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WO2002032346A1 - Filet chirurgical enrobe - Google Patents

Filet chirurgical enrobe Download PDF

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Publication number
WO2002032346A1
WO2002032346A1 PCT/US2000/028497 US0028497W WO0232346A1 WO 2002032346 A1 WO2002032346 A1 WO 2002032346A1 US 0028497 W US0028497 W US 0028497W WO 0232346 A1 WO0232346 A1 WO 0232346A1
Authority
WO
WIPO (PCT)
Prior art keywords
surgical
glucan
surgical mesh
mesh
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/028497
Other languages
English (en)
Inventor
Barbara Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brennen Medical Inc
Original Assignee
Brennen Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brennen Medical Inc filed Critical Brennen Medical Inc
Priority to PCT/US2000/028497 priority Critical patent/WO2002032346A1/fr
Priority to AU2001212050A priority patent/AU2001212050A1/en
Priority to EP00973550A priority patent/EP2341866A4/fr
Priority to JP2002535585A priority patent/JP2004524059A/ja
Publication of WO2002032346A1 publication Critical patent/WO2002032346A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes

Definitions

  • the present invention is drawn to a surgical mesh coating which facilitates the incorporation of a surgical mesh into a surgical site.
  • Surgical meshes typically take the form of porous, gauze-like sheets of material.
  • Common uses of surgical meshes include the repair of herniations and use as a structural member in gynecological surgeries.
  • Surgical meshes are porous, gauze-like sheet materials which may be woven or spun from a variety of organic and synthetic materials.
  • the materials from which surgical meshes are made must be biocompatible, chemically and physically inert, non-carcinogenic, mechanically strong, and easily fabricated and sterilized.
  • Most synthetic surgical meshes are woven from monofilament or multifilament fibers to form a mesh having pores of varying sizes and geometries.
  • Other synthetic surgical meshes are formed in a node and fibril arrangement in which the mesh is comprised of larger sections or nodes which are interconnected by fibrils of the mesh material.
  • Table 1 A non-exhaustive list of common surgical meshes is given in Table 1 below.
  • Organic surgical meshes are typically derived from human or animal sources.
  • Homologous surgical meshes may be derived from the tissues of a donor, from animal tissues, or from cadaveric tissues.
  • Autologous surgical meshes are meshes that are derived from a patient's own body, and may comprise dermographs, fascia tissues, and dura mater.
  • Surgical meshes are also used in gynecological procedures including abdominal sacrocolopopexy and as suburethral slings. Other procedures which require surgical meshes include laparosopic retropubic urethropexy, intraperitoneal placement for adhesion prevention, the repair of pelvic floor hernias, rectoceles, and cystoceles. It is to be understood that the aforementioned surgical procedures do not comprise a complete list of all uses of organic and synthetic surgical meshes. New and varied uses for surgical meshes are being discovered on an ongoing basis and the present invention is to be construed to be applicable to all present and future uses of surgical meshes.
  • a surgical mesh become incorporated into the tissues surrounding a surgical site.
  • One example of such a surgical procedure is the reinforcement of a herniation.
  • a surgical mesh of appropriate size and shape is placed over the newly repaired hernia and secured in place using sutures, staples, surgical adhesives, or any other suitable connecting means.
  • sutures, staples, surgical adhesives, or any other suitable connecting means As the tissues surrounding the surgical site heal, granulation tissues growing at and around the surgical site begin to produce an extracellular matrix which, in a process called fibrosis, infiltrates and attaches to the material of the surgical mesh secured over the surgical site. Incorporation of the surgical mesh into the surgical site by the extracellular matrix strengthens the tissues at the surgical site and helps prevent re-injury.
  • the rate of recovery of a patient who has undergone a surgery utilizing a surgical mesh is strongly related to the rate at which the surgical mesh is incorporated into the tissues surrounding the surgical site.
