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WO2002030877A1 - Procede de production d'un desinfectant - Google Patents

Procede de production d'un desinfectant Download PDF

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Publication number
WO2002030877A1
WO2002030877A1 PCT/RU2000/000388 RU0000388W WO0230877A1 WO 2002030877 A1 WO2002030877 A1 WO 2002030877A1 RU 0000388 W RU0000388 W RU 0000388W WO 0230877 A1 WO0230877 A1 WO 0230877A1
Authority
WO
WIPO (PCT)
Prior art keywords
χlορisτοgο
ρasτvορa
naτρiya
ποliguanidina
ammοniya
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2000/000388
Other languages
English (en)
Russian (ru)
Inventor
Konstantin Mikhailovich Efimov
Petr Alexandrovich Gembitsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REGIONALNAYA OBSCHESTVENNAYA ORGANIZATSYA-INSTITUT EKOLOGO-TEKHNOLOGICHESKIKH PROBLEM
Original Assignee
REGIONALNAYA OBSCHESTVENNAYA ORGANIZATSYA-INSTITUT EKOLOGO-TEKHNOLOGICHESKIKH PROBLEM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by REGIONALNAYA OBSCHESTVENNAYA ORGANIZATSYA-INSTITUT EKOLOGO-TEKHNOLOGICHESKIKH PROBLEM filed Critical REGIONALNAYA OBSCHESTVENNAYA ORGANIZATSYA-INSTITUT EKOLOGO-TEKHNOLOGICHESKIKH PROBLEM
Priority to PCT/RU2000/000388 priority Critical patent/WO2002030877A1/fr
Publication of WO2002030877A1 publication Critical patent/WO2002030877A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Definitions

