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WO2002011613A2 - Apparatus for aspirating sample fluids - Google Patents

Apparatus for aspirating sample fluids Download PDF

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Publication number
WO2002011613A2
WO2002011613A2 PCT/GB2001/003535 GB0103535W WO0211613A2 WO 2002011613 A2 WO2002011613 A2 WO 2002011613A2 GB 0103535 W GB0103535 W GB 0103535W WO 0211613 A2 WO0211613 A2 WO 0211613A2
Authority
WO
WIPO (PCT)
Prior art keywords
source
valve
chamber
suction
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/003535
Other languages
French (fr)
Other versions
WO2002011613A3 (en
Inventor
Sam Chhaya
Geoffrey Cusick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London Hospitals NHS Foundation Trust (UCLH)
Original Assignee
University College London Hospitals NHS Foundation Trust (UCLH)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College London Hospitals NHS Foundation Trust (UCLH) filed Critical University College London Hospitals NHS Foundation Trust (UCLH)
Priority to AU2001276523A priority Critical patent/AU2001276523A1/en
Publication of WO2002011613A2 publication Critical patent/WO2002011613A2/en
Publication of WO2002011613A3 publication Critical patent/WO2002011613A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe

Definitions

  • the present invention relates to apparatus for the aspiration of samples
  • Such samples are used for example in cytological examination.
  • hypodermic needle Typically this is achieved by the use of a hypodermic needle and
  • the technique requires medical staff to insert the needle at the correct location
  • sample of cellular material is drawn up (aspirated) into the needle.
  • the material can be any material that can be used to release and the needle withdrawn from the patient.
  • the material can be any material that can be used to release the needle withdrawn from the patient.
  • the target is usually either a visible or palpable mass or lesion seen
  • US-A-2460641 describes a system in which a previously evacuated flask is
  • the present invention seeks to enable the single handed operation of a device
  • the present invention therefore provides apparatus comprising a sample receiving chamber connectable to a source of suction via a valve within the chamber, and an externally accessible operating mechanism linked to the valve thereby to permit selective connection between the chamber and the source.
  • the source of suction is preferably a previously evacuated vessel. This will ideally have a wall section made of a penetrable membrane such as rubber.
  • a cannula or other sharp tipped conduit will thus be able to gain access to the vacuum.
  • the evacuated vessel could be integrated into the apparatus if desired.
  • the valve preferably comprises a resilient member normally biased to rest in a sealing fashion against an outlet of the source of suction.
  • the operating mechanism is preferably operable by squeezing the apparatus.
  • a suitable mechanism is a compressible portion of the apparatus within which at least one substantially rigid rod members is attached at one end to the interior of the compressible portion and at the other to the valve and disposed at an angle to the compression direction. This arrangement results in the valve being displaced when the compressible portion is compressed.
  • a preferred arrangement is one in which the apparatus is elongate with an annular thinned region thereabout to enable local compression.
  • the valve can be located within the chamber to selectively seal a conduit leading to the chamber from the source of suction.
  • Figure 1 is a cross section through the example of the invention prior to use
  • Figure 2 is a cross section corresponding to figure 1 , showing the example in use;
  • Figure 3 is a cross section on Ill-Ill of figure 1 ;
  • Figure 4 shows the manner of expulsion of a sample from the example.
  • figure 1 shows an apparatus 10 according to the invention which comprises an elongate barrel 1 2.
  • the barrel has an open rear end 14 and a front end 1 6 which tapers to a conventional fitting 1 8 for a hypodermic needle 8, such as a Luer fitting.
  • a disposable reservoir 20 is pre-evacuated and in the form of a cylinder sized to fit within the barrel.
  • One end of the reservoir is sealed with a membrane 22 which extends across that end and attaches to the outer face of the cylinder.
  • Sealing fins 24 extend outwardly to take up the tolerance between the outside of the reservoir and the inside of the barrel.
  • an interior wall 26 divides the interior of the barrel into a sample region 28 and a reservoir-receiving region 30.
  • the interior wall 26 is solid except for a central flow passage 32 extending into the reservoir-receiving region 30 and ending in a spike 34.
  • a valve member 36 is located in the sample region 28 and has a tapered tip adapted to fit into the flow passage 32 in a sealing manner.
  • the valve member 36 is held in place by a plurality of substantially rigid rod members 38 which are attached at another end to internal faces of the barrel. These rod members are shown in more detail in figure 3 and form spokes about the valve member 36 in order to support it without preventing fluid flow in its vicinity.
  • the rod members are disposed within the barrel 1 2 at an acute angle to the radial dimension.
  • the barrel wall is locally thinned in the region 40 where the rod members 38 are attached. This allows the barrel to be compressed in this region, deflecting the rod members due to the angle between them and the radial compression direction. This lifts the valve member 36 from the flow passage 32.
  • FIG. 1 A hypodermic needle 8 is fitted onto the fitting 1 8.
  • the reservoir is pushed home onto the spike 34, piercing the membrane 22.
  • the valve member 36 prevents loss of the vacuum within the reservoir.
  • the operator holds the apparatus as in the manner of a pencil, with thumb and forefinger lying gently on the locally thinned region 40, and the hypodermic is inserted into the appropriate area of the patient.
  • the operator squeezes with thumb and forefinger, lifting the valve member from the passage 32 and allowing fluid communication between the reservoir 20 and the sample region 28.
  • This evacuates the sample region 28 and a sample from the patient is drawn in the manner of US 2,460,641 .
  • the pressure on the thinned region 40 is relaxed allowing the valve member to return to the a sealing position on the passage 32. Flow then stops and the hypodermic can be removed from the patient.
  • the hypodermic 8 can (if desired) be removed, and the reservoir is removed and re-inserted in the barrel in a reversed orientation as shown in figure 4.
  • the rear end of the reservoir is for this purpose formed with a sealing ring 42 about its outer edge to seal against the interior of the barrel 1 2, and a recess 44 adapted to accommodate the spike 34 when fully home.
  • a suitably positioned receptacle can then be employed to collect the sample.
  • the present invention permits the extraction of a sample from a patient with only single-handed operation at all material times.
  • the reservoir could be replaced with a switchable source of vacuum or gas.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Manufacturing & Machinery (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

