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WO2002018631A3 - Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen - Google Patents

Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen Download PDF

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Publication number
WO2002018631A3
WO2002018631A3 PCT/EP2001/010073 EP0110073W WO0218631A3 WO 2002018631 A3 WO2002018631 A3 WO 2002018631A3 EP 0110073 W EP0110073 W EP 0110073W WO 0218631 A3 WO0218631 A3 WO 0218631A3
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WO
WIPO (PCT)
Prior art keywords
illnesses
predisposition
diagnosis
certain
probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/010073
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English (en)
French (fr)
Other versions
WO2002018631A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics AG filed Critical Epigenomics AG
Priority to EP01980314A priority Critical patent/EP1373564A2/de
Priority to US10/363,483 priority patent/US20050064401A1/en
Priority to JP2002522536A priority patent/JP2005512499A/ja
Priority to AU2002212187A priority patent/AU2002212187A1/en
Publication of WO2002018631A2 publication Critical patent/WO2002018631A2/de
Anticipated expiration legal-status Critical
Publication of WO2002018631A3 publication Critical patent/WO2002018631A3/de
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Die vorliegende Erfindung beschreibt einen Satz von Oligomersonden (Oligonukleotiden und/oder PNA-Oligomeren), die zur Detektion des Cytosinmethylierungszustandes in Nukleinsäuren dienen. Diese Sonden sind für die Diagnose von bestehenden Erkrankungen durch Analyse eines Satzes genetischer und/oder epigenetischer Parameter besonders geeignet.
PCT/EP2001/010073 2000-09-01 2001-09-01 Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen Ceased WO2002018631A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01980314A EP1373564A2 (de) 2000-09-01 2001-09-01 Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen
US10/363,483 US20050064401A1 (en) 2000-09-01 2001-09-01 Diagnosis of illnesses or predisposition to certain illnesses
JP2002522536A JP2005512499A (ja) 2000-09-01 2001-09-01 進行中の疾病または特定の疾病の発病素質の診断
AU2002212187A AU2002212187A1 (en) 2000-09-01 2001-09-01 Diagnosis of illnesses or predisposition to certain illnesses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10043826.1 2000-09-01
DE10043826 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002018631A2 WO2002018631A2 (de) 2002-03-07
WO2002018631A3 true WO2002018631A3 (de) 2003-10-16

Family

ID=7655132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010073 Ceased WO2002018631A2 (de) 2000-09-01 2001-09-01 Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen

Country Status (5)

