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WO2002031132A3 - 8843, a human dual specificity phosphatase family member and uses therefor - Google Patents

8843, a human dual specificity phosphatase family member and uses therefor Download PDF

Info

Publication number
WO2002031132A3
WO2002031132A3 PCT/US2001/031661 US0131661W WO0231132A3 WO 2002031132 A3 WO2002031132 A3 WO 2002031132A3 US 0131661 W US0131661 W US 0131661W WO 0231132 A3 WO0231132 A3 WO 0231132A3
Authority
WO
WIPO (PCT)
Prior art keywords
dual specificity
specificity phosphatase
family member
uses therefor
phosphatase family
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/031661
Other languages
French (fr)
Other versions
WO2002031132A2 (en
Inventor
Nadine Weich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU2002211597A priority Critical patent/AU2002211597A1/en
Priority to EP01979662A priority patent/EP1402010A2/en
Publication of WO2002031132A2 publication Critical patent/WO2002031132A2/en
Publication of WO2002031132A3 publication Critical patent/WO2002031132A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 8843 nucleic acid molecules, which encode novel dual specificity phosphatase members. The invention also provides methods of modulating the differentiation and proliferation of erythroid progenitors, and CD34 positive cells. The invention further provides methods of treating, preventing and diagnosing eythroid-associated disorders such as anemias, leukemias, and erythrocytosis.
PCT/US2001/031661 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor Ceased WO2002031132A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002211597A AU2002211597A1 (en) 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor
EP01979662A EP1402010A2 (en) 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68667300A 2000-10-11 2000-10-11
US09/686,673 2000-10-11

Publications (2)

Publication Number Publication Date
WO2002031132A2 WO2002031132A2 (en) 2002-04-18
WO2002031132A3 true WO2002031132A3 (en) 2003-03-13

Family

ID=24757266

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031661 Ceased WO2002031132A2 (en) 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor

Country Status (3)

Country Link
EP (1) EP1402010A2 (en)
AU (1) AU2002211597A1 (en)
WO (1) WO2002031132A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015658A2 (en) * 1997-09-23 1999-04-01 Incyte Pharmaceuticals, Inc. Human regulatory molecules
WO2000018890A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Protein phosphatase molecules and uses therefor
WO2001055163A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001092491A2 (en) * 2000-05-30 2001-12-06 Sugen, Inc. Mammalian protein phosphatases identified by in-silico analysis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015658A2 (en) * 1997-09-23 1999-04-01 Incyte Pharmaceuticals, Inc. Human regulatory molecules
WO2000018890A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Protein phosphatase molecules and uses therefor
WO2001055163A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001055301A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001092491A2 (en) * 2000-05-30 2001-12-06 Sugen, Inc. Mammalian protein phosphatases identified by in-silico analysis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GSP [online] 17 December 2001 (2001-12-17), ROSEN CA ET AL: "Novel human enzyme polypeptide #606", XP002222369, retrieved from EBI Database accession no. AAU23520 *
DATABASE GSP [online] 4 December 2001 (2001-12-04), ROSEN CA ET AL: "Novel human neoplastic disease associated polypeptide #141", XP002222370, retrieved from EBI Database accession no. AAU21708 *
DATABASE GSP [online] 4 December 2001 (2001-12-04), ROSEN CA ET AL: "Novel human neoplastic disease associated polypeptide #258.", XP002222371, retrieved from EBI Database accession no. AAU21825 *
FAUMAN E B ET AL: "Structure and function of the protein tyrosine phosphatases", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 21, no. 11, 1 November 1996 (1996-11-01), pages 413 - 417, XP004071016, ISSN: 0968-0004 *
MARTELL K J ET AL: "THE VH1-LIKE DUAL-SPECIFICITY PROTEIN TYROSINE PHOSPHATASES", MOLECULAR AND CELLS, KOREAN SOCIETY FOR MOLECULAR SOCIETY, KR, vol. 8, no. 1, 28 February 1998 (1998-02-28), pages 2 - 11, XP001057593 *

Also Published As

Publication number Publication date
AU2002211597A1 (en) 2002-04-22
WO2002031132A2 (en) 2002-04-18
EP1402010A2 (en) 2004-03-31

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