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WO2002016548A3 - Novel g protein-coupled receptor - Google Patents

Novel g protein-coupled receptor Download PDF

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Publication number
WO2002016548A3
WO2002016548A3 PCT/IB2001/001446 IB0101446W WO0216548A3 WO 2002016548 A3 WO2002016548 A3 WO 2002016548A3 IB 0101446 W IB0101446 W IB 0101446W WO 0216548 A3 WO0216548 A3 WO 0216548A3
Authority
WO
WIPO (PCT)
Prior art keywords
orfs
gene
gpcr
protein
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/001446
Other languages
French (fr)
Japanese (ja)
Other versions
WO2002016548A2 (en
WO2002016548A8 (en
Inventor
Tatsuya Haga
Shigeki Takeda
Shigeki Mitaku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Corp filed Critical Japan Science and Technology Corp
Priority to US10/343,650 priority Critical patent/US20040067499A1/en
Priority to CA002418130A priority patent/CA2418130A1/en
Publication of WO2002016548A2 publication Critical patent/WO2002016548A2/en
Publication of WO2002016548A3 publication Critical patent/WO2002016548A3/en
Anticipated expiration legal-status Critical
Publication of WO2002016548A8 publication Critical patent/WO2002016548A8/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

It is intended to provide a novel G protein-coupled receptor (GPCR) gene which makes it possible to find a signal transduction mechanism in vivo or to identify a novel drug-target protein and a method of totally searching for a GPCR protein on data base. Open reading frames (ORFs) consisting of from 250 to 1000 amino acid residues are extracted from human-origin genome data and ORFs originating in DNA repeated sequences, ORFs containing many indefinite amino acids and ORFs having a single amino acid at a ratio of 20% or more are excluded therefrom. Then ORFs containing 6 to 8 transmembrane domains are extracted by using SOSUI. Among the ORFs thus obtained, a gene homologous with a known GPCR gene (preferably a gene showing the highest homology with a GPCR gene or a GPCR-associated gene in homology searching) is searched for.
PCT/IB2001/001446 2000-08-04 2001-07-30 Novel g protein-coupled receptor Ceased WO2002016548A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/343,650 US20040067499A1 (en) 2000-08-04 2001-07-30 Novel g protein-coupled receptor
CA002418130A CA2418130A1 (en) 2000-08-04 2001-07-30 Novel g protein-coupled receptor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000237818 2000-08-04
JP2000-237818 2000-08-04
JP2001-34434 2001-02-09
JP2001034434A JP2002112793A (en) 2000-08-04 2001-02-09 Novel G protein-coupled receptor

Publications (3)

Publication Number Publication Date
WO2002016548A2 WO2002016548A2 (en) 2002-02-28
WO2002016548A3 true WO2002016548A3 (en) 2002-06-27
WO2002016548A8 WO2002016548A8 (en) 2003-02-27

Family

ID=26597447

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001446 Ceased WO2002016548A2 (en) 2000-08-04 2001-07-30 Novel g protein-coupled receptor

Country Status (3)

