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WO2002012523A3 - Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires - Google Patents

Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires Download PDF

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Publication number
WO2002012523A3
WO2002012523A3 PCT/NL2001/000595 NL0100595W WO0212523A3 WO 2002012523 A3 WO2002012523 A3 WO 2002012523A3 NL 0100595 W NL0100595 W NL 0100595W WO 0212523 A3 WO0212523 A3 WO 0212523A3
Authority
WO
WIPO (PCT)
Prior art keywords
chondrocytes
transduction
adenoviral vectors
nucleic acid
delivery vehicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NL2001/000595
Other languages
English (en)
Other versions
WO2002012523A2 (fr
Inventor
Menzo Jans Emco Havenga
Ronald Vogels
Abraham Bout
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Vaccines and Prevention BV
Original Assignee
Crucell Holand BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holand BV filed Critical Crucell Holand BV
Priority to CA2418977A priority Critical patent/CA2418977C/fr
Priority to DE60116513T priority patent/DE60116513T2/de
Priority to EP01974977A priority patent/EP1307573B1/fr
Priority to AU9434801A priority patent/AU9434801A/xx
Publication of WO2002012523A2 publication Critical patent/WO2002012523A2/fr
Publication of WO2002012523A3 publication Critical patent/WO2002012523A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10345—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C12N2810/6018—Adenoviridae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
PCT/NL2001/000595 2000-08-10 2001-08-09 Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires Ceased WO2002012523A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2418977A CA2418977C (fr) 2000-08-10 2001-08-09 Vecteurs de transfert de genes presentant une specificite vis-a-vis des chondrocytes humains primaires
DE60116513T DE60116513T2 (de) 2000-08-10 2001-08-09 Adenovirenvektoren zur transduktion der chondrozyten
EP01974977A EP1307573B1 (fr) 2000-08-10 2001-08-09 Vecteurs adenoviraux pour la transduction de chondrocytes
AU9434801A AU9434801A (en) 2000-08-10 2001-08-09 Gene delivery vectors with cell type specificity for primary human chondrocytes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00202835 2000-08-10
EP00202835.5 2000-08-10
US22491100P 2000-08-11 2000-08-11
US60/224,911 2000-08-11

Publications (2)

Publication Number Publication Date
WO2002012523A2 WO2002012523A2 (fr) 2002-02-14
WO2002012523A3 true WO2002012523A3 (fr) 2002-04-25

Family

ID=26072592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2001/000595 Ceased WO2002012523A2 (fr) 2000-08-10 2001-08-09 Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires

Country Status (8)

Country Link
US (2) US6803234B2 (fr)
EP (1) EP1307573B1 (fr)
AT (1) ATE315095T1 (fr)
AU (1) AU9434801A (fr)
CA (1) CA2418977C (fr)
DE (1) DE60116513T2 (fr)
ES (1) ES2256302T3 (fr)
WO (1) WO2002012523A2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017138A1 (en) * 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US20060238702A1 (en) 1999-04-30 2006-10-26 Advanced Medical Optics, Inc. Ophthalmic lens combinations
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
EP1157999A1 (fr) * 2000-05-24 2001-11-28 Introgene B.V. Méthodes et moyens pour améliorer la transplantation de la peau en utilisant des vecteurs d'apport de genes munis d'un tropisme pour des fibroblastes primaires ainsi que d'autres utilisations de celles-ci
ES2256302T3 (es) * 2000-08-10 2006-07-16 Crucell Holland B.V. Vectores adenovirales para la transduccion de condrocitos.
US7763069B2 (en) 2002-01-14 2010-07-27 Abbott Medical Optics Inc. Accommodating intraocular lens with outer support structure
US7662180B2 (en) 2002-12-05 2010-02-16 Abbott Medical Optics Inc. Accommodating intraocular lens and method of manufacture thereof
US8257963B2 (en) 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7927599B2 (en) * 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US20050131535A1 (en) 2003-12-15 2005-06-16 Randall Woods Intraocular lens implant having posterior bendable optic
CN100361710C (zh) * 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
WO2006061824A2 (fr) * 2004-12-06 2006-06-15 Prochon Biotech Limited Implant a base de chondrocytes pour l'administration d'agents therapeutiques
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US9636213B2 (en) 2005-09-30 2017-05-02 Abbott Medical Optics Inc. Deformable intraocular lenses and lens systems
US20080161914A1 (en) 2006-12-29 2008-07-03 Advanced Medical Optics, Inc. Pre-stressed haptic for accommodating intraocular lens
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8034108B2 (en) 2008-03-28 2011-10-11 Abbott Medical Optics Inc. Intraocular lens having a haptic that includes a cap
WO2010151693A2 (fr) 2009-06-26 2010-12-29 Abbott Medical Optics Inc. Lentilles intraoculaires pour accommodation
EP2461768B1 (fr) 2009-08-03 2020-02-19 Johnson & Johnson Surgical Vision, Inc. Lentille intraoculaire pour assurer une vision adaptative
IN2014CN04742A (fr) 2011-11-28 2015-09-18 Crucell Holland Bv
US9084674B2 (en) 2012-05-02 2015-07-21 Abbott Medical Optics Inc. Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity
KR102089121B1 (ko) 2013-03-14 2020-03-13 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양살상형 아데노바이러스 조성물
KR20250081944A (ko) 2014-09-24 2025-06-05 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
AU2017222568B2 (en) 2016-02-23 2020-09-10 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CN108699566B (zh) 2016-02-23 2023-06-30 萨克生物研究学院 对病毒动力学影响最小的治疗性腺病毒中的外源基因表达
CN110062630A (zh) 2016-12-12 2019-07-26 萨克生物研究学院 肿瘤靶向合成腺病毒及其用途
EP3681438A1 (fr) 2017-09-11 2020-07-22 AMO Groningen B.V. Procédés et appareils pour augmenter la stabilité de position de lentilles intraoculaires
CN112292449A (zh) 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000003029A2 (fr) * 1998-07-08 2000-01-20 Introgene B.V. Adenovirus chimeres
WO2000052186A1 (fr) * 1999-03-04 2000-09-08 Introgene B.V. Transduction de cellules ressemblant a des fibroblastes ou a des macrophages et moyens a cet effet