  • polyalkylene guanidines are in the 3rd class of moderately dangerous compounds in the stomach and in the 4th class of small connections. More generally less toxic polyalkylene guanidines.
  • Polymexamethylene guanidine in a dose of 1-1.5 mg / l is disinfected for drinking water instead of water, and in the form of a 0, 1-1.0% drug, it is disinfectant Safonov, P. ⁇ . Gembitsky and others. 3 “Chemical Industry,” 1989, ° 12, p. 903].
  • Acidic acid or anionic acid ⁇ a ⁇ from av ⁇ s ⁇ g ⁇ svide ⁇ els ⁇ va SSS ⁇ 1616898, 1990 g. izves ⁇ en s ⁇ s ⁇ b ⁇ lucheniya dezin ⁇ itsi ⁇ uyuscheg ⁇ s ⁇ eds ⁇ va - ⁇ l ⁇ ida ⁇ lige ⁇ same ⁇ ilenguanidina ⁇ u ⁇ em vzaim ⁇ deys ⁇ viya ge ⁇ same ⁇ ilendiamina with ⁇ as ⁇ lav ⁇ m gid ⁇ l ⁇ ida guanidine ⁇ i ⁇ avn ⁇ me ⁇ n ⁇ m d ⁇ bavlenii ⁇ as ⁇ lava ge ⁇ same ⁇ ilendiamina ⁇ ⁇ as ⁇ lavu guanidine gid ⁇ l ⁇ ida ⁇ i 180 ° C ⁇ sleduyuschim ⁇ vysheniem ⁇ em ⁇ e ⁇ a ⁇
  • guanidingid ⁇ l ⁇ ida with diamin ⁇ m (D ⁇ ) (diamin ⁇ e ⁇ i ⁇ y or mixtures i ⁇ with al ⁇ ilendiamin ⁇ m, vyb ⁇ annym of g ⁇ u ⁇ y, v ⁇ lyuchayuschey ge ⁇ same ⁇ ilendiamin, diamin ⁇ de ⁇ an, diamin ⁇ d ⁇ de ⁇ an) ⁇ i e ⁇ vim ⁇ lya ⁇ ny ⁇ s ⁇ n ⁇ sheniya ⁇ between GG ⁇ and D ⁇ , ⁇ i e ⁇ m ⁇ li ⁇ ndensatsigo ⁇ susches ⁇ vlyayu ⁇ ⁇ e ⁇ v ⁇ y at step 100- ⁇ i January 10 ° C .
  • the method allows for the addition of alkali after the separation of ammonia and the subsequent addition of acid (inorganic or discontinued).
  • This method is obtained by an antiseptic (disinfectant), possessing increased antisynthetic properties, a high antibacterial and non-hazardous.
  • the known method ensures that disinfections with good antisyptic properties are obtained, however
  • the hermetic package of such a package was included in the corresponding capacities, for example, dual-purpose packages, which protects the user from being at risk of power failure.
  • SIGNIFICANT FOX (DR. 26) After drying, the melting of oliguanidine is carried out by the separation of the melting into discrete droplets in the course of the air after it is granulated, it is used in the mixture of amine and diamine.
  • the device is provided on special equipment, for example, in a machine (Reactor), which is shown in Fig. 1.
  • FIG. 1 a schematic diagram of a process for receiving a disinfecting device is provided for a living invention.
  • the operation has a reactive camera 1, in which there is a compensation.
  • the mixer is equipped with two agitators 2, and the adjustable camcorders are equipped with 3 mixers.
  • the original camera 1 is loaded with the original components of the synthesis, including the heating of the heater 3 and the maintenance of it for the preset mode. At the end of the process
  • For acid use any suitable inorganic acid or acid which is consumed in water.
  • the invention uses various alkylenediamines (hexamethylenediamine, diaminedecane, diaminedecane), and diamine esters of the general formula:
  • the diamine esters used in the claimed invention are used in technology to exclude epoxy resins.
  • Raw materials for their use are oxide of ethylene or tetrahydride. They possess certain advantages as components of the compensation of ⁇ , ⁇ -alkylenediamines.
  • diamine compounds especially the highest members of the series, are minor substances of the IV class of safety. They are ecologically safe, since they are oxidized with the conversion of organic molecules of ethyl acetate, acetone, acid, and so on.
  • Diamine esters are non-volatile liquids that are convenient for handling and not flammable from a suitable mixture of suitable HYDROGEN.
  • monoamines in the invention, higher aliphatic and aromatic amines, for example, octadecylamine, oleylamine, benzylamine, are used in the invention.
  • mono-amines are the owners of chains in the condensation of diamines with guanidine. Therefore, the use of mono-amines in the process is limited to 5-20 mol.%.
  • I ⁇ is ⁇ lz ⁇ vanie ⁇ zv ⁇ lyae ⁇ ⁇ eguli ⁇ va ⁇ m ⁇ le ⁇ ulya ⁇ nuyu mass ⁇ liguanidin ⁇ v and i ⁇ gid ⁇ bnye sv ⁇ ys ⁇ va that are part s ⁇ s ⁇ avn ⁇ y an ⁇ iba ⁇ e ⁇ ialn ⁇ y a ⁇ ivn ⁇ s ⁇ i ⁇ liguanidin ⁇ v, ⁇ s ⁇ benn ⁇ suschestvenn ⁇ y for ne ⁇ y ⁇ ⁇ i ⁇ v mi ⁇ ganizm ⁇ v, na ⁇ ime ⁇ mi ⁇ ba ⁇ e ⁇ y ⁇ ube ⁇ uleza.
  • the patent 21 ⁇ 21> 2144929 was used to increase the availability of minerals for the convenience of the customers, but there were no accidental This invention allows you to solve the problem in this case as well.
  • the lower layer which presents a disruption to the ill-disposed state, is drained.
  • the outer layer provides a -62% aqueous solution of hydroxymethylene guanidine (PGHG), which has been cleaned to a lesser extent, which is lower.
  • PGHG hydroxymethylene guanidine
  • the HGGG hydraulics in the reactive chamber 1 add 20 liters of water and 5 amusement charges.
  • the lower layer which is a special solution of ammonia.
  • the outermost layer is the PGHG water solu- tion twice washed with 25% aqueous ammonia powder, dried at 120 ° ⁇ and granulated.
  • the reactor receives 15 liters of water and obtains the result of the delivery.
  • ⁇ committee ⁇ Received - 65% of the PGHG solution was introduced when stirring 14 kg of 40% caustic soda (150 moles), turn off mixer 2 and get the mixture mixed. After the merging, the lower layer is merged, which represents a special part of the CACC, which contains unacceptable monomers and other impurities.
  • Reactive camera 13.7 kg (150 moles) of crystalline sulfinic acid (pressurized and mixed). The process is driven by intense heating of the mixture. Received -75% of the participation of the amine-sulphate of PSGG is dried up to 90% of the content of the main substance at 120 ° ⁇ (3 hours) and granulated. I get -35 kg of a preparation (amine sulfate PG ⁇ G). Similarly, in Example 3, an admixture of the PGGG amino sulphate is BaCS, which was formed at the stage of leaching of the base of PGG.
  • the upper layer which is a self-contained water, is dried at 120 ° ⁇ (3 hours) and granulated. It produces -28 kg of non-food grade PGGG, containing in the form of an impurity of about 5% of CaC ⁇ (for this element analysis).
  • Reactivated camera 1 is loaded with 15 kg of preset HGI (-150 moles) (according to the approximate ⁇ ° 1) 5 15.4 kg (75 moles) 4.9-decadecane -1.12 necting diamine and 1.12 diamine and diamine, stand at a temperature of 120 ° ⁇ for 3 hours, increase temperature up to 150 ° ⁇ for 3 hours and take 1 hour at a temperature of 1 soporimera 4.9- dikosadodekan- and dodekanguanidinov.
  • Reacted camera 1 of the reactor is loaded with 15 kg of HGD (-150 moles), 16.2 kg (140 moles) of GDH and 2.7 kg (10 moles) of octadecylamine.
  • the reaction mixture is heated for 3 hours at 120 ° C, 5 hours at 150 ° C, and 2 hours at 180 ° C. Obtained by the comparison of polymexamethylene guanidine with octadecylguanidine (10: 1) granulate, as indicated above. Received 29 kg non-hazardous compiler.
  • the reaction chamber 1 is loaded with a close mixture of 14.8 kg (100 moles) of benzylamine hydride and 4.2 kg (50 moles) of dicyandiamide, including heating at a temperature of 170 ° C. After the complete melting of the mixture, it is sent to granulation. Received 19 kg (100 moles) of benzylguanidine hydrochloride.
  • Reacted chamber 1 of the reactor is loaded with 15 kg of HGY (-150 moles), 3.8 kg (20 moles) of benzylguanidine hydride, obtained at 10 and 20.9 g.
  • the reactive mixture is heated to 120 ° C and stirred for 3 hours, kept for 5 hours at 150 ° C and 2 hours at 170 ° C, after which it is dispensed, moreover, it is indicated above.
  • I receive 33 kg of PG ⁇ G compositor with benzylguanidine (5: 1).

