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WO2002010345A3 - Autologous bio-matrix from mammalian liver - Google Patents

Autologous bio-matrix from mammalian liver Download PDF

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Publication number
WO2002010345A3
WO2002010345A3 PCT/EP2001/008646 EP0108646W WO0210345A3 WO 2002010345 A3 WO2002010345 A3 WO 2002010345A3 EP 0108646 W EP0108646 W EP 0108646W WO 0210345 A3 WO0210345 A3 WO 0210345A3
Authority
WO
WIPO (PCT)
Prior art keywords
bio
matrix
liver
human
autologous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/008646
Other languages
French (fr)
Other versions
WO2002010345A2 (en
Inventor
Giovanni Ambrosino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2001289759A priority Critical patent/AU2001289759A1/en
Publication of WO2002010345A2 publication Critical patent/WO2002010345A2/en
Publication of WO2002010345A3 publication Critical patent/WO2002010345A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention concerns an autologous bio-matrix derived from liver of porcine or human origin, which is able to constitute a functional bio-artificial support of hepatic cells homologous with its origin. In fact, the bio-matrix allows the anchoring of the hepatocytes, taken from porcine or human liver and cultivated in vitro, according to a very precise polar arrangement and lets the same arrange themselves in culture in a functional and specific way. This important biological property makes the bio-matrix particularly useful in the support of hepatic cells, also human, used in extracorporeal type apparatuses, such as the bio-artificial liver, or in the transplantation of hepatic cells, both of which may be used for the treatment of acute or chronic hepatic pathologies. The bio-matrix can also be used for experimental purposes for in vitro studies on the function of hepatocytes.
PCT/EP2001/008646 2000-07-28 2001-07-26 Autologous bio-matrix from mammalian liver Ceased WO2002010345A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289759A AU2001289759A1 (en) 2000-07-28 2001-07-26 Autologous bio-matrix from mammalian liver

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2000A001744 2000-07-28
IT2000MI001744A IT1318655B1 (en) 2000-07-28 2000-07-28 AUTOLOGOUS BIO-MATRIX FROM LIVER OF MAMMALS AND METHOD FOR OBTAINING THE SAME.

Publications (2)

Publication Number Publication Date
WO2002010345A2 WO2002010345A2 (en) 2002-02-07
WO2002010345A3 true WO2002010345A3 (en) 2002-08-15

Family

ID=11445601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008646 Ceased WO2002010345A2 (en) 2000-07-28 2001-07-26 Autologous bio-matrix from mammalian liver

Country Status (3)

Country Link
AU (1) AU2001289759A1 (en)
IT (1) IT1318655B1 (en)
WO (1) WO2002010345A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998025637A1 (en) * 1996-12-10 1998-06-18 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998025637A1 (en) * 1996-12-10 1998-06-18 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AMBROSINO G ET AL: "A new acellular autologus biomatrix as a hepatocytes support for bioartificial liver: A model to prolong cultured hepatocytes function and survival in swine.", HEPATOLOGY, vol. 28, no. 4 PART 2, October 1998 (1998-10-01), Biennial Scientific Meeting of the International Association for the Study of the Liver and the 49th Annual Meeting and Postgraduate Courses of the American Association for the Study of Liver Diseases, pages 331A, XP002198138, ISSN: 0270-9139 *
AMBROSINO G ET AL: "Hepatocyte transplantation: An experimental study to treat acute liver failure in pigs.", TRANSPLANTATION PROCEEDINGS, vol. 33, no. 1-2, February 2001 (2001-02-01), XVIII International Congress of the Transplantation Society;Rome, Italy; August 29-September 01, 2000, pages 62 - 65, XP001064735, ISSN: 0041-1345 *
AMBROSINO GIOVANNI ET AL: "A new artificial liver bioreactor containing acellular autologus biomatrix (ABM) and hepatic cells.", GASTROENTEROLOGY, vol. 116, no. 4 PART 2, April 1999 (1999-04-01), Digestive Disease Week and the 100th Annual Meeting of the American Gastroenterological Association;Orlando, Florida, USA; May 16-19, 1999, pages A1182 - A1183, XP001073641, ISSN: 0016-5085 *
ROJKIND M ET AL: "CONNECTIVE TISSUE BIO MATRIX ITS ISOLATION AND UTILIZATION FOR LONG-TERM CULTURES OF NORMAL RAT HEPATOCYTES", JOURNAL OF CELL BIOLOGY, vol. 87, no. 1, 1980, pages 255 - 263, XP001073638, ISSN: 0021-9525 *
SAITO S ET AL: "A new hybrid artificial liver using a combination of hepatocytes and biomatrix.", ASAIO TRANSACTIONS / AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS. UNITED STATES 1987 JUL-SEP, vol. 33, no. 3, July 1987 (1987-07-01), pages 459 - 462, XP001073646, ISSN: 0889-7190 *

Also Published As

Publication number Publication date
IT1318655B1 (en) 2003-08-27
ITMI20001744A0 (en) 2000-07-28
WO2002010345A2 (en) 2002-02-07
AU2001289759A1 (en) 2002-02-13
ITMI20001744A1 (en) 2002-01-28

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