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WO2002038031A3 - System and method for determining stimulation parameters for the treatment of epileptic seizures - Google Patents

System and method for determining stimulation parameters for the treatment of epileptic seizures Download PDF

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Publication number
WO2002038031A3
WO2002038031A3 PCT/US2000/041704 US0041704W WO0238031A3 WO 2002038031 A3 WO2002038031 A3 WO 2002038031A3 US 0041704 W US0041704 W US 0041704W WO 0238031 A3 WO0238031 A3 WO 0238031A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
stimulation parameters
epileptic seizures
parameters
stimulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/041704
Other languages
French (fr)
Other versions
WO2002038031A2 (en
Inventor
Robert E Fischell
David R Fischell
Martha J Morrell
Barbara Gibb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuropace Inc
Original Assignee
Neuropace Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuropace Inc filed Critical Neuropace Inc
Priority to PCT/US2000/041704 priority Critical patent/WO2002038031A2/en
Priority to AU2001237911A priority patent/AU2001237911A1/en
Publication of WO2002038031A2 publication Critical patent/WO2002038031A2/en
Anticipated expiration legal-status Critical
Publication of WO2002038031A3 publication Critical patent/WO2002038031A3/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064—Epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Electrotherapy Devices (AREA)

Abstract

A method for selecting electrical stimulation parameters for controlling epileptiform activity in a patient includes implanting brain electrodes (6, 11, 12) in the patient, connecting the brain electrodes to an EEG analysis system (19) including a display workstation (16) and a stimulator (18), and collecting and analyzing EEG signals to determine whether electrical stimulation applied via the stimulator is effective to initiate or terminate epileptiform activity. If not, parameters are adjusted and stimulation, collection, and analysis steps are repeated.
PCT/US2000/041704 2000-10-30 2000-10-30 System and method for determining stimulation parameters for the treatment of epileptic seizures Ceased WO2002038031A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/US2000/041704 WO2002038031A2 (en) 2000-10-30 2000-10-30 System and method for determining stimulation parameters for the treatment of epileptic seizures
AU2001237911A AU2001237911A1 (en) 2000-10-30 2000-10-30 System and method for determining stimulation parameters for the treatment of epileptic seizures

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/041704 WO2002038031A2 (en) 2000-10-30 2000-10-30 System and method for determining stimulation parameters for the treatment of epileptic seizures

Publications (2)

Publication Number Publication Date
WO2002038031A2 WO2002038031A2 (en) 2002-05-16
WO2002038031A3 true WO2002038031A3 (en) 2003-10-23

Family

ID=21742172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041704 Ceased WO2002038031A2 (en) 2000-10-30 2000-10-30 System and method for determining stimulation parameters for the treatment of epileptic seizures

Country Status (2)

Country Link
AU (1) AU2001237911A1 (en)
WO (1) WO2002038031A2 (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6959215B2 (en) 2002-12-09 2005-10-25 Northstar Neuroscience, Inc. Methods for treating essential tremor
US6990377B2 (en) 2003-04-24 2006-01-24 Northstar Neuroscience, Inc. Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation
US7146217B2 (en) 2000-07-13 2006-12-05 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a change in a neural-function of a patient
US7221981B2 (en) 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US7236831B2 (en) 2000-07-13 2007-06-26 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7236830B2 (en) 2002-12-10 2007-06-26 Northstar Neuroscience, Inc. Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders
US7299096B2 (en) 2001-03-08 2007-11-20 Northstar Neuroscience, Inc. System and method for treating Parkinson's Disease and other movement disorders
US7302298B2 (en) 2002-11-27 2007-11-27 Northstar Neuroscience, Inc Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography
US7305268B2 (en) 2000-07-13 2007-12-04 Northstar Neurscience, Inc. Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US7437196B2 (en) 2004-11-12 2008-10-14 Northstar Neuroscience, Inc. Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US7483747B2 (en) 2004-07-15 2009-01-27 Northstar Neuroscience, Inc. Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
US7565199B2 (en) 2002-12-09 2009-07-21 Advanced Neuromodulation Systems, Inc. Methods for treating and/or collecting information regarding neurological disorders, including language disorders
US7577481B2 (en) 2000-07-13 2009-08-18 Advanced Neuromodulation Systems, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7620456B2 (en) 2000-07-13 2009-11-17 Advanced Neuromodulation Systems, Inc. Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures
US8855775B2 (en) 2006-11-14 2014-10-07 Cyberonics, Inc. Systems and methods of reducing artifact in neurological stimulation systems
US8929991B2 (en) 2005-10-19 2015-01-06 Advanced Neuromodulation Systems, Inc. Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits
US9289595B2 (en) 2009-01-09 2016-03-22 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US9445730B2 (en) 2007-03-21 2016-09-20 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject
US11554265B2 (en) 2011-05-13 2023-01-17 Saluda Medical Pty Ltd Method and apparatus for application of a neural stimulus

