[go: up one dir, main page]

WO2002003929A1 - Composition de filtre solaire presentant un facteur de protection solaire (fps) et une resistance a l'eau ameliores - Google Patents

Composition de filtre solaire presentant un facteur de protection solaire (fps) et une resistance a l'eau ameliores Download PDF

Info

Publication number
WO2002003929A1
WO2002003929A1 PCT/US2001/021588 US0121588W WO0203929A1 WO 2002003929 A1 WO2002003929 A1 WO 2002003929A1 US 0121588 W US0121588 W US 0121588W WO 0203929 A1 WO0203929 A1 WO 0203929A1
Authority
WO
WIPO (PCT)
Prior art keywords
sunscreen
formulation
sunscreen formulation
agent
dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/021588
Other languages
English (en)
Inventor
Duncan T. Aust
James M. Wilmott
James A. Hayward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Collaborative Technologies Inc
Original Assignee
Collaborative Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collaborative Technologies Inc filed Critical Collaborative Technologies Inc
Priority to US10/332,393 priority Critical patent/US20030228267A1/en
Priority to AU2001278885A priority patent/AU2001278885A1/en
Publication of WO2002003929A1 publication Critical patent/WO2002003929A1/fr
Anticipated expiration legal-status Critical
Priority to US11/114,668 priority patent/US7175834B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof

