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WO2002034773A3 - Streptococcal genes - Google Patents

Streptococcal genes Download PDF

Info

Publication number
WO2002034773A3
WO2002034773A3 PCT/GB2001/004749 GB0104749W WO0234773A3 WO 2002034773 A3 WO2002034773 A3 WO 2002034773A3 GB 0104749 W GB0104749 W GB 0104749W WO 0234773 A3 WO0234773 A3 WO 0234773A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
streptococcal genes
vaccines
peptides
streptococcal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/004749
Other languages
French (fr)
Other versions
WO2002034773A2 (en
Inventor
David William Holden
Jeremy Stuart Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ip2ipo Innovations Ltd
Original Assignee
Imperial College Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0026231A external-priority patent/GB0026231D0/en
Priority claimed from GB0028345A external-priority patent/GB0028345D0/en
Priority claimed from GB0102666A external-priority patent/GB0102666D0/en
Priority to EP01976527A priority Critical patent/EP1330473A2/en
Priority to AU2001295795A priority patent/AU2001295795A1/en
Priority to JP2002537762A priority patent/JP4183504B2/en
Application filed by Imperial College Innovations Ltd filed Critical Imperial College Innovations Ltd
Priority to CA002426738A priority patent/CA2426738A1/en
Priority to US10/415,478 priority patent/US20040116661A1/en
Publication of WO2002034773A2 publication Critical patent/WO2002034773A2/en
Publication of WO2002034773A3 publication Critical patent/WO2002034773A3/en
Anticipated expiration legal-status Critical
Priority to US11/941,513 priority patent/US20090280141A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Peptides derived from S. pneumoniae are identified as virulence determinants and may be useful in the preparation of vaccines for the treatment of infection. The peptides may be used as antigens or in the preparation of attenuated microorganisms for use as live oral vaccines.
PCT/GB2001/004749 2000-10-26 2001-10-26 Streptococcal genes Ceased WO2002034773A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/415,478 US20040116661A1 (en) 2000-10-26 2001-10-26 Streptococcal genes
CA002426738A CA2426738A1 (en) 2000-10-26 2001-10-26 Streptococcal genes
EP01976527A EP1330473A2 (en) 2000-10-26 2001-10-26 Streptococcal genes
AU2001295795A AU2001295795A1 (en) 2000-10-26 2001-10-26 Streptococcal genes
JP2002537762A JP4183504B2 (en) 2000-10-26 2001-10-26 Streptococcus gene
US11/941,513 US20090280141A1 (en) 2000-10-26 2007-11-16 Streptococcal Genes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0026231A GB0026231D0 (en) 2000-10-26 2000-10-26 Streptococcal genes
GB0026231.1 2000-10-26
GB0028345.7 2000-11-21
GB0028345A GB0028345D0 (en) 2000-11-21 2000-11-21 Streptococcal genes
GB0102666.5 2001-02-02
GB0102666A GB0102666D0 (en) 2001-02-02 2001-02-02 Streptococcal Genes
US28811801P 2001-05-02 2001-05-02
US60/288,118 2001-05-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/941,513 Continuation US20090280141A1 (en) 2000-10-26 2007-11-16 Streptococcal Genes

Publications (2)

Publication Number Publication Date
WO2002034773A2 WO2002034773A2 (en) 2002-05-02
WO2002034773A3 true WO2002034773A3 (en) 2003-03-13

Family

ID=27447899

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/004749 Ceased WO2002034773A2 (en) 2000-10-26 2001-10-26 Streptococcal genes

Country Status (4)

