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WO2003041582A1 - Method of measuring biological component concentration and apparatus therefor - Google Patents

Method of measuring biological component concentration and apparatus therefor Download PDF

Info

Publication number
WO2003041582A1
WO2003041582A1 PCT/JP2002/011871 JP0211871W WO03041582A1 WO 2003041582 A1 WO2003041582 A1 WO 2003041582A1 JP 0211871 W JP0211871 W JP 0211871W WO 03041582 A1 WO03041582 A1 WO 03041582A1
Authority
WO
WIPO (PCT)
Prior art keywords
subject
biological component
skin
component concentration
skin thickness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/011871
Other languages
English (en)
French (fr)
Inventor
Katsuhiko Maruo
Mitsuhiro Tsurugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panasonic Electric Works Co Ltd
Original Assignee
Matsushita Electric Works Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Works Ltd filed Critical Matsushita Electric Works Ltd
Priority to EP20020803116 priority Critical patent/EP1452135B1/en
Priority to US10/478,276 priority patent/US7333841B2/en
Publication of WO2003041582A1 publication Critical patent/WO2003041582A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1495—Calibrating or testing of in-vivo probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1075—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Artificial Intelligence (AREA)
  • Mathematical Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Computation (AREA)
  • Fuzzy Systems (AREA)
  • Emergency Medicine (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
PCT/JP2002/011871 2001-11-15 2002-11-14 Method of measuring biological component concentration and apparatus therefor Ceased WO2003041582A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP20020803116 EP1452135B1 (en) 2001-11-15 2002-11-14 Method for calculating a biological component density of a subject
US10/478,276 US7333841B2 (en) 2001-11-15 2002-11-14 Method and device for calculating a biological component density of a subject

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001350746A JP3931638B2 (ja) 2001-11-15 2001-11-15 生体成分の定量装置
JP2001-350746 2001-11-15

Publications (1)

Publication Number Publication Date
WO2003041582A1 true WO2003041582A1 (en) 2003-05-22

Family

ID=19163183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/011871 Ceased WO2003041582A1 (en) 2001-11-15 2002-11-14 Method of measuring biological component concentration and apparatus therefor

Country Status (4)

Country Link
US (1) US7333841B2 (ja)
EP (1) EP1452135B1 (ja)
JP (1) JP3931638B2 (ja)
WO (1) WO2003041582A1 (ja)

Cited By (3)

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WO2007026884A1 (ja) * 2005-09-02 2007-03-08 Pola Chemical Industries Inc. 皮膚の状態の判定方法及び皮膚の厚みの予測方法
EP1732435A4 (en) * 2004-04-07 2009-07-29 Sensys Medical Inc COMPACT DEVICE FOR NONINVASIVE MEASUREMENT OF GLUCOSE BY NEAR-INFRARED SPECTROSCOPY
JP2013103094A (ja) * 2011-11-16 2013-05-30 Sony Corp 測定装置、測定方法、プログラム及び記録媒体