Definitions

  • the present invention relates to a surfactant-free sunscreen composition
  • a surfactant-free sunscreen composition comprising a base and dispersion of a sunscreen active agent, and a method of use thereof.
  • these emulsion-based formulations often include waterproofing agents, such as high molecular weight resins such as high molecular weight silicon fluids, to improve the water resistant properties of the sunscreen formulations.
  • waterproofing agents adds cost to the formulations and causes a deterioration of the product's aesthetic properties.
  • the present invention provides a sunscreen formulation comprising (a) a dispersion comprising a sunscreen active agent and (b) a base composition comprising a rheological modifying agent and water.
  • the sunscreen formulation is substantially free of surfactants.
  • the dispersion has a particle size of from about 50 to 1000 nm, preferably from about 300 to 800 nm.
  • the dispersion contains suspended particles in an amount of from about 0.01 to about 70% by weight of suspended particles, based upon 100% weight of total dispersion.
  • the dispersion contains from about 1.0 to 60% by weight of suspended particles, based upon 100% weight of total dispersion.
  • the base composition typically comprises from about 0.001 to about 50% and preferably from about 0.01 to about 10%, and more preferably from about 0.1 to about 5% by weight of rheological modifying agents.
  • the base composition typically comprises from about
  • the sunscreen formulation contains from about 0.1 to about 60% by weight, preferably from about 1 to about 60% by weight, and more preferably from about 10 to about 50% by weight of the sunscreen agent containing dispersion, based upon 100% weight of total sunscreen formulation.
  • the sunscreen formulation also typically contains from about 0.01 to about 100% by weight, preferably from about 0.1 to about 90% by weight, and more preferably from about 5 to about 80% by weight of the base composition, based upon 100% weight of total sunscreen formulation.
  • the dispersion is preferably prepared by high pressure/high shear processing.
  • the sunscreen active agent is selected from the group consisting of ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, octocrylane, octyl salicylate, benzophenone-3, or a combination thereof.
  • the base composition preferably comprises a phosphorylated starch derivative as a rheological modifying agent.
  • the sunscreen formulation of the present invention exhibits superior ultraviolet protection to the skin and hair and demonstrates enhanced water resistance over prior art sunscreen compositions containing emulsions.
  • Another embodiment of the present invention is a method of protecting skin or hair from ultraviolet (UN) radiation by applying an effective amount of the sunscreen formulation of the present invention to the skin or hair.
  • the formulation remains on the skin or hair for longer periods of time due to enhanced water resistance.
  • a most preferred sunscreen formulation of the invention comprises a dispersion comprising water, ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, cyclomethicone, and phospholipids.
  • HPHS high pressure high shear
  • the compositions of the present invention exhibit a high degree of uniformity as a consequence of the high pressure and high shear process by which the aqueous and hydrophobic phases are mixed.
  • the particles in the suspended phase of the dispersion typically have a very small particle size of less than lOOOnm.
  • the sunscreen formulation of the present invention exhibits superior ultraviolet protection (against UV-A (320-400 nm) and UN-B (280-320 nm) radiation) and water resistance than prior art sunscreen compositions.
  • water resistance is defined as the inability of the material to be removed from the surface to which it is applied in the presence of water. Since the sunscreen formulation is highly water resistant, frequent application of the formulation is not needed, thereby reducing the likelihood of sunburn and the cost to the consumer. Furthermore, since dispersions of the sunscreen agent are homogeneous, the sunscreen agent in the formulation applies uniformly and evenly to the skin and hair to provide comprehensive coverage. Dispersions of Sunscreen Agents
  • the term "dispersion” as used herein refers to a suspension of liquid or solid particles of colloidal size or larger in a liquid medium.
  • the dispersion contains suspended particles, such as oil particles (or oil droplets), having a diameter less than about 1000 nm.
  • the sunscreen agent is typically incorporated into the dispersion as suspended particles.
  • the diameter of the suspended particles preferably ranges from about 50 nm to about 1000 nm and more preferably from about 300 to about 800 nm.
  • the suspended particles contain one or more lipophilic materials.
  • the suspended particles may have a charge as determined by zeta potential measurements.
  • the dispersion is preferably prepared by high pressure/high shear mixing, such as described in US Patent #4,533,254.
  • High pressure or high shear mixing maybe be performed in equipment which includes homogenizers such as a Microfluidizer, DeBee high pressure homogenizer, a french press and a Gaulin homogenizer or "Rotor Stator” devices such as a Symex mill, a Silverson mill and a Ross mill.
  • the dispersion containing the suspended particles generally contains from about
  • the dispersion contains from about 1.0 to about 60% by weight of suspended particles, based upon 100% weight of total dispersion.
  • the dispersion may contain hydrophobic active agents and hydrophobic adjuvants.
  • a hydrophobic active agent or hydrophobic adjuvant is an active agent or adjuvant that has a non polar property which makes it essentially insoluble in water or water and polar solvent solutions.
  • Hydrophobic active agents and hydrophobic adjuvants of the present invention include, but are not limited to, partially and fully hydrophobic active agents and partially and fully hydrophobic adjuvants.