Country Link
EP (1) EP1330473A2 (en)
AU (1) AU2001295795A1 (en)
CA (1) CA2426738A1 (en)
WO (1) WO2002034773A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0208499D0 (en) * 2002-04-12 2002-05-22 Microscience Ltd Streptococcal genes
EP1670505B1 (en) 2003-09-18 2012-11-14 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Dna promoters and anthrax vaccines
US8729013B2 (en) 2004-08-26 2014-05-20 The University Of Western Ontario Methods of inhibiting staphylobactin-mediated iron uptake in S. aureus
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
ES2546213T3 (en) 2008-03-03 2015-09-21 Novartis Ag Compounds and compositions as modulators of TLR activity
JP5753098B2 (en) * 2009-02-20 2015-07-22 オーストラリアン ポールトリー シーアールシー ピーティーワイ リミテッド Live attenuated vaccine
CN102762226A (en) 2009-06-10 2012-10-31 诺华有限公司 Benzonaphthyridine-containing vaccines
TWI445708B (en) 2009-09-02 2014-07-21 Irm Llc Compounds and compositions as regulators of TLR activity
CN102844047B (en) 2009-09-02 2017-04-05 诺华股份有限公司 Immunogenic composition containing TLR active regulators
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
WO2011084549A1 (en) 2009-12-15 2011-07-14 Novartis Ag Homogeneous suspension of immunopotentiating compounds and uses thereof
EP2549990A1 (en) 2010-03-23 2013-01-30 Irm Llc Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc.
US20150132339A1 (en) 2012-03-07 2015-05-14 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
US9827190B2 (en) 2013-02-01 2017-11-28 Glaxosmithkline Biologicals Sa Intradermal delivery of immunological compositions comprising toll-like receptor 7 agonists
US11098349B2 (en) * 2015-11-04 2021-08-24 The Translational Genomics Research Institute Systems and methods of diagnosing and characterizing infections
BR112020016314A2 (en) 2018-02-12 2020-12-15 Inimmune Corporation PHARMACEUTICALLY ACCEPTABLE COMPOUNDS OR SALTS, PHARMACEUTICAL COMPOSITION, KIT, AND, METHODS FOR ELICITATING, INTENSIFYING OR MODIFYING AN IMMUNOLOGICAL RESPONSE, TO TREAT, PREVENT OR REDUCE THE SUSCETIBILITY TO CANCER, TO REDUCE, UNDERSTAND TREAT, PREVENT OR REDUCE SUSCEPTIBILITY TO AN ALLERGY, TO TREAT, PREVENT OR REDUCE SUSCETIBILITY TO AUTOIMMUNE AFFECTION, TO TREAT, PREVENT OR REDUCE SUSCETIBILITY IN A SUBJECT TO BACTERIAL INFECTION, ALTERNATE, VENEER, NAVAL, NAVARI TREAT, PREVENT OR REDUCE SUSCEPTIBILITY TO AUTOIMMUNITY, ALLERGY, ISCHEMIA OR SEPSIS REPERFUSION, TO TREAT, PREVENT OR REDUCE THE GRAVITY OF EPILETIC ATTACKS AND TO TREAT, PREVENT OR REDUCE THE MACANTIC HERITAGE OF HERITAGE,
KR20230098825A (en) 2020-11-04 2023-07-04 엘리고 바이오사이언스 Seed. Phage-Derived Particles for In Situ Delivery of DNA Payloads to the Acnes Population
GB2600962A (en) * 2020-11-12 2022-05-18 Ucl Business Plc Live attenuated strain of Streptococcus pneumoniae and pharmaceutical compositions comprising a live attenuated strain of S. pneumoniae

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434065A (en) * 1993-05-06 1995-07-18 President And Fellows Of Harvard College In vivo selection of microbial virulence genes
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses
WO1998018930A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
WO1998023631A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Corporation Novel bacterial polypeptides and polynucleotides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434065A (en) * 1993-05-06 1995-07-18 President And Fellows Of Harvard College In vivo selection of microbial virulence genes
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses
WO1998018930A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
WO1998023631A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Corporation Novel bacterial polypeptides and polynucleotides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BROWN J S ET AL: "A STREPTOCOCCUS PNEUMONIAE PATHOGENICITY ISLAND ENCODING AN ABC TRANSPORTER INVOLVED IN IRON UPTAKE AND VIRULENCE", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENTIFIC, OXFORD, GB, VOL. 40, NR. 3, PAGE(S) 572-585, ISSN: 0950-382X, XP001057233 *
DATABASE EMBL 17 October 1998 (1998-10-17), XP002191216 *
DATABASE EMBL 3 February 1992 (1992-02-03), XP002191215 *
DATABASE EMBL 31 July 2001 (2001-07-31), XP002191217 *
DATABASE EMBL XP002198687 *
FONTAN P A ET AL: "B-437. A CHOLINE TRANSPORTER AS A VIRULENCE DETERMINANT OF STREPTOCOCCUS PNEUMONIAE", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, VOL. 97, NR. 97, PAGE(S) 103, ISSN: 0067-2777, XP000892162 *
SPELLERBERG B ET AL: "PYRUVATE OXIDASE, AS A DETERMINANT OF VIRULENCE IN STREPTOCOCCUS PNEUMONIAE", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENTIFIC, OXFORD, GB, VOL. 19, NR. 4, PAGE(S) 803-813, ISSN: 0950-382X, XP002070537 *

Also Published As

Publication number Publication date
CA2426738A1 (en) 2002-05-02
AU2001295795A1 (en) 2002-05-06
WO2002034773A2 (en) 2002-05-02
EP1330473A2 (en) 2003-07-30

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