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH064222B2 (ja) 1985-09-18 1994-01-19 株式会社岡本工作機械製作所 吸振器式砥石カバ−
JP4533603B2 (ja) * 2003-07-14 2010-09-01 ポーラ化成工業株式会社 皮膚状態の測定方法
JP4348467B2 (ja) 2003-09-30 2009-10-21 学校法人日本大学 光を用いた生体の物質特性検査装置
US7215983B2 (en) 2004-06-30 2007-05-08 Hitachi, Ltd. Blood sugar level measuring apparatus
US7251517B2 (en) 2004-06-30 2007-07-31 Hitachi, Ltd. Blood sugar level measuring apparatus
JP4586680B2 (ja) * 2004-08-25 2010-11-24 パナソニック電工株式会社 体内成分の定量分析用検量線の作成方法、および同検量線を用いた定量分析装置
EP1629767B1 (en) 2004-08-25 2010-07-21 Panasonic Electric Works Co., Ltd. Quantitative analyzer using a calibration curve
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
US20070232872A1 (en) * 2006-03-16 2007-10-04 The Board Of Regents Of The University Of Texas System Continuous noninvasive glucose monitoring in diabetic, non-diabetic, and critically ill patients with oct
US8485016B2 (en) 2006-06-12 2013-07-16 Trefford Simpson Method of calibrating a biometric device
JP2008005988A (ja) * 2006-06-28 2008-01-17 Jasco Corp 血糖値分析方法、及び血糖値分析装置
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
JP5684443B2 (ja) * 2007-06-06 2015-03-11 横河電機株式会社 生体成分測定装置
JP2010005047A (ja) * 2008-06-25 2010-01-14 Panasonic Electric Works Co Ltd 光学式生体成分測定用の検量モデルの作成方法及び非侵襲血糖値測定装置
FR2940904B1 (fr) * 2009-01-13 2012-08-31 Urgo Laboratoires Systeme de mesure de pression d'interface
JP4715930B2 (ja) * 2009-02-03 2011-07-06 パナソニック電工株式会社 光学式皮下脂肪厚測定装置
KR20130086245A (ko) * 2009-03-05 2013-07-31 싸이노슈어, 인코포레이티드 열 수술 안전 장치 및 방법
CN102469962A (zh) * 2009-07-28 2012-05-23 松下电工株式会社 血糖值推定装置
US9464983B2 (en) 2010-07-12 2016-10-11 Seiko Epson Corporation Concentration determination apparatus, probe, concentration determination method, and program
JP5626880B2 (ja) * 2010-10-20 2014-11-19 セイコーエプソン株式会社 濃度定量装置及び濃度定量方法並びにプログラム
JP5626879B2 (ja) 2010-10-20 2014-11-19 セイコーエプソン株式会社 濃度定量装置及び濃度定量方法並びにプログラム
WO2012158007A1 (es) * 2011-05-18 2012-11-22 Instituto Politecnico Nacional Dispositivo láser para la medición de espesores de la epidermis
JP5838517B2 (ja) 2011-06-21 2016-01-06 セイコーエプソン株式会社 濃度定量装置、濃度定量方法
JP2013122443A (ja) 2011-11-11 2013-06-20 Hideo Ando 生体活動測定方法、生体活動測定装置、生体活動検出信号の転送方法および生体活動情報を利用したサービスの提供方法
JP2013138811A (ja) * 2012-01-06 2013-07-18 Seiko Epson Corp 濃度定量装置、濃度定量方法及びプログラム
JP2013140126A (ja) * 2012-01-06 2013-07-18 Seiko Epson Corp 濃度定量装置、濃度定量方法及びプログラム
EP2829225A1 (en) * 2012-03-20 2015-01-28 BIRMELE, Kalyna Maya Method and device for non-invasive checking of the glucose level in the blood
EP2839552A4 (en) 2012-04-18 2015-12-30 Cynosure Inc PICOSCOPE LASER DEVICE AND METHOD FOR THE TREATMENT OF TARGET FABRICS THEREWITH
US9693694B2 (en) 2012-11-21 2017-07-04 Folim G. Halaka Cancer cell detection using dielectrophoretic dynamic light scattering (DDLS) spectroscopy
US8843186B2 (en) 2012-11-21 2014-09-23 Folim G. Halaka Non-invasive reagentless glucose determination
JP5511033B1 (ja) 2012-12-04 2014-06-04 Ｎｅｃシステムテクノロジー株式会社 血糖値予測装置、測定装置、血糖値予測方法、及びプログラム
WO2014145707A2 (en) 2013-03-15 2014-09-18 Cynosure, Inc. Picosecond optical radiation systems and methods of use
JP2014239871A (ja) 2013-05-07 2014-12-25 安東　秀夫 生体活動検出方法、生体活動測定装置、生体活動検出信号の転送方法および生体活動情報を利用したサービスの提供方法
JP6387610B2 (ja) * 2013-12-27 2018-09-12 ミツミ電機株式会社 生体情報測定装置
JP5911113B2 (ja) * 2014-02-05 2016-04-27 Ｎｅｃソリューションイノベータ株式会社 測定装置
US20160008556A1 (en) * 2014-07-10 2016-01-14 Elwha Llc Needle insertion system and method for inserting a movable needle into a vertebrate subject
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
JP2016075522A (ja) * 2014-10-03 2016-05-12 セイコーエプソン株式会社 目的成分検量装置及び電子機器
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
CN105866067A (zh) * 2016-06-16 2016-08-17 江西出入境检验检疫局检验检疫综合技术中心 一种基于近红外光谱技术的茶粕中茶皂素快速测定方法
KR102498120B1 (ko) 2017-10-17 2023-02-09 삼성전자주식회사 생체정보 센서의 오차 보정 장치 및 방법과, 생체정보 추정 장치 및 방법
KR102539144B1 (ko) 2017-10-19 2023-06-01 삼성전자주식회사 개인화된 단위 스펙트럼 획득 장치 및 방법과, 생체 성분 추정 장치 및 방법
WO2019165426A1 (en) 2018-02-26 2019-08-29 Cynosure, Inc. Q-switched cavity dumped sub-nanosecond laser
KR102658237B1 (ko) * 2018-10-02 2024-04-16 삼성전자주식회사 분석 물질의 혈중 농도 추정 장치 및 방법과, 모델 생성 장치 및 방법
DK3809118T3 (da) * 2019-10-17 2023-09-18 Evonik Operations Gmbh Fremgangsmåde til at forudsige en egenskabsværdi af et materiale ved anvendelse af hovedkomponentanalyse
CN113303793B (zh) * 2020-02-26 2022-08-26 先阳科技有限公司 一种组织成分无创检测方法、装置、系统及可穿戴设备
EP4254421A4 (en) * 2020-11-24 2024-10-16 Suntory Holdings Limited HEALTH ASSISTANCE DEVICE, HEALTH ASSISTANCE METHOD, AND RECORDING MEDIUM
WO2024034312A1 (ja) * 2022-08-09 2024-02-15 バイオニクス株式会社 バイタル情報測定装置、バイタル情報測定方法、生体管理システム、及び生体管理方法
CN115963068B (zh) * 2023-03-16 2023-05-05 北京心联光电科技有限公司 皮肤组织成分含量的测定方法及装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09215679A (ja) * 1996-02-09 1997-08-19 Matsushita Electric Works Ltd 体液成分濃度測定装置
EP0843986A2 (en) 1996-11-26 1998-05-27 Matsushita Electric Works, Ltd. Device for non-invasive determination of glucose concentration in blood
JP2000506048A (ja) * 1996-03-06 2000-05-23 アボット・ラボラトリーズ 生物化合物の後続監視のための校正
WO2000042907A1 (en) * 1999-01-22 2000-07-27 Instrumentation Metrics, Inc. System and method for noninvasive blood analyte measurements
JP2000237195A (ja) * 1998-12-24 2000-09-05 Matsushita Electric Ind Co Ltd 生体情報測定装置、生体情報測定方法、体脂肪測定装置、体脂肪測定方法およびプログラム記録媒体
JP2001212116A (ja) * 2000-02-02 2001-08-07 Matsushita Electric Ind Co Ltd 血液成分測定装置
US20010021803A1 (en) 1999-07-22 2001-09-13 Blank Thomas B. Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460177A (en) * 1993-05-07 1995-10-24 Diasense, Inc. Method for non-invasive measurement of concentration of analytes in blood using continuous spectrum radiation
JP2000131322A (ja) 1998-10-29 2000-05-12 Matsushita Electric Works Ltd グルコース濃度の定量方法及びその装置
JP2000186998A (ja) * 1998-12-22 2000-07-04 Matsushita Electric Works Ltd 生体スペクトル測定装置
US6587702B1 (en) * 1999-01-22 2003-07-01 Instrumentation Metrics, Inc Classification and characterization of tissue through features related to adipose tissue
US6738652B2 (en) * 2000-06-15 2004-05-18 Sensys Medical, Inc. Classification and screening of test subjects according to optical thickness of skin

