavirin
control
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2001/001641
Other languages
English (en)
Chinese (zh)
Inventor
Qinfu Zhang
Derong An
Chi Ma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XI AN HI-LEVEL CHEMICAL INDUSTRY Co Ltd
Original Assignee
XI AN HI-LEVEL CHEMICAL INDUSTRY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XI AN HI-LEVEL CHEMICAL INDUSTRY Co Ltd filed Critical XI AN HI-LEVEL CHEMICAL INDUSTRY Co Ltd
Priority to PCT/CN2001/001641 priority Critical patent/WO2003063591A1/fr
Publication of WO2003063591A1 publication Critical patent/WO2003063591A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Definitions

  • the invention relates to pesticides for controlling plant viruses, in particular to a plant virus inhibitory control agent.
  • a plant virus is an absolutely endoparasite non-cellular organism that has only nucleic acids and coat proteins. After invading the plant, it completely depends on the place, energy and synthetic system provided by the parasitic cells for self-replication and proliferation. The serious harm to the plants is the consumption of nutrients, disrupting the growth balance and reducing the immunity of the plants.
  • the susceptible plants show symptoms such as mosaic, dwarfing, shrinking, deformity, bushing, and decline.
  • Plant virus is called "plant cancer” because of its special survival mode and difficult control.
  • plant cancer because of its special survival mode and difficult control.
  • the representative varieties such as Zhibingling (produced by Shandong Penglai Pesticide Factory) and virus A (produced by Qiqihar Pesticide Factory), etc., not only have small output, but also have only control effect About 40%, it is difficult to meet the actual needs of agricultural production.
  • ribavirin has been widely used as a viral inhibitor to treat diseases such as human viral influenza, and also for livestock viral diseases. However, no reports have been reported for plant virus control.
  • Plant viruses and animal viruses are: very different. The inventors have been engaged in plant virus induced resistance, surface passivation, and virus replication inhibitor tests for many years, and have accumulated a large amount of relevant data and materials. Studies have shown that ribavirin also inhibits and controls plant viruses; copper sulfate, zinc sulfate, and the like have virus surface-active deactivators. But any single component virus inhibitor ribavirin or virus surface active deactivator copper sulfate, sulfuric acid Zinc, etc., are not effective in controlling plant virus diseases. For example, if triazole riboside 2.0% concentrated solution is used alone, its control effect is lower than 40%, and there is almost no control effect.
  • the purpose of the present invention is to overcome the shortcomings of the existing single ribavirin single component to prevent and control plant virus diseases, and to improve on this basis, so as to provide a cheap and highly effective plant virus suppression control agent.
  • the plant virus suppressing and controlling agent of the present invention contains the following components (the sum of the weight percentages of the components is 100%):
  • the preferred composition of the virus inhibitory agent of the present invention is:
  • additives such as penetrant, emulsifier or surfactant can be added to the solution to improve its performance.
  • auxiliaries are commonly used materials, which are easy for ordinary professional technicians to understand and not to be confused.
  • the method for using the above-mentioned preferred component virus inhibitory agent can be diluted by water to 400-600 times, and sprayed on the plant surface. It is best to dilute to 500 times with water. The application frequency is 1 to 3 times, and the effect is better in the early stage of onset.
  • the virus suppressing and controlling agent can be used as a plant virus disease controlling agent caused by cucumber mosaic virus (CMV) or tobacco mosaic virus (TMV) and other viruses in vegetables, grains, tobacco or fruit trees. It has significant preventive effects on symptoms such as mosaic disease, leaflet disease, yellow leaf disease, fern leaf disease, downy mildew, dwarf disease, sarcoidosis, shrinkage, rugosity, and decline. Especially for vegetable, tobacco, pepper, melon and fruit crops caused by cucumber mosaic virus (CMV), tobacco mosaic virus (TMV) caused by plant virus disease, the control effect reached 80%.
  • CMV cucumber mosaic virus
  • TMV tobacco mosaic virus
  • ribavirin is a plant virus inhibitor
  • copper sulfate and zinc sulfate are plant virus passivating agents, which passivate the surface activity of the virus.
  • only one component of ribavirin can inhibit and prevent plant viruses.
  • copper sulfate and zinc sulfate when used together with copper sulfate and zinc sulfate, the inhibitory effect of ribavirin was significantly enhanced, and at the same time, copper sulfate and zinc sulfate showed a strong virus surface active passivation. Therefore, the combination of the three ingredients has a significant synergistic effect, which can achieve a control effect of more than 80%. This is far from being achieved by any single component.
  • the present invention is a highly effective plant virus inhibitory control agent developed on the basis of plant virus replication inhibitors, which integrates inactivated virus activity, inhibits virus reproduction, induces and improves plant resistance. By inactivating the virus activity and inhibiting the virus from multiplying in the plant, it achieves the purposes of controlling diseases, increasing crop yield and improving crop quality.
  • the preparation has a strong systemic action and conduction activity, and has a control effect on plant diseases caused by cucumber yellow leaf disease (CMV), tobacco mosaic disease (TMV) and other viruses of various plants by more than 80%. This preparation has been tested by the country's designated toxicity testing unit. LD50> 10000, it is "actually non-toxic", non-toxic and pollution-free, and no pollution to the environment.
  • Plant surfaces are usually oily and have poor wetting effects. Additives such as penetration should be added to the formulation to facilitate the formation of a continuous medicinal film on the foliage of the crop.
  • this formulation is also in the form of a wettable powder.
  • the ratio of three active ingredients of ribavirin, copper sulfate and zinc sulfate is basically the same as that of the aforementioned water emulsion.
  • Fillers such as bentonite and diatomaceous earth can be added to the wettable powder. Both of these preparation forms are within the protection scope of the present invention.
  • the production process of the plant virus control agent is as follows:
  • the floatation agent formulated according to the above ratio has a control effect of more than 80%, which is the best ratio. Because the total content of the three active ingredients is 3.85%, the pesticide of this kind is called "3.85% Virus Bic"-the commercial name of this product.
  • the control effect is 58%, which means that the content is too high and it will affect the control effect. If it is higher than this ratio, it may cause phytotoxicity to plants.
  • the experiment was conducted in a field plot, with 4 repetitions arranged randomly.
  • the test pesticide was prepared by diluting the various formulations of the present invention to 400-fold, 500-fold, and 600-fold liquids with water; using conventional virus disease control agents virus, Zhikangling II and Bacterial Clear corresponding dilutions and water as comparison. Foliar spray is applied to the plants 1-3 times, and then the crops are classified according to the following criteria:
  • this level-the disease grade value such as the value of level 0 is 0, the value of level 3 is 3; the total number of plants surveyed in the test area and the control area;
  • CKo a disease index before administration in a control area
  • Pti Iron index after application in the test area
  • the plant virus control agent of the present invention takes “3.85%% virus bike” in Example 1, and has the following obvious effects:
  • the 500-fold solution of this agent has a control effect on corn virus disease (CMV) of 84.7%, the disease index in the treatment area is 2.65, and the control area is 32.30.
  • CMV corn virus disease
  • TMV tobacco virus disease
  • Pesticide safety toxicology test report confirms low toxicity and is non-irritating to eyes and skin.
  • the preparation is non-toxic and non-polluting, has low production cost, and has good effects in inhibiting and treating diseases. It is an urgently needed pesticide product in agricultural production.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un agent pour inhiber des phytovirus et lutter contre ces derniers, ledit agent contenant 0,02 à 2,0 % en poids de ribavirine, 0,5 à 15,0 % en poids de sulfate de cuivre, 1,0 à 25,0 % en poids de sulfate de zinc, et de l'eau comme solvant. De préférence, cet agent comprend 0,08 à 0,12 % en poids de ribavirine, 1,2 à 1,3 % en poids de sulfate de cuivre, 2,0 à 3,0 % en poids de sulfate de zinc, et de l'eau comme solvant. Pendant une période pilote, l'agent est testé, sur plus de vingt parcelles d'essai, sur des plantes, par exemple sur du tabac, des arbres fruitiers, des légumes, etc. Les résultats montrent que le produit permet de lutter efficacement contre différentes viroses provoquées par le virus de la mosaïque du concombre (CMV) et le virus de la mosaïque du tabac (TMV), avec un taux d'efficacité de 80 %, sans effets secondaires toxiques. Cet agent à activité systémique et transmissible permet ainsi d'inhiber des phytovirus et de lutter contre ces derniers.
PCT/CN2001/001641 2001-12-25 2001-12-25 Agent servant a inhiber des phytovirus et a lutter contre ces derniers Ceased WO2003063591A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2001/001641 WO2003063591A1 (fr) 2001-12-25 2001-12-25 Agent servant a inhiber des phytovirus et a lutter contre ces derniers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2001/001641 WO2003063591A1 (fr) 2001-12-25 2001-12-25 Agent servant a inhiber des phytovirus et a lutter contre ces derniers