  • the rate of incorporation of the surgical mesh as well as the potential for infection and the potential for clinical complications is in turn related to the physical properties of the surgical mesh used.
  • synthetic meshes having pores or interstices of less than 10 ⁇ m in size may theoretically promote infection in that small bacteria (less than 1 ⁇ m in size) may enter the surgical site through the mesh, while important and larger macrophages and polymorphonuclear leukocytes are prevented from passing through the mesh to the surgical site.
  • the number, size, and shape of the pores play an important role in tissue bonding to the surgical mesh.
  • an object of the present invention to provide a coating for a surgical mesh that promotes the rapid incorporation of the surgical mesh into the tissues surrounding the surgical site to which the mesh has been grafted. Another object of the present invention is to stimulate the immune system to prevent surgical site infections. Yet another object of the present invention is permit the use of synthetic surgical meshes that are more difficult to incorporate into the tissue surrounding a surgical site.
  • the present invention essentially comprises a biocompatible surgical mesh having applied thereto a ⁇ -D-glucan composition.
  • the ⁇ -D-glucan composition is a cereal derived ⁇ -D-glucan made from one of oats, barley, or wheat, however other sources of ⁇ -D-glucan are also contemplated. Examples of other suitable sources of ⁇ -D-glucan include microbial sources such as yeast, bacteria, and fungus.
  • the biocompatible surgical mesh is typically used for reinforcing a surgical site and may be synthetic or organic in origin.
  • Synthetic surgical meshes are commonly made from polypropylene, polytetrafluoroethylene, expanded polytetrafluoroethylene, polyethylene terephthalate, polyglycolic acid, polyglactin, dacron-polythene reinforced silicone and polyethylene among others.
  • Organic surgical meshes may be derived from human sources, animal sources, and cadaveric sources.
  • One method of applying an imunostimulating agent such as ⁇ -D-glucan to a biocompatible surgical mesh comprises the steps of preparing an aqueous solution of a cereal derived ⁇ -D-glucan , immersing a pre-selected surgical mesh in the aqueous solution of ⁇ -D-glucan , and evaporating the water component of the aqueous solution.
  • an imunostimulating agent such as ⁇ -D-glucan
  • the sheets are formed by preparing an aqueous solution comprising a cereal derived ⁇ -D-glucan and placing the aqueous solution in a drying tray to evaporate the water component of the solution, the residue is in the form of a ⁇ -D-glucan sheet. Sheets of ⁇ -D- glucan so formed are then applied to the surgical mesh by means of a suitable adhesive or by wetting the surgical mesh to partially dissolve the sheet of ⁇ -D-glucan
  • Figure 1 is an electron micrograph of a portion of an uncoated polypropylene surgical mesh that was implanted in a test animal for a duration of five days;
  • Figure 2 is an electron micrograph of a portion of a ⁇ -D-glucan coated polypropylene surgical mesh that was implanted in a test animal for a duration of five days;
  • Figure 3 is a drawing of a generalized chemical structure of a microbe-derived (1-3) ⁇ -D-glucan that may be used in the surgical mesh coating of the present invention
  • Figure 4 is a drawing of a generalized chemical structure of a microbe-derived (1-3)(1 -6) ⁇ -D-glucan that may be used in the surgical mesh coating of the present invention.
  • Figure 5 is a drawing of the generalized chemical structure of mixed-linkage cereal-derived (1 -3)(1 -4) ⁇ -D-glucan that may be used in the surgical mesh coating of the present invention.
  • a surgical mesh constructed and arranged according to the present invention comprises a pre-selected surgical mesh material, either organic or synthetic, which has applied thereto a ⁇ -D-glucan composition.
  • a ⁇ -D-glucan composition As used herein, the term “applied” is intended to embrace both coating and/or impregnating. Based on animal studies, it is anticipated that the addition of the ⁇ -D-glucan coating of the present invention will significantly reduce the recovery time of a patient.
  • B-D-glucan s may be derived from a number of different materials but in general, ⁇ -D-glucan s are derived from cereal sources such as oats, barley and wheat or microbial sources such as bacteria, yeast, and fungi.