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09215679A (ja) * 1996-02-09 1997-08-19 Matsushita Electric Works Ltd 体液成分濃度測定装置
JP2000506048A (ja) * 1996-03-06 2000-05-23 アボット・ラボラトリーズ 生物化合物の後続監視のための校正
EP0843986A2 (en) 1996-11-26 1998-05-27 Matsushita Electric Works, Ltd. Device for non-invasive determination of glucose concentration in blood
JP2000237195A (ja) * 1998-12-24 2000-09-05 Matsushita Electric Ind Co Ltd 生体情報測定装置、生体情報測定方法、体脂肪測定装置、体脂肪測定方法およびプログラム記録媒体
WO2000042907A1 (en) * 1999-01-22 2000-07-27 Instrumentation Metrics, Inc. System and method for noninvasive blood analyte measurements
US20010021803A1 (en) 1999-07-22 2001-09-13 Blank Thomas B. Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction
JP2001212116A (ja) * 2000-02-02 2001-08-07 Matsushita Electric Ind Co Ltd 血液成分測定装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1452135A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1732435A4 (en) * 2004-04-07 2009-07-29 Sensys Medical Inc COMPACT DEVICE FOR NONINVASIVE MEASUREMENT OF GLUCOSE BY NEAR-INFRARED SPECTROSCOPY
WO2007026884A1 (ja) * 2005-09-02 2007-03-08 Pola Chemical Industries Inc. 皮膚の状態の判定方法及び皮膚の厚みの予測方法
US7820972B2 (en) 2005-09-02 2010-10-26 Pola Chemical Industries Inc. Method of evaluating skin conditions and method of estimating skin thickness
JP5306651B2 (ja) * 2005-09-02 2013-10-02 ポーラ化成工業株式会社 皮膚の状態の判定方法及び皮膚の厚みの予測方法
JP2013103094A (ja) * 2011-11-16 2013-05-30 Sony Corp 測定装置、測定方法、プログラム及び記録媒体

Also Published As

Publication number Publication date
JP2003144421A (ja) 2003-05-20
US20040142402A1 (en) 2004-07-22
US7333841B2 (en) 2008-02-19
EP1452135B1 (en) 2013-02-13
JP3931638B2 (ja) 2007-06-20
EP1452135A1 (en) 2004-09-01
EP1452135A4 (en) 2008-11-05

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