  • hydrophobic active agents encompassed by the present invention include compounds and complexes which contain a hydrophobic moiety.
  • Suitable sunscreen agents include, but are not limited to, agents that absorb ultraviolet radiation, such as UN-A (320-400 nm) and UN-B (280-320 nm) radiation.
  • Preferred sunscreen agents include those which form a physical and/or chemical barrier between UN radiation and the surface to which they are applied.
  • sunscreen agents include ethylhexylmethoxycinnamate (OMC), butylmethoxydibenzoylmethane, methoxydibenzoylmethane, avobenzone, benzophenone-3, octacrylene, titanium dioxide, zinc oxide, aminobenzoic acid, cinoxate, dioxybenzone, homosalate, menthyl anthranilate, octocrylene, octisalate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzone, trolamine salicylate and any combination of any of the foregoing.
  • the dispersion contains ethylhexyl methoxycinnamate, butylmethoxydibenzoylmethane, or a combination thereof.
  • Rheological modifying agents within the scope of the invention include any substance which increases or decreases the viscosity of the sunscreen formulation.
  • Suitable rheological modifying agents include, but are not limited to, phosphorylated starch derivatives, carbohydrate based rheological modifying agents, polymeric and copolymeric rheological modifying agents, inorganic rheological modifying agents, protein rheological modifying agents, polypeptide rheological modifying agents, and any combination of any of the foregoing.
  • the term "phosphorylated starch derivative" includes, but is not limited to, starches containing a phosphate group.
  • Suitable phosphorylated starch derivatives include, but are not limited to, hydroxyalkyl starch phosphates, hydroxyalkyl distarch phosphates, and any combination of any of the foregoing.
  • Non-limiting examples of hydroxyalkyl starch phosphates and hydroxyalkyl distarch phosphates include hydroxyethyl starch phosphate, hydroxypropyl starch phosphate, hydroxypropyl distarch phosphate (including sodium hydroxypropyl starch phosphate), and any combination of any of the foregoing.
  • Non-limiting examples of suitable carbohydrate based rheological modifying agents include algin and derivatives and salts thereof, such as algin, calcium alginate, propylene glycol alginate, and ammonium alginate; carrageenan (Chondrus crispus) and derivatives and salts thereof, such as calcium carrageenan and sodium carrageenan; agar; cellulose and derivatives thereof, such as carboxymethyl hydroxyethylcellulose, cellulose gum, cetyl hydroxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methylcellulose, ethylcellulose, and cellulose gum; chitosan and derivatives and salts thereof, such as hydroxypropyl chitosan, carboxymethyl chitosan, and chitin; gellan gum; guar (Cyanopsis tetragonoloba) and derivatives thereof, such as guar hydroxypropyltrimonium chloride
  • Non-limiting examples of suitable polymeric and copolymeric rheological modifying agents include acrylates, methacrylates, polyethylene and derivatives thereof, and any combination of any of the foregoing.
  • Suitable acrylates and methacrylates include, but are not limited to, carbomer and derivatives and salts thereof, acrylate/C ⁇ o-C 3 o alkyl acrylate crosspolymer, acrylate/ceteth-20 itaconate copolymer, acrylate/ceteth-20 methacrylate copolymers, acrylate/steareth-20 methacrylate copolymers, acrylate/steareth-20 itaconate copolymers, acrylate/steareth-50 acrylate copolymers, acrylate/NA crosspolymers, acrylate/vinyl isodecanoate crosspolymers, acrylic acid/acrylonitrogen copolymers, ammonium acrylate/acrylonitrogen copolymers, glyceryl polymethacrylate, poly
  • suitable inorganic thickening agents include clays and derivatives thereof, silicates, silicas and derivatives thereof, and any combination of any of the foregoing.
  • Suitable clays and derivatives thereof include, but are not limited to, bentonite and derivatives thereof, such as quaternium- 18 bentonite; hectorite and derivatives thereof, such as quaternium- 18 dectorite; montmorillonite; and any combination of any of the foregoing.
  • Suitable silicates include, but are not limited to, magnesium aluminum silicate, sodium magnesium silicate, lithium magnesium silicate, tromethamine magnesium aluminum silicate, and any combination of any of the foregoing.
  • Suitable silicas and derivatives thereof include, but are not limited to, hydrated silica, hydrophobic silica, and any combination of any of the foregoing.
  • Suitable protein and polypeptide rheological modifying agents include, but are not limited to, proteins and derivatives and salts thereof, polypeptides and derivatives and salts thereof, and any combination of any of the foregoing.
  • Non-limiting examples of protein and polypeptide rheological modifying agents include albumin, gelatin, keratin and derivatives thereof, fish protein and derivatives thereof, milk protein and derivatives thereof, wheat protein and derivatives thereof, soy protein and derivatives thereof, elastin and derivatives thereof, silk protein and derivatives thereof, and any combination of any of the foregoing.
  • Preferred rheological modifying agents include, but are not limited to, carbomer, acrylate/alkyl acrylate crosspolymers, acrylate/vinyl isododecanoate crosspolymer, xantham gum, locust bean gum, guar gum, and any combination of any of the foregoing.
  • a more preferred combination of rheological modifying agents comprises carbomer and an acrylate/alkyl acrylate copolymer, such as an acrylate/C ⁇ o-C o alkyl acrylate crosspolymer.
  • carbomer is a homoporyrner of acrylic acid crosslinked with an allyl ether of pentaerythritol, an allyl ether of sucrose, or an allyl ether of propylene.
  • acrylate/alkyl acrylate crosspolymer includes, but is not limited to,
  • the base composition typically comprises from about 0.001 to about 50% and preferably from about 0.01 to about 10%, and more preferably from about 0.1 to about 5% by weight of rheological modifying agents.