An apparatus (10) for aspirating a sample is disclosed that comprises a sample-receiving chamber (28) connectable to a source of suction (20) via a valve (369 within the chamber (28), and an externally accessible operating mechanism (40) linked to the valve (36), thereby to permit selective connection between the chamber (28) and the source (20). The apparatus (10) allows for the single-handed fine needle aspiration of cytological specimens.

Description

ASPIRATION OF SAMPLES
The present invention relates to apparatus for the aspiration of samples,
particularly (but not exclusively) from solid human tissue and fluid samples.
Such samples are used for example in cytological examination.
It is common in medical practice to draw (aspirate) samples of tissue from a
patient so that cells within the sample can be analysed to assist in the diagnosis
of the patient. Typically this is achieved by the use of a hypodermic needle and
syringe to withdraw a sample of tissue from the appropriate location.
The technique requires medical staff to insert the needle at the correct location
and then withdraw the plunger to create a vacuum within the syringe. The
whole apparatus is then manipulated back and forth through the region of interest with continual vacuum being applied. In the case of a fluid or cystic
lesion such manipulation would not be required. The aim being that a small
sample of cellular material is drawn up (aspirated) into the needle. The vacuum
is then released and the needle withdrawn from the patient. The material can
then be sent for cytological examination. This technique requires targeting of
the needle. The target is usually either a visible or palpable mass or lesion seen
under some form of radiological imaging. One hand is needed to either stabilise
the lesion or manipulate the imaging device leaving only one hand free to
operate the syringe. Ensuring the accurate placement of the needle tip when
withdrawing the plunger of the syringe with one hand is difficult.
US-A-2460641 describes a system in which a previously evacuated flask is
impaled on a cannula which has been inserted into a vein. Thus, the vacuum
in the flask withdraws blood from the patient.
The present invention seeks to enable the single handed operation of a device
to assist in the fine needle aspiration of cytological specimens. This would free
the operator's spare hand for other uses, such as manipulation of an imaging
device used to ensure that the needle is in the correct location of stabilisation of the lesion or the like. In this way, a signal handed operation would be more
reliable and accurate.
The present invention therefore provides apparatus comprising a sample receiving chamber connectable to a source of suction via a valve within the chamber, and an externally accessible operating mechanism linked to the valve thereby to permit selective connection between the chamber and the source.
The source of suction is preferably a previously evacuated vessel. This will ideally have a wall section made of a penetrable membrane such as rubber.
A cannula or other sharp tipped conduit will thus be able to gain access to the vacuum. However, the evacuated vessel could be integrated into the apparatus if desired.
The valve preferably comprises a resilient member normally biased to rest in a sealing fashion against an outlet of the source of suction. The operating mechanism is preferably operable by squeezing the apparatus. A suitable mechanism is a compressible portion of the apparatus within which at least one substantially rigid rod members is attached at one end to the interior of the compressible portion and at the other to the valve and disposed at an angle to the compression direction. This arrangement results in the valve being displaced when the compressible portion is compressed.
Thus, a preferred arrangement is one in which the apparatus is elongate with an annular thinned region thereabout to enable local compression. The valve can be located within the chamber to selectively seal a conduit leading to the chamber from the source of suction.
An embodiment of the invention will now be described by way of example with reference to the accompanying drawings, in which;
Figure 1 is a cross section through the example of the invention prior to use;
Figure 2 is a cross section corresponding to figure 1 , showing the example in use;
Figure 3 is a cross section on Ill-Ill of figure 1 ; and
Figure 4 shows the manner of expulsion of a sample from the example.
Referring to the figures, figure 1 shows an apparatus 10 according to the invention which comprises an elongate barrel 1 2. The barrel has an open rear end 14 and a front end 1 6 which tapers to a conventional fitting 1 8 for a hypodermic needle 8, such as a Luer fitting.
A disposable reservoir 20 is pre-evacuated and in the form of a cylinder sized to fit within the barrel. One end of the reservoir is sealed with a membrane 22 which extends across that end and attaches to the outer face of the cylinder. Sealing fins 24 extend outwardly to take up the tolerance between the outside of the reservoir and the inside of the barrel. Within the barrel, an interior wall 26 divides the interior of the barrel into a sample region 28 and a reservoir-receiving region 30. The interior wall 26 is solid except for a central flow passage 32 extending into the reservoir-receiving region 30 and ending in a spike 34.
