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WO2002003919A3 - Structural targets in hepatitis c virus ires element - Google Patents

Structural targets in hepatitis c virus ires element Download PDF

Info

Publication number
WO2002003919A3
WO2002003919A3 PCT/US2001/021871 US0121871W WO0203919A3 WO 2002003919 A3 WO2002003919 A3 WO 2002003919A3 US 0121871 W US0121871 W US 0121871W WO 0203919 A3 WO0203919 A3 WO 0203919A3
Authority
WO
WIPO (PCT)
Prior art keywords
loop
hepatitis
domain
ires element
virus ires
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/021871
Other languages
French (fr)
Other versions
WO2002003919A2 (en
WO2002003919A9 (en
Inventor
Joseph D Puglisi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Priority to AU2001273365A priority Critical patent/AU2001273365A1/en
Priority to US10/332,626 priority patent/US20040073380A1/en
Publication of WO2002003919A2 publication Critical patent/WO2002003919A2/en
Publication of WO2002003919A3 publication Critical patent/WO2002003919A3/en
Anticipated expiration legal-status Critical
Publication of WO2002003919A9 publication Critical patent/WO2002003919A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Molecular structures, computer representations thereof, and methods of analysis are provided for the hepatitis C virus internal ribosome entry site (HCV IRES). Novel features of the structure include the tetraloop fold in domain IIIe, including the array of three major groove exposed Watson-Crick faces (G295, A296, and U297), which loop has been found to be a point of direct contact with the 40S subunit; and the structure comprising the domain IIId loop E and hairpin loop backdone reversion, which places two S turns on the same side of hairpin loop structure.
PCT/US2001/021871 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element Ceased WO2002003919A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001273365A AU2001273365A1 (en) 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element
US10/332,626 US20040073380A1 (en) 2001-07-10 2001-07-10 Structural targets in hepatittis c virus ires element

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21767300P 2000-07-10 2000-07-10
US60/217,673 2000-07-10

Publications (3)

Publication Number Publication Date
WO2002003919A2 WO2002003919A2 (en) 2002-01-17
WO2002003919A3 true WO2002003919A3 (en) 2002-04-18
WO2002003919A9 WO2002003919A9 (en) 2003-04-03

Family

ID=22812031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021871 Ceased WO2002003919A2 (en) 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element

Country Status (2)

Country Link
AU (1) AU2001273365A1 (en)
WO (1) WO2002003919A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017616A1 (en) * 1997-10-07 1999-04-15 New England Medical Center Hospitals, Inc. Structure-based rational design of compounds to inhibit papillomavirus infection
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
WO1999017616A1 (en) * 1997-10-07 1999-04-15 New England Medical Center Hospitals, Inc. Structure-based rational design of compounds to inhibit papillomavirus infection

Also Published As

Publication number Publication date
WO2002003919A2 (en) 2002-01-17
WO2002003919A9 (en) 2003-04-03
AU2001273365A1 (en) 2002-01-21

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