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WO2002014877A3 - Microarray retrieval unit - Google Patents

Microarray retrieval unit Download PDF

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Publication number
WO2002014877A3
WO2002014877A3 PCT/US2001/024850 US0124850W WO0214877A3 WO 2002014877 A3 WO2002014877 A3 WO 2002014877A3 US 0124850 W US0124850 W US 0124850W WO 0214877 A3 WO0214877 A3 WO 0214877A3
Authority
WO
WIPO (PCT)
Prior art keywords
microscope slide
loader arm
storage rack
motor
storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024850
Other languages
French (fr)
Other versions
WO2002014877A2 (en
Inventor
Eric J Rollins
Joeben Bevirt
Joshua N Guyot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to AU2001281182A priority Critical patent/AU2001281182A1/en
Publication of WO2002014877A2 publication Critical patent/WO2002014877A2/en
Publication of WO2002014877A3 publication Critical patent/WO2002014877A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00533—Sheets essentially rectangular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0491—Position sensing, encoding; closed-loop control
    • G01N2035/0494—Detecting or compensating piositioning errors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Specific Conveyance Elements (AREA)
  • Jigs For Machine Tools (AREA)

Abstract

The present invention provides a retrieval unit for a microarray processing device to transport a workpiece such as a microscope slide before or after processing operations by the microarray processing device. The retrieval unit may include a storage unit and a lifter unit. The storage unit has a storage frame, a storage rack and a first motor. The storage rack is adapted to store microscope slides. The storage rack is mounted to the storage frame and capable of sliding in a first plane by the first motor. The lifter unit has a loader frame, a loader arm and a second motor. The loader arm is mounted to the loader frame and capable of sliding in a second plane by the second motor. The loader arm is capable of accessing a selected microscope slide from the storage rack. The loader arm uses a vacuum chuck to retain the microscope slide on the loader arm. The loader arm may also have a motor to enable it to extend the vacuum chuck below the bottom surface of a microscope slide. After the microscope slide is secured to the loader arm, the microscope slide may be transported from the storage rack to a selected workstation such as an alignment mechanism. The retrieval unit is automated by having a computer control the operations of the motors. The present invention also includes a method within a microarray processing machine for retrieving a microscope slide in a storage rack and transporting the microscope slide to a workstation such as an alignment mechanism.
PCT/US2001/024850 2000-08-11 2001-08-08 Microarray retrieval unit Ceased WO2002014877A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281182A AU2001281182A1 (en) 2000-08-11 2001-08-08 Microarray retrieval unit

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US22433600P 2000-08-11 2000-08-11
US22433500P 2000-08-11 2000-08-11
US22433700P 2000-08-11 2000-08-11
US22433800P 2000-08-11 2000-08-11
US60/224,335 2000-08-11
US60/224,336 2000-08-11
US60/224,338 2000-08-11
US60/224,337 2000-08-11
US63973400A 2000-08-15 2000-08-15
US63973100A 2000-08-15 2000-08-15
US63973200A 2000-08-15 2000-08-15
US63973300A 2000-08-15 2000-08-15
US09/639,731 2000-08-15
US09/639,734 2000-08-15
US09/638,733 2000-08-15
US09/639,732 2000-08-15

Publications (2)

Publication Number Publication Date
WO2002014877A2 WO2002014877A2 (en) 2002-02-21
WO2002014877A3 true WO2002014877A3 (en) 2003-01-03

Family

ID=27575221

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2001/024850 Ceased WO2002014877A2 (en) 2000-08-11 2001-08-08 Microarray retrieval unit
PCT/US2001/024844 Ceased WO2002013967A2 (en) 2000-08-11 2001-08-08 Microarray alignment mechanism
PCT/US2001/024994 Ceased WO2002014531A2 (en) 2000-08-11 2001-08-09 Microarray platen
PCT/US2001/024996 Ceased WO2002013968A2 (en) 2000-08-11 2001-08-09 Microarray placer unit

Family Applications After (3)

Application Number Title Priority Date Filing Date
PCT/US2001/024844 Ceased WO2002013967A2 (en) 2000-08-11 2001-08-08 Microarray alignment mechanism
PCT/US2001/024994 Ceased WO2002014531A2 (en) 2000-08-11 2001-08-09 Microarray platen
PCT/US2001/024996 Ceased WO2002013968A2 (en) 2000-08-11 2001-08-09 Microarray placer unit

