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WO2002036750A3 - Cellules t a reconnaissance specifique des antigenes mineurs d'histocompatibilite et leurs utilisations dans l'elimination des cellules visees - Google Patents

Cellules t a reconnaissance specifique des antigenes mineurs d'histocompatibilite et leurs utilisations dans l'elimination des cellules visees Download PDF

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Publication number
WO2002036750A3
WO2002036750A3 PCT/CA2001/001477 CA0101477W WO0236750A3 WO 2002036750 A3 WO2002036750 A3 WO 2002036750A3 CA 0101477 W CA0101477 W CA 0101477W WO 0236750 A3 WO0236750 A3 WO 0236750A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
target cells
histocompatibility antigen
minor histocompatibility
eliminating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2001/001477
Other languages
English (en)
Other versions
WO2002036750A2 (fr
Inventor
Claude Perreault
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Compatigene Inc
Original Assignee
Compatigene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Compatigene Inc filed Critical Compatigene Inc
Priority to AU2002213694A priority Critical patent/AU2002213694A1/en
Publication of WO2002036750A2 publication Critical patent/WO2002036750A2/fr
Publication of WO2002036750A3 publication Critical patent/WO2002036750A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des cellules T qui reconnaissent spécifiquement les antigènes mineurs d'histocompatibilité, ainsi que des méthodes de sélection de ces cellules T et leurs utilisations pour éliminer les cellules visées, plus particulièrement pour éliminer les cellules cancéreuses hématopoïétiques. L'invention repose sur: 1) l'amorçage de cellules T réagissant spécifiquement contre un antigène mineur d'histocompatibilité (MiHA) immunodominant ubiquiste sélectionné, exprimé par les cellules visées et par les cellules non visées; et 2) la sélection d'une population de cellules T 100 % purifiée qui réagit spécifiquement contre un antigène mineur d'histocompatibilité immunodominant exprimé de façon ubiquiste par les cellules du receveur, ou sélectivement exprimé par des cellules visées spécifiques du receveur uniquement. Le principal avantage de l'invention réside dans le fait que les cellules T utilisées dans l'invention peuvent être transférées d'un donneur à un receveur compatible sans entraîner chez ce dernier une réaction de rejet de greffe (GVHD).
PCT/CA2001/001477 2000-11-02 2001-10-19 Cellules t a reconnaissance specifique des antigenes mineurs d'histocompatibilite et leurs utilisations dans l'elimination des cellules visees Ceased WO2002036750A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213694A AU2002213694A1 (en) 2000-11-02 2001-10-19 T-cells specifically recognizing minor histocompatibility antigen(s) and uses thereof for eliminating target cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70491100A 2000-11-02 2000-11-02
US09/704,911 2000-11-02

Publications (2)

Publication Number Publication Date
WO2002036750A2 WO2002036750A2 (fr) 2002-05-10
WO2002036750A3 true WO2002036750A3 (fr) 2002-12-27

Family

ID=24831346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/001477 Ceased WO2002036750A2 (fr) 2000-11-02 2001-10-19 Cellules t a reconnaissance specifique des antigenes mineurs d'histocompatibilite et leurs utilisations dans l'elimination des cellules visees

Country Status (2)

Country Link
AU (1) AU2002213694A1 (fr)
WO (1) WO2002036750A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148285A1 (en) * 2001-12-20 2003-08-07 Claude Perreault Mammalian SIMP protein, gene sequence and uses thereof in cancer therapy
US10414813B2 (en) 2015-02-09 2019-09-17 Université de Montréal Minor histocompatibility antigens and uses thereof
EP3585800A4 (fr) * 2017-02-22 2021-06-02 The Universite de Montreal Nouveaux antigènes mineurs d'histocompatibilité et leurs utilisations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020519A1 (fr) * 1999-01-15 2000-07-19 Introgene B.V. Antigènes d'histocompatibilité mineurs et leur utilisation pour le diagnostic et le traitement des tumeurs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020519A1 (fr) * 1999-01-15 2000-07-19 Introgene B.V. Antigènes d'histocompatibilité mineurs et leur utilisation pour le diagnostic et le traitement des tumeurs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DIJK VAN A M C ET AL: "SELECTIVE DEPLETION OF MAJOR AND MINO HISTOCOMPATIBILITY ANTIGEN REACTIVE T CELLS: TOWARDS PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE", BRITISH JOURNAL OF HAEMATOLOGY, OXFORD, GB, vol. 1, no. 107, October 1999 (1999-10-01), pages 169 - 175, XP001074673, ISSN: 0007-1048 *
FONTAINE P ET AL: "Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease.", NATURE MEDICINE. UNITED STATES JUL 2001, vol. 7, no. 7, July 2001 (2001-07-01), pages 789 - 794, XP002210314, ISSN: 1078-8956 *
MUTIS TUNA ET AL: "Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompatibility antigens.", BLOOD, vol. 93, no. 7, 1 April 1999 (1999-04-01), pages 2336 - 2341, XP002210313, ISSN: 0006-4971 *
PERREAULT C ET AL: "Immunodominant minor histocompatibility antigens: the major ones", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 19, no. 2, 1 February 1998 (1998-02-01), pages 69 - 74, XP004107029, ISSN: 0167-5699 *

Also Published As

Publication number Publication date
WO2002036750A2 (fr) 2002-05-10
AU2002213694A1 (en) 2002-05-15

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