  • the base composition typically comprises from about 0.001 to about 99.99%, preferably from about 1 to about 99.99%, and more preferably from about 20 to about 99.99% by weight of water.
  • the sunscreen formulation contains from about 0.1 to about 60% by weight, preferably from about 1 to about 60% by weight, and more preferably from about 10 to about 50% by weight of the sunscreen agent containing dispersion, based upon 100% weight of total sunscreen formulation.
  • the sunscreen formulation also typically contains from about 0.01 to about 100% by weight, preferably from about 0.1 to about 90% by weight, and more preferably from about 5 to about 80% by weight of the base composition, based upon
  • the sunscreen formulation is substantially free of (emulsifying) surfactants.
  • composition preferably contains less than about 3% by weight and more preferably less than about 1% by weight of surfactants, based upon 100% weight of total composition.
  • hydrophobic ingredients which are not in the form of dispersions are not included in the sunscreen formulation, or at least not in any substantial amounts.
  • composition of the present invention may also include active agents and adjuvants, including those described in Remington 's Pharmaceutical Sciences, 19 Edition, A.
  • Hydrophobic active agents and hydrophobic adjuvants are preferably incorporated into the formulation as dispersions.
  • the sunscreen formulation may be a cream, gel, lotion, serum or spray.
  • the sunscreen formulation of the present invention may be topically applied to the skin or hair of an animal, such as a human, to protect skin or hair from ultraviolet radiation and reduce water penetration in the skin and hair.
  • Suitable active agents include, but are not limited to, anti-acne agents, antimicrobial agents, antiinflammatory agents, analgesics, antierythemal agents, antipruritic agents, antiedemal agents, antipsoriatic agents, antifungal agents, skin protectants, vitamins, antioxidants, scavengers, antiirritants, antibacterial agents, antiviral agents, antiaging agents, protoprotection agents, hair growth enhancers, hair growth inhibitors, hair removal agents, antidandruff agents, anti-seborrheic agents, exfoliating agents, wound healing agents, anti- ectoparacitic agents, sebum modulators, immunomodulators, hormones, botanicals, moisturizers, astringents, cleansers, sensates, antibiotics, anesthetics, steroids, tissue healing substances, tissue regenerating substances, amino acids, peptides, minerals,
  • the composition preferably includes at least one aesthetic modifying agent.
  • An aesthetic modifying agent is a material that imparts desirable tactile, olfactory, taste or visual properties to the surface to which the composition is applied.
  • the aesthetic modifying agent may be hydrophobic or hydrophilic.
  • the aesthetic modifying agent is preferably hydrophobic and is more preferably an oil, wax, solid or paste.
  • a dispersion of one or more hydrophobic aesthetic modifying agents is preferably prepared before the hydrophobic aesthetic modifying agents are incorporated into the composition.
  • the hydrophobic aesthetic modifying agents may be dispersed into an aqueous phase by methods known in the art, such as by ultra high shear mixing and microfluidization.
  • the final composition may be prepared by mixing the dispersions containing the hydrophobic aesthetic modifying agents with the base composition and any other adjuvants. Since the hydrophobic aesthetic modifying agents are added to the base composition as dispersions, heating and other expensive processing steps are not required to obtain a homogenous final composition.
  • An example of an aesthetic modifying agent is a mono, di, tri or poly alkyl ester or ether of a di, tri, or polyhydroxy compound, such as ethylene glycol, propylene glycol, glycerin, sorbitol or other polyol compound.
  • hydrophobic aesthetic modifying agent is a compound having the formula C n H(2 n+ 2- m) wherein n is an integer greater than or equal to 6 and m is 0 or an even integer no greater than n.
  • Such compounds include, but are not limited to, saturated and unsaturated, linear, branched, and cyclic hydrocarbon chains.
  • Preferred examples of such compounds include, but are not limited to mineral oil, petrolatum, permethyl fluids, polybutylenes, and polyisobutylenes.
  • Another example of a hydrophobic aesthetic modifying agent has the formula
  • Ri is a saturated or unsaturated, linear, branched or cyclic C ⁇ -C2 4 alkyl group
  • R2 is hydrogen or a saturated or unsaturated, liner, branched or cyclic C ⁇ -C2 4 alkyl group
  • n is an integer from 0 to 20.
  • aesthetic modifying agents include, but are not limited to, isopropyl palmitate and diisopropyl adipate.
  • esters and ethers include but are not limited to, saturated and unsaturated, linear and branched vegetable oils, such as soybean oil, babassu oil, castor oil, cottonseed oil, Chinese tallow oil, crambe oil, perilla oil, danish rapeseed oil, rice bran oil, palm oil, palm kernel oil, olive oil, linseed oil, coconut oil, sunflower oil, safflower oil, peanut oil and corn oil.
  • Preferred saturated and unsaturated vegetable oils are those having fatty acid components with 6 to 24 carbon atoms.
  • a more preferred vegetable oil is soybean oil.
  • Silicone may provide lubrication and/or shine to the composition.
  • the silicone is insoluble in water.
  • Suitable water-insoluble silicone materials include, but are not limited to, polyalkylsiloxanes, polyarylsiloxanes, polyalkylarylsiloxanes, polysiloxane gums and polyethersiloxane copolymers. Examples of suitable silicone materials are disclosed in U.S. PatentNos. 4,788,006; 4,341,799; 4,152,416; 3,964,500; 3,208,911; 4,364,837 and 4,465,619, all of which are incorporated herein by reference.
  • Another suitable hydrophobic material which can be suspended in the composition has the formula
  • Ri is a saturated or unsaturated, linear, branched or cyclic alkyl having 2 to 24 carbon atoms
  • M (+) is N + R 2 R 3 R 4 R 5 ;
