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WO2002033060A3 - Nucleic acid sequences to proteins involved in tocopherol synthesis - Google Patents

Nucleic acid sequences to proteins involved in tocopherol synthesis Download PDF

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Publication number
WO2002033060A3
WO2002033060A3 PCT/US2001/042673 US0142673W WO0233060A3 WO 2002033060 A3 WO2002033060 A3 WO 2002033060A3 US 0142673 W US0142673 W US 0142673W WO 0233060 A3 WO0233060 A3 WO 0233060A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid sequences
tocopherol
proteins involved
tocopherol synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/042673
Other languages
French (fr)
Other versions
WO2002033060A2 (en
Inventor
Michael W Lassner
Beth Savidge
James D Weiss
Timothy A Mitsky
Martha Ann Post-Beittenmiller
Henry E Valentin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Calgene LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calgene LLC filed Critical Calgene LLC
Priority to BR0114847-8A priority Critical patent/BR0114847A/en
Priority to EP01981862A priority patent/EP1360309A2/en
Priority to AU2002213478A priority patent/AU2002213478A1/en
Publication of WO2002033060A2 publication Critical patent/WO2002033060A2/en
Anticipated expiration legal-status Critical
Publication of WO2002033060A3 publication Critical patent/WO2002033060A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
PCT/US2001/042673 2000-10-14 2001-10-12 Nucleic acid sequences to proteins involved in tocopherol synthesis Ceased WO2002033060A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BR0114847-8A BR0114847A (en) 2000-10-14 2001-10-12 Nucleic acid sequences for proteins involved in tocopherol synthesis
EP01981862A EP1360309A2 (en) 2000-10-14 2001-10-12 Nucleic acid sequences to proteins involved in tocopherol synthesis
AU2002213478A AU2002213478A1 (en) 2000-10-14 2001-10-12 Nucleic acid sequences to proteins involved in tocopherol synthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68807100A 2000-10-14 2000-10-14
US09/688,071 2000-10-14

Publications (2)

Publication Number Publication Date
WO2002033060A2 WO2002033060A2 (en) 2002-04-25
WO2002033060A3 true WO2002033060A3 (en) 2003-08-14

Family

ID=24762997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042673 Ceased WO2002033060A2 (en) 2000-10-14 2001-10-12 Nucleic acid sequences to proteins involved in tocopherol synthesis

Country Status (4)

Country Link
EP (1) EP1360309A2 (en)
AU (1) AU2002213478A1 (en)
BR (1) BR0114847A (en)
WO (1) WO2002033060A2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
US7067647B2 (en) 1999-04-15 2006-06-27 Calgene Llc Nucleic acid sequences to proteins involved in isoprenoid synthesis
US7112717B2 (en) 2002-03-19 2006-09-26 Monsanto Technology Llc Homogentisate prenyl transferase gene (HPT2) from arabidopsis and uses thereof
US7230165B2 (en) 2002-08-05 2007-06-12 Monsanto Technology Llc Tocopherol biosynthesis related genes and uses thereof
US7238855B2 (en) 2001-05-09 2007-07-03 Monsanto Technology Llc TyrA genes and uses thereof
US7244877B2 (en) 2001-08-17 2007-07-17 Monsanto Technology Llc Methyltransferase from cotton and uses thereof
US7262339B2 (en) 2001-10-25 2007-08-28 Monsanto Technology Llc Tocopherol methyltransferase tMT2 and uses thereof
US7405343B2 (en) 2000-08-07 2008-07-29 Monsanto Technology Llc Methyl-D-erythritol phosphate pathway genes
US11274320B2 (en) 2019-02-25 2022-03-15 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642434B1 (en) 1997-07-25 2003-11-04 University Of Community College System Of Nevada Transgenic plants with γ-tocopherol methyltransferase
EP1177303A1 (en) 1999-05-07 2002-02-06 Pioneer Hi-Bred International, Inc. Phytyl/prenyltransferase nucleic acids, polypeptides and uses thereof
US6977269B1 (en) 2001-05-03 2005-12-20 Pioneer Hi-Bred International, Inc Method of improving animal tissue quality
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
DE10231587A1 (en) * 2002-07-11 2004-01-29 Sungene Gmbh & Co. Kgaa Transgenic expression constructs and methods for increasing the vitamin E content in plant organisms
DE10232483A1 (en) * 2002-07-17 2004-02-05 Sungene Gmbh & Co. Kgaa Transgenic expression constructs and methods for increasing the vitamin E content in plant organisms
CA2598792A1 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
EP1874934B1 (en) 2005-04-19 2013-11-27 University of Kentucky Research Foundation Transformed plants accumulating terpenes
AU2021249316A1 (en) * 2020-04-03 2022-11-03 Bondi Bio Pty Ltd Methods for transforming cyanobacteria
CN116135971B (en) * 2023-03-30 2025-03-14 同路生物制药有限公司 Human giant cell method for culturing virus