Country Link
US (1) US20050064401A1 (de)
EP (1) EP1373564A2 (de)
JP (1) JP2005512499A (de)
AU (1) AU2002212187A1 (de)
WO (1) WO2002018631A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871732B2 (en) 2002-12-23 2014-10-28 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727230B1 (en) * 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
EP0855184A1 (de) * 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmazeutisches Präparat das ein Polynukleotid und ein Antigen enthält, insbesondere zur Impfung
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6693086B1 (en) * 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US20040131628A1 (en) * 2000-03-08 2004-07-08 Bratzler Robert L. Nucleic acids for the treatment of disorders associated with microorganisms
KR100917101B1 (ko) * 2000-08-04 2009-09-15 도요 보세키 가부시키가이샤 플렉시블 금속적층체 및 그 제조방법
US7576066B2 (en) * 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) * 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) * 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) * 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AU2003257587A1 (en) * 2002-08-23 2004-03-11 Japan As Represented By President Of National Cancer Center Method of evaluating degree of canceration of human-origin specimen
CN101948835A (zh) * 2002-10-29 2011-01-19 科勒制药集团股份有限公司 Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用
WO2004053104A2 (en) * 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5’ cpg nucleic acids and methods of use
SG173219A1 (en) * 2002-12-23 2011-08-29 Dynavax Tech Corp Immunostimulatory sequence oligonucleotides and methods of using the same
US20040235770A1 (en) * 2003-04-02 2004-11-25 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations and related methods of use
US20050013812A1 (en) * 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
KR100558851B1 (ko) * 2004-01-08 2006-03-10 학교법인연세대학교 면역조절능력이 증가된 ＣｐＧ 올리고데옥시뉴클레오티드변형체
EP2013360A2 (de) * 2006-04-17 2009-01-14 Epigenomics AG Verfahren und nukleinsäuren zum nachweis von proliferativen störungen kolorektaler zellen
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
EP2229456A2 (de) * 2007-12-11 2010-09-22 Epigenomics AG Verfahren und nukleinsäuren für analysen von lungenkrebs
EP2250287B1 (de) * 2008-02-19 2013-09-18 MDxHealth SA Nachweis und prognose von lungenkrebs
WO2010028256A2 (en) * 2008-09-05 2010-03-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Predictive biomarkers
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
US20120164238A1 (en) 2009-02-03 2012-06-28 Mdxhealth Sa Methods of detecting colorectal cancer
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
ES2669439T3 (es) * 2009-06-26 2018-05-25 Epigenomics Ag Métodos y ácidos nucleicos para el análisis del carcinoma de vejiga
EP2707506B1 (de) * 2011-05-12 2018-07-11 The Johns Hopkins University Verfahren zum nachweis von krebs durch allgemeinen stabilitätsverlust epigenetischer domänen und zusammensetzungen dafür
GB201121924D0 (en) * 2011-12-20 2012-02-01 Fahy Gurteen Labs Ltd Detection of breast cancer
EP3889611A1 (de) * 2014-12-12 2021-10-06 Exact Sciences Development Company, LLC Vorrichtungen und verfahren zur durchführung von methylierungsdetektionstests
WO2016094839A2 (en) * 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
EP3274440A4 (de) 2015-03-27 2019-03-06 Exact Sciences Corporation Nachweis von erkrankungen der speiseröhre
DE102015009187B3 (de) * 2015-07-16 2016-10-13 Dimo Dietrich Verfahren zur Bestimmung einer Mutation in genomischer DNA, Verwendung des Verfahrens und Kit zur Durchführung des Verfahrens
PL3336197T3 (pl) 2016-12-16 2022-08-08 Eurofins Genomics Europe Sequencing GmbH Markery epigenetyczne oraz powiązane sposoby i środki wykrywania i leczenia raka jajnika
CN111635938B (zh) * 2020-04-30 2022-07-29 广州康立明生物科技股份有限公司 一种肿瘤检测试剂及试剂盒
CN111676287B (zh) * 2020-06-03 2022-04-29 广州康立明生物科技股份有限公司 一种基因标志物组合及其应用
CN112195243A (zh) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 一种检测多基因甲基化的试剂盒及其应用
WO2023122508A2 (en) * 2021-12-23 2023-06-29 Mammoth Biosciences, Inc. Programmable nuclease-based assay improvements

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 23 September 1998 (1998-09-23), XP002230584, retrieved from EMBL Database accession no. AF089750 *
HERMAN J G ET AL: "METHYLATION-SPECIFIC PCR: A NOVEL PCR ASSAY FOR METHYLATION STATUS OF CPG ISLANDS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 September 1996 (1996-09-01), pages 9821 - 9826, XP002910406, ISSN: 0027-8424 *
NIEMEYER C M ET AL: "DNA MICROARRAYS**", ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 38, no. 19, 1999, pages 3039 - 3043, XP000961724, ISSN: 0044-8249 *
REIN ET AL: "Identifying 5-methylcytosine and related modifications in DNA genomes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 1998, pages 2255 - 2264, XP002143106, ISSN: 0305-1048 *
VOLONTE D ET AL: "Flotillins/cavatellins are differentially expressed in cells and tissues and form hetero-oligomeric complex with caveolins in vivo", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 18, 30 April 1999 (1999-04-30), pages 12702 - 12709, XP002171909, ISSN: 0021-9258 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871732B2 (en) 2002-12-23 2014-10-28 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US9422564B2 (en) 2002-12-23 2016-08-23 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US10196643B2 (en) 2002-12-23 2019-02-05 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US11312965B2 (en) 2002-12-23 2022-04-26 Trisalus Life Sciences, Inc. Immunostimulatory sequence oligonucleotides and methods of using the same

Also Published As

Publication number Publication date
JP2005512499A (ja) 2005-05-12
US20050064401A1 (en) 2005-03-24
EP1373564A2 (de) 2004-01-02
WO2002018631A2 (de) 2002-03-07
AU2002212187A1 (en) 2002-03-13

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