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WO2002030959A3 - Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci - Google Patents

Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci Download PDF

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Publication number
WO2002030959A3
WO2002030959A3 PCT/US2001/032121 US0132121W WO0230959A3 WO 2002030959 A3 WO2002030959 A3 WO 2002030959A3 US 0132121 W US0132121 W US 0132121W WO 0230959 A3 WO0230959 A3 WO 0230959A3
Authority
WO
WIPO (PCT)
Prior art keywords
diablo
smac
peptides derived
methods
use therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/032121
Other languages
English (en)
Other versions
WO2002030959A2 (fr
Inventor
Stephen W Fesik
Robert P Meadows
Stephen P Betz
Zhihong Liu
Edward T Olejniczak
Chaohong Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of WO2002030959A2 publication Critical patent/WO2002030959A2/fr
Publication of WO2002030959A3 publication Critical patent/WO2002030959A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des peptides dérivés de la protéine humaine smac (DIABLO) de type sauvage qui se lie avec un membre de la famille des IAP (inhibitor of apoptosis proteins : protéines inhibant l'apoptose). Ces peptides peuvent être utilisés dans un procédé permettant l'identification de substances candidates induisant ou favorisant l'apoptose dans les cellules..
PCT/US2001/032121 2000-10-13 2001-10-12 Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci Ceased WO2002030959A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68754900A 2000-10-13 2000-10-13
US09/687,549 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002030959A2 WO2002030959A2 (fr) 2002-04-18
WO2002030959A3 true WO2002030959A3 (fr) 2002-09-26

Family

ID=24760847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/032121 Ceased WO2002030959A2 (fr) 2000-10-13 2001-10-12 Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci

Country Status (1)

Country Link
WO (1) WO2002030959A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835393B2 (en) 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP
US8907092B2 (en) 2007-04-30 2014-12-09 Genentech, Inc. Inhibitors of IAP
US9040706B2 (en) 2004-12-20 2015-05-26 Genentech, Inc. Pyrrolidine inhibitors of IAP

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026775A2 (fr) * 2000-09-29 2002-04-04 Trustees Of Princeton University Compositions et methodes de regulation de l'apoptose
WO2004005248A1 (fr) * 2002-07-02 2004-01-15 Novartis Ag Inhibiteurs peptidiques de la liaison de la proteine smac avec les proteines inhibitrices de l'apoptose (iap)
EP1723122B1 (fr) 2004-03-01 2014-11-19 Board of Regents, The University of Texas System Petites molécules dimères inductrices d'apoptose
WO2005094818A1 (fr) 2004-03-23 2005-10-13 Genentech, Inc. Inhibiteurs azabicyclo-octane de l'iap
CN101035802A (zh) 2004-07-02 2007-09-12 健泰科生物技术公司 Iap抑制剂
US7749520B2 (en) 2004-07-07 2010-07-06 Statens Serum Institut Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids
AU2005274937B2 (en) 2004-07-15 2011-08-18 Medivir Ab IAP binding compounds
AU2006216450C1 (en) 2005-02-25 2013-01-10 Medivir Ab Dimeric IAP inhibitors
EP1883627B1 (fr) 2005-05-18 2018-04-18 Pharmascience Inc. Composes liants de domaine bir
US7589118B2 (en) 2005-10-25 2009-09-15 Aegera Therapeutics, Inc. IAP BIR domain binding compounds
WO2007106192A2 (fr) 2005-12-19 2007-09-20 Genentech, Inc. Inhibiteurs iap (inhibiteurs de l'apoptose)
TWI543988B (zh) 2006-03-16 2016-08-01 科學製藥股份有限公司 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
SG10201407457UA (en) 2006-05-16 2014-12-30 Pharmascience Inc Iap bir domain binding compounds
US8143426B2 (en) 2006-07-24 2012-03-27 Tetralogic Pharmaceuticals Corporation IAP inhibitors
BRPI0715195A2 (pt) 2006-07-24 2013-06-11 Tetralogic Pharm Corp composto, mÉtodos para induzir e para estimular a apoptose em uma cÉlula, para intensificar a apoptose de cÉlulas patogÊnicas in vivo em um indivÍduo, e para tratar uma doenÇa, e, composiÇço farmacÊutica
WO2008079735A1 (fr) 2006-12-19 2008-07-03 Genentech, Inc. Inhibiteurs imidazopyridine de iap
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
CN102985439B9 (zh) 2010-02-12 2016-08-03 制药科学股份有限公司 Iap bir结构域结合化合物
CN110713546B (zh) * 2019-10-31 2021-04-20 中国医科大学附属第一医院 靶向survivin-XIAP复合物的抗肿瘤多肽Sur-X与用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021015A2 (fr) * 1997-10-21 1999-04-29 Cranfield University Ligands d'affinite, leur production, et leur utilisation
WO2002016402A2 (fr) * 2000-08-23 2002-02-28 Board Of Regents, The University Of Texas System Composes apoptotiques
WO2002016418A2 (fr) * 2000-08-24 2002-02-28 Thomas Jefferson University Peptide ou polypeptide capable de liaison avec l'inhibiteur de la proteine de l'apoptose
WO2002026775A2 (fr) * 2000-09-29 2002-04-04 Trustees Of Princeton University Compositions et methodes de regulation de l'apoptose

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021015A2 (fr) * 1997-10-21 1999-04-29 Cranfield University Ligands d'affinite, leur production, et leur utilisation
WO2002016402A2 (fr) * 2000-08-23 2002-02-28 Board Of Regents, The University Of Texas System Composes apoptotiques
WO2002016418A2 (fr) * 2000-08-24 2002-02-28 Thomas Jefferson University Peptide ou polypeptide capable de liaison avec l'inhibiteur de la proteine de l'apoptose
WO2002026775A2 (fr) * 2000-09-29 2002-04-04 Trustees Of Princeton University Compositions et methodes de regulation de l'apoptose

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAI JIJIE ET AL: "STRUCTURAL AND BIOCHEMICAL BASIS OF APOPTOTIC ACTIVATION BY SMAC/DIABLO.", NATURE (LONDON), vol. 406, no. 6798, 2000, pages 855 - 862, XP002200489, ISSN: 0028-0836 *
DU CHUNYING ET AL: "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 102, no. 1, 7 July 2000 (2000-07-07), pages 33 - 42, XP002175396, ISSN: 0092-8674 *
VERHAGEN ANNE M ET AL: "IDENTIFICATION OF DIABLO, A MAMMALIAN PROTEIN THAT PROMOTES APOPTOSIS BY BINDING TO AND ANTAGONIZING IAP PROTEINS", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 102, 7 July 2000 (2000-07-07), pages 43 - 53, XP002175397, ISSN: 0092-8674 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040706B2 (en) 2004-12-20 2015-05-26 Genentech, Inc. Pyrrolidine inhibitors of IAP
US8907092B2 (en) 2007-04-30 2014-12-09 Genentech, Inc. Inhibitors of IAP
US8835393B2 (en) 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP

Also Published As

Publication number Publication date
WO2002030959A2 (fr) 2002-04-18

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