A valve member 36 is located in the sample region 28 and has a tapered tip adapted to fit into the flow passage 32 in a sealing manner. The valve member 36 is held in place by a plurality of substantially rigid rod members 38 which are attached at another end to internal faces of the barrel. These rod members are shown in more detail in figure 3 and form spokes about the valve member 36 in order to support it without preventing fluid flow in its vicinity. The rod members are disposed within the barrel 1 2 at an acute angle to the radial dimension.
The barrel wall is locally thinned in the region 40 where the rod members 38 are attached. This allows the barrel to be compressed in this region, deflecting the rod members due to the angle between them and the radial compression direction. This lifts the valve member 36 from the flow passage 32.
The use of the apparatus 10 is illustrated in figure 2. A hypodermic needle 8 is fitted onto the fitting 1 8. The reservoir is pushed home onto the spike 34, piercing the membrane 22. At this point, the valve member 36 prevents loss of the vacuum within the reservoir. The operator holds the apparatus as in the manner of a pencil, with thumb and forefinger lying gently on the locally thinned region 40, and the hypodermic is inserted into the appropriate area of the patient. When it is located correctly, the operator squeezes with thumb and forefinger, lifting the valve member from the passage 32 and allowing fluid communication between the reservoir 20 and the sample region 28. This evacuates the sample region 28 and a sample from the patient is drawn in the manner of US 2,460,641 . When an adequate sample has been drawn, the pressure on the thinned region 40 is relaxed allowing the valve member to return to the a sealing position on the passage 32. Flow then stops and the hypodermic can be removed from the patient.
To expel the sample, the hypodermic 8 can (if desired) be removed, and the reservoir is removed and re-inserted in the barrel in a reversed orientation as shown in figure 4. The rear end of the reservoir is for this purpose formed with a sealing ring 42 about its outer edge to seal against the interior of the barrel 1 2, and a recess 44 adapted to accommodate the spike 34 when fully home. As the reservoir travels along the barrel, an air pressure will build up in front of it which will lift the valve member 36 and expel the sample through the fitting 1 8 or hypodermic 8. A suitably positioned receptacle can then be employed to collect the sample.
Thus, the present invention permits the extraction of a sample from a patient with only single-handed operation at all material times.
Many variations could be made to the above-described apparatus without departing from the present invention. For example, the reservoir could be replaced with a switchable source of vacuum or gas.

Claims

CLAIMS:
1 . Apparatus for aspirating a sample comprising a sample-receiving chamber connectable to a source of suction via a valve within the chamber, and an externally accessible operating mechanism linked to the valve thereby to permit selective connection between the chamber and the source.
2. Apparatus as claimed in claim 1 , wherein the source of suction is a previously evacuated vessel.
3. Apparatus as claimed in claim 2, wherein the evacuated vessel is integrated into the apparatus.
4. Apparatus as claimed in any preceding claim, wherein the source of suction comprises a wall section made of a penetrable membrane such as rubber.
5. Apparatus as claimed in any preceding claim, wherein the valve comprises a resilient member.
6. Apparatus as claimed in claim 5, wherein the resilient member is biased to rest in a sealing fashion against an outlet of the source of suction.
7. Apparatus as claimed in any preceding claim, wherein the operating mechanism is operable by squeezing the apparatus.
8. Apparatus as claimed in any preceding claim, wherein the operating mechanism is a compressible portion of the apparatus within which at least one substantially rigid rod members is attached at one end to the interior of the compressible portion and at the other to the valve and disposed at an angle to the compression direction.
9. Apparatus as claimed in any preceding claim, wherein the apparatus is elongate with an annular thinned region thereabout to enable local compression.
1 0. Apparatus as claimed in any preceding claim, wherein the valve is located within the chamber to selectively seal a conduit leading to the chamber from the source of suction.
PCT/GB2001/003535 2000-08-08 2001-08-06 Apparatus for aspirating sample fluids Ceased WO2002011613A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001276523A AU2001276523A1 (en) 2000-08-08 2001-08-06 Aspiration of samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0019466A GB2368286A (en) 2000-08-08 2000-08-08 Aspirating sample collection device
GB0019466.2 2000-08-08