  • R 2 , R 3 and P are hydrogen or a saturated or unsaturated, linear or branched alkyl or hydroxyalkyl having from 1 to 10 carbon atoms;
  • R 5 is a saturated or unsaturated, linear, branched or cyclic alkyl or substituted alkyl having 2 to 24 carbon atoms.
  • An example of such a material is lauramine oleate.
  • Suitable adjuvants which may be incorporated in the sunscreen formulation include, but are not limited to, pH adjusters, emollients, conditioning agents, moisturizers, chelating agents, gelling agents, colorants, fragrances, odor masking agents, UV stabilizer, preservatives, and any combination of any of the foregoing.
  • Preferred pH adjusters include, but are not limited to, aminomethyl propanol, aminomethylpropane diol, triethanolamine, triethylamine, citric acid, sodium hydroxide, acetic acid, potassium hydroxide, lactic acid, and any combination of any of the foregoing.
  • Suitable conditioning agents include, but are not limited to, cyclomethicone; petrolatum; dimethicone; dimethiconol; silicone, such as cyclopentasiloxane and diisostearoyl trimethylolpropane siloxy silicate; sodium hyaluronate; isopropyl palmitate; soybean oil; linoleic acid; PPG-12/saturated methylene diphenyldiisocyanate copolymer; urea; amodimethicone; trideceth-12; cetrimonium chloride; diphenyl dimethicone; propylene glycol; glycerin; quaternary amines; and any combination of any of the foregoing Suitable preservatives include, but are not limited to, chlorophenesin, sorbic acid, disodium ethylenedinitrilotetraacetate, phenoxyethanol, methylparaben, ethylparaben, propylparab
  • Compositions 1-5 in Table 1 are dispersions of organic sunscreens in water.
  • phase A The ingredients in phase "A” were combined and mixed, and the mixture was heated until a uniform solution was formed.
  • the ingredients in phase “B” were combined and mixed at ambient conditions until a uniform solution was formed.
  • Phase A was combined with phase B using high shear homogenization followed by high pressure/high shear mixing until a particle size of less than 1000 nm and preferably 250-500 nm was obtained.
  • Composition 6 in Table 2 is an example of a finished goods formulation comprising an emulsion, prepared using conventional materials and processing. This emulsion was manufactured as follows:
  • Phase A was mixed until homogenous.
  • Phase B was added to A (step 1). The mixture was heated on a water bath to 75-80°C, and propel mixed until homogenous. 3. Phase C was heated to 80°C on a water bath until homogenous, and Phase D was added; the temperature was maintained at 80°C.
  • Phase (C+D) (step 3) was added to Phase (A+B) (step 2) at approximately 80°C.
  • step 4 The mixture of step 4 was homogenized using a Silverson mill for about 5 minutes.
  • the homogenate was cooled using a cold water bath. When the temperature was approximately 40°C, Phase E was added, and the mixture was mixed using a propel.
  • Phase F was added to the mixture of step 6 and the mixture was mixed using a propel until the mixture was homogenous.
  • compositions 7-23 in Tables 3-6 are surfactant-free finished goods formulations of the present invention containing dispersions prepared using high pressure/high shear technology.
  • Compositions 7-9 in Table 3 were prepared as follows:
  • Phase A The remaining ingredients in Phase A were added sequentially and mixed until completely uniform.
  • Phase B With paddle blade agitation, the ingredients in Phase B were added to Phase A (step 2) and mixed until completely uniform.
  • compositions 10-12 in Table 4 were prepared as follows:
  • Phase A The remaining ingredients in Phase A were added sequentially and mixed until completely uniform.
  • Phase B With paddle blade agitation, the ingredients in Phase B were added to Phase A (step 2) and mixed until homogenous.
  • Phase C The ingredients in Phase C were sequentially added to Phase (A+B) (step 3) and mixed until completely uniform.
  • compositions 13-17 in Table 5 were prepared as follows:
  • Phase A The remaining ingredients in Phase A were added sequentially and mixed until completely uniform.
  • Phase B With paddle blade agitation, the ingredients in Phase B were sequentially added to Phase A (step 2) and mixed until homogenous.
  • Phase C The ingredients in Phase C were sequentially added to Phase (A+B) (step 3) and mixed until completely uniform.
  • compositions 18-23 in Table 6 were prepared as follows:
  • Phase A The remaining ingredients in Phase A were added sequentially and mixed until completely uniform.
  • Phase B With paddle blade agitation, the ingredients in Phase B were sequentially added to Phase A (step 2) and mixed until homogenous.
  • Example 2 SPF Values of the Compositions of the Present Invention Panels were convened to evaluate the effectiveness of seven test materials as sunscreen products by determining the static and/or water resistant Sun Protection Factor (SPF) on human skin according to a procedure similar to that in the Tentative Final Monograph, "Sunscreen Drug Products For Over-The-Counter Human Drugs", (Federal Register Volume 58, Number 90 pages 28194-28302, 1993) using a Xenon arc solar simulator as the UV source.
  • SPF Sun Protection Factor
  • ii Standards of exclusion from the study: a. Individuals who are under doctor's care. b. Individuals who are currently taking any medication (topical or systemic) that may mask or interfere with the test results. c. Subjects with a history of any form of skin cancer, melanoma, lupus, psoriasis, connective tissue disease, diabetes or any disease that would increase the risk associated with study participation. d. Individuals diagnosed with chronic skin allergies. e. Individuals with a history of adverse effects upon sun exposure. f. Female volunteers who indicate that they are pregnant or nursing. g. Individuals with blemishes, nevi, sunburn, suntan, scars, moles, active dermal lesions or uneven pigmentation in the test sites. h. Individuals with known hypersensitivity to any sunscreen products. A trained technician performed a physical examination of the panelist's back to determine if study eligibility criteria were satisfied.