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019460A1 (en) * 1997-10-16 1999-04-22 Washington State University Research Foundation Geranyl diphosphate synthase from mint (mentha piperita)
WO2000028005A1 (en) * 1998-11-05 2000-05-18 Washington State University Research Foundation Nucleic acids encoding taxus geranylgeranyl diphosphate synthase, and methods of use
WO2000063391A2 (en) * 1999-04-15 2000-10-26 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
WO2000068393A1 (en) * 1999-05-07 2000-11-16 Pioneer Hi-Bred International, Inc. Phytyl/prenyltransferase nucleic acids, polypeptides and uses thereof
WO2001079472A2 (en) * 2000-04-14 2001-10-25 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019460A1 (en) * 1997-10-16 1999-04-22 Washington State University Research Foundation Geranyl diphosphate synthase from mint (mentha piperita)
WO2000028005A1 (en) * 1998-11-05 2000-05-18 Washington State University Research Foundation Nucleic acids encoding taxus geranylgeranyl diphosphate synthase, and methods of use
WO2000063391A2 (en) * 1999-04-15 2000-10-26 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
WO2000068393A1 (en) * 1999-05-07 2000-11-16 Pioneer Hi-Bred International, Inc. Phytyl/prenyltransferase nucleic acids, polypeptides and uses thereof
WO2001079472A2 (en) * 2000-04-14 2001-10-25 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CUNILLERA N ET AL: "Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis.", FEBS LETTERS. NETHERLANDS 21 JUL 2000, vol. 477, no. 3, 21 July 2000 (2000-07-21), pages 170 - 174, XP002223080, ISSN: 0014-5793 *
OH S K ET AL: "Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 16 JUN 2000, vol. 275, no. 24, 16 June 2000 (2000-06-16), pages 18482 - 18488, XP002223079, ISSN: 0021-9258 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7335815B2 (en) 1999-04-15 2008-02-26 Calgene Llc Nucleic acid sequences to proteins involved in isoprenoid synthesis
US7067647B2 (en) 1999-04-15 2006-06-27 Calgene Llc Nucleic acid sequences to proteins involved in isoprenoid synthesis
US7141718B2 (en) 1999-04-15 2006-11-28 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
US7265207B2 (en) 1999-04-15 2007-09-04 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
US7405343B2 (en) 2000-08-07 2008-07-29 Monsanto Technology Llc Methyl-D-erythritol phosphate pathway genes
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
US7238855B2 (en) 2001-05-09 2007-07-03 Monsanto Technology Llc TyrA genes and uses thereof
US7595382B2 (en) 2001-08-17 2009-09-29 Monsanto Technology Llc Gamma tocopherol methyltransferase coding sequences from Brassica and uses thereof
US7244877B2 (en) 2001-08-17 2007-07-17 Monsanto Technology Llc Methyltransferase from cotton and uses thereof
US7553952B2 (en) 2001-08-17 2009-06-30 Monsanto Technology Llc Gamma tocopherol methyltransferase coding sequence identified in Cuphea and uses thereof
US7262339B2 (en) 2001-10-25 2007-08-28 Monsanto Technology Llc Tocopherol methyltransferase tMT2 and uses thereof
US7112717B2 (en) 2002-03-19 2006-09-26 Monsanto Technology Llc Homogentisate prenyl transferase gene (HPT2) from arabidopsis and uses thereof
US7230165B2 (en) 2002-08-05 2007-06-12 Monsanto Technology Llc Tocopherol biosynthesis related genes and uses thereof
US11274320B2 (en) 2019-02-25 2022-03-15 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors

Also Published As

Publication number Publication date
BR0114847A (en) 2005-01-11
WO2002033060A2 (en) 2002-04-25
AU2002213478A1 (en) 2002-04-29
EP1360309A2 (en) 2003-11-12

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