Country Link
JP (1) JP2002112793A (en)
CA (1) CA2418130A1 (en)
WO (1) WO2002016548A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US7361338B2 (en) 1999-10-05 2008-04-22 Agensys, Inc. Methods to inhibit growth of prostate cancer cells
US6790631B1 (en) 1999-10-05 2004-09-14 Agensys, Inc. G protein-coupled receptor up-regulated in prostate cancer and uses thereof
US7208280B2 (en) 1999-10-05 2007-04-24 Agensys, Inc. Nucleic acid and corresponding protein entitled 101P3A41 useful in treatment and detection of cancer
AU5125801A (en) 2000-04-07 2001-10-23 Senomyx Inc T2r taste receptors and genes encoding same
DE60142592D1 (en) * 2000-09-22 2010-08-26 Chemcom Sa G-protein receptors for odor and pheromone molecules
ATE466939T1 (en) * 2000-11-17 2010-05-15 Banyu Pharma Co Ltd METHOD FOR SEARCHING FOR COMPONENTS USING THE GUANOSINTRIPHOSPHATE (GTP) BINDING PROTEIN COUPLED RECEPTOR PROTEIN BG37
US7312086B2 (en) 2000-12-07 2007-12-25 Bristol-Myers Squibb Company Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23
US20030143668A1 (en) * 2001-06-18 2003-07-31 National Institute Of Advanced Industrial Guanosine triphosphate-binding protein coupled receptors
US7314725B2 (en) 2001-07-20 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
WO2003031604A1 (en) * 2001-10-12 2003-04-17 The Regents Of The University Of California Gastrointestinal chemosensory receptors
WO2003085081A2 (en) * 2002-04-01 2003-10-16 Agensys, Inc. Nucleic acid and corresponding protein entitled 238p1b2 useful in treatment and detection of cancer
US20040016004A1 (en) 2002-04-01 2004-01-22 Raitano Arthur B. Nucleic acid and corresponding protein entitled 238P1B2 useful in treatment and detection of cancer
WO2003087362A1 (en) * 2002-04-03 2003-10-23 Banyu Pharmaceutical Co., Ltd. Novel g protein-coupled receptor gene and protein bg8
JP2004049043A (en) * 2002-07-17 2004-02-19 Univ Nihon GPCR gene isolation method and novel GPCR gene
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
AU2004258071A1 (en) 2003-06-19 2005-01-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Variants of human taste receptor genes
DE10344799A1 (en) * 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identification of surface-associated antigens for tumor diagnosis and therapy
AU2011213901B2 (en) * 2003-09-26 2012-07-05 BioNTech SE Identification of tumour-associated cell surface antigens for diagnosis and therapy
KR20100055536A (en) 2007-09-20 2010-05-26 아이알엠 엘엘씨 Compounds and compositions as modulators of gpr119 activity
JP5930266B2 (en) 2010-08-26 2016-06-08 国立研究開発法人医薬基盤・健康・栄養研究所 Gene narrowing device, gene narrowing method, and computer program

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005264A1 (en) * 1998-07-23 2000-02-03 Takeda Chemical Industries, Ltd. Novel g protein-conjugated receptor protein and dna thereof
WO2000008053A1 (en) * 1998-08-07 2000-02-17 Takeda Chemical Industries, Ltd. Novel g-protein coupled receptor protein and dna thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005264A1 (en) * 1998-07-23 2000-02-03 Takeda Chemical Industries, Ltd. Novel g protein-conjugated receptor protein and dna thereof
WO2000008053A1 (en) * 1998-08-07 2000-02-17 Takeda Chemical Industries, Ltd. Novel g-protein coupled receptor protein and dna thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
MITAKU S. ET AL.: "Proportion of membrane proteins in proteomes of 15 single-cell organisms analyzed by the SOSUI prediction system", BIOPHYS. CHEM., vol. 82, no. 2-3, 1999, pages 165 - 171, XP002908501 *
MITAKU S.: "Homology no nai amino-san hairetsu kara no tanpakushitsu kozo kino joho no chuushutsu", GENOME SCIENCE; HITO GENOME KAISEKI NI MOTOZUKU BIOSCIENCE NO SHIN-TENKAI, 1999, pages 367 - 370, XP002908502 *
MOMBAERTS P.: "Seven-transmembrane proteins as odorant and chemosensory receptors", SCIENCE, vol. 286, no. 5440, 1999, pages 707 - 711, XP002945076 *
SUWA MAKIKO ET AL.: "Amino-san hairetsu joho kara no receptor tanpakushitsu no kozo yosoku to drug design ni okeru igi", FINE CHEMICAL, vol. 27, no. 19, 1998, pages 7 - 17, XP002908503 *
TAKEDA S. ET AL.: "Systematic search for G-protein-coupled receptor genes from human genome database", JPN. J. PHARMACOL., vol. 85, no. SUPPL. 1, March 2001 (2001-03-01), pages 167P, XP002908505 *
ZHAO H. ET AL.: "Vertebrate odorant receptors", CELL. MOL. LIFE SCI., vol. 56, no. 7-8, 1999, pages 647 - 659, XP002908504 *

Also Published As

Publication number Publication date
JP2002112793A (en) 2002-04-16
CA2418130A1 (en) 2003-02-03
WO2002016548A2 (en) 2002-02-28
WO2002016548A8 (en) 2003-02-27

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