  • Panel composition Healthy volunteers over the age of 18 years were recruited for this study.
  • the panel consisted of fair-skin individuals with skin types I, II or III defined as follows
  • Type I Always burns easily; never tans Type II - Always burns easily; tans minimally Type III - Burns moderately; tans gradually - Based on the first 30 to 45 minutes sun exposure after a winter season of no sun exposure.
  • the light source employed was a 150 watt Xenon Arc Solar Simulator (Solar Light Co., Philadelphia, Pennsylvania, Model 12S, Model 14S or Model 600) having a continuous emission spectrum in the UVB range from 290 to 320 nm.
  • Xenon arc was selected on the basis of its black body radiation temperature of 6000° K which produced continuous UV spectra (All wavelengths) substantially equivalent to that of natural sunlight.
  • This device was equipped with a dichroic mirror (which reflects all radiation below 400nm) and worked in conjunction with a 1 mm thick Schott WG-320 filter (which absorbed all radiation below 290nm) to produce simulation of the solar UVA- UVB spectrum.
  • a 1 mm thick UG 11 filter black lens
  • UVB radiation was monitored continuously during exposure using a Model DCS-1 Sunburn UV Meter/Dose Controller System (Solar Light Co.) formerly known as the Robertson-Berger Sunburn Meter (R-B meter). Measurements were taken at a position within 8 mm from the surface of the skin. The field of irradiation was 1 cm in diameter.
  • the solar simulator was allowed a warm up time of at least 15 minutes before use and power supply output was recorded. Realignment of the Light Sources and calibration of the sunburn meters were conducted semi-annually by independent certification facilities and more often as necessary at the discretion of the operating technician or investigator.
  • the infrascapular area of the back to the right and left of the midline was used. Within this area, 50 cm 2 rectangular test sites were delineated with a gentian violet surgical skin marker. Sites were observed to ensure uniform pigmentation, skin tone and texture, and absence of warts, moles, nevi, scars, blemishes and active dermal lesions. Any areas that might be expected to produce erratic results were not used for UV exposures. *
  • test material and 8% homosalate standard were shaken and/or swirled with a glass rod before use and were evenly applied using plastic volumetric syringes to rectangular areas measuring 5 cm x 10 cm (50 cm 2 ) for a final concentration of 2.0 mg/cm . Evenness of application was verified by observation with a Woods Lamp.
  • SPF 15 MED times 0.69x, 0.83x, 0.91x, l.OOx, 1.09x, 1.20x and 1.44x where x equals the expected SPF of the product.
  • This test was employed to determine the substantivity of a test product and its ability to resist water immersion.
  • On the day of the test following exposure of the homosalate standard, MED's and static determination, another area measuring 5 cm x 10 cm, was designated. Again the test product was spread uniformly throughout the area at a concentration of 2.0 mg/cm 2 , then allowed a fifteen minute drying period as before.
  • One other adjacent site was selected to perform a waterproof SPF bracketing the intended label claim of the test material. Immersion was achieved indoors in a whirlpool tub with water circulating by a 1 h.p. pump at 3450 RPM. Each panelist spent twenty minutes in the water, immediately followed by a twenty minute rest period out of the water until a total of forty minutes in the water was achieved.
  • the whirlpool bath was maintained at an average temperature of 74-89°F at moderate agitation. After the last immersion, the test sites were air dried without toweling for at least fifteen minutes prior to irradiation. The water and air temperatures and relative humidity were recorded.
  • the second series of test material exposures was administered to the protected area.
  • the exact series of exposures given was determined by the MED and the expected SPF of the product as before.
  • UV exposures were not the same person to have applied the sunscreen product to the test site or to have administered the doses of UV radiation.
  • the label SPF was the largest whole number less than the mean SPF minus A.
  • PCD Product Category Designation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une formulation de filtre solaire caractérisée par une protection anti-ultraviolets et une résistance à l'eau supérieures par rapport aux compositions de filtres solaires de l'état de la technique. Cette formulation de filtre solaire contient: (a) une dispersion renfermant un principe actif de filtre solaire et (b) une composition de base renfermant un agent de modification rhéologique, et de l'eau. La formulation de filtre solaire est pratiquement exempte de tensioactifs. Selon un mode préféré de réalisation, le principe actif de filtre solaire est l'éthylhexylméthoxycinnamate, ou le butylméthoxydibenzoylméthane, ou une association des deux. De préférence, la formulation de filtre solaire contient un dérivé d'amidon phosphorylé comme agent de modification rhéologique. Un autre mode de réalisation de l'invention concerne une méthode de protection de la peau ou des cheveux contre le rayonnement ultraviolet, consistant à appliquer une quantité efficace de cette formulation de filtre solaire sur la peau ou les cheveux.
PCT/US2001/021588 2000-07-07 2001-07-09 Composition de filtre solaire presentant un facteur de protection solaire (fps) et une resistance a l'eau ameliores Ceased WO2002003929A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/332,393 US20030228267A1 (en) 2001-07-09 2001-07-09 Suncreen composition wit enhanced spf and water resistant properties
AU2001278885A AU2001278885A1 (en) 2000-07-07 2001-07-09 Sunscreen composition with enhanced spf and water resistant properties
US11/114,668 US7175834B2 (en) 2000-07-07 2005-04-26 Sunscreen composition with enhanced SPF and water resistant properties

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21657300P 2000-07-07 2000-07-07
US60/216,573 2000-07-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/332,393 Continuation US20030228267A1 (en) 2000-07-07 2001-07-09 Suncreen composition wit enhanced spf and water resistant properties
US11/114,668 Continuation US7175834B2 (en) 2000-07-07 2005-04-26 Sunscreen composition with enhanced SPF and water resistant properties

Publications (1)

Publication Number Publication Date
WO2002003929A1 true WO2002003929A1 (fr) 2002-01-17

Family

ID=22807604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021588 Ceased WO2002003929A1 (fr) 2000-07-07 2001-07-09 Composition de filtre solaire presentant un facteur de protection solaire (fps) et une resistance a l'eau ameliores

Country Status (2)

Country Link
AU (1) AU2001278885A1 (fr)
WO (1) WO2002003929A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003013246A1 (fr) * 2001-08-06 2003-02-20 Dow Corning Corporation Dispersion aqueuse de particules durcies de caoutchouc de silicone
EP1389459A1 (fr) * 2002-08-16 2004-02-18 Beiersdorf AG Utilisation des phosphates d'amidon hydroxypropylés
US6783766B2 (en) 2002-03-06 2004-08-31 Dow Global Technologies Inc. Process for preparing a cosmetic formulation
JP2004329014A (ja) * 2003-04-30 2004-11-25 Id Technica:Kk 偽造行為防止機能を備えた識別手段を付加する識別添加物質及び識別情報保持物並びに識別情報保持物の不正使用検出方法
WO2008092674A1 (fr) * 2007-02-01 2008-08-07 Beiersdorf Ag Combinaison de filtrage uv comprenant des dérivés de pipérazine
EP2153813A1 (fr) * 2008-08-15 2010-02-17 Lonza, Inc. Mélanges synergiques de conservateurs
US8097264B2 (en) * 2003-07-01 2012-01-17 HallStar Italia S.r.l. Natural emulsifying agent
US20120128609A1 (en) * 2008-11-13 2012-05-24 Sergio Amari Cosmetic use of natural emulsifiers
US8796217B2 (en) 2008-01-25 2014-08-05 HallStar Italia S.r.l. Use of transesterified olive oil in the cosmetic field
EP2982363A1 (fr) 2014-08-04 2016-02-10 Omya International AG Système à deux composants pour formulations cosmétiques
US9549891B2 (en) 2012-03-19 2017-01-24 The Procter & Gamble Company Superabsorbent polymers and sunscreen actives for use in skin care compositions
US10285926B2 (en) 2015-06-29 2019-05-14 The Procter & Gamble Company Superabsorbent polymers and starch powders for use in skin care compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968528A (en) * 1997-05-23 1999-10-19 The Procter & Gamble Company Skin care compositions
US5972359A (en) * 1997-05-23 1999-10-26 The Procter & Gamble Company Skin care compositions and method of improving skin appearance
US5997890A (en) * 1997-05-23 1999-12-07 The Procter & Gamble Company Skin care compositions and method of improving skin appearance

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968528A (en) * 1997-05-23 1999-10-19 The Procter & Gamble Company Skin care compositions
US5972359A (en) * 1997-05-23 1999-10-26 The Procter & Gamble Company Skin care compositions and method of improving skin appearance
US5997890A (en) * 1997-05-23 1999-12-07 The Procter & Gamble Company Skin care compositions and method of improving skin appearance

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003013246A1 (fr) * 2001-08-06 2003-02-20 Dow Corning Corporation Dispersion aqueuse de particules durcies de caoutchouc de silicone
US6783766B2 (en) 2002-03-06 2004-08-31 Dow Global Technologies Inc. Process for preparing a cosmetic formulation
US7056496B2 (en) 2002-03-06 2006-06-06 Dow Global Technologies Inc. Sunscreen composition and a process for preparing it
EP1389459A1 (fr) * 2002-08-16 2004-02-18 Beiersdorf AG Utilisation des phosphates d'amidon hydroxypropylés
JP2004329014A (ja) * 2003-04-30 2004-11-25 Id Technica:Kk 偽造行為防止機能を備えた識別手段を付加する識別添加物質及び識別情報保持物並びに識別情報保持物の不正使用検出方法
US8097264B2 (en) * 2003-07-01 2012-01-17 HallStar Italia S.r.l. Natural emulsifying agent
WO2008092674A1 (fr) * 2007-02-01 2008-08-07 Beiersdorf Ag Combinaison de filtrage uv comprenant des dérivés de pipérazine
US8796217B2 (en) 2008-01-25 2014-08-05 HallStar Italia S.r.l. Use of transesterified olive oil in the cosmetic field
WO2009146800A3 (fr) * 2008-06-03 2010-07-22 Lonza Inc. Mélanges synergétiques de conservateurs
AU2009254255B2 (en) * 2008-06-03 2014-02-27 Lonza Inc. Synergistic preservative blends
EA021050B1 (ru) * 2008-06-03 2015-03-31 Лонца Инк. Синергетические профилактические смеси
EP2153813A1 (fr) * 2008-08-15 2010-02-17 Lonza, Inc. Mélanges synergiques de conservateurs
US20120128609A1 (en) * 2008-11-13 2012-05-24 Sergio Amari Cosmetic use of natural emulsifiers
US9549891B2 (en) 2012-03-19 2017-01-24 The Procter & Gamble Company Superabsorbent polymers and sunscreen actives for use in skin care compositions
US9839598B2 (en) 2012-03-19 2017-12-12 The Procter & Gamble Company Superabsorbent polymers and sunscreen actives for use in skin care compositions
EP2982363A1 (fr) 2014-08-04 2016-02-10 Omya International AG Système à deux composants pour formulations cosmétiques
US10285926B2 (en) 2015-06-29 2019-05-14 The Procter & Gamble Company Superabsorbent polymers and starch powders for use in skin care compositions

Also Published As

Publication number Publication date
AU2001278885A1 (en) 2002-01-21

Similar Documents

Publication Publication Date Title
US7175834B2 (en) Sunscreen composition with enhanced SPF and water resistant properties
JP3596891B2 (ja) 植物の抽出物を含むサンスクリーン
US6197281B1 (en) Wet appliable, instant protection sunscreen and makeup and method of use
CN1547475B (zh) 含电子转移试剂的磷酸酯衍生物的皮肤制剂
US6692728B2 (en) Polyesters based on hydroxy fatty acids and lower hydroxy alkyl acids and uses thereof
JP2000063263A (ja) サリチル酸又はサリチル酸誘導体を含む化粧品及び／又は皮膚科学的組成物及びその使用
US20160136083A1 (en) Personal Care Products That Do Not Contain Tetramer And/or Pentamer Cyclomethicones
US11304887B2 (en) Synergistic photoprotective compositions
US11497942B2 (en) Cosmetic or dermatological preparation comprising a combination of a dye and an anti-inflammatory active ingredient
WO2002003929A1 (fr) Composition de filtre solaire presentant un facteur de protection solaire (fps) et une resistance a l'eau ameliores
JP2007533690A (ja) 日焼け用製品セットおよび日焼け用製品で肌を手入れする美容方法
JP3842558B2 (ja) 角質層機能の増強のための硫酸コレステロール組成物
ES2562494T3 (es) Composiciones estabilizadas para administración tópica y métodos para preparar las mismas
CN1357321A (zh) 减少炎症和红斑的方法
JP3766070B2 (ja) 紫外線防御効果を有する耐水性ｏ／ｗ型化粧料
JP2003095844A (ja) 化粧料
KR101289431B1 (ko) 캠페리트린을 함유한 자외선 차단 화장료 조성물
JP7091282B2 (ja) ジェル状化粧料
JP2003055185A (ja) 皮膚外用剤
EP4327824A1 (fr) Composition topique comprenant du chlore e6 et du du l-pyroglutamate de zinc
CA2156930C (fr) Ecrans solaires a base d'extraits de plantes
EP3013313B1 (fr) Compositions photoprotectrices non irritantes, non blanchissantes
JPH1192327A (ja) 清涼感組成物

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM EC EE ES FI GB GD GE HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10332393

Country of ref document: US

122 Ep: pct application non-entry in european phase
WWE Wipo information: entry into national phase

Ref document number: 11114668

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP