[go: up one dir, main page]

WO2002003919A3 - Structural targets in hepatitis c virus ires element - Google Patents

Structural targets in hepatitis c virus ires element Download PDF

Info

Publication number
WO2002003919A3
WO2002003919A3 PCT/US2001/021871 US0121871W WO0203919A3 WO 2002003919 A3 WO2002003919 A3 WO 2002003919A3 US 0121871 W US0121871 W US 0121871W WO 0203919 A3 WO0203919 A3 WO 0203919A3
Authority
WO
WIPO (PCT)
Prior art keywords
loop
hepatitis
domain
ires element
virus ires
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/021871
Other languages
French (fr)
Other versions
WO2002003919A2 (en
WO2002003919A9 (en
Inventor
Joseph D Puglisi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Priority to AU2001273365A priority Critical patent/AU2001273365A1/en
Priority to US10/332,626 priority patent/US20040073380A1/en
Publication of WO2002003919A2 publication Critical patent/WO2002003919A2/en
Publication of WO2002003919A3 publication Critical patent/WO2002003919A3/en
Anticipated expiration legal-status Critical
Publication of WO2002003919A9 publication Critical patent/WO2002003919A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Molecular structures, computer representations thereof, and methods of analysis are provided for the hepatitis C virus internal ribosome entry site (HCV IRES). Novel features of the structure include the tetraloop fold in domain IIIe, including the array of three major groove exposed Watson-Crick faces (G295, A296, and U297), which loop has been found to be a point of direct contact with the 40S subunit; and the structure comprising the domain IIId loop E and hairpin loop backdone reversion, which places two S turns on the same side of hairpin loop structure.
PCT/US2001/021871 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element Ceased WO2002003919A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001273365A AU2001273365A1 (en) 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element
US10/332,626 US20040073380A1 (en) 2001-07-10 2001-07-10 Structural targets in hepatittis c virus ires element

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21767300P 2000-07-10 2000-07-10
US60/217,673 2000-07-10

Publications (3)

Publication Number Publication Date
WO2002003919A2 WO2002003919A2 (en) 2002-01-17
WO2002003919A3 true WO2002003919A3 (en) 2002-04-18
WO2002003919A9 WO2002003919A9 (en) 2003-04-03

Family

ID=22812031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021871 Ceased WO2002003919A2 (en) 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element

Country Status (2)

Country Link
AU (1) AU2001273365A1 (en)
WO (1) WO2002003919A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017616A1 (en) * 1997-10-07 1999-04-15 New England Medical Center Hospitals, Inc. Structure-based rational design of compounds to inhibit papillomavirus infection
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
WO1999017616A1 (en) * 1997-10-07 1999-04-15 New England Medical Center Hospitals, Inc. Structure-based rational design of compounds to inhibit papillomavirus infection

Also Published As

Publication number Publication date
WO2002003919A2 (en) 2002-01-17
AU2001273365A1 (en) 2002-01-21
WO2002003919A9 (en) 2003-04-03

Similar Documents

Publication Publication Date Title
WO2004014852A3 (en) Iminothiazolidinones as inhibitors of hcv replication
DK1706457T3 (en) PREPARATION OF 3-HYDROXYPROPIONIC ACID USING BETA-ALANINE / PYRUVATAMINOTRANSPHERASE
EE200300102A (en) Methods for delaying the recovery of herpes virus symptoms
NO20014626D0 (en) Stabilized bromine solutions, method of preparation and use thereof for bio pollution control
AU2003284689A1 (en) NUCLEIC ACID CONSTRUCT CONTAINING HEPATITIS C VIRUS (HCV) OF GENOCYPE 2a GENOME-ORIGIN NUCLEIC ACID AND CELL HAVING THE NUCLEIC ACID CONSTRUCT TRANSFERRED THEREINTO
DE50110932D1 (en) Exhaust system with Helmholtz resonator
AU2002221033A1 (en) Cells to be used in producing virus vector, process for producing the same and process for producing virus vector with the use of the cells
ATE481494T1 (en) TWO-COMPONENT PLANT EXPRESSION SYSTEM DERIVED FROM RNA VIRUSES
DE60115463D1 (en) SPECTROMETRICAL INSTRUMENT WITH SMALL BURN AND REDUCED POLARIZATION
NO20030239L (en) Modified virus
NO20024632D0 (en) Multistage combustion for fuel processing for use with fuel cell
IS5777A (en) Vaccine hepatitis B virus variants and its use
WO2002003919A3 (en) Structural targets in hepatitis c virus ires element
AU3605901A (en) Nucleic acid sequences showing enhanced expression in benign neuroblastoma compared with acritical human neuroblastoma
AU3184701A (en) Mutated hepatitis B virus, its nucleic and protein constituents and uses thereof
NO20024105L (en) Memnopeptides, Methods for their Preparation and Use
FI20001477A0 (en) Influenza virus binding substance and its use
AU2001249928A1 (en) Full-length gb virus c (hepatitis g virus) rna transcripts are infectious in primary cd4 positive t cells and methods of treating hiv
SE0102198D0 (en) New sequences
AU2001257505A1 (en) Hepatitis c virus helicase crystals, crystallographic structure and methods
AU2001256745A1 (en) Vector for analysing replication mechanism of rna virus and use thereof
王雪松 et al. Nonlinear optimization method of radar target polarization enhancement
AU2003257299A1 (en) Method for inducing complete hepatitis c virus (hcv) replication in vitro
ES2172383B1 (en) PROCEDURE FOR THE CONSTRUCTION OF POLICISTRONIC RETROVIRAL VECTORS.
Horning HISTORY OF BIOLOGY

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

COP Corrected version of pamphlet

Free format text: PAGES 1/11-11/11, DRAWINGS, REPLACED BY NEW PAGES 1/9-9/9; DUE TO LATE TRANSMITTAL BY THE RECEIVINGOFFICE

122 Ep: pct application non-entry in european phase
WWE Wipo information: entry into national phase

Ref document number: 10332626

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP