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WO2002030983A3 - Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung - Google Patents

Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung Download PDF

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Publication number
WO2002030983A3
WO2002030983A3 PCT/EP2001/011994 EP0111994W WO0230983A3 WO 2002030983 A3 WO2002030983 A3 WO 2002030983A3 EP 0111994 W EP0111994 W EP 0111994W WO 0230983 A3 WO0230983 A3 WO 0230983A3
Authority
WO
WIPO (PCT)
Prior art keywords
bikunin
plasma fraction
production
same
fraction containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/011994
Other languages
English (en)
French (fr)
Other versions
WO2002030983A2 (de
Inventor
Djuro Josic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma AG
Original Assignee
Octapharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octapharma AG filed Critical Octapharma AG
Priority to AU2002216968A priority Critical patent/AU2002216968A1/en
Priority to JP2002534368A priority patent/JP2004511492A/ja
Priority to EP01986698A priority patent/EP1326893A2/de
Publication of WO2002030983A2 publication Critical patent/WO2002030983A2/de
Publication of WO2002030983A3 publication Critical patent/WO2002030983A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Verfahren zur Herstellung einer Bikunin-Plasmafraktion mit Antitrypsin Aktivität, wobei eine die Bikunin-Plasmafraktion enthaltende Quelle mittels Molekularausschluss-Chromatographie in Komponenten getrennt wird und eine Fraktion mit Antitrypsin Aktivität gesammelt wird.
PCT/EP2001/011994 2000-10-13 2001-10-11 Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung Ceased WO2002030983A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002216968A AU2002216968A1 (en) 2000-10-13 2001-10-11 Plasma fraction containing bikunin, method for the production thereof and use of the same
JP2002534368A JP2004511492A (ja) 2000-10-13 2001-10-11 ビクニンを含む血漿画分、その調製方法、およびその使用
EP01986698A EP1326893A2 (de) 2000-10-13 2001-10-11 Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050665.8 2000-10-13
DE10050665 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002030983A2 WO2002030983A2 (de) 2002-04-18
WO2002030983A3 true WO2002030983A3 (de) 2002-12-12

Family

ID=7659599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011994 Ceased WO2002030983A2 (de) 2000-10-13 2001-10-11 Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung

Country Status (5)

Country Link
US (1) US20030190732A1 (de)
EP (1) EP1326893A2 (de)
JP (1) JP2004511492A (de)
AU (1) AU2002216968A1 (de)
WO (1) WO2002030983A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7419665B2 (en) * 2003-10-16 2008-09-02 Siemens Healthcare Diagnostics Inc. Monoclonal antibodies for detection of urinary trypsin inhibitors
EP1691820A4 (de) * 2003-11-08 2010-03-03 Prothera Biolog Herstellung und zusammensetzung von inter-alpha-hemmer-proteinen aus menschlichem plasma für die therapeutische anwendung
CN103142650B (zh) * 2004-11-05 2016-05-11 普罗瑟拉生物公司 治疗用途的来自人血浆的内-α抑制剂蛋白质的制备和组合物
CN101160133B (zh) * 2004-11-05 2013-01-09 普罗瑟拉生物公司 治疗用途的来自人血浆的内-α抑制剂蛋白质的制备和组合物
FR2894145B1 (fr) * 2005-12-07 2008-10-17 Lab Francais Du Fractionnement Utilisation de facteur h du complement a titre de medicament
DK2291654T3 (en) * 2008-05-28 2018-06-14 Prothera Biologics Inc PREPARATION AND COMPOSITION OF BLOOD INTER-ALPHA INHIBITOR PROTEINS
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
US8841248B2 (en) 2010-07-23 2014-09-23 Baxter International Inc. Manufacture of inter-alpha-inhibitor (IaIp) from plasma
US9572872B2 (en) 2012-09-09 2017-02-21 Prothera Biologics, Inc. Treatment of disease using inter-alpha inhibitor proteins
US20140206844A1 (en) 2013-01-18 2014-07-24 Prothera Biologics Methods for isolating blood products from an inter-alpha inhibitor protein-depleted blood product material
WO2018053029A1 (en) 2016-09-13 2018-03-22 Prothera Biologics, Inc. Methods for treating pulmonary disease using inter-alpha inhibitor proteins
CA3061164A1 (en) 2017-04-25 2018-11-01 Prothera Biologics, Inc. Methods for quantifying inter-alpha inhibitor proteins
WO2022104282A1 (en) 2020-11-16 2022-05-19 Prothera Biologics, Inc. Methods for purifying inter-alpha inhibitor proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5777081A (en) * 1993-10-18 1998-07-07 Association Pour L'essor De La Transfusion Sanguine Dans La Region Du Nord Process for producing an inter-alpha-trypsin inhibitor concentrate for therapeutic use and concentrate thus obtained
US5846763A (en) * 1991-01-14 1998-12-08 New York University DNA encoding tumor necrosis factor stimulated gene 6 (TSG-6)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846763A (en) * 1991-01-14 1998-12-08 New York University DNA encoding tumor necrosis factor stimulated gene 6 (TSG-6)
US5777081A (en) * 1993-10-18 1998-07-07 Association Pour L'essor De La Transfusion Sanguine Dans La Region Du Nord Process for producing an inter-alpha-trypsin inhibitor concentrate for therapeutic use and concentrate thus obtained

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ATMANI ET AL: "Role of inter-alpha-inhibitor and its related proteins in urolithiasis. Purification of an inter-alpha-inhibitor related protein from the bovine kidney.", UROLOGICAL RESEARCH, vol. 27, 1999, pages 57 - 61, XP000994523 *
JOSIC ET AL: "Size-exclusion chromatography of plasma proteins with high molecular masses", JOURNAL OF CHROMATOGRAPHY A, vol. 796, no. 2, 20 February 1998 (1998-02-20), pages 289 - 298, XP004110809, ISSN: 0021-9673 *

Also Published As

Publication number Publication date
AU2002216968A1 (en) 2002-04-22
US20030190732A1 (en) 2003-10-09
EP1326893A2 (de) 2003-07-16
JP2004511492A (ja) 2004-04-15
WO2002030983A2 (de) 2002-04-18

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