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WO2003048185A3 - Angiopioetin related factors - Google Patents

Angiopioetin related factors Download PDF

Info

Publication number
WO2003048185A3
WO2003048185A3 PCT/US2002/037660 US0237660W WO03048185A3 WO 2003048185 A3 WO2003048185 A3 WO 2003048185A3 US 0237660 W US0237660 W US 0237660W WO 03048185 A3 WO03048185 A3 WO 03048185A3
Authority
WO
WIPO (PCT)
Prior art keywords
wild
domain
amino acid
acid sequence
fusion proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/037660
Other languages
French (fr)
Other versions
WO2003048185A2 (en
Inventor
Paul D Kessler
Imre Kovesdi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genvec Inc
Original Assignee
Genvec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genvec Inc filed Critical Genvec Inc
Priority to AU2002359464A priority Critical patent/AU2002359464A1/en
Publication of WO2003048185A2 publication Critical patent/WO2003048185A2/en
Anticipated expiration legal-status Critical
Publication of WO2003048185A3 publication Critical patent/WO2003048185A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides fusion proteins comprising a fibrinogen-like domain comprising an amino acid sequence identical or homologous to the amino acid sequence of the fibrinogen-like domain of a first wild-type angiopoietin-related factor and a coiled-coil domain comprising an amino acid sequence identical or homologous to the coiled-coil domain of a second wild-type angiopoietin-related factor, where the first and second wild-type angiopoietin related factors are different. The invention further provides polynucleotides encoding such fusion proteins, vectors comprising such polynucleotides, and methods of making and administering such fusion proteins, polynucleotides, and vectors.
PCT/US2002/037660 2001-11-30 2002-11-21 Angiopioetin related factors Ceased WO2003048185A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002359464A AU2002359464A1 (en) 2001-11-30 2002-11-21 Angiopioetin related factors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33448801P 2001-11-30 2001-11-30
US60/334,488 2001-11-30

Publications (2)

Publication Number Publication Date
WO2003048185A2 WO2003048185A2 (en) 2003-06-12
WO2003048185A3 true WO2003048185A3 (en) 2004-06-24

Family

ID=23307442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/037660 Ceased WO2003048185A2 (en) 2001-11-30 2002-11-21 Angiopioetin related factors

Country Status (2)

Country Link
AU (1) AU2002359464A1 (en)
WO (1) WO2003048185A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7081443B2 (en) 2002-05-21 2006-07-25 Korea Advanced Institutes Of Science And Technology (Kaist) Chimeric comp-ang1 molecule
LT1781698T (en) 2004-07-20 2016-09-26 Genentech, Inc. Compositions and methods of using angiopoietin-like 4 protein
WO2006014729A2 (en) 2004-07-20 2006-02-09 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
CA2581769C (en) * 2004-09-28 2014-03-11 Genexel-Sein, Inc. Methods of using chimeric coiled-coil molecule
EP2446897A1 (en) 2005-01-06 2012-05-02 Novo Nordisk A/S Anti-KIR combination treatments and methods
EA015584B1 (en) 2005-03-23 2011-10-31 Генмаб А/С ANTIBODY TO CD38 PERSON AND ITS APPLICATION
SG195082A1 (en) 2011-05-25 2013-12-30 Innate Pharma Sa Anti-kir antibodies for the treatment of inflammatory disorders
WO2013154744A1 (en) * 2012-04-13 2013-10-17 Cornell University Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction
US9540428B2 (en) * 2012-07-03 2017-01-10 Ecole Polytechnique Federale De Lausanne (Epfl) Extracellular matrix heparin-binding domains
GB202108761D0 (en) * 2021-06-18 2021-08-04 Ikarovec Ltd Ocular disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074873A (en) * 1997-09-19 2000-06-13 Genentech, Inc. Nucleic acids encoding NL-3
US6265564B1 (en) * 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US6406693B1 (en) * 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265564B1 (en) * 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US20030092891A1 (en) * 1996-08-02 2003-05-15 Samuel Davis Expressed ligand - vascular intercellular signalling molecule
US6074873A (en) * 1997-09-19 2000-06-13 Genentech, Inc. Nucleic acids encoding NL-3
US6406693B1 (en) * 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids

Also Published As

Publication number Publication date
AU2002359464A8 (en) 2003-06-17
WO2003048185A2 (en) 2003-06-12
AU2002359464A1 (en) 2003-06-17

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