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WO2002014348A3 - Glycoproteins and methods of use thereof - Google Patents

Glycoproteins and methods of use thereof Download PDF

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Publication number
WO2002014348A3
WO2002014348A3 PCT/US2001/025240 US0125240W WO0214348A3 WO 2002014348 A3 WO2002014348 A3 WO 2002014348A3 US 0125240 W US0125240 W US 0125240W WO 0214348 A3 WO0214348 A3 WO 0214348A3
Authority
WO
WIPO (PCT)
Prior art keywords
arp
brp
polypeptide
polynucleotides
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/025240
Other languages
French (fr)
Other versions
WO2002014348B1 (en
WO2002014348A2 (en
Inventor
Robert K Campbell
Tayar Nabil El
Chaomei He
Christie A Kelton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Priority to EP01962112A priority Critical patent/EP1330469A2/en
Priority to AU2001283319A priority patent/AU2001283319A1/en
Priority to JP2002519485A priority patent/JP2004527214A/en
Priority to IL15429701A priority patent/IL154297A0/en
Priority to CA002417141A priority patent/CA2417141A1/en
Publication of WO2002014348A2 publication Critical patent/WO2002014348A2/en
Anticipated expiration legal-status Critical
Publication of WO2002014348A3 publication Critical patent/WO2002014348A3/en
Publication of WO2002014348B1 publication Critical patent/WO2002014348B1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides novel isolated ARP/BRP polynucleotides and the membrane-associated or secreted polypeptides encoded by the ARP/BRP polynucleotides. Also provided are ARP and BRP protein multimers. Further provided are the antibodies that immunospecifically bind to a ARP/BRP polypeptide or any derivative, variant, mutant or fragment of the ARP/BRP polypeptide, a ARP/BRP multimer polynucleotide or antibody. The invention additionally provides methods in which the ARP/BRP polypeptide, multimer, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, e.g. reproductive disorder, as well as to other uses.
PCT/US2001/025240 2000-08-11 2001-08-10 Glycoproteins and methods of use thereof Ceased WO2002014348A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01962112A EP1330469A2 (en) 2000-08-11 2001-08-10 Glycoproteins and methods of use therefof
AU2001283319A AU2001283319A1 (en) 2000-08-11 2001-08-10 Glycoproteins and methods of use thereof
JP2002519485A JP2004527214A (en) 2000-08-11 2001-08-10 Novel glycoproteins and methods of their use
IL15429701A IL154297A0 (en) 2000-08-11 2001-08-10 Glycoproteins, their preparation and use
CA002417141A CA2417141A1 (en) 2000-08-11 2001-08-10 Novel glycoproteins and methods of use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22503500P 2000-08-11 2000-08-11
US60/225,035 2000-08-11
US85146501A 2001-05-08 2001-05-08
US09/851,465 2001-05-08

Publications (3)

Publication Number Publication Date
WO2002014348A2 WO2002014348A2 (en) 2002-02-21
WO2002014348A3 true WO2002014348A3 (en) 2003-05-15
WO2002014348B1 WO2002014348B1 (en) 2003-11-13

Family

ID=26919244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/025240 Ceased WO2002014348A2 (en) 2000-08-11 2001-08-10 Glycoproteins and methods of use thereof

Country Status (6)

Country Link
EP (1) EP1330469A2 (en)
JP (1) JP2004527214A (en)
AU (1) AU2001283319A1 (en)
CA (1) CA2417141A1 (en)
IL (1) IL154297A0 (en)
WO (1) WO2002014348A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2487419A1 (en) 2002-05-28 2003-12-04 Regents Of The University Of Minnesota Crisp polypeptides as contraceptives and inhibitors of sperm capacitation
CA2487924A1 (en) * 2002-06-10 2003-12-18 Zymogenetics, Inc. Use of corticotroph-derived glycoprotein hormone to treat inflammation and potentiate glucocorticoid action
WO2005058953A2 (en) * 2003-12-12 2005-06-30 Regeneron Pharmaceuticals, Inc. Ogh fusion polypeptides and therapeutic uses thereof
CN116676324B (en) * 2023-07-28 2023-10-27 四川大学华西医院 Constructing a system and method for releasing anti-tumor effector proteins based on Kil protein