  • B-D-glucan s and especially cereal derived ⁇ -D-glucan s, induce rapid differentiation of human monocytes into macrophages, the primary cell type associated with both wound healing and immunostimulation. While any ⁇ -D-glucan may be used to coat a surgical mesh in accordance with the present invention, it is preferred to utilize cereal derived ⁇ -D-glucan s to coat a chosen surgical mesh.
  • the stimulating effect of the ⁇ -D-glucan compound helps to prevent or to fight infection at the surgical site and will promote the rapid incorporation of the surgical mesh into the tissues at the surgical site.
  • surgical meshes to which tissues do not easily adhere such as polytetrafluoroethylene (PTFE) and expanded polytetrafluoroethylene (ePTFE) may, through the increased stimulation of fibrosis made possible by the use of a ⁇ -D-glucan coating, be more successfully used in situations requiring the surgical mesh to become incorporated into the tissues surrounding the surgical site.
  • PTFE polytetrafluoroethylene
  • ePTFE expanded polytetrafluoroethylene
  • ⁇ -D-glucan composition to a surgical mesh will also allow the use of more flexible surgical meshes which might not otherwise be conducive to tissue incorporation or adhesion in place of more rigid surgical meshes which are more prone to causing clinical complications.
  • B-D-glucan coatings may also be applied to organic surgical meshes derived from autologous and homologous sources.
  • a ⁇ -D-glucan coating will provide a smooth lubricated surface on a surgical mesh which will facilitate the surgical placement of the mesh.
  • Beta-glucans are found in essentially all living cells which are enclosed by cell walls, with considerable structural variation dependent on source. They are highly unbranched homopolysaccharides and isomehcally diaposed to ⁇ -D-glucan (e.g. starch) which is typically non-functional as a structural support component of the cell.
  • glucans derived from microbes have been generally characterized as essentially comprising (1-3) - linked chains of glucopyranosyl units.
  • yeast-derived glucans having primarily (1 -3)-linkages with a relatively small number of (1-6)-linkages ( Figure 4) have been identified.
  • Yeast-derived glucan polymers are often associated with mannose, and typically have a helically coiled chain shape.
  • CDG Cereal-derived glucan
  • CDG is a long chain, unbranched polysaccharide which typically comprises about 3-4 percent of oat and barley grains.
  • the CDG concentration is greater, e.g. 7-10 percent, in the milled bran fraction of oats.
  • CDG is found in the endosperm and aleurone cell walls of most cereal grains.
  • the microbe-derived glucans occur in the cell wall of the yeast or bacteria.
  • CDG is a mixed-linkage molecule containing about 70 percent (1 -4)- linkages and about 30 percent (1 -3)-linkages.
  • the (1 -3)-linked units mostly occur singly whereas the (1 -4)-linked units typically occur in groups of three or four glucopyranosyl units.
  • the resultant structure is a series of short runs of 3 or 4 (1 -4)-linked glucopyranosyl units, adjacent runs connected by (1 -3) linkages.
  • the frequencies of the groups of three (cellotriosyl) and four (cellotetraosyl) glucopyranosyl units also tend to be characteristic of the source, being affected by cereal variety, tissue age, and stage of maturity.
  • Oat-derived CDG typically has more of the groups of three consecutive (1 -4)-linked glucopyranosyl units than does barley- derived CDG.
  • the ratio of trisaccharide to tetrasaccharide groups is about 2:1 for oats and closer to 3:1 for barley.
  • CDG differs from microbe-derived glucans, which have all (1 -3)-linkages or mostly (1 -3)-linkages with some
  • CDG is a linear molecule, while yeast-derived glucan forms a helical shape.
  • the degree of polymerization of CDG is in the range of about 1200-1800.
  • yeast-derived ⁇ -D-glucan has a much lower degree of polymerization, i e about 60-80 Cellulose, the primary constituent of plant cell walls, has all ⁇ (1 -4) linkages and a degree of polymerization of about 10,000 to 15,000
  • yeast- derived glucan forms viscous solutions in warm water
  • yeast- derived glucan is insoluble in water but dispersible in aqueous systems
  • g CDG occurs within the grain with a fairly broad range of MW, i e about 200,000 to 700,000
  • the molecular weight is believed to be dependent upon the grain species, grain source, glucan extraction conditions and particular laboratory Microbe-derived glucan has a much lower molecular weight, in the range of about 10,000 to 14,000 Cellulose has a molecular weight of about 700,000