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'invention concerne le domaine de la chimie et notamment la production de désinfectants, à partir de polyalkylèneguanidines et de polyoxyalkylèneguanidines, qui peuvent être utilisés, de manière efficace et sans danger pour l'environnement, en médecine, en médecine vétérinaire, dans la purification de l'eau et dans divers secteurs économiques où l'on utilise des agents biocides (préparations antiseptiques). Afin d'accroître les propriétés antiseptiques du produit final, le procédé de production de ce désinfectant utilise des sels de guanidine de polycondensation avec des amines dans un rapport équimolaire et consiste à chauffer et éliminer, si nécessaire, des impuretés dans des substances n'ayant pas réagi, et à sécher et refroidir le produit. La purification s'effectue après la polycondensation. Le refroidissement du bain de fusion se traduit par la séparation de celui-ci en gouttelettes distinctes dans le flux d'air, ces gouttelettes étant ensuite transformées en granules. Le produit obtenu n'est pas toxique et possède de bonnes propriétés antiseptiques.
PCT/RU2000/000388 2000-09-29 2000-09-29 Procede de production d'un desinfectant Ceased WO2002030877A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU2000/000388 WO2002030877A1 (fr) 2000-09-29 2000-09-29 Procede de production d'un desinfectant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2000/000388 WO2002030877A1 (fr) 2000-09-29 2000-09-29 Procede de production d'un desinfectant