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7231254B2 (en) 1998-08-05 2007-06-12 Bioneuronics Corporation Closed-loop feedback-driven neuromodulation
US7403820B2 (en) 1998-08-05 2008-07-22 Neurovista Corporation Closed-loop feedback-driven neuromodulation
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US7277758B2 (en) 1998-08-05 2007-10-02 Neurovista Corporation Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US7853329B2 (en) 1998-08-05 2010-12-14 Neurovista Corporation Monitoring efficacy of neural modulation therapy
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US7242984B2 (en) 1998-08-05 2007-07-10 Neurovista Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7324851B1 (en) 1998-08-05 2008-01-29 Neurovista Corporation Closed-loop feedback-driven neuromodulation
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US7676263B2 (en) 2006-06-23 2010-03-09 Neurovista Corporation Minimally invasive system for selecting patient-specific therapy parameters
US9898656B2 (en) 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject
EP2124734A2 (en) 2007-01-25 2009-12-02 NeuroVista Corporation Methods and systems for measuring a subject's susceptibility to a seizure
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US7983757B2 (en) 2007-10-26 2011-07-19 Medtronic, Inc. Medical device configuration based on sensed brain signals
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
US10588524B2 (en) 2011-05-13 2020-03-17 Saluda Medical Pty Ltd Method and apparatus for measurement of neural response
WO2012155187A1 (en) 2011-05-13 2012-11-22 National Ict Australia Ltd Method and apparatus for application of a neural stimulus - i
WO2012155189A1 (en) 2011-05-13 2012-11-22 National Ict Australia Ltd Method and apparatus for estimating neural recruitment - f
AU2012255676B2 (en) 2011-05-13 2017-04-06 Saluda Medical Pty Limited Method and apparatus for controlling a neural stimulus - e
WO2012155185A1 (en) 2011-05-13 2012-11-22 National Ict Australia Ltd Method and apparatus for measurement of neural response
CN103648583B (en) 2011-05-13 2016-01-20 萨鲁达医疗有限公司 For measuring method and the instrument of nerves reaction-A
EP2814565B1 (en) * 2012-02-19 2019-04-03 Medtronic Inc. Brain stimulation response profiling
US8706237B2 (en) 2012-02-19 2014-04-22 Medtronic, Inc. Brain stimulation response profiling
WO2014071446A1 (en) 2012-11-06 2014-05-15 Saluda Medical Pty Ltd Method and system for controlling electrical conditions of tissue ii
EP2908904B1 (en) 2012-11-06 2020-09-23 Saluda Medical Pty Limited System for controlling electrical conditions of tissue
US11172864B2 (en) 2013-11-15 2021-11-16 Closed Loop Medical Pty Ltd Monitoring brain neural potentials
CA2929874C (en) 2013-11-22 2023-06-13 Saluda Medical Pty Ltd Method and device for detecting a neural response in a neural measurement
WO2015143509A1 (en) 2014-03-28 2015-10-01 Saluda Medical Pty Ltd Assessing neural state from action potentials
CA2944042C (en) 2014-05-05 2023-08-29 Saluda Medical Pty Ltd Improved neural measurement
WO2016011512A1 (en) 2014-07-25 2016-01-28 Saluda Medical Pty Ltd Neural stimulation dosing
US11006846B2 (en) 2014-11-17 2021-05-18 Saluda Medical Pty Ltd Method and device for detecting a neural response in neural measurements
US10500399B2 (en) 2014-12-11 2019-12-10 Saluda Medical Pty Ltd Method and device for feedback control of neural stimulation
EP3229890B1 (en) 2014-12-11 2020-05-27 Saluda Medical Pty Limited Implantable electrode positioning
US10918872B2 (en) 2015-01-19 2021-02-16 Saluda Medical Pty Ltd Method and device for neural implant communication
EP3280487B1 (en) 2015-04-09 2021-09-15 Saluda Medical Pty Limited Electrode to nerve distance estimation
EP3302692B1 (en) 2015-05-31 2024-07-24 Closed Loop Medical Pty Ltd Brain neurostimulator electrode fitting
EP3302258A4 (en) 2015-05-31 2018-11-21 Saluda Medical Pty Limited Monitoring brain neural activity
CA2980482C (en) 2015-06-01 2023-09-26 Saluda Medical Pty Ltd Motor fibre neuromodulation
CA3019701A1 (en) 2016-04-05 2017-10-12 Saluda Medical Pty Ltd Improved feedback control of neuromodulation
AU2017280112B2 (en) 2016-06-24 2022-11-17 Saluda Medical Pty Ltd Neural stimulation for reduced artefact
