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WO2002019985A3 - Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure - Google Patents

Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure Download PDF

Info

Publication number
WO2002019985A3
WO2002019985A3 PCT/US2001/027551 US0127551W WO0219985A3 WO 2002019985 A3 WO2002019985 A3 WO 2002019985A3 US 0127551 W US0127551 W US 0127551W WO 0219985 A3 WO0219985 A3 WO 0219985A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
inhibiting
inhibition
decrease
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/027551
Other languages
French (fr)
Other versions
WO2002019985A2 (en
Inventor
Weiqi Lin
Michel J N Cormier
Peter E Daddona
Juanita A Johnson
James A Matriano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2002524470A priority Critical patent/JP5507030B2/en
Priority to CA002422200A priority patent/CA2422200A1/en
Priority to AU8877401A priority patent/AU8877401A/en
Priority to IL15481101A priority patent/IL154811A0/en
Priority to BR0113749-2A priority patent/BR0113749A/en
Priority to EP01968531A priority patent/EP1335711B1/en
Priority to KR1020037003472A priority patent/KR100764699B1/en
Priority to MXPA03002122A priority patent/MXPA03002122A/en
Priority to AU2001288774A priority patent/AU2001288774B2/en
Application filed by Alza Corp filed Critical Alza Corp
Priority to EEP200300095A priority patent/EE200300095A/en
Priority to NZ524646A priority patent/NZ524646A/en
Priority to DE60129585T priority patent/DE60129585T2/en
Priority to DK01968531T priority patent/DK1335711T3/en
Publication of WO2002019985A2 publication Critical patent/WO2002019985A2/en
Publication of WO2002019985A3 publication Critical patent/WO2002019985A3/en
Priority to NO20031071A priority patent/NO20031071L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)

Abstract

This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to form pathways through which the agent passes. The desired result is achieved by co-delivering or co-sampling the agent with an amount of at least one anti-healing agent wherein the amount of the anti-healing agent is effective in inhibiting a decrease in the agent transdermal flux compared to when the delivery or sampling of the agent is done under substantially identical conditions except in the absence of the anti-healing agent(s).
PCT/US2001/027551 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure Ceased WO2002019985A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
AU2001288774A AU2001288774B2 (en) 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
AU8877401A AU8877401A (en) 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
EEP200300095A EE200300095A (en) 2000-09-08 2001-09-06 Methods of Inhibiting Decrease in Drug Transdermal Transportation by Inhibiting Canal Closure
BR0113749-2A BR0113749A (en) 2000-09-08 2001-09-06 Methods to inhibit decrease in transdermal drug flow by inhibiting pathway closure
EP01968531A EP1335711B1 (en) 2000-09-08 2001-09-06 Transdermal device
KR1020037003472A KR100764699B1 (en) 2000-09-08 2001-09-06 Inhibition of Percutaneous Drug Flux Reduction by Pathway Inhibition
MXPA03002122A MXPA03002122A (en) 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure.
JP2002524470A JP5507030B2 (en) 2000-09-08 2001-09-06 Methods for suppressing reduction in transdermal drug flow by inhibiting pathway closure
IL15481101A IL154811A0 (en) 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
CA002422200A CA2422200A1 (en) 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
NZ524646A NZ524646A (en) 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
DE60129585T DE60129585T2 (en) 2000-09-08 2001-09-06 TRANSDERMALE DEVICE
DK01968531T DK1335711T3 (en) 2000-09-08 2001-09-06 Transdermal device
NO20031071A NO20031071L (en) 2000-09-08 2003-03-07 Method of Inhibiting Decrease in Transdermal Drug Flow Through Inhibition by Closing the Reaction Pathway

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23116000P 2000-09-08 2000-09-08
US60/231,160 2000-09-08

Publications (2)

Publication Number Publication Date
WO2002019985A2 WO2002019985A2 (en) 2002-03-14
WO2002019985A3 true WO2002019985A3 (en) 2002-09-06

Family

ID=22867983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/027551 Ceased WO2002019985A2 (en) 2000-09-08 2001-09-06 Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure

Country Status (24)

Country Link
US (1) US7438926B2 (en)
EP (1) EP1335711B1 (en)
JP (2) JP5507030B2 (en)
KR (1) KR100764699B1 (en)
CN (1) CN100421653C (en)
AT (1) ATE367805T1 (en)
AU (2) AU2001288774B2 (en)
BR (1) BR0113749A (en)
CA (1) CA2422200A1 (en)
CZ (1) CZ2003687A3 (en)
DE (1) DE60129585T2 (en)
DK (1) DK1335711T3 (en)
EE (1) EE200300095A (en)
ES (1) ES2290166T3 (en)
IL (1) IL154811A0 (en)
MA (1) MA25958A1 (en)
MX (1) MXPA03002122A (en)
NO (1) NO20031071L (en)
NZ (1) NZ524646A (en)
PL (1) PL365603A1 (en)
PT (1) PT1335711E (en)
RU (1) RU2272618C2 (en)
WO (1) WO2002019985A2 (en)
ZA (1) ZA200302700B (en)