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005224A1 (en) * 1994-08-12 1996-02-22 Washington University Single-chain forms of the glycoprotein hormone quartet
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
WO1999041377A1 (en) * 1998-02-13 1999-08-19 Zymogenetics, Inc. Novel cystine knot protein and materials and methods for making it
WO2000023473A1 (en) * 1998-10-19 2000-04-27 Washington University Multiple domain glycoprotein hormones and methods of using
WO2001040291A2 (en) * 1999-12-06 2001-06-07 Curagen Corporation Proteins and nucleic acids encoding the same
WO2001044475A1 (en) * 1999-12-17 2001-06-21 Takeda Chemical Industries, Ltd. Novel polypeptide and dna thereof
WO2001053346A1 (en) * 2000-01-18 2001-07-26 Akzo Nobel N.V. Human cystine knot polypeptide
WO2001060850A1 (en) * 2000-02-14 2001-08-23 Smithkline Beecham Corporation Novel compounds
WO2001073034A2 (en) * 2000-03-28 2001-10-04 Amgen Inc. Beta-like glycoprotein hormone polypeptide and heterodimer
WO2001085783A2 (en) * 2000-05-08 2001-11-15 Serono, Inc. Nucleic acids encoding polypeptides related to the alpha subunit of the glycoprotein hormone family and methods of use thereof
WO2002030978A1 (en) * 2000-10-06 2002-04-18 Regeneron Pharmaceuticals, Inc. Polypeptides, methods of making, and uses thereof

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
WO1996005224A1 (en) * 1994-08-12 1996-02-22 Washington University Single-chain forms of the glycoprotein hormone quartet
WO1999041377A1 (en) * 1998-02-13 1999-08-19 Zymogenetics, Inc. Novel cystine knot protein and materials and methods for making it
WO2000023473A1 (en) * 1998-10-19 2000-04-27 Washington University Multiple domain glycoprotein hormones and methods of using
WO2001040291A2 (en) * 1999-12-06 2001-06-07 Curagen Corporation Proteins and nucleic acids encoding the same
WO2001044475A1 (en) * 1999-12-17 2001-06-21 Takeda Chemical Industries, Ltd. Novel polypeptide and dna thereof
WO2001053346A1 (en) * 2000-01-18 2001-07-26 Akzo Nobel N.V. Human cystine knot polypeptide
WO2001060850A1 (en) * 2000-02-14 2001-08-23 Smithkline Beecham Corporation Novel compounds
WO2001073034A2 (en) * 2000-03-28 2001-10-04 Amgen Inc. Beta-like glycoprotein hormone polypeptide and heterodimer
WO2001085783A2 (en) * 2000-05-08 2001-11-15 Serono, Inc. Nucleic acids encoding polypeptides related to the alpha subunit of the glycoprotein hormone family and methods of use thereof
WO2002030978A1 (en) * 2000-10-06 2002-04-18 Regeneron Pharmaceuticals, Inc. Polypeptides, methods of making, and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 24 September 1999 (1999-09-24), HEILIG, R. ET AL.: "Human chromosome 14 DNA sequence BAC C-2011M8 of library CalTech-D from chromosome 14 of Homo sapiens (Human)", XP002210860, Database accession no. AL118555 *
DATABASE EMBL [online] CLIFTON, S. ET AL.: "db40d09.y1 Blackshear/Soares normalized Xenopus egg library Xenopus laevis cDNA clone IMAGE:3300977 5' similar to SW:GTHB_CYPCA P01235 GONADOTROPIN BETA CHAIN PRECURSOR. [2] SW:GTHB_CYPCA ;, mRNA sequence.", XP002210859, Database accession no. BE131943 *
NARAYAN PREMA ET AL: "A biologically active single chain human chorionic gonadotropin analog with altered receptor binding properties.", ENDOCRINOLOGY, vol. 141, no. 1, January 2000 (2000-01-01), pages 67 - 71, XP008007175, ISSN: 0013-7227 *

Also Published As

Publication number Publication date
EP1330469A2 (en) 2003-07-30
AU2001283319A1 (en) 2002-02-25
JP2004527214A (en) 2004-09-09
WO2002014348B1 (en) 2003-11-13
WO2002014348A2 (en) 2002-02-21
IL154297A0 (en) 2003-09-17
CA2417141A1 (en) 2002-02-21

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