JP2021521985A (en) 2018-04-27 2021-08-30 サルーダ・メディカル・ピーティーワイ・リミテッド Nerve stimulation of mixed nerves
CN111584031B (en) * 2020-04-30 2023-04-07 天津大学 Brain-controlled intelligent limb rehabilitation system based on portable electroencephalogram acquisition equipment and application
GB202214441D0 (en) * 2022-09-30 2022-11-16 Univ Dublin Technological Seizure detection system
CN116251295A (en) * 2023-03-09 2023-06-13 北京工业大学 Focal epileptic electric guidance-nerve electric regulation and control system and method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850161A (en) * 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US5797965A (en) * 1994-08-19 1998-08-25 The United States Of America As Represented By The Secretary Of The Navy Suppression of epileptiform activity
US6016449A (en) * 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6066163A (en) * 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850161A (en) * 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US5797965A (en) * 1994-08-19 1998-08-25 The United States Of America As Represented By The Secretary Of The Navy Suppression of epileptiform activity
US6066163A (en) * 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
US6016449A (en) * 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7146217B2 (en) 2000-07-13 2006-12-05 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a change in a neural-function of a patient
US7236831B2 (en) 2000-07-13 2007-06-26 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7305268B2 (en) 2000-07-13 2007-12-04 Northstar Neurscience, Inc. Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US7620456B2 (en) 2000-07-13 2009-11-17 Advanced Neuromodulation Systems, Inc. Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures
US7577481B2 (en) 2000-07-13 2009-08-18 Advanced Neuromodulation Systems, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7299096B2 (en) 2001-03-08 2007-11-20 Northstar Neuroscience, Inc. System and method for treating Parkinson's Disease and other movement disorders
US7221981B2 (en) 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US9427585B2 (en) 2002-11-01 2016-08-30 Advanced Neuromodulation Systems, Inc. Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of parkinsons disease and or other movement disorders
US7302298B2 (en) 2002-11-27 2007-11-27 Northstar Neuroscience, Inc Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography
US7565199B2 (en) 2002-12-09 2009-07-21 Advanced Neuromodulation Systems, Inc. Methods for treating and/or collecting information regarding neurological disorders, including language disorders
US6959215B2 (en) 2002-12-09 2005-10-25 Northstar Neuroscience, Inc. Methods for treating essential tremor
US7236830B2 (en) 2002-12-10 2007-06-26 Northstar Neuroscience, Inc. Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders
US7353064B2 (en) 2002-12-10 2008-04-01 Northstar Neuroscience, Inc. Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction
US6990377B2 (en) 2003-04-24 2006-01-24 Northstar Neuroscience, Inc. Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation
US7483747B2 (en) 2004-07-15 2009-01-27 Northstar Neuroscience, Inc. Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
US7565200B2 (en) 2004-11-12 2009-07-21 Advanced Neuromodulation Systems, Inc. Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US7437196B2 (en) 2004-11-12 2008-10-14 Northstar Neuroscience, Inc. Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US8929991B2 (en) 2005-10-19 2015-01-06 Advanced Neuromodulation Systems, Inc. Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits
US8855775B2 (en) 2006-11-14 2014-10-07 Cyberonics, Inc. Systems and methods of reducing artifact in neurological stimulation systems
US9445730B2 (en) 2007-03-21 2016-09-20 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject
US9289595B2 (en) 2009-01-09 2016-03-22 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US11554265B2 (en) 2011-05-13 2023-01-17 Saluda Medical Pty Ltd Method and apparatus for application of a neural stimulus

Also Published As

Publication number Publication date
AU2001237911A1 (en) 2002-05-21
WO2002038031A2 (en) 2002-05-16

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