  • CDG as a food component has been studied extensively by various researchers, studies have included the use of CDG in regulation of glucose metabolism, hypoglycemic response, reduction in serum cholesterol, and the like
  • CDG is much more like cellulose than are the microbial-de ⁇ ved glucans CDG, especially that derived from oats and barley, induces rapid differentiation of human monocytes into macrophages, the primary cell type associated with both wound healing and immunostimulation
  • a ⁇ -D-glucan coating is applied to a surgical mesh by being sprayed onto the surgical mesh Alternatively, a surgical mesh may be immersed in the beta glucan composition which is later dried
  • Other methods for applying a ⁇ -D- glucan coating to a surgical mesh include painting the beta glucan onto a surgical mesh using a brush or rollers or bonding a preformed sheet or film of ⁇ -D-glucan to a surgical mesh.
  • an aqueous solution of ⁇ -D- glucan is prepared and placed in a drying tray.
  • B-D-glucan will, upon evaporation of the water of the aqueous solution, form a pliable sheet or film which may be glued to a pre-selected surgical mesh using a suitable adhesive.
  • the ⁇ -D-glucan sheet or film may be adhered to a pre-selected surgical mesh by first wetting the mesh and then applying the ⁇ -D-glucan film to the prepared mesh.
  • a ⁇ -D-glucan coating may be applied to a surgical mesh in any manner and is not limited to the examples set forth herein.
  • a suitable polypropylene surgical mesh was obtained from Cousins Biotech, SAS, France (BIOMESH® W1 ).
  • the selected surgical mesh had characteristics including a weight of 50g/m2 and a thickness of 0.30 mm.
  • a 0.5 weight percent ⁇ -D-glucan (oat derived) aqueous solution was prepared.
  • Two 10 cm x 30 cm BIOMESH® W1 surgical meshes were placed in a 10 inch x 15 inch drying tray in a laminar flow hood.
  • 250g of a ⁇ -D-glucan aqueous solution was poured into the trays with the prepared surgical meshes.
  • Each of the surgical meshes were completely immersed in the ⁇ -D-glucan solution.
  • the surgical meshes were then allowed to dry at 20-25°C over a period of 48 hours.
  • the now- coated surgical meshes were then packaged, sealed, and sterilized using commonly known procedures.
  • the coated and uncoated surgical meshes were removed from their intramuscular implantation sites. Macroscopic observations of the respective surgical meshes showed dramatic differences between the two biopsies.
  • the uncoated surgical mesh was relatively clear of ingrown fibrous tissues and was very easily removed from the surrounding tissue by simply pulling on the surgical mesh.
  • the ⁇ -D-glucan coated surgical mesh was difficult to distinguish from the surrounding tissue at the biopsy site and was difficult to remove.
  • the ⁇ -D-glucan coated surgical mesh showed substantial integration of the surrounding tissue whereas the uncoated mesh was still relatively unincorporated.
  • Figure 1 is an electron micrograph of a portion of the uncoated surgical mesh after being implanted for a duration of five days. The magnification of Figure 1 is approximately 250X. As can be seen in Figure 1 , incorporation of the uncoated surgical mesh by an extracellular matrix has only begun. The fibers of the uncoated polypropylene surgical mesh are clearly visible. Referring next to Figure 2 which is an electron micrograph of a portion of the ⁇ -D-glucan coated polypropylene surgical mesh after a duration of five days, it can be seen that considerable colonization by fibrous tissue has taken place within the coated surgical mesh. In Figure 2, the coated surgical mesh itself is not clearly visible and is extensively covered by a new extracellular matrix.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne des filets chirurgicaux sur lesquels on applique un agent immunostimulateur pour favoriser l'intégration rapide du filet chirurgical dans les tissus au niveau du champ opératoire.
PCT/US2000/028497 2000-10-13 2000-10-13 Filet chirurgical enrobe Ceased WO2002032346A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PCT/US2000/028497 WO2002032346A1 (fr) 2000-10-13 2000-10-13 Filet chirurgical enrobe
AU2001212050A AU2001212050A1 (en) 2000-10-13 2000-10-13 Coated surgical mesh
EP00973550A EP2341866A4 (fr) 2000-10-13 2000-10-13 Filet chirurgical enrobe
JP2002535585A JP2004524059A (ja) 2000-10-13 2000-10-13 被覆された外科手術用メッシュ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028497 WO2002032346A1 (fr) 2000-10-13 2000-10-13 Filet chirurgical enrobe