Country Status (2)

Country Link
AU (4) AU2001281179A1 (en)
WO (4) WO2002014877A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6955788B2 (en) 2001-09-07 2005-10-18 Affymetrix, Inc. Apparatus and method for aligning microarray printing head
DE10261533A1 (en) * 2002-12-23 2004-07-15 BioChip Technologies GmbH Gesellschaft für Entwicklung und Produktion von Detektionssystemen Holder for slide onto which droplet array is deposited, includes locating stops on long side of slide support surface, used in conjunction with clamping system
JP2006126204A (en) * 2004-10-29 2006-05-18 Affymetrix Inc Automated method for manufacturing polymer array
HUP0700404A2 (en) * 2007-06-08 2009-03-30 3D Histech Kft Catch frame for slide and slide feeding unit
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
US10509216B2 (en) 2012-12-26 2019-12-17 Ventana Medical Systems, Inc. Specimen processing systems and methods for aligning slides
CN102010817B (en) * 2010-08-06 2013-05-22 博奥生物有限公司 Chip automatic loading device of microarray chip scanner
US10036690B2 (en) 2011-11-16 2018-07-31 Leica Biosystems Melbourne Pty Ltd Biological sample treatment apparatus
WO2013071357A2 (en) * 2011-11-16 2013-05-23 Leica Biosystems Melbourne Pty Ltd An automated system and method of treating tissue samples on slides
CA2893501A1 (en) * 2012-12-26 2014-07-03 Ventana Medical Systems, Inc. Specimen processing systems and methods for aligning slides
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN104007274B (en) * 2014-06-04 2016-02-03 上海宏莘科技发展有限公司 Folder off-type digital-code type fully-automatic intelligent sampler
DE102016125691B4 (en) 2016-12-23 2018-10-25 Leica Microsystems Cms Gmbh Holder for microscope slide, microscope and method for controlling a microscope
JP7126809B2 (en) * 2017-04-13 2022-08-29 浜松ホトニクス株式会社 Image acquisition device and image acquisition method

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US4224032A (en) * 1976-12-17 1980-09-23 Eastman Kodak Company Method and apparatus for chemical analysis
US4761075A (en) * 1985-12-10 1988-08-02 Hitachi, Ltd. Cellular analysis system
WO1992012233A1 (en) * 1991-01-11 1992-07-23 Medical Research Council Transfer of biological samples
US5690892A (en) * 1995-09-15 1997-11-25 Accumed, Inc. Cassette for use with automated specimen handling system
WO1998041531A2 (en) * 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US5853666A (en) * 1997-02-12 1998-12-29 Biomerieux Vitek, Inc. Optical reader and sample card transport stations for biological sample testing machine

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US4118280A (en) * 1976-05-03 1978-10-03 Mcdonnell Douglas Corporation Automated microbial analyzer
US4224032A (en) * 1976-12-17 1980-09-23 Eastman Kodak Company Method and apparatus for chemical analysis
US4761075A (en) * 1985-12-10 1988-08-02 Hitachi, Ltd. Cellular analysis system
WO1992012233A1 (en) * 1991-01-11 1992-07-23 Medical Research Council Transfer of biological samples
US5690892A (en) * 1995-09-15 1997-11-25 Accumed, Inc. Cassette for use with automated specimen handling system
US5853666A (en) * 1997-02-12 1998-12-29 Biomerieux Vitek, Inc. Optical reader and sample card transport stations for biological sample testing machine
WO1998041531A2 (en) * 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use

Also Published As

Publication number Publication date
WO2002013968A3 (en) 2003-01-16
WO2002013967A2 (en) 2002-02-21
AU2001281182A1 (en) 2002-02-25
WO2002014531A3 (en) 2003-01-16
WO2002014531A2 (en) 2002-02-21
WO2002014877A2 (en) 2002-02-21
AU2001281217A1 (en) 2002-02-25
AU2001279251A1 (en) 2002-02-25
WO2002013967A3 (en) 2002-08-08
WO2002013968A2 (en) 2002-02-21
AU2001281179A1 (en) 2002-02-25

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