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WO2002038185A3 - Injectable sustained release delivery system with loperamide - Google Patents

Injectable sustained release delivery system with loperamide Download PDF

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Publication number
WO2002038185A3
WO2002038185A3 PCT/US2001/047116 US0147116W WO0238185A3 WO 2002038185 A3 WO2002038185 A3 WO 2002038185A3 US 0147116 W US0147116 W US 0147116W WO 0238185 A3 WO0238185 A3 WO 0238185A3
Authority
WO
WIPO (PCT)
Prior art keywords
loperamide
delivery system
sustained release
release delivery
injectable sustained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/047116
Other languages
French (fr)
Other versions
WO2002038185A2 (en
Inventor
Richard L Dunn
David W Osborne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tolmar Therapeutics Inc
Original Assignee
Atrix Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atrix Laboratories Inc filed Critical Atrix Laboratories Inc
Priority to AU2002226000A priority Critical patent/AU2002226000A1/en
Publication of WO2002038185A2 publication Critical patent/WO2002038185A2/en
Publication of WO2002038185A3 publication Critical patent/WO2002038185A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides for a flowable composition suitable for use as a controlled release implant, a method for forming a flowable composition for use as a controlled release implant, and methods for using the flowable composition. The composition comprises a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid; a biocompatible organic solvent that is miscible to dispersible in aqueous medium or body fluid and can effectively dissolve the thermoplastic polyester; and an antihyperalgesic opiate.
PCT/US2001/047116 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide Ceased WO2002038185A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002226000A AU2002226000A1 (en) 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71082500A 2000-11-13 2000-11-13
US09/710,825 2000-11-13

Publications (2)

Publication Number Publication Date
WO2002038185A2 WO2002038185A2 (en) 2002-05-16
WO2002038185A3 true WO2002038185A3 (en) 2003-01-16

Family

ID=24855703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047116 Ceased WO2002038185A2 (en) 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide

Country Status (2)

Country Link
AU (1) AU2002226000A1 (en)
WO (1) WO2002038185A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875697B2 (en) 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US10010612B2 (en) 2007-05-25 2018-07-03 Indivior Uk Limited Sustained delivery formulations of risperidone compounds
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions
US10058554B2 (en) 2005-09-30 2018-08-28 Indivior Uk Limited Sustained release small molecule drug formulation
US10172849B2 (en) 2010-06-08 2019-01-08 Indivior Uk Limited Compositions comprising buprenorphine
US10198218B2 (en) 2010-06-08 2019-02-05 Indivior Uk Limited Injectable flowable composition comprising buprenorphine

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
TWI353854B (en) * 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
DE60325742D1 (en) * 2002-07-31 2009-02-26 Alza Corp INJECTABLE MULTIMODAL POLYMERS DEPOT COMPOSITIONS AND THEIR USES
AU2003295409B2 (en) 2002-11-06 2010-02-11 Durect Corporation Controlled release depot formulations
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
KR20060023140A (en) * 2003-05-30 2006-03-13 알자 코포레이션 Implantable Elastomer Depot Compositions, Uses thereof, and Methods of Making the Same
US20080319020A1 (en) 2005-11-21 2008-12-25 Purdue Pharma L.P. 4-Oxadiazolyl-Piperidine Compounds and Use Thereof
SI2079485T1 (en) 2006-11-01 2012-09-28 Purdue Pharma Lp Phenylpropionamide compounds and the use thereof
CA2726763A1 (en) * 2008-06-03 2009-12-10 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
ES2897976T3 (en) 2010-05-31 2022-03-03 Farm Rovi Lab Sa Injectable Biodegradable In Situ Implant Compositions
US10881605B2 (en) 2010-05-31 2021-01-05 Laboratorios Farmaceuticos Rovi, S.A. Methods for the preparation of injectable depot compositions
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
CA2994704A1 (en) 2015-08-03 2017-02-09 Tolmar International Limited Liquid polymer delivery system for extended administration of drugs
PE20210047A1 (en) 2018-06-12 2021-01-08 Farm Rovi Lab Sa INJECTABLE COMPOSITION
US20220040201A1 (en) * 2018-09-25 2022-02-10 Tolmar International, Ltd. Liquid polymer delivery system for extended administration of drugs
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
EP4277702A1 (en) 2021-01-12 2023-11-22 Durect Corporation Sustained release drug delivery systems and related methods
US12318387B2 (en) 2021-07-16 2025-06-03 Laboratorios Farmaceuticos Rovi, S.A. Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition
TW202313047A (en) 2021-09-21 2023-04-01 西班牙商禾霏藥品實驗室有限公司 Antipsychotic injectable depot composition
CA3248062A1 (en) 2022-05-18 2025-07-10 Laboratorios Farm Rovi S A Prolonged-release injectable compositions for use in treatment with risperidone together with cyp2d6 enzyme inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10058554B2 (en) 2005-09-30 2018-08-28 Indivior Uk Limited Sustained release small molecule drug formulation
US11110093B2 (en) 2005-09-30 2021-09-07 Indivior Uk Limited Sustained release small molecule drug formulation
US8133968B2 (en) 2006-06-29 2012-03-13 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US7875697B2 (en) 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US10376590B2 (en) 2007-05-25 2019-08-13 Indivior Uk Limited Sustained delivery formulations of risperidone compound
US10010612B2 (en) 2007-05-25 2018-07-03 Indivior Uk Limited Sustained delivery formulations of risperidone compounds
US11712475B2 (en) 2007-05-25 2023-08-01 Indivior Uk Limited Sustained delivery formulations of risperidone compound
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US10172849B2 (en) 2010-06-08 2019-01-08 Indivior Uk Limited Compositions comprising buprenorphine
US10558394B2 (en) 2010-06-08 2020-02-11 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10592168B1 (en) 2010-06-08 2020-03-17 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10198218B2 (en) 2010-06-08 2019-02-05 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10517864B2 (en) 2014-03-10 2019-12-31 Indivior Uk Limited Sustained-release buprenorphine solutions
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions

Also Published As

Publication number Publication date
WO2002038185A2 (en) 2002-05-16
AU2002226000A1 (en) 2002-05-21

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