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846782A (en) * 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
JP2002525065A (ja) * 1998-09-11 2002-08-13 ジェンベク、インコーポレイティッド 選択的にターゲッティングされるアデノウイルス
US6869936B1 (en) * 1999-03-04 2005-03-22 Crucell Holland B.V. Means and methods for fibroblast-like or macrophage-like cell transduction
US6315992B1 (en) * 1999-06-30 2001-11-13 Tissuegene Co. Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1
US6445314B1 (en) * 2000-03-01 2002-09-03 Cisco Technology Inc. System and method for the decoding of variable length codes
US6939540B1 (en) * 2000-07-31 2005-09-06 Cornell Research Foundation, Inc. Method of enhancing bone density
ES2256302T3 (es) * 2000-08-10 2006-07-16 Crucell Holland B.V. Vectores adenovirales para la transduccion de condrocitos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000003029A2 (fr) * 1998-07-08 2000-01-20 Introgene B.V. Adenovirus chimeres
WO2000052186A1 (fr) * 1999-03-04 2000-09-08 Introgene B.V. Transduction de cellules ressemblant a des fibroblastes ou a des macrophages et moyens a cet effet

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ARTHRITIS AND RHEUMATISM, (2000 MAY) 43 (5) 1156-64. *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, BARAGI VIJAYKUMAR M ET AL: "Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation.", XP002162078, Database accession no. PREV199698588719 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, DUPREZ DELPHINE ET AL: "Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb.", XP002162080, Database accession no. PREV199699148352 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, ARAI YUJI ET AL: "Adenovirus vector-mediated gene transduction to chondrocytes: In vitro evaluation of therapeutic efficacy of transforming growth factor-beta-1 and heat shock protein 70 gene transduction.", XP002162076, Database accession no. PREV199799748286 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; August 1999 (1999-08-01), ARAI YUJI ET AL: "Control of delivered gene expression in chondrocytes using heat shock protein 70B promoter.", XP002162077, Database accession no. PREV199900386530 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; SMITH P ET AL: "Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin -1.", XP002162079, retrieved from STN Database accession no. 2000275271 *
JOURNAL OF CLINICAL INVESTIGATION, vol. 96, no. 5, 1995, pages 2454 - 2460, ISSN: 0021-9738 *
JOURNAL OF RHEUMATOLOGY, vol. 24, no. 9, 1997, pages 1787 - 1795, ISSN: 0315-162X *
JOURNAL OF RHEUMATOLOGY, vol. 26, no. 8, August 1999 (1999-08-01), pages 1769 - 1774, ISSN: 0315-162X *
MECHANISMS OF DEVELOPMENT, vol. 57, no. 2, 1996, pages 145 - 157, ISSN: 0925-4773 *

Also Published As

Publication number Publication date
DE60116513T2 (de) 2006-09-21
AU9434801A (en) 2002-02-18
ATE315095T1 (de) 2006-02-15
DE60116513D1 (de) 2006-03-30
EP1307573B1 (fr) 2006-01-04
EP1307573A2 (fr) 2003-05-07
CA2418977C (fr) 2011-01-18
US6803234B2 (en) 2004-10-12
US20040142472A1 (en) 2004-07-22
US20020115218A1 (en) 2002-08-22
ES2256302T3 (es) 2006-07-16
CA2418977A1 (fr) 2002-02-14
WO2002012523A2 (fr) 2002-02-14

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