Publications (1)

Publication Number Publication Date
WO2002032346A1 true WO2002032346A1 (fr) 2002-04-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028497 Ceased WO2002032346A1 (fr) 2000-10-13 2000-10-13 Filet chirurgical enrobe

Country Status (4)

Country Link
EP (1) EP2341866A4 (fr)
JP (1) JP2004524059A (fr)
AU (1) AU2001212050A1 (fr)
WO (1) WO2002032346A1 (fr)

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EP1377245A4 (fr) * 2001-03-21 2006-08-02 Brennen Medical Inc Revetement immunostimulant destine a des dispositifs chirurgicaux
US7494495B2 (en) 2003-03-28 2009-02-24 Coloplast A/S Method and implant for curing cystocele
US7588598B2 (en) 2003-03-28 2009-09-15 Coloplast A/S Implant for treating rectocele and a device for putting said implant into place
US7621864B2 (en) 2000-07-05 2009-11-24 Coloplast A/S Method for treating urinary incontinence in women and implantable device intended to correct urinary incontinence
US7758615B2 (en) 2004-06-15 2010-07-20 Colopast A/S Parietal hook
US8007430B2 (en) * 2000-10-12 2011-08-30 Coloplast A/S Apparatus and method for treating female urinary incontinence
US8128554B2 (en) 2000-10-12 2012-03-06 Coloplast A/S System for introducing a pelvic implant
US8215310B2 (en) 2004-05-21 2012-07-10 Coloplast A/S Implant for treatment of vaginal and/or uterine prolapse
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8668635B2 (en) 2000-10-12 2014-03-11 Coloplast A/S Pelvic implant with suspending system
US8709471B2 (en) 2003-03-27 2014-04-29 Coloplast A/S Medicament delivery device and a method of medicament delivery
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US8920304B2 (en) 2000-07-05 2014-12-30 Coloplast A/S Method and device for treating urinary incontinence
US9005222B2 (en) 2002-08-02 2015-04-14 Coloplast A/S Self-anchoring sling and introducer system
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
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US12004937B1 (en) 2023-01-13 2024-06-11 Sheridan Technologies Llc Blunt dissector, delivery and deployment device for delivery and deployment of surgical mesh during soft tissue repairs

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US7621864B2 (en) 2000-07-05 2009-11-24 Coloplast A/S Method for treating urinary incontinence in women and implantable device intended to correct urinary incontinence
US10278800B2 (en) 2000-07-05 2019-05-07 Coloplast A/S Method and device for treating urinary incontinence
US8920304B2 (en) 2000-07-05 2014-12-30 Coloplast A/S Method and device for treating urinary incontinence
US8932202B2 (en) 2000-10-12 2015-01-13 Coloplast A/S Incontinence implant with soft tissue anchors and length not allowing abdominal wall penetration
US8574148B2 (en) 2000-10-12 2013-11-05 Coloplast A/S System for introducing soft tissue anchors
US8007430B2 (en) * 2000-10-12 2011-08-30 Coloplast A/S Apparatus and method for treating female urinary incontinence
US8118727B2 (en) 2000-10-12 2012-02-21 Coloplast A/S Method for supporting pelvic anatomy
US8118728B2 (en) 2000-10-12 2012-02-21 Coloplast A/S Method for implanting an adjustable surgical implant for treating urinary incontinence
US8123673B2 (en) 2000-10-12 2012-02-28 Coloplast A/S Adjustable surgical implant for treating urinary incontinence
US8128554B2 (en) 2000-10-12 2012-03-06 Coloplast A/S System for introducing a pelvic implant
US8162818B2 (en) 2000-10-12 2012-04-24 Coloplast A/S Adjustable surgical implant for pelvic anatomy
US8182412B2 (en) 2000-10-12 2012-05-22 Coloplast A/S Pelvic implant with fibrous anchor
US8182413B2 (en) 2000-10-12 2012-05-22 Coloplast A/S Method for fibrous anchoring of a pelvic support
US10449025B2 (en) 2000-10-12 2019-10-22 Coloplast A/S Surgical device implantable to treat female urinary incontinence
US8273011B2 (en) 2000-10-12 2012-09-25 Coloplast A/S Adjustable surgical implant and method for treating urinary incontinence
US10076394B2 (en) 2000-10-12 2018-09-18 Coloplast A/S Method of treating urinary incontinence
US8449450B2 (en) 2000-10-12 2013-05-28 Coloplast A/S Pass through introducer and sling
US8454492B2 (en) 2000-10-12 2013-06-04 Coloplast A/S Absorbable anchor and method for mounting mesh to tissue
US8469877B2 (en) 2000-10-12 2013-06-25 Coloplast A/S System for introducing a pelvic implant
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EP2341866A4 (fr) 2011-12-07
AU2001212050A1 (en) 2002-04-29
EP2341866A1 (fr) 2011-07-13
JP2004524059A (ja) 2004-08-12

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