Publications (1)

Publication Number Publication Date
WO2003063591A1 true WO2003063591A1 (fr) 2003-08-07

Family

ID=27626707

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2001/001641 Ceased WO2003063591A1 (fr) 2001-12-25 2001-12-25 Agent servant a inhiber des phytovirus et a lutter contre ces derniers

Country Status (1)

Country Link
WO (1) WO2003063591A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007104669A3 (fr) * 2006-03-14 2008-02-21 Basf Ag Procédé d'induction d'une tolérance aux virus chez les végétaux
WO2008020998A3 (fr) * 2006-08-08 2008-12-24 Bayer Cropscience Lp Procédé pour améliorer la croissance des plantes par réduction des infections virales

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189629A1 (fr) * 1985-01-16 1986-08-06 Viratek, Inc. Procédé pour traiter des maladies à virus en utilisant la ribavirine
CN1095891A (zh) * 1993-06-05 1994-12-07 杨德山 克病毒
CN1117795A (zh) * 1995-05-24 1996-03-06 张燮先 植物病毒病防治剂
CN1125045A (zh) * 1994-08-21 1996-06-26 沂南县农药厂 病毒净水剂及制备方法
CN1257056A (zh) * 1998-12-17 2000-06-21 陈支年 多效叶面复合剂

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189629A1 (fr) * 1985-01-16 1986-08-06 Viratek, Inc. Procédé pour traiter des maladies à virus en utilisant la ribavirine
CN1095891A (zh) * 1993-06-05 1994-12-07 杨德山 克病毒
CN1125045A (zh) * 1994-08-21 1996-06-26 沂南县农药厂 病毒净水剂及制备方法
CN1117795A (zh) * 1995-05-24 1996-03-06 张燮先 植物病毒病防治剂
CN1257056A (zh) * 1998-12-17 2000-06-21 陈支年 多效叶面复合剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007104669A3 (fr) * 2006-03-14 2008-02-21 Basf Ag Procédé d'induction d'une tolérance aux virus chez les végétaux
WO2008020998A3 (fr) * 2006-08-08 2008-12-24 Bayer Cropscience Lp Procédé pour améliorer la croissance des plantes par réduction des infections virales

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