Publications (2)

Publication Number Publication Date
WO2002011613A2 true WO2002011613A2 (en) 2002-02-14
WO2002011613A3 WO2002011613A3 (en) 2002-04-11

Family

ID=9897216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/003535 Ceased WO2002011613A2 (en) 2000-08-08 2001-08-06 Apparatus for aspirating sample fluids

Country Status (3)

Country Link
AU (1) AU2001276523A1 (en)
GB (1) GB2368286A (en)
WO (1) WO2002011613A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020439A2 (en) 2006-08-17 2008-02-21 Sialo Technology Israel Ltd All-in-one optical microscopic handle
WO2014185904A1 (en) * 2013-05-15 2014-11-20 Becton, Dickinson And Company Vacuum pressure regulators for use during blood collection
CN109069133A (en) * 2016-01-28 2018-12-21 陶乐发展有限公司 Bioassay syringe
CN109777725A (en) * 2019-02-25 2019-05-21 珠海迪尔生物工程有限公司 A kind of automatic transferred species formula Blood culture machine
US10888262B2 (en) 2013-05-15 2021-01-12 Becton, Dickinson And Company Vacuum pressure regulators for use during blood collection

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0608046D0 (en) 2006-04-25 2006-05-31 Star Syringe Ltd Syringe

Family Cites Families (11)

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US3906930A (en) * 1973-03-23 1975-09-23 Dr Luis A Guerra Blood taking device
US3939822A (en) * 1974-08-14 1976-02-24 Jack Markowitz Disposable blood collection and filtering device
US4073288A (en) * 1976-06-21 1978-02-14 Chapman Samuel L Blood sampling syringe
US4166450A (en) * 1977-07-22 1979-09-04 Metatech Corporation Device and procedure for collecting a succession of intravenous blood samples
DE2750454C3 (en) * 1977-11-11 1981-01-08 Walter Sorstedt Kunststoff-Spritzgusswerk, 5223 Nuembrecht Device for taking blood
US4215702A (en) * 1978-01-12 1980-08-05 Patrick Ayer Arterial blood extraction device
US4326541A (en) * 1980-03-24 1982-04-27 Arnold M. Heyman Blood sample taking device
US4340068A (en) * 1980-06-18 1982-07-20 Becton, Dickinson And Company Multiple sample needle with vein entry indicator
US5097842A (en) * 1990-07-23 1992-03-24 Bonn Gina B Device for withdrawing fluids
US5368029A (en) * 1992-04-16 1994-11-29 Holcombe; David A. Integral catheter and blood tester
IES81031B2 (en) * 1998-03-25 1999-10-20 Trinity College Dublin A device for acquiring body samples for analysis

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020439A2 (en) 2006-08-17 2008-02-21 Sialo Technology Israel Ltd All-in-one optical microscopic handle
WO2014185904A1 (en) * 2013-05-15 2014-11-20 Becton, Dickinson And Company Vacuum pressure regulators for use during blood collection
CN105307707A (en) * 2013-05-15 2016-02-03 贝克顿·迪金森公司 Vacuum pressure regulators for use during blood collection
CN105307707B (en) * 2013-05-15 2018-07-27 贝克顿·迪金森公司 The vacuum pressure adjuster used during blood collection
US10357192B2 (en) 2013-05-15 2019-07-23 Becton, Dickinson And Company Vacuum pressure regulators for use during blood collection
US10888262B2 (en) 2013-05-15 2021-01-12 Becton, Dickinson And Company Vacuum pressure regulators for use during blood collection
CN109069133A (en) * 2016-01-28 2018-12-21 陶乐发展有限公司 Bioassay syringe
CN109777725A (en) * 2019-02-25 2019-05-21 珠海迪尔生物工程有限公司 A kind of automatic transferred species formula Blood culture machine
CN109777725B (en) * 2019-02-25 2023-12-01 珠海迪尔生物工程股份有限公司 Automatic seed-transferring type blood culture instrument

Also Published As

Publication number Publication date
GB0019466D0 (en) 2000-09-27
GB2368286A (en) 2002-05-01
WO2002011613A3 (en) 2002-04-11
AU2001276523A1 (en) 2002-02-18

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