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PL365603A1 (en) * 2000-09-08 2005-01-10 Alza Corporation Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
CZ20031164A3 (en) * 2000-10-26 2004-04-14 Alza Corporation Device for percutaneous transdermal delivery having coated micro-protrusions
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
ES2437565T3 (en) * 2003-06-30 2014-01-13 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
WO2005002453A1 (en) * 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
CA2536249A1 (en) 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
CN101415443A (en) * 2003-10-23 2009-04-22 阿尔扎公司 Compositions of stabilized DNA for coating microprojctions
EP1675539A4 (en) * 2003-10-24 2007-09-12 Alza Corp Pretreatment method and system for enhancing transdermal drug delivery
MXPA06005510A (en) * 2003-11-13 2006-12-14 Johnson & Johnson Composition and apparatus for transdermal delivery.
EP1734993A4 (en) 2004-04-01 2009-10-21 Alza Corp Apparatus and method for transdermal delivery of influenza vaccine
WO2005103303A2 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of multiple vaccines
EP1737434A2 (en) * 2004-04-13 2007-01-03 Alza Corporation Apparatus and method for transdermal delivery of fentanyl-based agents
CN101232874A (en) * 2004-08-11 2008-07-30 阿尔扎公司 Devices and methods for transdermal delivery of natriuretic peptides
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CA2588080C (en) * 2004-11-18 2013-01-08 3M Innovative Properties Company Masking method for coating a microneedle array
AU2005306372B2 (en) 2004-11-18 2011-01-06 Kindeva Drug Delivery L.P. Method of contact coating a microneedle array
AU2006214236A1 (en) * 2005-02-16 2006-08-24 Alza Corporation Apparatus and method for transdermal delivery of erythropoetin-based agents
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
EP1948139A4 (en) * 2005-11-18 2012-04-04 3M Innovative Properties Co Coatable compositions, coatings derived therefrom and microarrays having such coatings
EP2018835B1 (en) * 2007-07-09 2014-03-05 Augustinus Bader Agent-eluting plaster
US8617487B2 (en) 2009-03-25 2013-12-31 Venture Lending & Leasing Vi, Inc. Saliva sample collection systems
JPWO2011010456A1 (en) * 2009-07-24 2012-12-27 株式会社ネクスト２１ NSAIDs-containing external preparation and method for producing the external preparation
EP2818159A1 (en) * 2013-06-25 2014-12-31 LTS LOHMANN Therapie-Systeme AG Device having transdermal therapeutic system, positioning and penetration aid
US9987361B1 (en) * 2014-12-29 2018-06-05 Noven Pharmaceuticals, Inc. Compositions and method for sustained drug delivery by active transdermal technology
DE102017126501A1 (en) 2017-11-10 2019-05-16 Lts Lohmann Therapie-Systeme Ag Micro needle system for the application of a hepatitis vaccine
US20190231925A1 (en) * 2018-01-31 2019-08-01 Changchun Ja Biotech. Co., Ltd. Heparin sodium supported hydrogel sustained-release paster

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WO1996017648A1 (en) * 1994-12-09 1996-06-13 Novartis Ag Transdermal system
WO1997048440A1 (en) * 1996-06-18 1997-12-24 Alza Corporation Device for enhancing transdermal agent delivery or sampling
WO2000074763A2 (en) * 1999-06-04 2000-12-14 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
WO2001041864A1 (en) * 1999-12-10 2001-06-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery

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CZ20031164A3 (en) * 2000-10-26 2004-04-14 Alza Corporation Device for percutaneous transdermal delivery having coated micro-protrusions
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WO1997048440A1 (en) * 1996-06-18 1997-12-24 Alza Corporation Device for enhancing transdermal agent delivery or sampling
WO2000074763A2 (en) * 1999-06-04 2000-12-14 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
WO2001041864A1 (en) * 1999-12-10 2001-06-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery

Also Published As

Publication number Publication date
DE60129585D1 (en) 2007-09-06
EP1335711A2 (en) 2003-08-20
ES2290166T3 (en) 2008-02-16
EE200300095A (en) 2005-02-15
JP2004508319A (en) 2004-03-18
RU2272618C2 (en) 2006-03-27
CZ2003687A3 (en) 2004-01-14
NO20031071D0 (en) 2003-03-07
CN1473037A (en) 2004-02-04
EP1335711B1 (en) 2007-07-25
KR20030074595A (en) 2003-09-19
ATE367805T1 (en) 2007-08-15
NZ524646A (en) 2004-10-29
WO2002019985A2 (en) 2002-03-14
PL365603A1 (en) 2005-01-10
MXPA03002122A (en) 2004-09-10
PT1335711E (en) 2007-09-05
JP2013256500A (en) 2013-12-26
ZA200302700B (en) 2004-08-13
US20020102292A1 (en) 2002-08-01
AU8877401A (en) 2002-03-22
CA2422200A1 (en) 2002-03-14
NO20031071L (en) 2003-05-06
DK1335711T3 (en) 2007-11-26
BR0113749A (en) 2004-06-22
MA25958A1 (en) 2003-12-31
KR100764699B1 (en) 2007-10-08
AU2001288774B2 (en) 2006-06-29
DE60129585T2 (en) 2008-04-17
US7438926B2 (en) 2008-10-21
CN100421653C (en) 2008-10-01
JP5507030B2 (en) 2014-05-28
IL154811A0 (en) 2003-10-31

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