Publications (1)

Publication Number Publication Date
WO2002030877A1 true WO2002030877A1 (fr) 2002-04-18

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PCT/RU2000/000388 Ceased WO2002030877A1 (fr) 2000-09-29 2000-09-29 Procede de production d'un desinfectant

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047800A1 (fr) * 2004-11-05 2006-05-11 Oskar Schmidt Produit biocide, en particulier fongicide
CN100406496C (zh) * 2003-07-23 2008-07-30 上海塑杰科技有限公司 一种多元胺与胍盐聚合物及其在抗菌聚酯和聚酰胺材料中的应用
WO2014113835A1 (fr) 2013-01-25 2014-07-31 Sealife Pharma Gmbh Nouveaux polymères bioactifs
EP3524055A1 (fr) 2018-02-08 2019-08-14 BCSK Biocid GmbH Agent lubrifiant antibactérien et spermicide
CN110128667A (zh) * 2019-05-21 2019-08-16 华东理工大学 聚烯烃抗菌母粒及其制备和用于制备抗菌缩聚物的应用
WO2021262113A1 (fr) * 2020-06-24 2021-12-30 Ak-Kim Kimya Sanayi Ve Ticaret Anonim Sirketi Coagulant décolorant

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1616898A1 (ru) * 1987-12-11 1990-12-30 Московский научно-исследовательский и проектно-изыскательский институт "МосводоканалНИИпроект" Способ получени дезинфицирующего средства
EP0472093A1 (fr) * 1990-08-22 1992-02-26 BASF Aktiengesellschaft Bis guanidines et fongicides qui les contiennent
WO1999054291A1 (fr) * 1998-04-22 1999-10-28 P.O.C. Oil Industry Technology Beratungsges.Mbh Procede de preparation de polyhexamethylene-guanidine
RU2142452C1 (ru) * 1998-08-10 1999-12-10 Институт эколого-технологических проблем Способ получения полигуанидинового дезинфицирующего средства

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1616898A1 (ru) * 1987-12-11 1990-12-30 Московский научно-исследовательский и проектно-изыскательский институт "МосводоканалНИИпроект" Способ получени дезинфицирующего средства
EP0472093A1 (fr) * 1990-08-22 1992-02-26 BASF Aktiengesellschaft Bis guanidines et fongicides qui les contiennent
WO1999054291A1 (fr) * 1998-04-22 1999-10-28 P.O.C. Oil Industry Technology Beratungsges.Mbh Procede de preparation de polyhexamethylene-guanidine
RU2142452C1 (ru) * 1998-08-10 1999-12-10 Институт эколого-технологических проблем Способ получения полигуанидинового дезинфицирующего средства

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100406496C (zh) * 2003-07-23 2008-07-30 上海塑杰科技有限公司 一种多元胺与胍盐聚合物及其在抗菌聚酯和聚酰胺材料中的应用
WO2006047800A1 (fr) * 2004-11-05 2006-05-11 Oskar Schmidt Produit biocide, en particulier fongicide
WO2014113835A1 (fr) 2013-01-25 2014-07-31 Sealife Pharma Gmbh Nouveaux polymères bioactifs
US9567294B2 (en) 2013-01-25 2017-02-14 Sealife Pharma Gmbh Bioactive polymers
EP3524055A1 (fr) 2018-02-08 2019-08-14 BCSK Biocid GmbH Agent lubrifiant antibactérien et spermicide
WO2019154983A1 (fr) 2018-02-08 2019-08-15 Bcsk Biocid Gmbh Lubrifiant antibactérien et spermicide
CN110128667A (zh) * 2019-05-21 2019-08-16 华东理工大学 聚烯烃抗菌母粒及其制备和用于制备抗菌缩聚物的应用
CN110128667B (zh) * 2019-05-21 2020-11-13 华东理工大学 聚烯烃抗菌母粒及其制备和用于制备抗菌缩聚物的应用
WO2021262113A1 (fr) * 2020-06-24 2021-12-30 Ak-Kim Kimya Sanayi Ve Ticaret Anonim Sirketi Coagulant décolorant

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